SwissPalm

P07947 YES_HUMAN

General info Cross-references Sequences Orthologs Ortholog sequences Validation experiments Sites Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

12/22 articles for human
8 orthologs

Palmitoyl-proteome experiments

Validation experiments

2 experiments
1 ortholog

Validation experiments

Curated sites & Enzymes

0 site from validation experiments^*
1 site from palmitoyl-proteomes^* Cys⁴²
No PAT known
No APT known
^*In main isoform only

Sites

Predictions

Predicted

2 cysteines in main isoform

Predictions

Protein general information from UniProt

Protein names

Tyrosine-protein kinase Yes, EC 2.7.10.2; Proto-oncogene c-Yes; p61-Yes

Subcellular location

Cell membrane (By similarity); Cytoplasm (Probable); cytoskeleton; microtubule organizing center; centrosome; cytosol; Cytoskeleton (Probable); Microtubule organizing center (Probable); Centrosome (Probable); Cytosol (Probable)

Isoforms & protein length

Isoform 1 (main): 543 aa

Known functions

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] Interacts with YAP1 and CSF1R (By similarity). Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with FASLG. Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition. Palmitoylation at Cys-3 promotes membrane localization. Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Interacts with YAP1 and CSF1R (By similarity). Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with FASLG. Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition. Palmitoylation at Cys-3 promotes membrane localization. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] Interacts with YAP1 and CSF1R (By similarity). Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with FASLG. Interacts with IL6ST/gp130 (PubMed:25731159). Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition. Palmitoylation at Cys-3 promotes membrane localization. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Cross-references

Source	Identifiers
UniProt gene names	YES1, YES
UniProt secondary AC	A6NLB3, D3DUH1
Refseq protein ID	XP_011524038.1, NP_005424.1
IPI ID	IPI00013981, IPI00032519, IPI00004875, NP_005424.1

Source	Identifiers
Ensembl protein	ENSP00000324740, ENSP00000462468
Ensembl gene	ENSG00000176105

