SwissPalm

P29323 EPHB2_HUMAN

General info Cross-references Sequences Orthologs Ortholog sequences Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

4/22 articles for human
14 orthologs

Palmitoyl-proteome experiments

Validation experiments

0 experiment
1 ortholog

Curated sites & Enzymes

0 site from validation experiments^*
0 site from palmitoyl-proteomes^*
No PAT known
No APT known
^*In main isoform only

Predictions

Predicted

2 cysteines in main isoform

Predictions

Protein general information from UniProt

Protein names

Ephrin type-B receptor 2, EC 2.7.10.1; Developmentally-regulated Eph-related tyrosine kinase; ELK-related tyrosine kinase; EPH tyrosine kinase 3; EPH-like kinase 5, EK5, hEK5; Renal carcinoma antigen NY-REN-47; Tyrosine-protein kinase TYRO5; Tyrosine-protein kinase receptor EPH-3 [Cleaved into: EphB2/CTF1; EphB2/CTF2 ]

Subcellular location

Cell membrane (By similarity); Cell projection; axon; dendrite; Axon (Probable); Dendrite (Probable)

Isoforms & protein length

Isoform 1 (main): 1055 aa; Isoform 2 : 986 aa; Isoform 3 : 987 aa

Known functions

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] Heterotetramer upon binding of the ligand (By similarity). The heterotetramer is composed of an ephrin dimer and a receptor dimer (PubMed:17897949). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome (By similarity). Interacts with AQP1; involved in endolymph production in the inner ear (By similarity). Interacts with SPSB1 and SPSB4 (PubMed:28931592). The phosphorylated form interacts with RASA1 (via SH2 domain 1) (By similarity). Interacts with EFNA5 (By similarity). Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome. Interacts with AQP1; involved in endolymph production in the inner ear. Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] Heterotetramer upon binding of the ligand (By similarity). The heterotetramer is composed of an ephrin dimer and a receptor dimer (PubMed:17897949). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome (By similarity). Interacts with AQP1; involved in endolymph production in the inner ear (By similarity). Interacts with SPSB1 and SPSB4 (PubMed:28931592). The phosphorylated form interacts with RASA1 (via SH2 domain 1) (By similarity). Interacts with EFNA5 (By similarity). Interacts with SH2D3C (By similarity).

Cross-references

Source	Identifiers
UniProt gene names	EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5
UniProt secondary AC	O43477, Q5T0U6, Q5T0U7, Q5T0U8
Refseq protein ID	NP_001296122.1, NP_004433.2, NP_059145.2, XP_005245832.1
IPI ID	IPI00021275, IPI00219421, IPI00252979, IPI00642253, IPI00301834, IPI00184151, IPI00180087, IPI00005499

Source	Identifiers
Ensembl protein	ENSP00000363761, ENSP00000363763, ENSP00000383053
Ensembl gene	ENSG00000133216

