SwissPalm

P04388 RAS2_DROME

General info Cross-references Enzymes Sequences Orthologs Ortholog sequences Validation experiments Sites Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

1/1 article for fruit fly
26 orthologs

Palmitoyl-proteome experiments

Validation experiments

2 experiments
14 orthologs

Validation experiments

Curated sites & Enzymes

5 sites from validation experiments^* Cys⁴⁶, Cys¹²⁰, Cys¹⁴⁷, Cys¹⁸⁹, Cys¹⁹⁰
0 site from palmitoyl-proteomes^*
DHHC-PATs : A8JUM5_DROME
No APT known
^*In main isoform only

Sites Enzymes

Predictions

Predicted

1 cysteine in main isoform

Predictions

Protein general information from UniProt

Protein names

Ras-like protein 2, EC 3.6.5.2

Subcellular location

Cell membrane (By similarity)

Isoforms & protein length

Isoform 1 (main): 192 aa

Known functions

May be involved in endocytic processes and/or other transport pathways mediated by vesicle trafficking. May interact functionally with ROP protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). A uniform expression is seen in unfertilized eggs, embryos, larvae, pupae and adult flies. Expression during embryogenesis is restricted to the CNS and the Garland cells, a small group of nephrocytes that takes up waste materials from the hemolymph by endocytosis. In post-embryonic stages, expression is seen in the larval salivary glands and the CNS, and in the adult CNS and reproductive systems. Belongs to the small GTPase superfamily. Ras family. May be involved in endocytic processes and/or other transport pathways mediated by vesicle trafficking. May interact functionally with ROP protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. GTP + H2O = GDP + H(+) + phosphate Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Interacts with hzg. A uniform expression is seen in unfertilized eggs, embryos, larvae, pupae and adult flies. Expression during embryogenesis is restricted to the CNS and the Garland cells, a small group of nephrocytes that takes up waste materials from the hemolymph by endocytosis. In post-embryonic stages, expression is seen in the larval salivary glands and the CNS, and in the adult CNS and reproductive systems. Belongs to the small GTPase superfamily. Ras family. May be involved in endocytic processes and/or other transport pathways mediated by vesicle trafficking. May interact functionally with ROP protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). A uniform expression is seen in unfertilized eggs, embryos, larvae, pupae and adult flies. Expression during embryogenesis is restricted to the CNS and the Garland cells, a small group of nephrocytes that takes up waste materials from the hemolymph by endocytosis. In post-embryonic stages, expression is seen in the larval salivary glands and the CNS, and in the adult CNS and reproductive systems. Belongs to the small GTPase superfamily. Ras family.

Cross-references

Source	Identifiers
UniProt gene names	Ras64B, ras2, CG1167
UniProt secondary AC	Q9VZH7
Refseq protein ID	NP_523917.2

Source	Identifiers
Ensembl gene	FBgn0003206

Enzymes

PAT/APT	Enzyme	Experiments
PAT	A8JUM5_DROME	SPalmE:1256 Strassburger K et al. (2019) []

