SwissPalm

P00186 CP1A2_MOUSE

General info Cross-references Sequences Orthologs Ortholog sequences Sites Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

2/23 articles for mouse
1 ortholog

Palmitoyl-proteome experiments

Validation experiments

0 experiment
0 ortholog

Curated sites & Enzymes

0 site from validation experiments^*
3 sites from palmitoyl-proteomes^* Cys²⁰³, Cys⁴⁰⁴, Cys¹⁵⁸
No PAT known
No APT known
^*In main isoform only

Sites

Predictions

Predicted

1 cysteine in main isoform

Predictions

Protein general information from UniProt

Protein names

Cytochrome P450 1A2, EC 1.14.14.1; CYPIA2; Cholesterol 25-hydroxylase; Cytochrome P450-P2; Cytochrome P450-P3; Hydroperoxy icosatetraenoate dehydratase, EC 4.2.1.152

Subcellular location

Endoplasmic reticulum membrane; Microsome membrane (Potential); Endoplasmic reticulum membrane (Potential)

Isoforms & protein length

Isoform 1 (main): 513 aa

Known functions

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. an alkane + O2 + reduced [NADPH--hemoprotein reductase] = a primary alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] By 3-methylcholanthrene (3MC). Belongs to the cytochrome P450 family. A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation. an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O (13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] Cofactor metabolism; retinol metabolism. Steroid metabolism; cholesterol metabolism. Lipid metabolism; arachidonate metabolism. Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization. By 3-methylcholanthrene (3MC). Belongs to the cytochrome P450 family. Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O. By 3-methylcholanthrene (3MC). Belongs to the cytochrome P450 family.

Cross-references

Source	Identifiers
UniProt gene names	Cyp1a2, Cyp1a-2
UniProt secondary AC	Q9QWJ4
Refseq protein ID	NP_034123.1
IPI ID	IPI00128287

Source	Identifiers
Ensembl protein	ENSMUSP00000034860
Ensembl gene	ENSMUSG00000032310
MGI ID	MGI:88589

