SwissPalm

Protein general information from UniProt

Protein names

Uninflatable, isoform C; Uninflatable, isoform D; Uninflatable, isoform E; Uninflatable, isoform F

Subcellular location

Isoforms & protein length

Isoform 1 (main): 3589 aa

Known functions

Source	Identifiers
UniProt gene names	Dmel_CG9138, CG9138, Uif, sp1070, SP1070, poly-EGF, Poly-EGF, Dmel\CG9138, CT26172, uif

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Techniques	Sites	Predicted
Q61406	Q61406_MOUSE	MetaPhors	M. musculus	Cfhl1, Cfhr1	Complement factor H-related 1	0/17	0	0	No
Q4LDF6	Q4LDF6_MOUSE	MetaPhors	M. musculus	Cfhrb_4/2, Cfh, BC026782, Cfhr2	Complement factor H-related 2	0/17	0	0	No
F1MNH3	F1MNH3_BOVIN	InParanoid	B. taurus	SVEP1	Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0/1	0	0	Yes
Q8BH32	SUSD4_MOUSE	MetaPhors	M. musculus	Susd4	Sushi domain-containing protein 4	0/17	0	0	No
Q6P1D5	SE6L1_MOUSE	MetaPhors	M. musculus	Kiaa0927, Aig1l, Sez6l	Seizure 6-like protein	0/17	0	0	Yes
P08607	C4BPA_MOUSE	MetaPhors	M. musculus	C4bp, C4bpa	C4b-binding protein	0/17	0	0	Yes
Q61475	DAF1_MOUSE	MetaPhors	M. musculus	Daf1, Daf, Cd55a, Cd55	Complement decay-accelerating factor, GPI-anchored	0/17	0	0	No
Q01339	APOH_MOUSE	MetaPhors	M. musculus	B2gp1, Apoh	Beta-2-glycoprotein 1	2/17	1	5	Yes
G3X973	G3X973_MOUSE	MetaPhors	M. musculus	mCG_145753, Stab1	Stabilin 1, isoform CRA_a	1/17	1	5	Yes
F1MBG4	F1MBG4_BOVIN	MetaPhors	B. taurus	SUSD4	Sushi domain containing 4	0/1	0	0	No
D4A6P1	D4A6P1_RAT	MetaPhors	R. norvegicus	rCG_40132, Sez6l2	RCG40132, isoform CRA_a	0/2	0	0	Yes
D4A231	D4A231_RAT	MetaPhors	R. norvegicus	rCG_20488, RGD1564043_predicted, Susd4	Similar to RIKEN cDNA E430021N18	0/2	0	0	No
Q4LDE5	SVEP1_HUMAN	InParanoid	H. sapiens	SELOB, CCP22, C9orf13, SVEP1	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1	0/17	0	0	Yes
P0C6B8	SVEP1_RAT	InParanoid	R. norvegicus	Svep1	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1	0/2	0	0	Yes
A2AVA0	SVEP1_MOUSE	InParanoid	M. musculus	Svep1	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1	0/17	0	0	Yes
Q96WV6	YHU2_SCHPO	MetaPhors	S. pombe	SPBPJ4664.02	Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02	0/1	0	0	Yes
O43854	EDIL3_HUMAN	MetaPhors	H. sapiens	DEL1, EDIL3	EGF-like repeat and discoidin I-like domain-containing protein 3	0/17	0	0	No
Q02985	FHR3_HUMAN	MetaPhors	H. sapiens	FHR3, CFHL3, CFHR3	Complement factor H-related protein 3	0/17	0	0	Yes
Q5VX71	SUSD4_HUMAN	MetaPhors	H. sapiens	UNQ196/PRO222, SUSD4	Sushi domain-containing protein 4	0/17	0	0	No
Q03591	FHR1_HUMAN	MetaPhors	H. sapiens	HFL2, HFL1, FHR1, CFHR1P, CFHL1P, CFHL1, CFHL, CFHR1	Complement factor H-related protein 1	0/17	0	0	No
Q9BXR6	FHR5_HUMAN	MetaPhors	H. sapiens	FHR5, CFHL5, CFHR5	Complement factor H-related protein 5	0/17	0	0	Yes
P01133	EGF_HUMAN	MetaPhors	H. sapiens	EGF	Pro-epidermal growth factor	0/17	0	0	Yes
P36980	FHR2_HUMAN	MetaPhors	H. sapiens	HFL3, FHR2, CFHL2, CFHR2	Complement factor H-related protein 2	0/17	0	0	Yes
Q6V0I7	FAT4_HUMAN	MetaPhors	H. sapiens	Nbla00548, FATJ, CDHF14, FAT4	Protocadherin Fat 4	0/17	0	0	Yes
P98073	ENTK_HUMAN	MetaPhors	H. sapiens	PRSS7, ENTK, TMPRSS15	Enteropeptidase	0/17	0	0	Yes
Q29RN8	SE6L2_BOVIN	MetaPhors	B. taurus	SEZ6L2	Seizure 6-like protein 2	0/1	0	0	Yes
F1MRZ6	F1MRZ6_BOVIN	MetaPhors	B. taurus	TNC	Tenascin C	0/1	0	0	Yes
G3X6M2	G3X6M2_BOVIN	MetaPhors	B. taurus	CD55	Uncharacterized protein	0/1	0	0	Yes
F1MF04	F1MF04_BOVIN	MetaPhors	B. taurus	SEZ6L	Seizure related 6 homolog like	0/1	0	0	Yes
F1MAN8	F1MAN8_RAT	MetaPhors	R. norvegicus	rCG_38528, Lama5	Laminin subunit alpha 5	0/2	0	0	Yes