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Times validated	Techniques	Sites	Predicted
F1N3R6	F1N3R6_BOVIN	Ensembl, OrthoDB, OMA, InParanoid, MetaPhors	B. taurus	EPHB2	Receptor protein-tyrosine kinase	0/2	0	0	0	Yes
F1PAF1	F1PAF1_CANLF	Ensembl, OrthoDB, OMA, InParanoid	C. familiaris	EPHB2	EPH receptor B2	0/1	0	0	0	Yes
A3KG01	A3KG01_MOUSE	Ensembl, OrthoDB	M. musculus	Ephb2	Receptor protein-tyrosine kinase	0/23	0	0	0	No
F1MAJ0	F1MAJ0_RAT	Ensembl, OrthoDB, InParanoid, MetaPhors	R. norvegicus	Ephb2	Receptor protein-tyrosine kinase	0/3	0	0	0	Yes
D1YSF9	D1YSF9_DROME	Ensembl, OrthoDB	D. melanogaster	CT3831, DEK, Dek, dek, Dek7, Deph, Dmel\CG1511, Ek7, eph, lincRNA.923, RPTK Dek7, Eph, CG1511, Dmel_CG1511	Receptor protein-tyrosine kinase	0/1	0	0	0	No
Q9USY7	FZO1_SCHPO	MetaPhors	S. pombe	fzo1, SPBC1706.03, SPBC839.01	Transmembrane GTPase fzo1	0/1	0	0	0	Yes
O94487	PPK35_SCHPO	MetaPhors	S. pombe	ppk35, mug27, SPCC417.06c	Serine/threonine-protein kinase ppk35	0/1	0	0	0	No
C0LGN2	Y3148_ARATH	MetaPhors	A. thaliana	LRR-RLK, At3g14840, T21E2.2	Probable leucine-rich repeat receptor-like serine/threonine-protein kinase At3g14840, EC 2.7.11.1	1/1	0	1	0	Yes
P54763	EPHB2_MOUSE	OMA, InParanoid, MetaPhors	M. musculus	Ephb2, Epth3, Nuk, Sek3	Ephrin type-B receptor 2, EC 2.7.10.1	1/23	0	1	0	Yes
O65238	Y5537_ARATH	InParanoid	A. thaliana	At5g35370, T26D22.12	G-type lectin S-receptor-like serine/threonine-protein kinase At5g35370, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FXF2	RKF1_ARATH	InParanoid	A. thaliana	RKF1, At1g29750, F1N18.19, T3M22.1	Probable LRR receptor-like serine/threonine-protein kinase RFK1, EC 2.7.11.1	0/1	0	0	0	Yes
Q8RWZ1	SUB_ARATH	InParanoid	A. thaliana	SUB, SCM, At1g11130, At1g11135, At1g11140, T19D16.1, T19D16.8, T28P6.18	Protein STRUBBELIG	0/1	0	0	0	Yes
C0LGE0	Y1765_ARATH	InParanoid	A. thaliana	At1g07650, F24B9.28, F24B9.29	Probable LRR receptor-like serine/threonine-protein kinase At1g07650, EC 2.7.11.1	0/1	0	0	0	Yes
C0LGG7	Y1534_ARATH	InParanoid, MetaPhors	A. thaliana	At1g53420, F12M16.30	Probable LRR receptor-like serine/threonine-protein kinase At1g53420, EC 2.7.11.1	0/1	0	0	0	Yes
F4I337	F4I337_ARATH	InParanoid	A. thaliana	At1g29740, F1N18.20, F1N18_20	Leucine-rich repeat transmembrane protein kinase	0/1	0	0	0	Yes
Q9ASQ6	Y1972_ARATH	InParanoid	A. thaliana	RFK1, At1g29720, F1N18.22, T3M22.6	Probable LRR receptor-like serine/threonine-protein kinase At1g29720, EC 2.7.11.1	0/1	0	0	0	Yes
Q6R2K3	SRF3_ARATH	InParanoid	A. thaliana	SRF3, At4g03390, F4C21.35	Protein STRUBBELIG-RECEPTOR FAMILY 3	1/1	0	1	0	Yes
F4I336	F4I336_ARATH	InParanoid	A. thaliana	At1g29730, T3M22.3	Leucine-rich repeat transmembrane protein kinase	0/1	0	0	0	Yes
C0LGG8	Y5343_ARATH	InParanoid	A. thaliana	At1g53430, T3F20.25	Probable LRR receptor-like serine/threonine-protein kinase At1g53430, EC 2.7.11.1	0/1	0	0	0	Yes
C0LGG9	Y5344_ARATH	InParanoid	A. thaliana	At1g53440, T3F20.24	Probable LRR receptor-like serine/threonine-protein kinase At1g53440, EC 2.7.11.1	0/1	0	0	0	Yes
Q06BH3	SRF1_ARATH	InParanoid	A. thaliana	SRF1, At2g20850, F5H14.18	Protein STRUBBELIG-RECEPTOR FAMILY 1	0/1	0	0	0	Yes
