SwissPalm

P06241 FYN_HUMAN

General info Cross-references Enzymes Sequences Orthologs Ortholog sequences Validation experiments Sites Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

9/22 articles for human
11 orthologs

Palmitoyl-proteome experiments

Validation experiments

17 experiments
4 orthologs

Validation experiments

Curated sites & Enzymes

2 sites from validation experiments^* Cys³, Cys⁶
0 site from palmitoyl-proteomes^*
DHHC-PATs : ZDHC2_HUMAN, ZDHC3_HUMAN, ZDHC7_HUMAN, ZDH15_HUMAN, ZDH20_HUMAN, ZDH21_HUMAN
No APT known
^*In main isoform only

Sites Enzymes

Predictions

Predicted

5 cysteines in main isoform

Predictions

Protein general information from UniProt

Protein names

Tyrosine-protein kinase Fyn, EC 2.7.10.2; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase, SLK; p59-Fyn

Subcellular location

Cytoplasm (Probable); Nucleus (Probable); Cell membrane (By similarity)

Isoforms & protein length

Isoform 1 (main): 537 aa; Isoform 2 : 534 aa; Isoform 3 : 482 aa

Known functions

Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site. Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB1, PAG1, and SH2D1A. Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity). Interacts with SH2D1A and SLAMF1. Interacts (via its SH3 domain) with HEV ORF3 protein. Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity. Interacts with FASLG. Interacts with RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation. Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway. Interacts with UNC119. Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity). Interacts with PTPRO (phosphorylated form) (By similarity). Interacts with PTPRB (phosphorylated form) (By similarity). Interacts with FYB2 (PubMed:27335501). Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking. Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site. Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB1, PAG1, and SH2D1A. Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity). Interacts with SH2D1A and SLAMF1. Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity. Interacts with FASLG. Interacts with RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation. Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway. Interacts with UNC119. Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity). Interacts with PTPRO (phosphorylated form) (By similarity). Interacts with PTPRB (phosphorylated form) (By similarity). Interacts with FYB2 (PubMed:27335501). Interacts with DSCAM (By similarity). (Microbial infection) Interacts (via its SH3 domain) with hepatitis E virus/HEV protein ORF3. Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking. Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site. Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB1, PAG1, and SH2D1A. Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity). Interacts with SH2D1A and SLAMF1. Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity. Interacts with FASLG. Interacts with RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation. Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway. Interacts with UNC119. Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity). Interacts with PTPRO (phosphorylated form) (By similarity). Interacts with PTPRB (phosphorylated form) (By similarity). Interacts with FYB2 (PubMed:27335501). Interacts with DSCAM (By similarity). Interacts with SKAP1 and FYB1; this interaction promotes the phosphorylation of CLNK (By similarity). (Microbial infection) Interacts (via its SH3 domain) with hepatitis E virus/HEV protein ORF3. Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.

Cross-references

Source	Identifiers
UniProt gene names	FYN
UniProt secondary AC	B5BU57, E1P557, H0UI48, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
Refseq protein ID	NP_002028.1, NP_694592.1, NP_694593.1, XP_005266944.1, XP_005266945.1, XP_005266946.1, XP_005266947.1, XP_005266949.1
IPI ID	IPI00166845, IPI00219012, IPI00640091, IPI00816301, IPI00657825, IPI00396264, IPI00292874, IPI00025838

Source	Identifiers
Ensembl protein	ENSP00000229471, ENSP00000346671, ENSP00000348295, ENSP00000357656, ENSP00000357667, ENSP00000357671, ENSP00000440646
Ensembl gene	ENSG00000010810

Enzymes

PAT/APT	Enzyme	Experiments
PAT	ZDHC2_HUMAN	SPalmE:148 Mill P et al. (2009)
PAT	ZDHC3_HUMAN	SPalmE:148 Mill P et al. (2009)
PAT	ZDHC7_HUMAN	SPalmE:148 Mill P et al. (2009)
PAT	ZDH15_HUMAN	SPalmE:148 Mill P et al. (2009)
PAT	ZDH20_HUMAN	SPalmE:148 Mill P et al. (2009)
PAT	ZDH21_HUMAN	SPalmE:148 Mill P et al. (2009)