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Techniques	Predicted
P56592	CP1A2_CANLF	InParanoid	C. familiaris	CYP1A2	Cytochrome P450 1A2, EC 1.14.14.1	0/1	0	Yes
F1MHN9	F1MHN9_BOVIN	InParanoid, MetaPhors	B. taurus	CYP1A2	Cytochrome P450 1A	0/2	0	Yes
Q9LNJ4	C70A2_ARATH	InParanoid	A. thaliana	DEX2, F6F3.8, CYP703A2, At1g01280	Cytochrome P450 703A2, EC 1.14.14.130	0/1	0	No
Q42600	C84A1_ARATH	InParanoid	A. thaliana	CYP84A1, FAH1, At4g36220, F23E13.110	Cytochrome P450 84A1, EC 1.14.-.-	0/1	0	Yes
P58050	C71BD_ARATH	InParanoid	A. thaliana	CYP71B13, At5g25140, T11H3.150	Cytochrome P450 71B13, EC 1.14.-.-	0/1	0	Yes
Q9LTL2	C71BP_ARATH	InParanoid	A. thaliana	CYP71B25, At3g26270, MTC11.20	Cytochrome P450 71B25, EC 1.14.-.-	0/1	0	Yes
Q9STK8	C71AP_ARATH	InParanoid	A. thaliana	CYP71A25, At3g48280, T29H11.200	Cytochrome P450 71A25, EC 1.14.-.-	0/1	0	No
F4JLY4	F4JLY4_ARATH	InParanoid	A. thaliana	CYP706A1, ''cytochrome P450, cytochrome P450, family 706, polypeptide 1, polypeptide 1'', subfamily A, At4g22690, T12H17.80, T12H17_80	Cytochrome P450, family 706, subfamily A, polypeptide 1	0/1	0	No
Q66GJ1	Q66GJ1_ARATH	InParanoid	A. thaliana	CYP706A6, ''cytochrome P450, cytochrome P450, family 706, polypeptide 6, polypeptide 6'', subfamily A, At4g12320, T4C9.160, T4C9_160	At4g12320	0/1	0	Yes
P58049	C71BB_ARATH	InParanoid	A. thaliana	CYP71B11, At5g25120, T11H3.130	Cytochrome P450 71B11, EC 1.14.-.-	0/1	0	Yes
Q9ZU07	C71BC_ARATH	InParanoid	A. thaliana	CYP71B12, At5g25130, F21J6.2	Cytochrome P450 71B12, EC 1.14.-.-	0/1	0	Yes
P58051	C71BE_ARATH	InParanoid	A. thaliana	CYP71B14, At5g25180, F21J6.102	Cytochrome P450 71B14, EC 1.14.-.-	0/1	0	Yes
Q9STK7	C71AQ_ARATH	InParanoid	A. thaliana	CYP71A26, At3g48270, T29H11.210	Cytochrome P450 71A26, EC 1.14.-.-	0/1	0	Yes
O65786	C71B4_ARATH	InParanoid	A. thaliana	CYP71B4, At3g26280, MTC11.21	Cytochrome P450 71B4, EC 1.14.-.-	0/1	0	Yes
Q9STK9	C71AO_ARATH	InParanoid	A. thaliana	CYP71A24, At3g48290, T29H11.190	Cytochrome P450 71A24, EC 1.14.-.-	0/1	0	Yes
Q9STL1	C71AM_ARATH	InParanoid	A. thaliana	CYP71A22, At3g48310, T29H11_170	Cytochrome P450 71A22, EC 1.14.-.-	0/1	0	No
Q9STL2	C71AL_ARATH	InParanoid	A. thaliana	CYP71A21, At3g48320, T29H11.160	Cytochrome P450 71A21, EC 1.14.-.-	0/1	0	No
O65785	C71B3_ARATH	InParanoid	A. thaliana	CYP71B3, At3g26220, MTC11.13	Cytochrome P450 71B3, EC 1.14.-.-	0/1	0	Yes
Q9STL0	C71AN_ARATH	InParanoid	A. thaliana	CYP71A23, At3g48300, T29H11.180	Cytochrome P450 71A23, EC 1.14.-.-	0/1	0	Yes
Q9LTL8	C71BO_ARATH	InParanoid	A. thaliana	CYP71B24, At3g26230, MTC11.14	Cytochrome P450 71B24, EC 1.14.-.-	0/1	0	Yes
F4JW83	C84A4_ARATH	InParanoid, MetaPhors	A. thaliana	CYP84A4, At5g04330, T19N18.60	Cytochrome P450 84A4, EC 1.14.-.-	0/1	0	No
Q9LTM4	C71BJ_ARATH	InParanoid	A. thaliana	CYP71B19, At3g26170, MTC11.8	Cytochrome P450 71B19, EC 1.14.-.-	0/1	0	Yes
Q9LTM0	C71BN_ARATH	InParanoid	A. thaliana	CYP71B23, At3g26210, MTC11.12	Cytochrome P450 71B23, EC 1.14.-.-	0/1	0	Yes