Q6R2K1	SRF5_ARATH	InParanoid	A. thaliana	SRF5, At1g78980, YUP8H12R.40	Protein STRUBBELIG-RECEPTOR FAMILY 5	0/1	0	0	0	No
Q6R2J8	SRF8_ARATH	InParanoid, MetaPhors	A. thaliana	SRF8, At4g22130, F1N20.230	Protein STRUBBELIG-RECEPTOR FAMILY 8	0/1	0	0	0	Yes
F4I3K4	F4I3K4_ARATH	InParanoid	A. thaliana	At1g56145	Leucine-rich repeat transmembrane protein kinase	0/1	0	0	0	Yes
C0LGH3	Y5614_ARATH	InParanoid	A. thaliana	At1g56140, F14G9.24, T6H22.8.1	Probable LRR receptor-like serine/threonine-protein kinase At1g56140, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LUL4	SRF7_ARATH	InParanoid	A. thaliana	SRF7, At3g14350, MLN21.15	Protein STRUBBELIG-RECEPTOR FAMILY 7	0/1	0	0	0	Yes
Q9C8M9	SRF6_ARATH	InParanoid	A. thaliana	SRF6, At1g53730, F22G10.3, F22G10.31	Protein STRUBBELIG-RECEPTOR FAMILY 6	0/1	0	0	0	Yes
C0LGH2	Y1561_ARATH	InParanoid	A. thaliana	At1g56130, F14G9.25, T6H22.8	Probable LRR receptor-like serine/threonine-protein kinase At1g56130, EC 2.7.11.1	0/1	0	0	0	Yes
F4I3K0	F4I3K0_ARATH	InParanoid	A. thaliana	At1g56120, T6H22.9, T6H22_9	Leucine-rich repeat transmembrane protein kinase	0/1	0	0	0	Yes
Q9FG24	SRF2_ARATH	InParanoid	A. thaliana	SRF2, At5g06820, MPH15.19	Protein STRUBBELIG-RECEPTOR FAMILY 2	0/1	0	0	0	No
Q8RWZ5	SD25_ARATH	InParanoid	A. thaliana	SD25, At4g32300, F10M6.60, F8B4.10	G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5, EC 2.7.11.1	1/1	0	1	0	Yes
Q6R2K2	SRF4_ARATH	InParanoid	A. thaliana	SRF4, At3g13065, MGH6.19	Protein STRUBBELIG-RECEPTOR FAMILY 4	0/1	0	0	0	Yes
Q9FLV4	Y5248_ARATH	InParanoid	A. thaliana	At5g24080, MZF18.3	G-type lectin S-receptor-like serine/threonine-protein kinase At5g24080, EC 2.7.11.1	0/1	0	0	0	Yes
Q9XID3	Y1343_ARATH	InParanoid	A. thaliana	At1g34300, F23M19.5	G-type lectin S-receptor-like serine/threonine-protein kinase At1g34300, EC 2.7.11.1	0/1	0	0	0	Yes
Q8VYT3	Y4052_ARATH	InParanoid	A. thaliana	At4g30520, F17I23_140	Probable LRR receptor-like serine/threonine-protein kinase At4g30520, EC 2.7.11.1	0/1	0	0	0	Yes
Q94AG2	SERK1_ARATH	InParanoid	A. thaliana	SERK1, At1g71830, F14O23.21, F14O23_24	Somatic embryogenesis receptor kinase 1, AtSERK1, EC 2.7.10.1, EC 2.7.11.1	0/1	0	0	0	Yes
Q9SKG5	SERK4_ARATH	InParanoid	A. thaliana	SERK4, BKK1, At2g13790, F13J11.14	Somatic embryogenesis receptor kinase 4, AtSERK4, EC 2.7.10.1, EC 2.7.11.1	0/1	0	0	0	No
Q8W4S5	Y5371_ARATH	InParanoid	A. thaliana	At5g63710, MBK5.19	Probable LRR receptor-like serine/threonine-protein kinase At5g63710, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LVI6	RLK90_ARATH	InParanoid	A. thaliana	RLK902, At3g17840, MEB5.6	Probable inactive receptor kinase RLK902	0/1	0	0	0	No
Q39202	RLK1_ARATH	InParanoid	A. thaliana	RLK1, At5g60900, MSL3.2	G-type lectin S-receptor-like serine/threonine-protein kinase RLK1, EC 2.7.11.1	0/1	0	0	0	Yes
Q8LFN2	Y3037_ARATH	InParanoid	A. thaliana	At3g03770, F20H23.20	Probable inactive leucine-rich repeat receptor-like protein kinase At3g03770	0/1	0	0	0	Yes
Q9LP77	Y1848_ARATH	InParanoid	A. thaliana	RKL1, At1g48480, T1N15.9	Probable inactive receptor kinase At1g48480	1/1	0	1	0	Yes