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Times validated	Techniques	Sites	Predicted
P39688	FYN_MOUSE	OMA, Ensembl, InParanoid, MetaPhors	M. musculus	Fyn	Tyrosine-protein kinase Fyn, EC 2.7.10.2	13/23	7	3	2	Yes
P50527	STE20_SCHPO	MetaPhors	S. pombe	shk1, orb2, pak1, ste20, SPBC1604.14c	Serine/threonine-protein kinase shk1/pak1	0/1	0	0	0	No
P50528	PLO1_SCHPO	MetaPhors	S. pombe	plo1, SPAC23C11.16	Serine/threonine-protein kinase plo1	0/1	0	0	0	No
P36582	PCK1_SCHPO	MetaPhors	S. pombe	pck1, SPAC17G8.14c, SPAC22H10.01c	Protein kinase C-like 1	0/1	0	0	0	Yes
P87169	MAD1_SCHPO	MetaPhors	S. pombe	mad1, SPBC3D6.04c	Spindle assembly checkpoint component mad1	0/1	0	0	0	No
P41892	CDC7_SCHPO	MetaPhors	S. pombe	cdc7, SPBC21.06c	Cell division control protein 7	0/1	0	0	0	Yes
Q9LVI6	RLK90_ARATH	MetaPhors	A. thaliana	RLK902, At3g17840, MEB5.6	Probable inactive receptor kinase RLK902	0/1	0	0	0	No
Q9FXF2	RKF1_ARATH	MetaPhors	A. thaliana	RKF1, At1g29750, F1N18.19, T3M22.1	Probable LRR receptor-like serine/threonine-protein kinase RFK1, EC 2.7.11.1	0/1	0	0	0	Yes
O04533	LRK52_ARATH	MetaPhors	A. thaliana	LECRK52, LECRKB1, At1g70130, F20P5.15	Putative L-type lectin-domain containing receptor kinase V.2, Arabidopsis thaliana lectin-receptor kinase b1, AthlecRK-b1, LecRK-V.2, EC 2.7.11.1	0/1	0	0	0	Yes
O22558	STY8_ARATH	InParanoid	A. thaliana	STY8, At2g17700	Serine/threonine-protein kinase STY8, EC 2.7.11.1	0/1	0	0	0	Yes
F4JTP5	STY46_ARATH	InParanoid, MetaPhors	A. thaliana	STY46, At4g38470, F20M13.30	Serine/threonine-protein kinase STY46, EC 2.7.11.1	0/1	0	0	0	No
Q9ZQ31	STY13_ARATH	InParanoid	A. thaliana	STY13, At2g24360, T28I24.9	Serine/threonine-protein kinase STY13, EC 2.7.11.1	0/1	0	0	0	Yes
Q9M085	Q9M085_ARATH	InParanoid	A. thaliana	At4g31170, F6E21.90, F6E21_90	AT4G31170 protein	0/1	0	0	0	Yes
Q8RWL6	STY17_ARATH	InParanoid	A. thaliana	STY17, At4g35780, F8D20.290	Serine/threonine-protein kinase STY17, EC 2.7.11.1	0/1	0	0	0	No
Q2MHE4	HT1_ARATH	InParanoid	A. thaliana	SUU, HT1, At1g62400, F24O1.13	Serine/threonine/tyrosine-protein kinase HT1, EC 2.7.10.1, EC 2.7.11.1	0/1	0	0	0	Yes
O22100	O22100_ARATH	InParanoid	A. thaliana	F16M2_110, ATMRK1, At3g63260	ATMRK1	1/1	0	1	0	Yes
Q9LT56	Q9LT56_ARATH	InParanoid	A. thaliana	ATN1, At3g27560	AT3g27560/MMJ24_11	0/1	0	0	0	Yes
Q9LUI6	Q9LUI6_ARATH	InParanoid	A. thaliana	At3g22750	Kinase-like protein	0/1	0	0	0	Yes
Q9FGS7	Q9FGS7_ARATH	InParanoid	A. thaliana	At5g50180, K6A12.4, K6A12_4	At5g50180	0/1	0	0	0	Yes