Ortholog sequence alignment (CLUSTALW)

Cysteine summary and predictions

Pos in alignment	36	47	64	142	159	167	172	179	184	191	197	206	210	236
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	no	no	no	no	yes	yes	yes	yes	yes	yes	no	no
PSIPRED v.4.02 prediction	coil	strand	helix	strand	coil	strand	coil	strand	strand	strand	coil	coil	coil	strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys³⁶ HC	Cys⁴⁷	Cys⁶⁴	Cys¹⁴²	Cys¹⁵⁹	Cys¹⁶⁷ MC	Cys¹⁷²	Cys¹⁷⁹	Cys¹⁸⁴	Cys¹⁹¹	Cys¹⁹⁷	Cys²⁰⁶ LC	Cys²¹⁰	Cys²³⁶

Pos in alignment	326	354	439	466	552	578	595	609	614	641	658	670	675	704
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	yes	yes	yes	no	yes	no	no	no	no	no	yes	yes
PSIPRED v.4.02 prediction	coil	strand	coil	strand	coil	strand	strand	strand	coil	strand	coil	strand	coil	strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys³²⁶	Cys³⁵⁴	Cys⁴³⁹	Cys⁴⁶⁶	Cys⁵⁵²	Cys⁵⁷⁸	Cys⁵⁹⁵	Cys⁶⁰⁹	Cys⁶¹⁴	Cys⁶⁴¹	Cys⁶⁵⁸	Cys⁶⁷⁰	Cys⁶⁷⁵	Cys⁷⁰⁴

Pos in alignment	718	731	736	764	778	790	796	801	808	817	819	829	869	969
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	yes	yes	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	strand	strand	coil	coil	strand	strand	coil	coil	strand	strand	strand	strand	coil	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁷¹⁸	Cys⁷³¹	Cys⁷³⁶	Cys⁷⁶⁴	Cys⁷⁷⁸	Cys⁷⁹⁰	Cys⁷⁹⁶	Cys⁸⁰¹	Cys⁸⁰⁸	Cys⁸¹⁷	Cys⁸¹⁹	Cys⁸²⁹	Cys⁸⁶⁹	Cys⁹⁶⁹ HC

Pos in alignment	977	982	988	995	999	1008	1010	1046	1051	1079	1093	1106	1111	1144
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	no	no	no	no	no	no	no	yes	no	yes	no	no
PSIPRED v.4.02 prediction	coil	strand	helix	coil	coil	strand	coil	strand	coil	strand	strand	strand	strand	strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁹⁷⁷	Cys⁹⁸²	Cys⁹⁸⁸	Cys⁹⁹⁵	Cys⁹⁹⁹	Cys¹⁰⁰⁸	Cys¹⁰¹⁰	Cys¹⁰⁴⁶	Cys¹⁰⁵¹	Cys¹⁰⁷⁹	Cys¹⁰⁹³	Cys¹¹⁰⁶	Cys¹¹¹¹	Cys¹¹⁴⁴