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Times validated	Techniques	Predicted
F1LM93	YES_RAT	Ensembl, InParanoid, MetaPhors, OMA	R. norvegicus	Yes1	Tyrosine-protein kinase Yes, EC 2.7.10.2	1/3	0	2	Yes
F1PSB7	F1PSB7_CANLF	Ensembl	C. familiaris	YES1	Tyrosine-protein kinase	0/1	0	0	Yes
A7MB57	A7MB57_BOVIN	Ensembl, InParanoid, MetaPhors, OMA	B. taurus	YES1	Tyrosine-protein kinase	0/2	0	0	Yes
P00528	SRC64_DROME	Ensembl, MetaPhors	D. melanogaster	Src64B, Src1, CG7524	Tyrosine-protein kinase Src64B, Dsrc64, EC 2.7.10.2	0/1	0	0	Yes
P50527	STE20_SCHPO	MetaPhors	S. pombe	shk1, orb2, pak1, ste20, SPBC1604.14c	Serine/threonine-protein kinase shk1/pak1	0/1	0	0	No
P36582	PCK1_SCHPO	MetaPhors	S. pombe	pck1, SPAC17G8.14c, SPAC22H10.01c	Protein kinase C-like 1	0/1	0	0	Yes
P41892	CDC7_SCHPO	MetaPhors	S. pombe	cdc7, SPBC21.06c	Cell division control protein 7	0/1	0	0	Yes
Q9LVI6	RLK90_ARATH	MetaPhors	A. thaliana	RLK902, At3g17840, MEB5.6	Probable inactive receptor kinase RLK902	0/1	0	0	No
Q9FXF2	RKF1_ARATH	MetaPhors	A. thaliana	RKF1, At1g29750, F1N18.19, T3M22.1	Probable LRR receptor-like serine/threonine-protein kinase RFK1, EC 2.7.11.1	0/1	0	0	Yes
O04533	LRK52_ARATH	MetaPhors	A. thaliana	LECRK52, LECRKB1, At1g70130, F20P5.15	Putative L-type lectin-domain containing receptor kinase V.2, Arabidopsis thaliana lectin-receptor kinase b1, AthlecRK-b1, LecRK-V.2, EC 2.7.11.1	0/1	0	0	Yes
Q9LTC0	PBL19_ARATH	MetaPhors	A. thaliana	PBL19, At5g47070, K14A3.2	Probable serine/threonine-protein kinase PBL19, EC 2.7.11.1	0/1	0	0	Yes
Q28923	YES_CANLF	InParanoid	C. familiaris	YES1, YES	Tyrosine-protein kinase Yes, EC 2.7.10.2	1/1	0	2	Yes
O22558	STY8_ARATH	InParanoid	A. thaliana	STY8, At2g17700	Serine/threonine-protein kinase STY8, EC 2.7.11.1	0/1	0	0	Yes
F4JTP5	STY46_ARATH	InParanoid	A. thaliana	STY46, At4g38470, F20M13.30	Serine/threonine-protein kinase STY46, EC 2.7.11.1	0/1	0	0	No
Q9ZQ31	STY13_ARATH	InParanoid	A. thaliana	STY13, At2g24360, T28I24.9	Serine/threonine-protein kinase STY13, EC 2.7.11.1	0/1	0	0	Yes
Q9M085	Q9M085_ARATH	InParanoid	A. thaliana	At4g31170, F6E21.90, F6E21_90	AT4G31170 protein	0/1	0	0	Yes
Q8RWL6	STY17_ARATH	InParanoid	A. thaliana	STY17, At4g35780, F8D20.290	Serine/threonine-protein kinase STY17, EC 2.7.11.1	0/1	0	0	No
Q2MHE4	HT1_ARATH	InParanoid	A. thaliana	SUU, HT1, At1g62400, F24O1.13	Serine/threonine/tyrosine-protein kinase HT1, EC 2.7.10.1, EC 2.7.11.1	0/1	0	0	Yes