Q9FM43	Q9FM43_ARATH	InParanoid	A. thaliana	MNF13.60, MNF13_60, At5g40540	Protein kinase ATN1	0/1	0	0	0	Yes
O23334	O23334_ARATH	InParanoid	A. thaliana	dl3430w, At4g14780, At4g14780/dl3430w, Dl3430W, FCAALL.308	Kinase like protein	0/1	0	0	0	Yes
Q8L6Y9	Q8L6Y9_ARATH	InParanoid	A. thaliana	At5g01850, T20L15.120, T20L15_120	Protein kinase ATN1-like protein	0/1	0	0	0	No
Q9SSA4	Q9SSA4_ARATH	InParanoid	A. thaliana	At3g01490, F4P13.4, F4P13_4	AT3g01490/F4P13_4	0/1	0	0	0	Yes
Q9FGB1	Q9FGB1_ARATH	InParanoid	A. thaliana	MPF21.1, MPF21_1, At5g50000	Protein kinase	1/1	0	1	0	Yes
F4K964	F4K964_ARATH	MetaPhors	A. thaliana	At5g57035	U-box domain-containing protein kinase family protein	0/1	0	0	0	Yes
O59790	ARK1_SCHPO	MetaPhors	S. pombe	ark1, sex1, SPCC320.13c, SPCC330.16	Serine/threonine-protein kinase ark1	1/1	0	1	0	No
Q9UU87	PPK34_SCHPO	MetaPhors	S. pombe	ppk34, SPCC1919.01, SPCC830.12	Serine/threonine-protein kinase ppk34	0/1	0	0	0	No
O74749	HSE1_SCHPO	MetaPhors	S. pombe	hse1, SPBC1734.08	Class E vacuolar protein-sorting machinery protein hse1	0/1	0	0	0	No
O64781	Y1639_ARATH	MetaPhors	A. thaliana	At1g61390, T1F9.12	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61390, EC 2.7.11.1	0/1	0	0	0	Yes
O81064	O81064_ARATH	MetaPhors	A. thaliana	At2g28940, T9I4.2, T9I4_2	At2g28940	0/1	0	0	0	Yes
Q9M2S4	LRKS4_ARATH	MetaPhors	A. thaliana	LECRKS4, At3g55550, T22E16.210	L-type lectin-domain containing receptor kinase S.4, LecRK-S.4, EC 2.7.11.1	0/1	0	0	0	No
Q7FK55	Q7FK55_ARATH	MetaPhors	A. thaliana	F18L15.130, At3g46410	Protein kinase superfamily protein	0/1	0	0	0	No
Q42371	ERECT_ARATH	MetaPhors	A. thaliana	ERECTA, ER, QRP1, QRS1, TE1, At2g26330, T1D16.3	LRR receptor-like serine/threonine-protein kinase ERECTA, EC 2.7.11.1	0/1	0	0	0	Yes
Q9SII6	PIX13_ARATH	MetaPhors	A. thaliana	PIX13, KIN3, At2g17220	Probable serine/threonine-protein kinase PIX13, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FE20	PBS1_ARATH	MetaPhors	A. thaliana	PBS1, At5g13160, T19L5.120	Serine/threonine-protein kinase PBS1, EC 2.7.11.1	0/1	2	0	2	Yes
P43298	TMK1_ARATH	MetaPhors	A. thaliana	BLK1, TMK1, At1g66150, F15E12.4	Receptor protein kinase TMK1, EC 2.7.11.1	0/1	0	0	0	Yes
O64770	Y1649_ARATH	MetaPhors	A. thaliana	At1g61490, T1F9.1	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490, EC 2.7.11.1	0/1	0	0	0	Yes
Q8RY11	AMPP2_ARATH	MetaPhors	A. thaliana	APP2, T12H1.32, T12H1_32, At3g05350	Aminopeptidase P2, AtAPP2, EC 3.4.11.9	0/1	0	0	0	No