Pos in alignment	1162	1182	1187	1214	1233	1246	1251	1277	1292	1298	1339	1436	1444	1462
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	coil	coil	strand	strand	strand	coil	strand	strand	strand	coil	strand	strand	strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys¹¹⁶²	Cys¹¹⁸²	Cys¹¹⁸⁷	Cys¹²¹⁴	Cys¹²³³	Cys¹²⁴⁶	Cys¹²⁵¹	Cys¹²⁷⁷	Cys¹²⁹²	Cys¹²⁹⁸	Cys¹³³⁹	Cys¹⁴³⁶ HC	Cys¹⁴⁴⁴	Cys¹⁴⁶²

Pos in alignment	1473	1541	1557	1625	1636	1651	1660	1664	1681	1696	1724	1747	1792	1824
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	strand	coil	strand	coil	strand	strand	strand	strand	coil	helix	coil	coil	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys¹⁴⁷³	Cys¹⁵⁴¹	Cys¹⁵⁵⁷	Cys¹⁶²⁵	Cys¹⁶³⁶	Cys¹⁶⁵¹	Cys¹⁶⁶⁰	Cys¹⁶⁶⁴	Cys¹⁶⁸¹	Cys¹⁶⁹⁶	Cys¹⁷²⁴	Cys¹⁷⁴⁷	Cys¹⁷⁹²	Cys¹⁸²⁴

Pos in alignment	1840	1856	1859	1872	1875	1889	1892	1909	1913	1926	1929	1946	1949	1966
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	coil	coil	strand	coil	strand	coil	strand	coil	coil	coil	coil	coil	strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys¹⁸⁴⁰	Cys¹⁸⁵⁶	Cys¹⁸⁵⁹	Cys¹⁸⁷²	Cys¹⁸⁷⁵	Cys¹⁸⁸⁹	Cys¹⁸⁹²	Cys¹⁹⁰⁹	Cys¹⁹¹³	Cys¹⁹²⁶	Cys¹⁹²⁹	Cys¹⁹⁴⁶	Cys¹⁹⁴⁹	Cys¹⁹⁶⁶

Pos in alignment	1970	1983	1986	2000	2003	2020	2025	2030	2036	2045	2047	2056	2063	2068
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	no	no	no	no	no	no	no	no	yes	yes	no	no
PSIPRED v.4.02 prediction	coil	coil	coil	strand	coil	coil	coil	coil	strand	strand	coil	coil	helix	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys¹⁹⁷⁰	Cys¹⁹⁸³	Cys¹⁹⁸⁶	Cys²⁰⁰⁰	Cys²⁰⁰³	Cys²⁰²⁰	Cys²⁰²⁵	Cys²⁰³⁰	Cys²⁰³⁶	Cys²⁰⁴⁵	Cys²⁰⁴⁷	Cys²⁰⁵⁶	Cys²⁰⁶³	Cys²⁰⁶⁸

Pos in alignment	2074	2083	2085	2094	2101	2106	2112	2123	2125	2134	2141	2148	2154	2164
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	yes	yes	no	yes	no	yes	yes	yes	no	no	no	no
PSIPRED v.4.02 prediction	strand	strand	coil	coil	coil	coil	strand	strand	coil	coil	helix	coil	strand	strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys²⁰⁷⁴	Cys²⁰⁸³	Cys²⁰⁸⁵	Cys²⁰⁹⁴	Cys²¹⁰¹	Cys²¹⁰⁶	Cys²¹¹² HC	Cys²¹²³	Cys²¹²⁵	Cys²¹³⁴	Cys²¹⁴¹	Cys²¹⁴⁸	Cys²¹⁵⁴	Cys²¹⁶⁴