Copy in clipboard UniProt feature viewer

Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

Select all Deselect all

UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Times validated	Techniques	Sites	Predicted
P01112	RASH_HUMAN	OrthoDB	H. sapiens	HRAS, HRAS1	GTPase HRas, EC 3.6.5.2	18/22	26	4	2	Yes
P63322	RALA_RAT	OrthoDB	R. norvegicus	Rala, Ral, Ral-a	Ras-related protein Ral-A, EC 3.6.5.2	2/3	0	2	0	Yes
P10833	RRAS_MOUSE	OrthoDB, Ensembl, MetaPhors	M. musculus	Rras	Ras-related protein R-Ras, EC 3.6.5.-	13/23	2	3	1	No
D3Z8L7	RRAS_RAT	OrthoDB, Ensembl, MetaPhors	R. norvegicus	Rras	Ras-related protein R-Ras, EC 3.6.5.-	2/3	0	2	0	No
P62071	RRAS2_MOUSE	OrthoDB, OMA, Ensembl, InParanoid, MetaPhors	M. musculus	Rras2	Ras-related protein R-Ras2, EC 3.6.5.-	12/23	0	3	0	Yes
Q9Y3L5	RAP2C_HUMAN	OrthoDB	H. sapiens	RAP2C	Ras-related protein Rap-2c, EC 3.6.5.2	18/22	2	4	3	Yes
P61226	RAP2B_MOUSE	OrthoDB	M. musculus	Rap2b	Ras-related protein Rap-2b, EC 3.6.5.2	16/23	0	3	0	Yes
Q9D091	Q9D091_MOUSE	OrthoDB	M. musculus	Nras	GTPase NRas	2/23	0	2	1	Yes
Q8BU31	RAP2C_MOUSE	OrthoDB	M. musculus	Rap2c	Ras-related protein Rap-2c, EC 3.6.5.2	14/23	0	3	0	Yes
P32883	RASK_MOUSE	OrthoDB	M. musculus	Kras, Kras2	GTPase KRas, EC 3.6.5.2	4/23	0	3	0	Yes
P62070	RRAS2_HUMAN	OMA, Ensembl, InParanoid, MetaPhors	H. sapiens	RRAS2, TC21	Ras-related protein R-Ras2, EC 3.6.5.-	15/22	0	4	0	Yes
P20171	RASH_RAT	OrthoDB	R. norvegicus	Hras1, Hras	GTPase HRas, EC 3.6.5.2	0/3	3	0	2	Yes
P10301	RRAS_HUMAN	OrthoDB, Ensembl, MetaPhors	H. sapiens	RRAS	Ras-related protein R-Ras, EC 3.6.5.-	15/22	4	4	1	Yes
P10114	RAP2A_HUMAN	OrthoDB	H. sapiens	RAP2A	Ras-related protein Rap-2a, EC 3.6.5.2	15/22	2	4	2	Yes
P61224	RAP1B_HUMAN	OrthoDB	H. sapiens	RAP1B, OK/SW-cl.11	Ras-related protein Rap-1b, EC 3.6.5.2	9/22	1	4	0	No
P11233	RALA_HUMAN	OrthoDB	H. sapiens	RALA, RAL	Ras-related protein Ral-A, EC 3.6.5.2	13/22	0	3	0	Yes
P62834	RAP1A_HUMAN	OrthoDB	H. sapiens	RAP1A, KREV1	Ras-related protein Rap-1A, EC 3.6.5.2	3/22	1	3	0	Yes
P01116	RASK_HUMAN	OrthoDB	H. sapiens	KRAS, KRAS2, RASK2	GTPase KRas, EC 3.6.5.2	10/22	0	3	0	No
P01111	RASN_HUMAN	OrthoDB	H. sapiens	NRAS, HRAS1	GTPase NRas, EC 3.6.5.2	17/22	15	4	1	Yes
P63321	RALA_MOUSE	OrthoDB	M. musculus	Rala, Ral, Ral-a	Ras-related protein Ral-A, EC 3.6.5.2	7/23	1	3	1	Yes
Q9JIW9	RALB_MOUSE	OrthoDB	M. musculus	Ralb	Ras-related protein Ral-B, EC 3.6.5.2	6/23	1	3	1	Yes
Q99JI6	RAP1B_MOUSE	OrthoDB	M. musculus	Rap1b	Ras-related protein Rap-1b, EC 3.6.5.2	6/23	0	3	0	No
P61225	RAP2B_HUMAN	OrthoDB	H. sapiens	RAP2B	Ras-related protein Rap-2b, EC 3.6.5.2	19/22	3	4	2	Yes
Q61411	RASH_MOUSE	OrthoDB	M. musculus	Hras1, Hras	GTPase HRas, EC 3.6.5.2	13/23	4	3	2	Yes
E2R5G6	E2R5G6_CANLF	Ensembl, InParanoid	C. familiaris	RRAS	RAS related	1/1	0	2	0	No
Q2TBH2	Q2TBH2_BOVIN	Ensembl, MetaPhors	B. taurus	RRAS	RAS related	0/2	0	0	0	No
P08647	RAS_SCHPO	MetaPhors, OMA, InParanoid	S. pombe	ras1, SPAC17H9.09c	Ras-like protein 1	0/1	2	0	1	Yes
Q38922	RAB1B_ARATH	MetaPhors	A. thaliana	RABB1B, GB2, RAB2C, At4g35860, F4B14.130	Ras-related protein RABB1b, AtRABB1b	0/1	0	0	0	Yes
O23561	RAB1A_ARATH	MetaPhors	A. thaliana	RABB1A, RAB2B, At4g17160, dl4615c, FCAALL.364	Ras-related protein RABB1a, AtRABB1a	0/1	0	0	0	Yes
Q9C9U7	RAA6A_ARATH	MetaPhors	A. thaliana	RABA6A, At1g73640, F25P22.5	Ras-related protein RABA6a, AtRABA6a	0/1	0	0	0	Yes
E9QX28	E9QX28_ASPFU	OMA	A. fumigatus	AFUA_5G11230	RAS small monomeric GTPase RasA	1/1	0	1	0	Yes
Q9SIP0	RAA5D_ARATH	MetaPhors	A. thaliana	RABA5D, At2g31680, T9H9.20	Ras-related protein RABA5d, AtRABA5d	0/1	0	0	0	Yes
Q9LH50	RAA4D_ARATH	MetaPhors	A. thaliana	RABA4D, At3g12160, F28J15.18, T21B14.2	Ras-related protein RABA4d, AtRABA4d	0/1	0	0	0	Yes
F1PBE5	F1PBE5_CANLF	OrthoDB	C. familiaris	RIT1	Ras like without CAAX 1	0/1	0	0	0	Yes
A5D7A4	A5D7A4_BOVIN	OrthoDB	B. taurus	RIT1	RIT1 protein	0/2	0	0	0	Yes
F1LQ62	F1LQ62_RAT	OrthoDB	R. norvegicus	Ralb	Small monomeric GTPase	0/3	0	0	0	Yes
P70426	RIT1_MOUSE	OrthoDB	M. musculus	Rit1, Rit	GTP-binding protein Rit1, EC 3.6.5.2	0/23	0	0	0	Yes
Q92963	RIT1_HUMAN	OrthoDB	H. sapiens	RIT1, RIBB, RIT, ROC1	GTP-binding protein Rit1, EC 3.6.5.2	0/22	0	0	0	Yes
B7Z5Z2	B7Z5Z2_HUMAN	OMA	H. sapiens	RRAS2	Ras-related protein R-Ras2	0/22	0	0	0	Yes
F1P9Z4	F1P9Z4_CANLF	OMA, Ensembl	C. familiaris	RRAS2	RAS related 2	1/1	0	2	0	Yes
Q5BJU0	Q5BJU0_RAT	OMA, Ensembl, InParanoid, MetaPhors	R. norvegicus	Rras2, rCG_40097	RAS-related 2	0/3	0	0	0	Yes
A5PKL2	A5PKL2_BOVIN	OMA, Ensembl, InParanoid, MetaPhors	B. taurus	RRAS2	RAS related 2	0/2	0	0	0	Yes