Q9LSI9	BIR2_ARATH	InParanoid	A. thaliana	BIR2, At3g28450, MFJ20.14	Inactive LRR receptor-like serine/threonine-protein kinase BIR2	0/1	0	0	0	Yes
Q9M9C5	Y1680_ARATH	InParanoid	A. thaliana	At1g68400, T2E12.5	Probable leucine-rich repeat receptor-like protein kinase At1g68400, EC 2.7.11.1	0/1	0	0	0	Yes
O48788	Y2267_ARATH	InParanoid	A. thaliana	At2g26730, F18A8.10	Probable inactive receptor kinase At2g26730	1/1	0	1	0	Yes
Q9FMD7	Y5659_ARATH	InParanoid	A. thaliana	At5g16590, MTG13.3	Probable inactive receptor kinase At5g16590	1/1	0	1	0	Yes
Q9FRI1	Q9FRI1_ARATH	InParanoid	A. thaliana	F4F7_29, F4F7.29, LRR-RLK, At1g25320	At1g25320/F4F7_17	1/1	0	1	0	Yes
C0LGK4	Y2165_ARATH	InParanoid	A. thaliana	At2g16250, F16F14.25	Probable LRR receptor-like serine/threonine-protein kinase At2g16250, EC 2.7.11.1	0/1	0	0	0	Yes
Q9M8T0	Y3288_ARATH	InParanoid	A. thaliana	At3g02880, F13E7.17	Probable inactive receptor kinase At3g02880	1/1	0	1	0	Yes
Q9LVN2	Y5815_ARATH	InParanoid	A. thaliana	At5g58150, MCK7.2	Probably inactive leucine-rich repeat receptor-like protein kinase At5g58150	0/1	0	0	0	No
Q9SUQ3	Y4374_ARATH	InParanoid	A. thaliana	At4g23740, F9D16.210	Probable inactive receptor kinase At4g23740	0/1	0	0	0	Yes
O04567	Y1719_ARATH	InParanoid	A. thaliana	At1g27190, T7N9.25	Probable inactive receptor kinase At1g27190	0/1	0	0	0	Yes
Q9FHK7	Y5516_ARATH	InParanoid	A. thaliana	At5g05160, K2A11.3	Probable leucine-rich repeat receptor-like protein kinase At5g05160, EC 2.7.11.-	0/1	0	0	0	No
C0LGI5	Y1699_ARATH	InParanoid	A. thaliana	At1g69990, F20P5.27	Probable LRR receptor-like serine/threonine-protein kinase At1g69990, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LVM0	Y5830_ARATH	InParanoid	A. thaliana	At5g58300, MCK7.17	Probable inactive receptor kinase At5g58300	1/1	0	1	0	Yes
Q9FK10	Y5332_ARATH	InParanoid	A. thaliana	At5g53320, K19E1.12	Probable inactive receptor kinase At5g53320	0/1	0	0	0	Yes
Q9M9S4	Y1143_ARATH	InParanoid	A. thaliana	At1g14390, F14L17.16	Probable LRR receptor-like serine/threonine-protein kinase At1g14390, EC 2.7.11.1	0/1	0	0	0	No
Q9SKB2	SBIR1_ARATH	InParanoid	A. thaliana	SOBIR1, EVR, At2g31880, F20M17.8	Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1, EC 2.7.10.1, EC 2.7.11.1	1/1	0	1	0	Yes
C0LGS3	Y4372_ARATH	InParanoid	A. thaliana	At4g37250, AP22.22, C7A10.110	Probable LRR receptor-like serine/threonine-protein kinase At4g37250, EC 2.7.11.1	0/1	0	0	0	Yes
Q3E991	PRK6_ARATH	InParanoid	A. thaliana	PRK6, At5g20690, T1M15.90	Pollen receptor-like kinase 6, AtPRK6	0/1	0	0	0	No
Q8LEB6	Y5185_ARATH	InParanoid	A. thaliana	At5g18500, T28N17.1	Probable receptor-like protein kinase At5g18500, EC 2.7.11.1	0/1	0	0	0	No
Q9SH71	Y1421_ARATH	InParanoid	A. thaliana	At1g64210, F22C12.3	Putative inactive receptor-like protein kinase At1g64210	0/1	0	0	0	Yes
Q9FIF0	LRK22_ARATH	InParanoid	A. thaliana	LECRK22, At5g59270, MNC17.20	Putative L-type lectin-domain containing receptor kinase II.2, LecRK-II.2, EC 2.7.11.1	0/1	0	0	0	Yes
Q9M1L7	PRK3_ARATH	InParanoid	A. thaliana	PRK3, At3g42880, F18P9.40	Pollen receptor-like kinase 3, AtPRK3, EC 2.7.11.1	0/1	0	0	0	Yes