Pos in alignment	2166	2175	2182	2187	2193	2202	2204	2213	2220	2225	2230	2239	2241	2250
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	yes	yes	no	no	no	no	yes	yes	yes	no	yes	no	yes	yes
PSIPRED v.4.02 prediction	strand	coil	coil	coil	strand	strand	coil	coil	coil	coil	strand	strand	strand	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys²¹⁶⁶	Cys²¹⁷⁵	Cys²¹⁸²	Cys²¹⁸⁷	Cys²¹⁹³	Cys²²⁰²	Cys²²⁰⁴	Cys²²¹³	Cys²²²⁰	Cys²²²⁵	Cys²²³⁰	Cys²²³⁹	Cys²²⁴¹	Cys²²⁵⁰

Pos in alignment	2257	2262	2268	2277	2279	2288	2295	2300	2306	2315	2317	2326	2333	2338
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	no	no	yes	yes	no	no	no	no	yes	yes	no	yes
PSIPRED v.4.02 prediction	coil	coil	strand	strand	strand	coil	coil	coil	strand	strand	strand	coil	helix	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys²²⁵⁷	Cys²²⁶² LC	Cys²²⁶⁸	Cys²²⁷⁷	Cys²²⁷⁹	Cys²²⁸⁸	Cys²²⁹⁵	Cys²³⁰⁰	Cys²³⁰⁶	Cys²³¹⁵	Cys²³¹⁷	Cys²³²⁶	Cys²³³³	Cys²³³⁸

Pos in alignment	2346	2355	2357	2366	2373	2378	2384	2393	2395	2404	2411	2417	2423	2432
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	yes	yes	yes	no	no	no	no	yes	yes	no	no	no	no
PSIPRED v.4.02 prediction	strand	strand	strand	coil	helix	coil	strand	strand	strand	coil	coil	coil	strand	strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys²³⁴⁶	Cys²³⁵⁵	Cys²³⁵⁷	Cys²³⁶⁶	Cys²³⁷³	Cys²³⁷⁸	Cys²³⁸⁴	Cys²³⁹³	Cys²³⁹⁵	Cys²⁴⁰⁴	Cys²⁴¹¹	Cys²⁴¹⁷	Cys²⁴²³	Cys²⁴³²

Pos in alignment	2434	2443	2450	2455	2461	2470	2472	2481	2488	2493	2499	2508	2510	2519
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	yes	yes	no	no	no	no	yes	yes	no	no	no	no	yes	yes
PSIPRED v.4.02 prediction	coil	coil	helix	coil	strand	strand	coil	coil	helix	coil	strand	strand	coil	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys²⁴³⁴	Cys²⁴⁴³	Cys²⁴⁵⁰	Cys²⁴⁵⁵	Cys²⁴⁶¹	Cys²⁴⁷⁰	Cys²⁴⁷²	Cys²⁴⁸¹	Cys²⁴⁸⁸	Cys²⁴⁹³	Cys²⁴⁹⁹	Cys²⁵⁰⁸	Cys²⁵¹⁰	Cys²⁵¹⁹

Pos in alignment	2526	2531	2537	2546	2548	2557	2748	2780	2785	2794	2809	2873	2884	2897
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	no	no	yes	yes	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	helix	coil	strand	strand	coil	coil	coil	coil	coil	coil	coil	strand	coil	strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys²⁵²⁶	Cys²⁵³¹	Cys²⁵³⁷	Cys²⁵⁴⁶	Cys²⁵⁴⁸	Cys²⁵⁵⁷	Cys²⁷⁴⁸	Cys²⁷⁸⁰	Cys²⁷⁸⁵	Cys²⁷⁹⁴	Cys²⁸⁰⁹	Cys²⁸⁷³	Cys²⁸⁸⁴	Cys²⁸⁹⁷

Pos in alignment	2909	2913	2929	2950	2972	2998	3008	3017	3132	3143	3146	3159	3162	3176
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	strand	strand	coil	coil	coil	coil	strand	coil	coil	strand	coil	strand	coil	strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys²⁹⁰⁹	Cys²⁹¹³	Cys²⁹²⁹	Cys²⁹⁵⁰	Cys²⁹⁷²	Cys²⁹⁹⁸	Cys³⁰⁰⁸	Cys³⁰¹⁷	Cys³¹³²	Cys³¹⁴³	Cys³¹⁴⁶	Cys³¹⁵⁹	Cys³¹⁶²	Cys³¹⁷⁶