Q96285	LRK55_ARATH	MetaPhors	A. thaliana	LECRK55, LECRKA1, At3g59700, T16L24.250	L-type lectin-domain containing receptor kinase V.5, Arabidopsis thaliana lectin-receptor kinase a1, Ath.lecRK1, AthlecRK-a1, LecRK-V.5, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FHG4	LRKS7_ARATH	MetaPhors	A. thaliana	LECRKS7, At5g55830, MDF20.27	Probable L-type lectin-domain containing receptor kinase S.7, LecRK-S.7, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FYK0	TMK2_ARATH	MetaPhors	A. thaliana	TMK2, BLK3, At1g24650, F21J9.31, F5A9.23	Receptor-like kinase TMK2, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LMN6	WAK4_ARATH	MetaPhors	A. thaliana	WAK4, At1g21210, F16F4.10	Wall-associated receptor kinase 4, EC 2.7.11.-	0/1	0	0	0	Yes
Q9SY95	Y1155_ARATH	MetaPhors	A. thaliana	At1g61550, T25B24.10	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550, EC 2.7.11.1	0/1	0	0	0	Yes
O64825	LYK4_ARATH	MetaPhors	A. thaliana	LYK4, At2g23770, F27L4.5	LysM domain receptor-like kinase 4, LysM-containing receptor-like kinase 4, EC 2.7.11.1	0/1	0	0	0	No
Q9CAD5	YODA_ARATH	MetaPhors	A. thaliana	YDA, At1g63700, F24D7.11	Mitogen-activated protein kinase kinase kinase YODA, EC 2.7.11.25	0/1	0	0	0	No
Q1PDV6	PBL27_ARATH	MetaPhors	A. thaliana	PBL27, T28N17.90, AT5G18610, At5g18610	Serine/threonine-protein kinase PBL27, EC 2.7.11.1	1/1	0	1	0	Yes
O48814	BIK1_ARATH	MetaPhors	A. thaliana	BIK1, At2g39660, F12L6.32, F17A14.3	Serine/threonine-protein kinase BIK1, EC 2.7.11.1	0/1	0	0	0	Yes
O49839	PBL2_ARATH	MetaPhors	A. thaliana	PBL2, KIN1, APK2A, At1g14370, F14L17.14	Probable serine/threonine-protein kinase PBL2, EC 2.7.11.1	0/1	0	0	0	Yes
O49840	PBL3_ARATH	MetaPhors	A. thaliana	PBL3, KIN2, PIX14, APK2B, At2g02800, T20F6.6	Probable serine/threonine-protein kinase PBL3, EC 2.7.11.1	0/1	0	0	0	Yes
O64842	PBL12_ARATH	MetaPhors	A. thaliana	PBL12, ARSK1, At2g26290	Probable serine/threonine-protein kinase PBL12, EC 2.7.11.1	0/1	0	0	0	Yes
Q7X8C5	WAKLB_ARATH	MetaPhors	A. thaliana	WAKL2, At1g16130, T24D18.21	Wall-associated receptor kinase-like 2, EC 2.7.11.-	0/1	0	0	0	Yes
Q8GXZ3	PBL8_ARATH	MetaPhors	A. thaliana	PBL8, PIX17, At5g01020, F7J8.5	Probable serine/threonine-protein kinase PBL8, EC 2.7.11.1	0/1	0	0	0	Yes
Q8H1E3	PBL17_ARATH	MetaPhors	A. thaliana	PBL17, At2g07180	Probable serine/threonine-protein kinase PBL17, EC 2.7.11.1	0/1	0	0	0	Yes