Q9LU04	Q9LU04_ARATH	InParanoid	A. thaliana	CYP706A3, ''cytochrome P450, cytochrome P450, family 706, polypeptide 3, polypeptide 3'', subfamily A, At5g44620, K15C23.6, K15C23_6	Cytochrome P450, family 706, subfamily A, polypeptide 3	0/1	0	No
Q9LTM3	C71BK_ARATH	InParanoid	A. thaliana	CYP71B20, At3g26180, MTC11.9	Cytochrome P450 71B20, EC 1.14.-.-	0/1	0	Yes
Q9LTM1	C71BM_ARATH	InParanoid	A. thaliana	CYP71B22, At3g26200, MTC11.11	Cytochrome P450 71B22, EC 1.14.-.-	0/1	0	No
Q9LTM6	C71BH_ARATH	InParanoid	A. thaliana	CYP71B17, At3g26160, MTC11.6	Cytochrome P450 71B17, EC 1.14.-.-	0/1	0	Yes
Q9LTM2	C71BL_ARATH	InParanoid	A. thaliana	CYP71B21, At3g26190, MTC11.10	Cytochrome P450 71B21, EC 1.14.-.-	0/1	0	Yes
O65788	C71B2_ARATH	InParanoid	A. thaliana	CYP71B2, At1g13080, F3F19.10	Cytochrome P450 71B2, EC 1.14.-.-	0/1	0	Yes
Q96514	C71B7_ARATH	InParanoid	A. thaliana	CYP71B7, At1g13110, F3F19.13	Cytochrome P450 71B7, EC 1.14.-.-	0/1	0	Yes
Q9LTM7	C71BG_ARATH	InParanoid	A. thaliana	CYP71B16, At3g26150, MTC11.5	Cytochrome P450 71B16, EC 1.14.-.-	0/1	0	Yes
Q9LXM3	C71BZ_ARATH	InParanoid	A. thaliana	CYP71B38, At3g44250, T10D17_40	Cytochrome P450 71B38, EC 1.14.-.-	0/1	0	Yes
Q9T0K2	C71AK_ARATH	InParanoid	A. thaliana	CYP71A20, At4g13310, T9E8.50	Cytochrome P450 71A20, EC 1.14.-.-	0/1	0	Yes
P58045	C71AE_ARATH	InParanoid	A. thaliana	CYP71A14, At5g24960, F6A4_170	Cytochrome P450 71A14, EC 1.14.-.-	0/1	0	Yes
O65784	C71B5_ARATH	InParanoid	A. thaliana	CYP71B5, At3g53280, T4D2.200	Cytochrome P450 71B5, EC 1.14.-.-	0/1	0	Yes
Q9SAE3	C71BS_ARATH	InParanoid	A. thaliana	CYP71B28, At1g13090, F3F19.11	Cytochrome P450 71B28, EC 1.14.-.-	0/1	0	Yes
O49342	C71AD_ARATH	InParanoid	A. thaliana	CYP71A13, At2g30770, T11J7.16	Indoleacetaldoxime dehydratase, EC 4.99.1.6	0/1	0	Yes
Q9LIP6	C71BV_ARATH	InParanoid	A. thaliana	CYP71B34, At3g26300, F20C19.2	Cytochrome P450 71B34, EC 1.14.-.-	0/1	0	Yes
P58046	C71AF_ARATH	InParanoid	A. thaliana	CYP71A15, At5g24950, F6A4_160	Cytochrome P450 71A15, EC 1.14.-.-	0/1	0	Yes
Q9SAE4	C71BT_ARATH	InParanoid	A. thaliana	CYP71B29, At1g13100, F3F19.12	Cytochrome P450 71B29, EC 1.14.-.-	0/1	0	Yes
O49340	C71AC_ARATH	InParanoid	A. thaliana	CYP71A12, At2g30750, T11J7.14	Cytochrome P450 71A12, EC 1.14.-.-	0/1	0	Yes
P58048	C71B8_ARATH	InParanoid	A. thaliana	CYP71B8, At5g35715, MXH1.7	Cytochrome P450 71B8, EC 1.14.-.-	0/1	0	Yes
Q9T0K0	C71AJ_ARATH	InParanoid	A. thaliana	CYP71A19, At4g13290, T9E8.30	Cytochrome P450 71A19, EC 1.14.-.-	0/1	0	Yes
Q9SCN2	C71BU_ARATH	InParanoid	A. thaliana	CYP71B31, At3g53300, T4D2.220	Cytochrome P450 71B31, EC 1.14.-.-	0/1	0	No
Q9SAB6	C71AI_ARATH	InParanoid	A. thaliana	CYP71A18, At1g11610, F25C20.24	Cytochrome P450 71A18, EC 1.14.-.-	0/1	0	Yes
Q9LVD2	C71BA_ARATH	InParanoid	A. thaliana	CYP71B10, At5g57260, MJB24.7	Cytochrome P450 71B10, EC 1.14.-.-	0/1	0	Yes
Q9LIP5	C71BW_ARATH	InParanoid	A. thaliana	CYP71B35, At3g26310, F20C19.3	Cytochrome P450 71B35, EC 1.14.-.-	0/1	0	Yes
Q9LTL0	C71BQ_ARATH	InParanoid	A. thaliana	CYP71B26, At3g26290, MTC11.22	Cytochrome P450 71B26, EC 1.14.-.-	0/1	0	Yes