Pos in alignment	3179	3200	3204	3217	3220	3234	3237	3254	3258	3270	3273	3287	3290	3307
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	helix	coil	strand	coil	strand	coil	coil	coil	coil	coil	strand	coil	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys³¹⁷⁹	Cys³²⁰⁰	Cys³²⁰⁴	Cys³²¹⁷	Cys³²²⁰	Cys³²³⁴	Cys³²³⁷	Cys³²⁵⁴	Cys³²⁵⁸	Cys³²⁷⁰	Cys³²⁷³ LC	Cys³²⁸⁷	Cys³²⁹⁰	Cys³³⁰⁷

Pos in alignment	3312	3325	3328	3342	3345	3362	3366	3376	3382	3393	3395	3406	3410	3414
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	no	no	no	no	no	yes	yes	yes	no	no	yes	no
PSIPRED v.4.02 prediction	coil	strand	strand	strand	coil	strand	coil	coil	strand	strand	strand	strand	coil	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys³³¹²	Cys³³²⁵	Cys³³²⁸	Cys³³⁴²	Cys³³⁴⁵	Cys³³⁶²	Cys³³⁶⁶	Cys³³⁷⁶	Cys³³⁸²	Cys³³⁹³	Cys³³⁹⁵	Cys³⁴⁰⁶ MC	Cys³⁴¹⁰ HC	Cys³⁴¹⁴

Pos in alignment	3420	3430	3432	3441	3472
Subcell. location	U	U	U	U	T
Disulfide	yes	no	yes	yes	no
PSIPRED v.4.02 prediction	strand	strand	strand	helix	helix
UniProt secondary structure	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys³⁴²⁰	Cys³⁴³⁰	Cys³⁴³²	Cys³⁴⁴¹	Cys³⁴⁷²

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

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ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	x		HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	x		HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	x		HC: 102 hits LC: 73 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	x		HC: 162 hits LC: 218 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	x		List: 214 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	x		HC HC: 352 hits LC LC: 8 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	x		List: 154 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	x		HC HC: 254 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	x		HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	x		List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	x		List: 238 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	x		List: 664 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	x		Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	x		List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	x		List: 436 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	x		List: 1348 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	x		List: 274 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	x		List: 226 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	Ortholog	in List [G3X973, APOH]	List: 780 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	x		List: 354 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	x		List: 354 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	x		HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	x		HC: 1079 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	Ortholog	in List [G3X973, APOH]	List: 865 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		List: 646 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		LPS treatment: 646 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	x		List: 1404 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	x		List: 1394 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	x		HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	Found	in List	List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	2	3	0	0.0	NA
H. sapiens	17	26	0	0.0	NA
M. musculus	17	25	2	8.0	G3X973_MOUSE , APOH_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	0	0.0	NA
S. pombe	1	1	0	0.0	NA
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	1	1	0	0.0	NA
D. melanogaster	1	2	1	50.0	NA

References

Authors	Year	Reference title	PMID
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Kang R et al.	2008	Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.	19092927
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Yang W et al.	2010	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	19801377
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Martin BR et al.	2009	Large-scale profiling of protein palmitoylation in mammalian cells.	19137006
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Wei X et al.	2014	Insulin-regulated protein palmitoylation impacts endothelial cell function.	24357059
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Peng T et al.	2015	Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.	25575299
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
Santiago-Tirado FH et al.	2015	A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.	25970403
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Martin BR et al.	2011	Global profiling of dynamic protein palmitoylation.	22056678
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
Foe IT et al.	2015	Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.	26468752
Gould NS et al.	2015	Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.	26165157
Serwa RA et al.	2015	Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.	26256475
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Morrison E et al.	2015	Quantitative analysis of the human T cell palmitome.	26111759
Marin EP et al.	2012	Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.	22496122
Merrick BA et al.	2011	Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.	21785166
Emmer BT et al.	2011	Global analysis of protein palmitoylation in African trypanosomes.	21193548
Ren W et al.	2013	Proteomic analysis of protein palmitoylation in adipocytes.	23599907
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Roth AF et al.	2006	Global analysis of protein palmitoylation in yeast.	16751107
Hemsley PA et al.	2013	A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis.	23252521

E1JHA6 E1JHA6_DROME