Q8L7V7	Q8L7V7_ARATH	MetaPhors	A. thaliana	At4g02010, T10M13.2, T10M13_2	AT4g02010/T10M13_2	0/1	0	0	0	Yes
Q94A51	PUB32_ARATH	MetaPhors	A. thaliana	PUB32, At3g49060, T2J13.100	U-box domain-containing protein 32, EC 2.3.2.27	0/1	0	0	0	Yes
Q9FLZ3	KIN12_ARATH	MetaPhors	A. thaliana	KIN12, AKIN12, KIN30, SNRK1.3, MUL8.12, MUL8.120, MUL8_120, SnRK1.3, At5g39440	SNF1-related protein kinase catalytic subunit alpha KIN12, AKIN12, EC 2.7.11.1	0/1	0	0	0	No
Q9FM85	PBL16_ARATH	MetaPhors	A. thaliana	PBL16, At5g56460, MCD7.23	Probable serine/threonine-protein kinase PBL16, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LFP7	PBL34_ARATH	MetaPhors	A. thaliana	PBL34, PIX7, At5g15080, F2G14.200	Serine/threonine-protein kinase PBL34, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LK43	TMK4_ARATH	MetaPhors	A. thaliana	TMK4, BARK1, At3g23750, MYM9.9	Receptor-like kinase TMK4, EC 2.7.11.1	0/1	0	0	0	No
Q9M1Q2	Q9M1Q2_ARATH	MetaPhors	A. thaliana	T17J13.180, At3g62220	At3g62220	0/1	0	0	0	Yes
Q9SIT1	TMK3_ARATH	MetaPhors	A. thaliana	TMK3, BLK2, T23K3.1, LRR-RLK, AT2G01820, At2g01820	Receptor-like kinase TMK3, EC 2.7.11.1	1/1	0	1	0	Yes
Q9SRH7	PBL35_ARATH	MetaPhors	A. thaliana	PBL35, At3g01300, T22N4.7, T4P13.2	Serine/threonine-protein kinase PBL35, EC 2.7.11.1	0/1	0	0	0	Yes
Q9SY91	PBL15_ARATH	MetaPhors	A. thaliana	PBL15, PIX1, At1g61590, T25B24.6	Probable serine/threonine-protein kinase PBL15, EC 2.7.11.1	0/1	0	0	0	Yes
Q9ZUF4	RIPK_ARATH	MetaPhors	A. thaliana	RIPK, PBL14, PIX8, At2g05940	Serine/threonine-protein kinase RIPK, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LMN8	WAK3_ARATH	MetaPhors	A. thaliana	WAK3, At1g21240, F16F4.8	Wall-associated receptor kinase 3, EC 2.7.11.-	0/1	0	0	0	Yes
Q0V7T5	Y1864_ARATH	MetaPhors	A. thaliana	At1g80640, T21F11.3	Probable receptor-like protein kinase At1g80640, EC 2.7.11.1	0/1	0	0	0	Yes
Q1PE89	PBL24_ARATH	MetaPhors	A. thaliana	PBL24, At4g13190, F17N18.80	Probable serine/threonine-protein kinase PBL24, EC 2.7.11.1	0/1	0	0	0	Yes
O64778	Y1142_ARATH	MetaPhors	A. thaliana	At1g61420, T1F9.9	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420, EC 2.7.11.1	0/1	0	0	0	Yes
O64783	Y1137_ARATH	MetaPhors	A. thaliana	At1g61370, T1F9.14	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370, EC 2.7.11.1	0/1	0	0	0	Yes
B9DFG5	PTI13_ARATH	MetaPhors	A. thaliana	PTI13, At3g59350, F25L23.210	PTI1-like tyrosine-protein kinase 3, PTI1-3, EC 2.7.10.2	1/1	0	1	0	Yes