Q9FH66	C71AG_ARATH	InParanoid	A. thaliana	MRNO, MRO, CYP71A16, At5g42590, K16E1.6	Cytochrome P450 71A16, EC 1.14.-.-	0/1	0	Yes
Q9LIP3	C71BY_ARATH	InParanoid	A. thaliana	CYP71B37, At3g26330, F20C19.5	Cytochrome P450 71B37, EC 1.14.-.-	0/1	0	Yes
O64718	C71B9_ARATH	InParanoid	A. thaliana	CYP71B9, At2g02580, T8K22.12	Cytochrome P450 71B9, EC 1.14.-.-	0/1	0	Yes
Q9LIP4	C71BX_ARATH	InParanoid	A. thaliana	CYP71B36, At3g26320, F20C19.4	Cytochrome P450 71B36, EC 1.14.-.-	0/1	0	Yes
Q9LW27	C71BF_ARATH	InParanoid	A. thaliana	CYP71B15, PAD3, At3g26830, MDJ14.15	Bifunctional dihydrocamalexate synthase/camalexin synthase, EC 1.14.19.52	0/1	0	Yes
P58047	C71AS_ARATH	InParanoid	A. thaliana	CYP71A28, At4g20235, F1C12.160	Putative cytochrome P450 71A28, EC 1.14.-.-	0/1	0	Yes
O65787	C71B6_ARATH	InParanoid	A. thaliana	CYP71B6, At2g24180, F27D4.9	Cytochrome P450 71B6, EC 1.14.-.-	0/1	0	Yes
O65782	C83B1_ARATH	InParanoid	A. thaliana	CYP83B1, ATR4, RED1, RNT1, RUNT1, SUR2, At4g31500, F3L17.70	Cytochrome P450 83B1, EC 1.14.14.45	0/1	0	No
O64637	C76C2_ARATH	InParanoid	A. thaliana	CYP76C2, At2g45570, F17K2.10, YLS6	Cytochrome P450 76C2, EC 1.14.-.-	0/1	0	Yes
O64635	C76C4_ARATH	InParanoid	A. thaliana	CYP76C4, At2g45550, F17K2.8	Cytochrome P450 76C4, EC 1.14.-.-	0/1	0	Yes
P48421	C83A1_ARATH	InParanoid	A. thaliana	REF2, CYP83A1, CYP83, At4g13770, F18A5.160	Cytochrome P450 83A1, EC 1.14.14.43	0/1	0	Yes
O64636	C76C1_ARATH	InParanoid	A. thaliana	CYP76C1, At2g45560, F17K2.9	Cytochrome P450 76C1, EC 1.14.-.-	0/1	0	Yes
Q9LEX2	Q9LEX2_ARATH	InParanoid	A. thaliana	T27I15_130, ''cytochrome P450, CYP76C7, cytochrome P450, family 76, polypeptide 7, polypeptide 7'', subfamily C, At3g61040	Cytochrome P450 monooxygenase-like protein	0/1	0	Yes
O48532	O48532_ARATH	InParanoid	A. thaliana	CYP712A1, ''cytochrome P450, cytochrome P450, family 712, polypeptide 1, polypeptide 1'', subfamily A, At2g42250, T24P15.16, T24P15_16	Cytochrome P450, family 712, subfamily A, polypeptide 1	0/1	0	Yes
O64638	C76C3_ARATH	InParanoid	A. thaliana	CYP76C3, At2g45580, F17K2.11	Cytochrome P450 76C3, EC 1.14.-.-	0/1	0	No
Q9FL56	Q9FL56_ARATH	InParanoid	A. thaliana	CYP93D1, ''cytochrome P450, cytochrome P450, family 93, MOJ9.6, MOJ9_6, polypeptide 1, polypeptide 1'', subfamily D, At5g06900	Cytochrome P450	0/1	0	Yes
O22203	C98A3_ARATH	InParanoid	A. thaliana	CYP98A3, C3'H, REF8, At2g40890, T20B5.9	Cytochrome P450 98A3, EC 1.14.-.-	0/1	0	No
F4J865	F4J865_ARATH	InParanoid	A. thaliana	CYP76G1, ''cytochrome P450, cytochrome P450, family 76, polypeptide 1, polypeptide 1'', subfamily G, At3g52970	Cytochrome P450, family 76, subfamily G, polypeptide 1	0/1	0	No
Q0WTF4	C81F3_ARATH	InParanoid	A. thaliana	CYP81F3, At4g37400, F6G17.50	Cytochrome P450 81F3, EC 1.14.-.-	0/1	0	No
O65790	C81F1_ARATH	InParanoid	A. thaliana	CYP81F1, CYP91A2, At4g37430, F6G17.80	Cytochrome P450 81F1, EC 1.14.-.-	0/1	0	No
Q9CA60	C98A9_ARATH	InParanoid	A. thaliana	CYP98A9, At1g74550, F1M20.23	Cytochrome P450 98A9, EC 1.14.-.-	0/1	0	No
F4JA71	F4JA71_ARATH	InParanoid	A. thaliana	At3g32047, F1M23.15	Cytochrome P450 superfamily protein	0/1	0	Yes