Ortholog sequence alignment (CLUSTALW)

Validation experiments

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)
SPalmE:1256	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L3 larvae	NA	ABE, NH2OH cleavage of thioester bond, PAT KO, Point mutation
SPalmE:1257	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L3 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, Point mutation

Sites (from validation or large-scale experiments)

Isoforms	Position	Probability	Studies	Techniques
P04388	189	NA	SPalmE:1256 Strassburger K et al. (2019) []	ABE, NH2OH cleavage of thioester bond, PAT KO, Point mutation
P04388	190	NA	SPalmE:1256 Strassburger K et al. (2019) []	ABE, NH2OH cleavage of thioester bond, PAT KO, Point mutation
P04388	46	NA	SPalmE:1257 Strassburger K et al. (2019) []	ABE, NH2OH cleavage of thioester bond, Point mutation
P04388	120	NA	SPalmE:1257 Strassburger K et al. (2019) []	ABE, NH2OH cleavage of thioester bond, Point mutation
P04388	147	NA	SPalmE:1257 Strassburger K et al. (2019) []	ABE, NH2OH cleavage of thioester bond, Point mutation

Cysteine summary and predictions

Pos in alignment	46	120	147	189	190
Subcell. location	U	U	U	U	U
Disulfide	no	no	no	no	no
PSIPRED v.4.02 prediction	strand	coil	coil	strand	strand
UniProt secondary structure	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁴⁶	Cys¹²⁰	Cys¹⁴⁷	Cys¹⁸⁹ HC	Cys¹⁹⁰ MC

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

Tip: Keep CTRL key pressed down while clicking on column headers to do multiple sorting. This applies to any sortable table on this site.