O22100	O22100_ARATH	InParanoid	A. thaliana	F16M2_110, ATMRK1, At3g63260	ATMRK1	1/1	0	1	Yes
Q9LT56	Q9LT56_ARATH	InParanoid	A. thaliana	ATN1, At3g27560	AT3g27560/MMJ24_11	0/1	0	0	Yes
Q9LUI6	Q9LUI6_ARATH	InParanoid	A. thaliana	At3g22750	Kinase-like protein	0/1	0	0	Yes
Q9FGS7	Q9FGS7_ARATH	InParanoid	A. thaliana	At5g50180, K6A12.4, K6A12_4	At5g50180	0/1	0	0	Yes
Q9FM43	Q9FM43_ARATH	InParanoid	A. thaliana	MNF13.60, MNF13_60, At5g40540	Protein kinase ATN1	0/1	0	0	Yes
O23334	O23334_ARATH	InParanoid	A. thaliana	dl3430w, At4g14780, At4g14780/dl3430w, Dl3430W, FCAALL.308	Kinase like protein	0/1	0	0	Yes
Q8L6Y9	Q8L6Y9_ARATH	InParanoid	A. thaliana	At5g01850, T20L15.120, T20L15_120	Protein kinase ATN1-like protein	0/1	0	0	No
Q9SSA4	Q9SSA4_ARATH	InParanoid	A. thaliana	At3g01490, F4P13.4, F4P13_4	AT3g01490/F4P13_4	0/1	0	0	Yes
Q9FGB1	Q9FGB1_ARATH	InParanoid	A. thaliana	MPF21.1, MPF21_1, At5g50000	Protein kinase	1/1	0	1	Yes
O59790	ARK1_SCHPO	MetaPhors	S. pombe	ark1, sex1, SPCC320.13c, SPCC330.16	Serine/threonine-protein kinase ark1	1/1	0	1	No
O74749	HSE1_SCHPO	MetaPhors	S. pombe	hse1, SPBC1734.08	Class E vacuolar protein-sorting machinery protein hse1	0/1	0	0	No
Q09822	CDC15_SCHPO	MetaPhors	S. pombe	cdc15, SPAC20G8.05c	Cell division control protein 15	0/1	0	0	No
Q09795	YAA1_SCHPO	MetaPhors	S. pombe	SPAC22G7.01c, SPAPJ696.03c	Uncharacterized peptidase C22G7.01c	0/1	0	0	No
F4JY37	RUK_ARATH	MetaPhors	A. thaliana	RUK, EMB3013, At5g18700, T1A4.80	Serine/threonine-protein kinase RUNKEL	0/1	0	0	Yes
P43298	TMK1_ARATH	MetaPhors	A. thaliana	BLK1, TMK1, At1g66150, F15E12.4	Receptor protein kinase TMK1, EC 2.7.11.1	0/1	0	0	Yes
Q66GN2	LRK64_ARATH	MetaPhors	A. thaliana	LECRK64, LECRKA4.3, At5g01560, F7A7.80	Lectin-domain containing receptor kinase VI.4, LecRK-VI.4, EC 2.7.11.1	0/1	0	0	Yes
Q8RY11	AMPP2_ARATH	MetaPhors	A. thaliana	APP2, T12H1.32, T12H1_32, At3g05350	Aminopeptidase P2, AtAPP2, EC 3.4.11.9	0/1	0	0	No
Q96285	LRK55_ARATH	MetaPhors	A. thaliana	LECRK55, LECRKA1, At3g59700, T16L24.250	L-type lectin-domain containing receptor kinase V.5, Arabidopsis thaliana lectin-receptor kinase a1, Ath.lecRK1, AthlecRK-a1, LecRK-V.5, EC 2.7.11.1	0/1	0	0	Yes
Q9M020	LRK63_ARATH	MetaPhors	A. thaliana	LECRK63, LECRKA4.2, At5g01550, F7A7.70	Lectin-domain containing receptor kinase VI.3, LecRK-VI.3, EC 2.7.11.1	0/1	0	0	Yes
Q9M1Z9	LRK58_ARATH	MetaPhors	A. thaliana	LECRK58, At3g59750, F24G16.20	Putative L-type lectin-domain containing receptor kinase V.8, LecRK-V.8, EC 2.7.11.1	0/1	0	0	No