Q9CA61	C98A8_ARATH	InParanoid	A. thaliana	CYP98A8, At1g74540, F1M20.22	Cytochrome P450 98A8, EC 1.14.-.-	0/1	0	Yes
Q9SW67	Q9SW67_ARATH	InParanoid	A. thaliana	C7A10.50, ''cytochrome P450, CYP81H1, cytochrome P450, family 81, polypeptide 1, polypeptide 1'', subfamily H, At4g37310, F6G17.6	Cytochrome P450, family 81, subfamily H, polypeptide 1	0/1	0	Yes
Q9SZU1	C81F4_ARATH	InParanoid	A. thaliana	CYP81F4, At4g37410, F6G17.60	Cytochrome P450 81F4, EC 1.14.-.-	0/1	0	No
Q9LJY5	C05AK_ARATH	InParanoid	A. thaliana	CYP705A22, GPS1, At3g20130, MAL21.16	Cytochrome P450 705A22, EC 1.14.-.-	0/1	0	Yes
Q8GZ20	Q8GZ20_ARATH	InParanoid	A. thaliana	CYP81G1, ''cytochrome P450, cytochrome P450, family 81, polypeptide 1, polypeptide 1'', subfamily G, At5g67310, At5g67310/K8K14_3, K8K14.3, K8K14_3	At5g67310	0/1	0	Yes
Q9SI49	Q9SI49_ARATH	InParanoid	A. thaliana	CYP705A13, ''cytochrome P450, cytochrome P450, family 705, polypeptide 13, polypeptide 13'', subfamily A, At2g14100, T22C12.3, T22C12_3	Cytochrome P450, family 705, subfamily A, polypeptide 13	0/1	0	No
O23155	O23155_ARATH	InParanoid	A. thaliana	C7A10.30, ''cytochrome P450, CYP81D4, cytochrome P450, family 81, polypeptide 4, polypeptide 4'', subfamily D, At4g37330, F6G17.5	At4g37330	0/1	0	Yes
Q9SZ46	C82C4_ARATH	InParanoid	A. thaliana	CYP82C4, At4g31940, F10N7.250	Xanthotoxin 5-hydroxylase CYP82C4, 8-methoxypsoralen 5-hydroxylase CYP82C4, EC 1.14.14.-	0/1	0	No
O23391	O23391_ARATH	InParanoid	A. thaliana	dl3720w, ''cytochrome P450, CYP705A2, cytochrome P450, family 705, polypeptide 2, polypeptide 2'', subfamily A, At4g15350, Dl3720W, FCAALL.274	Cytochrome P450 like protein	0/1	0	Yes
Q9FLC8	C79A2_ARATH	InParanoid	A. thaliana	CYP79A2, At5g05260, K18I23.6	Phenylalanine N-monooxygenase, EC 1.14.14.40	0/1	0	No
F4I6I6	F4I6I6_ARATH	InParanoid	A. thaliana	CYP705A27, ''cytochrome P450, cytochrome P450, family 705, polypeptide 27, polypeptide 27'', subfamily A, At1g50520, F11F12.13, F11F12_13	Cytochrome P450, family 705, subfamily A, polypeptide 27	0/1	0	Yes
Q9LVD6	C81F2_ARATH	InParanoid	A. thaliana	CYP81F2, IGM1, At5g57220, MJB24.3	Cytochrome P450 81F2, EC 1.14.-.-	0/1	0	No
Q9LJY4	Q9LJY4_ARATH	InParanoid	A. thaliana	CYP705A23, ''cytochrome P450, cytochrome P450, family 705, polypeptide 23, polypeptide 23'', subfamily A, At3g20140	Cytochrome P450 family protein	0/1	0	Yes
O23389	O23389_ARATH	InParanoid	A. thaliana	dl3725w, ''cytochrome P450, CYP705A3, cytochrome P450, family 705, polypeptide 3, polypeptide 3'', subfamily A, At4g15360, Dl3725W, FCAALL.277	Cytochrome P450 like protein	0/1	0	Yes
F4KI78	F4KI78_ARATH	InParanoid	A. thaliana	CYP81K2, ''cytochrome P450, cytochrome P450, family 81, polypeptide 2, polypeptide 2'', subfamily K, At5g10600, F12B17.50, F12B17_50	Cytochrome P450, family 81, subfamily K, polypeptide 2	0/1	0	No
O23154	O23154_ARATH	InParanoid	A. thaliana	C7A10.20, ''cytochrome P450, CYP81D3, cytochrome P450, family 81, polypeptide 3, polypeptide 3'', subfamily D, At4g37340, F6G17.1	Cytochrome P450, family 81, subfamily D, polypeptide 3	0/1	0	Yes