O64771	Y1148_ARATH	MetaPhors	A. thaliana	At1g61480, T1F9.2	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61480, EC 2.7.11.1	0/1	0	0	0	Yes
C0LGD8	Y1755_ARATH	MetaPhors	A. thaliana	At1g07550, F22G5.7	Probable LRR receptor-like serine/threonine-protein kinase At1g07550, EC 2.7.11.1	0/1	0	0	0	Yes
F4JPX3	PBL20_ARATH	MetaPhors	A. thaliana	PBL20, At4g17660, dl4865w	Probable serine/threonine-protein kinase PBL20, EC 2.7.11.1	0/1	0	0	0	Yes
F4I3K0	F4I3K0_ARATH	MetaPhors	A. thaliana	At1g56120, T6H22.9, T6H22_9	Leucine-rich repeat transmembrane protein kinase	0/1	0	0	0	Yes
C0LGE0	Y1765_ARATH	MetaPhors	A. thaliana	At1g07650, F24B9.28, F24B9.29	Probable LRR receptor-like serine/threonine-protein kinase At1g07650, EC 2.7.11.1	0/1	0	0	0	Yes
Q9SXB3	Y1112_ARATH	MetaPhors	A. thaliana	At1g11280, T28P6.7	G-type lectin S-receptor-like serine/threonine-protein kinase At1g11280, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FGG5	Q9FGG5_ARATH	MetaPhors	A. thaliana	MUF8.1, MUF8_1, At5g41730	Protein kinase family protein	0/1	0	0	0	No
Q9LMN9	Q9LMN9_ARATH	MetaPhors	A. thaliana	F16F4.7, At1g21245	F16F4.7 protein	0/1	0	0	0	No
A1L4W8	A1L4W8_ARATH	MetaPhors	A. thaliana	PK1B, APK1B, protein kinase 1B, At2g28930, T9I4.1, T9I4_1	At2g28930	0/1	0	0	0	No
A0A654EQA1	A0A654EQA1_ARATH	MetaPhors	A. thaliana	AN1_LOCUS5176, C24_LOCUS5055	Protein kinase domain-containing protein	0/1	0	0	0	No
F4JNP7	F4JNP7_ARATH	MetaPhors	A. thaliana	At4g29654	Protein kinase superfamily protein	0/1	0	0	0	No
Q62844	FYN_RAT	OrthoDB, OMA, Ensembl, InParanoid, MetaPhors	R. norvegicus	Fyn	Tyrosine-protein kinase Fyn, EC 2.7.10.2	1/3	1	2	0	Yes
A0JNB0	FYN_BOVIN	OrthoDB, OMA, Ensembl, InParanoid, MetaPhors	B. taurus	FYN	Tyrosine-protein kinase Fyn, EC 2.7.10.2	0/2	0	0	0	Yes
E2RC09	E2RC09_CANLF	OrthoDB, OMA, Ensembl, InParanoid	C. familiaris	FYN	Tyrosine-protein kinase	1/1	0	2	0	Yes
P05480	SRC_MOUSE	OrthoDB	M. musculus	Src	Proto-oncogene tyrosine-protein kinase Src, EC 2.7.10.2	3/23	0	2	0	Yes
P00528	SRC64_DROME	OrthoDB, Ensembl, MetaPhors	D. melanogaster	Src64B, Src1, CG7524	Tyrosine-protein kinase Src64B, Dsrc64, EC 2.7.10.2	0/1	0	0	0	Yes
Q04736	YES_MOUSE	OrthoDB	M. musculus	Yes1, Yes	Tyrosine-protein kinase Yes, EC 2.7.10.2	8/23	1	3	0	Yes
P00522	ABL_DROME	OrthoDB	D. melanogaster	Abl, ABL-1, Dash, CG4032	Tyrosine-protein kinase Abl, EC 2.7.10.2	0/1	0	0	0	No
Q8IIT5	PTKL_PLAF7	InParanoid	P. falciparum	pTKL, PF3D7_1106800	Inactive protein tyrosine kinase pTKL	0/1	0	0	0	Yes