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	Ortholog	in HC [RRAS, RALA]	HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	Ortholog	in HC [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	Ortholog	in HC,LC [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	HC: 162 hits LC: 218 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	Ortholog	in HC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC: 59 hits LC: 105 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	Ortholog	in HC [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	HC: 102 hits LC: 73 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	Ortholog	in HC,LC [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	HC: 63 hits LC: 147 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	Ortholog	in HC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC HC: 352 hits LC LC: 8 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 214 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 69 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	Ortholog	in LC,HC [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	HC: 164 hits LC: 178 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	Ortholog	in HC [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	HC HC: 93 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	Ortholog	in HC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC HC: 254 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 154 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	x		HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	x		List: 238 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 436 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 354 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 1348 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 354 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 226 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 113 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 274 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	Ortholog	in List [E9QX28]	List: 133 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	Ortholog	in MC,LC,HC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 1353 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 216 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	Ortholog	in HC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC: 1079 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 865 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	Ortholog	in HC,MC,LC [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	Ortholog	in HC,MC [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Ortholog	in HC,LC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	Ortholog	in LC,MC,HC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	Ortholog	in HC,MC,LC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	Ortholog	in LC,HC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in LPS treatment [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	LPS treatment: 646 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 646 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in Palm. up with LPS [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Ortholog	in HC,LC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	Found	in List	List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	Found	in List	List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 2929 hits
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 590 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 370 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	HC: 600 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	Ortholog	in Unstimulated [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 185 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	HC: 1869 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 1093 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 687 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Ortholog	in List [RRAS, RASH, RASN, RASK, RAP2B, RAP2C, RAP2A, RALA, RRAS2, RAP1B, RAP1A]	List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 199 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [RRAS, RALA]	List: 399 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 1040 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC,MC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [F1P9Z4, E2R5G6]	List: 464 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC,MC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC: 4107 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 1597 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	List: 1378 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [RASH, RAP2B, RRAS2, RALA, RALB, RAP2C, Q9D091, RRAS, RASK, RAP1B]	HC: 3870 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	3	4	2	50.0	RRAS_RAT , RALA_RAT
H. sapiens	22	38	35	92.1	RRAS_HUMAN , RASH_HUMAN , RASN_HUMAN , RASK_HUMAN , RAP2B_HUMAN , RAP2C_HUMAN , RAP2A_HUMAN , RALA_HUMAN , RRAS2_HUMAN , RAP1B_HUMAN , RAP1A_HUMAN
M. musculus	23	37	31	83.8	RASH_MOUSE , RAP2B_MOUSE , RRAS2_MOUSE , RALA_MOUSE , RALB_MOUSE , RAP2C_MOUSE , Q9D091_MOUSE , RRAS_MOUSE , RASK_MOUSE , RAP1B_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	0	0.0	NA
S. pombe	1	1	0	0.0	NA
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	1	100.0	E9QX28_ASPFU
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	2	100.0	NA
C. familiaris	1	1	1	100.0	F1P9Z4_CANLF , E2R5G6_CANLF

References

Authors	Year	Reference title	PMID
Kang R et al.	2008	Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.	19092927
Ren W et al.	2013	Proteomic analysis of protein palmitoylation in adipocytes.	23599907
Marin EP et al.	2012	Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.	22496122
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
Martin BR et al.	2011	Global profiling of dynamic protein palmitoylation.	22056678
Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Merrick BA et al.	2011	Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.	21785166
Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
Yang W et al.	2010	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	19801377
Martin BR et al.	2009	Large-scale profiling of protein palmitoylation in mammalian cells.	19137006
Roth AF et al.	2006	Global analysis of protein palmitoylation in yeast.	16751107
Hemsley PA et al.	2013	A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis.	23252521
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
Wei X et al.	2014	Insulin-regulated protein palmitoylation impacts endothelial cell function.	24357059
Serwa RA et al.	2015	Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.	26256475
Morrison E et al.	2015	Quantitative analysis of the human T cell palmitome.	26111759
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
Santiago-Tirado FH et al.	2015	A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.	25970403
Emmer BT et al.	2011	Global analysis of protein palmitoylation in African trypanosomes.	21193548
Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
Foe IT et al.	2015	Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.	26468752
Gould NS et al.	2015	Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.	26165157
Peng T et al.	2015	Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.	25575299
Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Zhou B et al.	2019	Low-background Acyl-biotinyl Exchange Largely Eliminates the Co-isolation of Non-S-acylated Proteins and Enables Deep S-acylproteomic Analysis.	31251020
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Wegleiter T et al.	2019	Palmitoylation of BMPR1a regulates neural stem cell fate.	31772009
Morrison E et al.	2020	Dynamic palmitoylation events following T-cell receptor signaling.	32651440
Mariscal J et al.	2020	Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles.	32944167
Gorenberg EL et al.	2022	Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.	35358180
Uzbekova S et al.	2021	Protein Palmitoylation in Bovine Ovarian Follicle.	34769186
Miles MR et al.	2021	Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart.	33636221
Pradhan AJ et al.	2021	Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis.	33848465
Ripamonti M et al.	2021	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.	33782527
Zaręba-Kozioł M et al.	2021	S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity.	34200797
Ziemlińska E et al.	2021	Palm Oil-Rich Diet Affects Murine Liver Proteome and <i>S</i>-Palmitoylome.	34884899
Gao J et al.	2022	Proteome-wide identification of palmitoylated proteins in mouse testis.	35477839