O49394	C82C2_ARATH	InParanoid	A. thaliana	CYP82C2, At4g31970, F10N7.220	Xanthotoxin 5-hydroxylase CYP82C2, 8-methoxypsoralen 5-hydroxylase CYP82C2, EC 1.14.14.-	0/1	0	No
Q9LSF8	C82G1_ARATH	InParanoid	A. thaliana	OR9, CYP82G1, At3g25180, MJL12.5	Dimethylnonatriene synthase, EC 1.14.14.59	0/1	0	Yes
O22185	O22185_ARATH	InParanoid	A. thaliana	CYP81D6, ''cytochrome P450, cytochrome P450, family 81, polypeptide 6, polypeptide 6'', subfamily D, At2g23220, T20D16.15, T20D16_15	Cytochrome P450, family 81, subfamily D, polypeptide 6	0/1	0	Yes
Q9FH67	C705C_ARATH	InParanoid	A. thaliana	CYP705A12, ''cytochrome P450, cytochrome P450, family 705, polypeptide 12, polypeptide 12'', subfamily A, At5g42580, K16E1.5, K16E1_5	Cytochrome P450 705A12, EC 1.14.-.-	0/1	0	Yes
Q9ZVD7	Q9ZVD7_ARATH	InParanoid	A. thaliana	CYP705A8, ''cytochrome P450, cytochrome P450, family 705, polypeptide 8, polypeptide 8'', subfamily A, At2g27000, T20P8.5, T20P8_5	Cytochrome P450, family 705, subfamily A, polypeptide 8	0/1	0	Yes
O23156	O23156_ARATH	InParanoid	A. thaliana	C7A10.40, ''cytochrome P450, CYP81D5, cytochrome P450, family 81, polypeptide 5, polypeptide 5'', subfamily D, At4g37320, F6G17.8	Cytochrome P450, family 81, subfamily D, polypeptide 5	0/1	0	Yes
O81346	C79B2_ARATH	InParanoid	A. thaliana	CYP79B2, At4g39950, T5J17.120	Tryptophan N-monooxygenase 1, EC 1.14.14.156	0/1	0	No
Q9SZT7	Q9SZT7_ARATH	InParanoid	A. thaliana	''cytochrome P450, cytochrome P450, family 81, polypeptide 8, polypeptide 8'', subfamily D, F6G17_20, F6G17.20, CYP81D8, At4g37370	Cytochrome P450, family 81, subfamily D, polypeptide 8	1/1	1	No
Q9FG65	C81D1_ARATH	InParanoid	A. thaliana	CYP81D1, CYP91A1, At5g36220, T30G6.3	Cytochrome P450 81D1, EC 1.14.-.-	0/1	0	No
F4HRA1	F4HRA1_ARATH	InParanoid	A. thaliana	CYP76C5, ''cytochrome P450, cytochrome P450, family 76, polypeptide 5, polypeptide 5'', subfamily C, At1g33730, F14M2.14, F14M2_14	Cytochrome P450, family 76, subfamily C, polypeptide 5	0/1	0	No
Q9LJZ2	Q9LJZ2_ARATH	InParanoid	A. thaliana	CYP705A15, ''cytochrome P450, cytochrome P450, family 705, polypeptide 15, polypeptide 15'', subfamily A, At3g20080	Cytochrome P450, family 705, subfamily A, polypeptide 15	0/1	0	Yes
F4K599	F4K599_ARATH	InParanoid	A. thaliana	CYP712A2, ''cytochrome P450, cytochrome P450, family 712, polypeptide 2, polypeptide 2'', subfamily A, At5g06905	Cytochrome P450, family 712, subfamily A, polypeptide 2	0/1	0	Yes
Q501D8	C79B3_ARATH	InParanoid	A. thaliana	CYP79B3, At2g22330, T26C19.1	Tryptophan N-monooxygenase 2, EC 1.14.14.156	0/1	0	No
Q9LJY8	Q9LJY8_ARATH	InParanoid	A. thaliana	CYP705A19, ''cytochrome P450, cytochrome P450, family 705, polypeptide 19, polypeptide 19'', subfamily A, At3g20100	AT3g20100/MAL21_14	0/1	0	Yes
Q9LJY7	C75AK_ARATH	InParanoid	A. thaliana	CYP705A20, At3g20110, MAL21.15	Cytochrome P450 705A20, EC 1.14.-.-	0/1	0	Yes
Q9SGP1	Q9SGP1_ARATH	InParanoid	A. thaliana	CYP705A24, ''cytochrome P450, cytochrome P450, family 705, polypeptide 24, polypeptide 24'', subfamily A, At1g28430, F3M18.13, F3M18_13	Cytochrome P450	0/1	0	Yes