Ortholog sequence alignment (CLUSTALW)

Validation experiments

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)
SPalmE:54	Yang X et al.	2002	Homo sapiens	A431	Total cell lysate	[3H]palmitic acid labeling
SPalmE:83	Maisse C et al.	2008	Homo sapiens	HEK293T	Lipid raft	13-oxypalmitate inhibition , Point mutation, Substrate truncation, [3H]palmitic acid labeling
SPalmE:148	Mill P et al.	2009	Homo sapiens	HEK293	NA	PAT overexpression, Point mutation, [3H]palmitic acid labeling
SPalmE:274	Guardiola-Serrano F et al.	2010	Homo sapiens	WSU-1	Lipid raft	2BP inhibition, ABE, NH2OH cleavage of thioester bond, Point mutation
SPalmE:484	Berthiaume L et al.	1995	Bos taurus	Brain	NA	NH2OH cleavage of thioester bond, Point mutation, [125I]IC16 labeling
SPalmE:545	Akimzhanov AM et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, Depletion of PAT by shRNA, Thioesterases drug inhibition
SPalmE:600	van't Hof W et al.	1999	Chlorocebus aethiops	COS1	Total membrane	[125I]-IC16 palmitate labeling
SPalmE:617	Webb Y et al.	2000	Chlorocebus aethiops	COS	Total cell lysate	2BP inhibition, Substrate localization by fluorescence tag, [125I]-IC16 palmitate labeling
SPalmE:625	van't Hof W et al.	1997	Chlorocebus aethiops	COS1	Total cell lysate	[125I]-IC16 palmitate labeling
SPalmE:677	Alland L et al.	1994	Chlorocebus aethiops	COS1	Total membrane	Point mutation, TLC, [125I]-IC16 palmitate labeling, [3H]palmitic acid labeling
SPalmE:788	Liang X et al.	2001	Homo sapiens	COS1	Total cell lysate	MS, Point mutation, TLC, [125I]IC16 labeling, [3H]palmitic acid labeling
SPalmE:1059	Charron G et al.	2009	Homo sapiens	HeLa	Total cell lysate	Alk12 labeling, Alk16 Labeling, Point mutation
SPalmE:1060	Charron G et al.	2009	Homo sapiens	Jurkat	Total cell lysate	, Alk12 labeling, Alk16 Labeling, Click-IT Palmitic Acid labeling, NH2OH cleavage of thioester bond
SPalmE:1261	Xiong X et al.	2019	Homo sapiens	U-373MG	Total cell lysate	ABE, NH2OH cleavage of thioester bond
SPalmE:21	Wolven A et al.	1997	Chlorocebus aethiops	NIH-3T3	Total cell lysate	Point mutation, [125I]-IC16 palmitate labeling
SPalmE:1392	Suzuki K et al.	2020	Homo sapiens	HeLa	Total cell lysate	2BP inhibition, ABE, NH2OH cleavage of thioester bond
SPalmE:1406	Li MY et al.	2020	Homo sapiens	Huh-7	Total cell lysate	[3H]palmitoyl-CoA labeling

Sites (from validation or large-scale experiments)

Isoforms	Position	Probability	Studies	Techniques
P06241	3	NA	SPalmE:677 Alland L et al. (1994) SPalmE:484 Berthiaume L et al. (1995) SPalmE:21 Wolven A et al. (1997) SPalmE:788 Liang X et al. (2001) SPalmE:1059 Charron G et al. (2009)	Alk12 labeling, Alk16 Labeling, MS, NH2OH cleavage of thioester bond, Point mutation, TLC, [125I]-IC16 palmitate labeling, [125I]IC16 labeling, [3H]palmitic acid labeling
P06241	6	NA	SPalmE:677 Alland L et al. (1994) SPalmE:484 Berthiaume L et al. (1995) SPalmE:21 Wolven A et al. (1997) SPalmE:788 Liang X et al. (2001) SPalmE:1059 Charron G et al. (2009)	Alk12 labeling, Alk16 Labeling, MS, NH2OH cleavage of thioester bond, Point mutation, TLC, [125I]-IC16 palmitate labeling, [125I]IC16 labeling, [3H]palmitic acid labeling