Q9FII5	TDR_ARATH	MetaPhors	A. thaliana	TDR, PXY, At5g61480, MCI2.4	Leucine-rich repeat receptor-like protein kinase TDR, EC 2.7.11.1	0/1	0	0	Yes
Q9C5H5	M3K5G_ARATH	MetaPhors	A. thaliana	MAPKKK5, MAP3KG, At5g66850, MUD21.11	Mitogen-activated protein kinase kinase kinase 5, EC 2.7.11.25	0/1	0	0	Yes
Q9CAD5	YODA_ARATH	MetaPhors	A. thaliana	YDA, At1g63700, F24D7.11	Mitogen-activated protein kinase kinase kinase YODA, EC 2.7.11.25	0/1	0	0	No
O49840	PBL3_ARATH	MetaPhors	A. thaliana	PBL3, KIN2, PIX14, APK2B, At2g02800, T20F6.6	Probable serine/threonine-protein kinase PBL3, EC 2.7.11.1	0/1	0	0	Yes
Q94A51	PUB32_ARATH	MetaPhors	A. thaliana	PUB32, At3g49060, T2J13.100	U-box domain-containing protein 32, EC 2.3.2.27	0/1	0	0	Yes
Q9FLZ3	KIN12_ARATH	MetaPhors	A. thaliana	KIN12, AKIN12, KIN30, SNRK1.3, MUL8.12, MUL8.120, MUL8_120, SnRK1.3, At5g39440	SNF1-related protein kinase catalytic subunit alpha KIN12, AKIN12, EC 2.7.11.1	0/1	0	0	No
Q9LSC2	Y3589_ARATH	MetaPhors	A. thaliana	At3g15890, MVC8.1	PTI1-like tyrosine-protein kinase At3g15890, EC 2.7.10.2	1/1	0	1	Yes
Q9M0X5	CRK25_ARATH	MetaPhors	A. thaliana	CRK25, At4g05200, C17L7.120, C6L9.3	Cysteine-rich receptor-like protein kinase 25, Cysteine-rich RLK25, EC 2.7.11.-	0/1	0	0	Yes
Q9ZR79	LRK57_ARATH	MetaPhors	A. thaliana	LECRK57, LECRKA3, At3g59740, F24G16.10, T16L24.290	L-type lectin-domain containing receptor kinase V.7, Arabidopsis thaliana lectin-receptor kinase a3, AthlecRK-a3, LecRK-V.7, EC 2.7.11.1	0/1	0	0	No
B9DFG5	PTI13_ARATH	MetaPhors	A. thaliana	PTI13, At3g59350, F25L23.210	PTI1-like tyrosine-protein kinase 3, PTI1-3, EC 2.7.10.2	1/1	0	1	Yes
C0LGD7	Y1684_ARATH	MetaPhors	A. thaliana	At1g06840, F4H5.8	Probable LRR receptor-like serine/threonine-protein kinase At1g06840, EC 2.7.11.1	0/1	0	0	Yes
F4JQH3	AMPP1_ARATH	MetaPhors	A. thaliana	C7A10.600, At4g36760, aminopeptidase P1, AP22.64, AP22_64, ATAPP1, APP1	Aminopeptidase P1, AtAPP1, EC 3.4.11.9	0/1	0	0	No
F4JWD4	F4JWD4_ARATH	MetaPhors	A. thaliana	At5g11020	Protein kinase superfamily protein	0/1	0	0	Yes
A0A654FKI5	A0A654FKI5_ARATH	MetaPhors	A. thaliana	AN1_LOCUS16800	Receptor-like serine/threonine-protein kinase	0/1	0	0	No
Q04736	YES_MOUSE	Ensembl, InParanoid, MetaPhors	M. musculus	Yes1, Yes	Tyrosine-protein kinase Yes, EC 2.7.10.2	8/23	1	3	Yes
Q8IIT5	PTKL_PLAF7	InParanoid	P. falciparum	pTKL, PF3D7_1106800	Inactive protein tyrosine kinase pTKL	0/1	0	0	Yes