Q9LIG9	Q9LIG9_ARATH	InParanoid	A. thaliana	CYP705A30, ''cytochrome P450, cytochrome P450, family 705, polypeptide 30, polypeptide 30'', subfamily A, At3g20940	Cytochrome P450, family 705, subfamily A, polypeptide 30	0/1	0	No
Q9SJ39	Q9SJ39_ARATH	InParanoid	A. thaliana	CYP705A6, ''cytochrome P450, cytochrome P450, family 705, polypeptide 6, polypeptide 6'', subfamily A, At2g05180, F5G3.8, F5G3_8	Cytochrome P450, family 705, subfamily A, polypeptide 6	0/1	0	Yes
O22188	O22188_ARATH	InParanoid	A. thaliana	CYP81D7, ''cytochrome P450, cytochrome P450, family 81, polypeptide 7, polypeptide 7'', subfamily D, At2g23190, T20D16.18, T20D16_18	Cytochrome P450, family 81, subfamily D, polypeptide 7	0/1	0	Yes
P92994	TCMO_ARATH	InParanoid	A. thaliana	REF3, CYP73A5, CYP73, At2g30490, T6B20.16	Trans-cinnamate 4-monooxygenase, EC 1.14.14.91	0/1	0	No
F4J9C1	F4J9C1_ARATH	InParanoid	A. thaliana	CYP71B32, ''cytochrome P450, cytochrome P450, family 71, polypeptide 32, polypeptide 32'', subfamily B, At3g53305	Cytochrome P450, family 71, subfamily B, polypeptide 32	0/1	0	No
Q9FI39	THAD_ARATH	InParanoid	A. thaliana	CYP705A5, THAD, At5g47990, MDN11.4	Cytochrome P450 705A5, EC 1.14.-.-	0/1	0	Yes
Q7Y222	Q7Y222_ARATH	InParanoid	A. thaliana	CYP82F1, ''cytochrome P450, cytochrome P450, family 82, polypeptide 1, polypeptide 1'', subfamily F, At2g25160, F13D4.120, F13D4_120	At2g25160	0/1	0	No
Q0WQ07	C7051_ARATH	InParanoid	A. thaliana	dl3710c, CYP705A1, ''cytochrome P450, cytochrome P450, family 705, polypeptide 1, polypeptide 1'', subfamily A, At4g15330, Dl3710c, FCAALL.270	Cytochrome P450 705A1, EC 1.14.-.-	0/1	0	Yes
O49396	C82C3_ARATH	InParanoid	A. thaliana	CYP82C3, At4g31950, F10N7.240	Cytochrome P450 82C3, EC 1.14.-.-	0/1	0	No
Q9LIG8	Q9LIG8_ARATH	InParanoid	A. thaliana	CYP705A32, ''cytochrome P450, cytochrome P450, family 705, polypeptide 32, polypeptide 32'', subfamily A, At3g20950	Cytochrome P450, family 705, subfamily A, polypeptide 32	0/1	0	Yes
Q8L7H7	Q8L7H7_ARATH	InParanoid	A. thaliana	CYP705A4, ''cytochrome P450, cytochrome P450, family 705, polypeptide 4, polypeptide 4'', subfamily A, At4g15380, Dl3735W, FCAALL.280	Cytochrome P450, family 705, subfamily A, polypeptide 4	0/1	0	Yes
Q9ZNR0	C78A6_ARATH	InParanoid	A. thaliana	CYP78A6, EOD3, At2g46660, T3A4.4	Cytochrome P450 78A6, EC 1.14.-.-	0/1	0	Yes
Q9LQB7	Q9LQB7_ARATH	InParanoid	A. thaliana	CYP79C2, CYP79C3P, cytochrome p450 79c2, F16M22.6, At1g58260, F19C14.12, F19C14_12	Cytochrome P450, putative	0/1	0	No
A2RVN3	A2RVN3_ARATH	InParanoid	A. thaliana	At1g66540, F28G11.4, F28G11_4	At1g66540	0/1	0	Yes
P05177	CP1A2_HUMAN	InParanoid, MetaPhors	H. sapiens	CYP1A2	Cytochrome P450 1A2, EC 1.14.14.1	0/22	0	Yes
P04799	CP1A2_RAT	InParanoid, OrthoDB, MetaPhors	R. norvegicus	Cyp1a2, Cyp1a-2	Cytochrome P450 1A2, EC 1.14.14.1	0/3	0	Yes
P04798	CP1A1_HUMAN	OrthoDB	H. sapiens	CYP1A1	Cytochrome P450 1A1, CYPIA1, EC 1.14.14.1	0/22	0	Yes
Q9MZY0	CP2E1_CANLF	OrthoDB	C. familiaris	CYP2E1	Cytochrome P450 2E1, EC 1.14.14.1	0/1	0	No