Cysteine summary and predictions

Pos in alignment	3	6	239	240	246	249	272	281	404	487	491	502
Subcell. location	C	C	C	C	C	U	U	U	C	C	C	C
Disulfide	no	no	no	no	no				no	no	no	no
PSIPRED v.4.02 prediction	coil	coil	coil	coil	coil				strand	coil	coil	helix
UniProt secondary structure	NA	NA	strand	strand	NA				strand	NA	NA	helix
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys³ HC HC	Cys⁶ HC	Cys²³⁹ HC	Cys²⁴⁰ HC	Cys²⁴⁶				Cys⁴⁰⁴	Cys⁴⁸⁷ HC	Cys⁴⁹¹	Cys⁵⁰²
Pos in isoform 2 CSS-Palm 4.0 PalmPred	Cys³ HC HC	Cys⁶ HC	Cys²³⁹			Cys²⁴⁹	Cys²⁶⁹	Cys²⁷⁸	Cys⁴⁰¹	Cys⁴⁸⁴ HC	Cys⁴⁸⁸	Cys⁴⁹⁹
Pos in isoform 3 CSS-Palm 4.0 PalmPred	Cys³ HC HC	Cys⁶ HC							Cys³⁴⁹	Cys⁴³² HC	Cys⁴³⁶	Cys⁴⁴⁷

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

Tip: Keep CTRL key pressed down while clicking on column headers to do multiple sorting. This applies to any sortable table on this site.

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	x		HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	Found	in HC	HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	x		HC: 162 hits LC: 218 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	x		HC: 102 hits LC: 73 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	Ortholog	in HC [YES, FYN, SRC]	HC HC: 352 hits LC LC: 8 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	Found	in List	List: 214 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	Ortholog	in List [YES, FYN, SRC]	List: 69 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	Found	in HC	HC HC: 93 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	Ortholog	in HC [YES, FYN, SRC]	HC HC: 254 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	Found	in List	List: 154 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	Ortholog	in List [YES, FYN, SRC]	List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	Ortholog	in HC,LC,MC [TMK3, Q9FGB1, O22100, PBL27, PTI13]	HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	Ortholog	in List [YES, FYN, SRC]	List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	Ortholog	in List [ARK1]	List: 238 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	Ortholog	in List [YES, FYN, SRC]	List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	Ortholog	in List [YES, FYN, SRC]	List: 436 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	Found	in List	Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	x		List: 354 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	x		List: 1348 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	x		List: 354 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	Found	in List	List: 226 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	Found	in List	List: 274 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	Ortholog	in MC [YES, FYN, SRC]	HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	x		HC: 1079 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		List: 865 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Ortholog	in LC [YES, FYN, SRC]	HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	Ortholog	in MC [YES, FYN, SRC]	HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	x		List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	x		List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	Ortholog	in LC,HC [YES, FYN, SRC]	HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in LPS treatment [YES, FYN, SRC]	LPS treatment: 646 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in List [YES, FYN, SRC]	List: 646 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	x		List: 2929 hits
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 590 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES, FYN, SRC]	List: 370 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 600 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	Found	in	Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	Found	in List	List: 185 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1869 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES, FYN, SRC]	List: 1093 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 687 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Found	in List	List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	x		List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES, FYN, SRC]	List: 199 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [FYN]	List: 399 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES, FYN, SRC]	List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES, FYN, SRC]	List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES, FYN, SRC]	List: 1040 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [YES, FYN, SRC]	HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [E2RC09]	List: 464 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in MC [YES, FYN, SRC]	HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [YES, FYN, SRC]	HC: 4107 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1597 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES, FYN, SRC]	List: 1378 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [YES, FYN, SRC]	HC: 3870 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	3	4	1	25.0	FYN_RAT
H. sapiens	22	38	11	28.9	NA
M. musculus	23	37	24	64.9	YES_MOUSE , FYN_MOUSE , SRC_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	1	100.0	TMK3_ARATH , Q9FGB1_ARATH , O22100_ARATH , PBL27_ARATH , PTI13_ARATH
S. pombe	1	1	1	100.0	ARK1_SCHPO
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	0	0.0	SRC64_DROME
C. familiaris	1	1	1	100.0	E2RC09_CANLF

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