Ortholog sequence alignment (CLUSTALW)

Validation experiments

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)
SPalmE:1261	Xiong X et al.	2019	Homo sapiens	U-373MG	Total cell lysate	ABE, NH2OH cleavage of thioester bond
SPalmE:1262	Xiong X et al.	2019	Homo sapiens	U-373MG	Total membrane	2BP inhibition, ABE, IF localization, NH2OH cleavage of thioester bond

Sites (from validation or large-scale experiments)

Isoforms	Position	Probability	Studies	Techniques
P07947	42	NA	SPalmE:578 Yang W et al. (2010)*	ABE

Cysteine summary and predictions

Pos in alignment	3	42	248	255	287	410	493	497	508
Subcell. location	C	C	C	C	C	C	C	C	C
Disulfide	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	coil	coil	coil	coil	strand	coil	coil	helix
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys³ HC HC	Cys⁴²	Cys²⁴⁸	Cys²⁵⁵	Cys²⁸⁷	Cys⁴¹⁰ HC	Cys⁴⁹³ MC	Cys⁴⁹⁷	Cys⁵⁰⁸

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

Tip: Keep CTRL key pressed down while clicking on column headers to do multiple sorting. This applies to any sortable table on this site.

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	x		HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	Found	in LC	HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	Found	in HC	HC: 162 hits LC: 218 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	Found	in HC	HC: 102 hits LC: 73 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	x		HC HC: 352 hits LC LC: 8 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	Found	in List	List: 214 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	Ortholog	in HC [YES, SRC]	HC HC: 254 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	Found	in List	List: 154 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	Ortholog	in List [YES, SRC]	List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	Ortholog	in LC,HC,MC [Q9FGB1, O22100, PTI13, Y3589]	HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	Ortholog	in List [YES, SRC]	List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	Ortholog	in List [ARK1]	List: 238 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	x		List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	Ortholog	in List [YES, SRC]	List: 436 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	x		Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	Ortholog	in List [J3QRU1]	List: 354 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	Found	in List	List: 1348 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	Ortholog	in List [J3QRU1]	List: 354 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	x		List: 226 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	x		List: 274 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	x		HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	Found	in List	List: 1353 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	x		HC: 1079 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		List: 865 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	Found	in MC	HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	Found	in HC	HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Ortholog	in LC [YES, SRC]	HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	Found	in List	List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	Found	in List	List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	Ortholog	in HC [YES, SRC]	HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		LPS treatment: 646 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		List: 646 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	Found	in List	List: 2929 hits
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 590 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES, SRC]	List: 370 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Found	in HC	HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Found	in HC	HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Found	in HC	HC: 600 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		List: 185 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Found	in HC	HC: 1869 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES, SRC]	List: 1093 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 687 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Found	in List	List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Found	in List	List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES, SRC]	List: 199 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES]	List: 399 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES, SRC]	List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES, SRC]	List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES, SRC]	List: 1040 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [YES, SRC]	HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [YES]	List: 464 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in MC [YES, SRC]	HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [YES, SRC]	HC: 4107 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1597 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1378 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [YES, SRC]	HC: 3870 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	3	4	1	25.0	YES_RAT
H. sapiens	22	38	22	57.9	J3QRU1_HUMAN
M. musculus	23	37	16	43.2	YES_MOUSE , SRC_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	1	100.0	Q9FGB1_ARATH , O22100_ARATH , PTI13_ARATH , Y3589_ARATH
S. pombe	1	1	1	100.0	ARK1_SCHPO
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	0	0.0	SRC64_DROME
C. familiaris	1	1	1	100.0	YES_CANLF

References

Authors	Year	Reference title	PMID
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Ren W et al.	2013	Proteomic analysis of protein palmitoylation in adipocytes.	23599907
Marin EP et al.	2012	Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.	22496122
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
Martin BR et al.	2011	Global profiling of dynamic protein palmitoylation.	22056678
Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Merrick BA et al.	2011	Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.	21785166
Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
Yang W et al.	2010	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	19801377
Martin BR et al.	2009	Large-scale profiling of protein palmitoylation in mammalian cells.	19137006
Roth AF et al.	2006	Global analysis of protein palmitoylation in yeast.	16751107
Hemsley PA et al.	2013	A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis.	23252521
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
Wei X et al.	2014	Insulin-regulated protein palmitoylation impacts endothelial cell function.	24357059
Serwa RA et al.	2015	Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.	26256475
Morrison E et al.	2015	Quantitative analysis of the human T cell palmitome.	26111759
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
Santiago-Tirado FH et al.	2015	A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.	25970403
Emmer BT et al.	2011	Global analysis of protein palmitoylation in African trypanosomes.	21193548
Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
Foe IT et al.	2015	Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.	26468752
Gould NS et al.	2015	Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.	26165157
Peng T et al.	2015	Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.	25575299
Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Xiong X et al.	2019	Acid Sphingomyelinase regulates the localization and trafficking of palmitoylated proteins.	31142470
Zhou B et al.	2019	Low-background Acyl-biotinyl Exchange Largely Eliminates the Co-isolation of Non-S-acylated Proteins and Enables Deep S-acylproteomic Analysis.	31251020
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Wegleiter T et al.	2019	Palmitoylation of BMPR1a regulates neural stem cell fate.	31772009
Morrison E et al.	2020	Dynamic palmitoylation events following T-cell receptor signaling.	32651440
Mariscal J et al.	2020	Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles.	32944167
Gorenberg EL et al.	2022	Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.	35358180
Uzbekova S et al.	2021	Protein Palmitoylation in Bovine Ovarian Follicle.	34769186
Miles MR et al.	2021	Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart.	33636221
Pradhan AJ et al.	2021	Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis.	33848465
Ripamonti M et al.	2021	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.	33782527
Zaręba-Kozioł M et al.	2021	S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity.	34200797
Ziemlińska E et al.	2021	Palm Oil-Rich Diet Affects Murine Liver Proteome and <i>S</i>-Palmitoylome.	34884899
Gao J et al.	2022	Proteome-wide identification of palmitoylated proteins in mouse testis.	35477839