Ortholog sequence alignment (CLUSTALW)

Sites (from validation or large-scale experiments)

Isoforms	Position	Probability	Studies	Techniques
P00186	203	NA	SPalmE:855 Shen LF et al. (2017)*	ARAC
P00186	404	NA	SPalmE:855 Shen LF et al. (2017)*	ARAC
P00186	158	NA	SPalmE:855 Shen LF et al. (2017)*	ARAC

Cysteine summary and predictions

Pos in alignment	21	158	203	404	456	502
Subcell. location	U	U	U	U	U	U
Disulfide	no	no	no	no	no	no
PSIPRED v.4.02 prediction	helix	helix	helix	strand	coil	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys²¹ HC	Cys¹⁵⁸	Cys²⁰³	Cys⁴⁰⁴	Cys⁴⁵⁶	Cys⁵⁰²

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

Tip: Keep CTRL key pressed down while clicking on column headers to do multiple sorting. This applies to any sortable table on this site.

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	x		HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	x		HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	x		HC: 162 hits LC: 218 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	x		HC: 102 hits LC: 73 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	x		HC HC: 352 hits LC LC: 8 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	x		List: 214 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	x		HC HC: 254 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	x		List: 154 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	x		List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	Ortholog	in HC [Q9SZT7]	HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	x		List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	x		List: 238 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	x		List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	x		List: 436 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	x		Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	x		List: 354 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	x		List: 1348 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	x		List: 354 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	x		List: 226 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	x		List: 274 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	x		HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	x		HC: 1079 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	Found	in List	List: 865 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	x		List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	x		List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	x		HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		LPS treatment: 646 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		List: 646 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	x		List: 2929 hits
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 590 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 370 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 600 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		List: 185 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1869 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1093 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 687 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	x		List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	x		List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 199 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 399 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1040 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in HC	HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 464 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 4107 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1597 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1378 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 3870 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	3	4	0	0.0	NA
H. sapiens	22	38	0	0.0	NA
M. musculus	23	37	2	5.4	NA
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	1	100.0	Q9SZT7_ARATH
S. pombe	1	1	0	0.0	NA
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	0	0.0	NA
C. familiaris	1	1	0	0.0	NA

References

Authors	Year	Reference title	PMID
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Marin EP et al.	2012	Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.	22496122
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
Martin BR et al.	2011	Global profiling of dynamic protein palmitoylation.	22056678
Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Merrick BA et al.	2011	Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.	21785166
Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
Yang W et al.	2010	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	19801377
Martin BR et al.	2009	Large-scale profiling of protein palmitoylation in mammalian cells.	19137006
Roth AF et al.	2006	Global analysis of protein palmitoylation in yeast.	16751107
Hemsley PA et al.	2013	A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis.	23252521
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
Wei X et al.	2014	Insulin-regulated protein palmitoylation impacts endothelial cell function.	24357059
Serwa RA et al.	2015	Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.	26256475
Morrison E et al.	2015	Quantitative analysis of the human T cell palmitome.	26111759
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
Santiago-Tirado FH et al.	2015	A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.	25970403
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Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
Foe IT et al.	2015	Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.	26468752
Gould NS et al.	2015	Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.	26165157
Peng T et al.	2015	Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.	25575299
Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Zhou B et al.	2019	Low-background Acyl-biotinyl Exchange Largely Eliminates the Co-isolation of Non-S-acylated Proteins and Enables Deep S-acylproteomic Analysis.	31251020
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Wegleiter T et al.	2019	Palmitoylation of BMPR1a regulates neural stem cell fate.	31772009
Morrison E et al.	2020	Dynamic palmitoylation events following T-cell receptor signaling.	32651440
Mariscal J et al.	2020	Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles.	32944167
Gorenberg EL et al.	2022	Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.	35358180
Uzbekova S et al.	2021	Protein Palmitoylation in Bovine Ovarian Follicle.	34769186
Miles MR et al.	2021	Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart.	33636221
Pradhan AJ et al.	2021	Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis.	33848465
Ripamonti M et al.	2021	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.	33782527
Zaręba-Kozioł M et al.	2021	S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity.	34200797
Ziemlińska E et al.	2021	Palm Oil-Rich Diet Affects Murine Liver Proteome and <i>S</i>-Palmitoylome.	34884899
Gao J et al.	2022	Proteome-wide identification of palmitoylated proteins in mouse testis.	35477839