Q9C9Y8	Y3868_ARATH	InParanoid	A. thaliana	At3g08680, F17O14.15	Probable inactive receptor kinase At3g08680	1/1	0	1	0	Yes
Q940B9	Q940B9_ARATH	InParanoid	A. thaliana	At1g10850, At1g10860	Leucine-rich repeat protein kinase family protein	0/1	0	0	0	No
Q9SNE4	Q9SNE4_ARATH	InParanoid	A. thaliana	F11C1_70, LRR-RLK, At3g50230	Leucine-rich repeat protein kinase family protein	0/1	0	0	0	No
C0LGR9	Y4312_ARATH	InParanoid	A. thaliana	At4g31250, F8F16.70	Probable LRR receptor-like serine/threonine-protein kinase At4g31250, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LPT1	PRK5_ARATH	InParanoid	A. thaliana	PRK5, PRKB, At1g50610, F11F12.7, F17J6.13	Pollen receptor-like kinase 5, AtPRK5, EC 2.7.11.1	0/1	0	0	0	No
Q84MA9	Y1063_ARATH	InParanoid	A. thaliana	At1g60630, F8A5.15	Inactive leucine-rich repeat receptor-like serine/threonine-protein kinase At1g60630	0/1	0	0	0	Yes
C0LGU0	PRK1_ARATH	InParanoid	A. thaliana	PRK1, PRKD, RLK, At5g35390, T26D22.9	Pollen receptor-like kinase 1, AtPRK1, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FL63	Y5410_ARATH	InParanoid	A. thaliana	At5g24100, MZF18.1	Inactive leucine-rich repeat receptor-like serine/threonine-protein kinase At5g24100	0/1	0	0	0	No
F4I5D4	F4I5D4_ARATH	InParanoid	A. thaliana	At1g70250, F20P5.3, F20P5_3	Receptor serine/threonine kinase	0/1	0	0	0	Yes
C0LGJ9	Y2278_ARATH	InParanoid	A. thaliana	At2g02780, T20F6.8	Probable LRR receptor-like serine/threonine-protein kinase At2g02780, EC 2.7.11.1	0/1	0	0	0	Yes
F4HRJ4	M3K3A_ARATH	MetaPhors	A. thaliana	MAPKKK3, MAP3KA, At1g53570, F22G10.18, T3F20.12	Mitogen-activated protein kinase kinase kinase 3, EC 2.7.11.25	0/1	0	0	0	Yes
Q9ZU46	ZAR1_ARATH	MetaPhors	A. thaliana	ZAR1, At2g01210, F10A8.9	Receptor protein kinase-like protein ZAR1, EC 2.7.11.1	0/1	0	0	0	Yes
O59790	ARK1_SCHPO	MetaPhors	S. pombe	ark1, sex1, SPCC320.13c, SPCC330.16	Serine/threonine-protein kinase ark1	1/1	0	1	0	No
Q10407	MKH1_SCHPO	MetaPhors	S. pombe	mkh1, SPAC1F3.02c	MAP kinase kinase kinase mkh1	0/1	0	0	0	Yes
P43298	TMK1_ARATH	MetaPhors	A. thaliana	BLK1, TMK1, At1g66150, F15E12.4	Receptor protein kinase TMK1, EC 2.7.11.1	0/1	0	0	0	Yes
Q9CAL8	PEK13_ARATH	MetaPhors	A. thaliana	PERK13, RHS10, At1g70460, F24J13.3	Proline-rich receptor-like protein kinase PERK13, EC 2.7.11.1	0/1	0	0	0	No
O49545	BAME1_ARATH	MetaPhors	A. thaliana	BAM1, At5g65700, F6H11.170, MPA24.5	Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1, EC 2.7.11.1	0/1	0	0	0	No
Q9C8I6	IOS1_ARATH	MetaPhors	A. thaliana	IOS1, At1g51800, F19C24.3	LRR receptor-like serine/threonine-protein kinase IOS1, EC 2.7.11.-	0/1	0	0	0	Yes
Q9FN92	Y5597_ARATH	MetaPhors	A. thaliana	At5g59700, T5I8.2	Probable receptor-like protein kinase At5g59700, EC 2.7.11.-	0/1	0	0	0	Yes
Q8RY17	WAKLI_ARATH	MetaPhors	A. thaliana	WAKL22, RFO1, At1g79670, F20B17_27	Wall-associated receptor kinase-like 22, EC 2.7.11.-	0/1	0	0	0	Yes
Q9FFW5	PERK8_ARATH	MetaPhors	A. thaliana	PERK8, At5g38560, MBB18.10	Proline-rich receptor-like protein kinase PERK8, EC 2.7.11.1	0/1	0	0	0	No
B9DFG5	PTI13_ARATH	MetaPhors	A. thaliana	PTI13, At3g59350, F25L23.210	PTI1-like tyrosine-protein kinase 3, PTI1-3, EC 2.7.10.2	1/1	0	1	0	Yes
Q8RX80	CRK18_ARATH	MetaPhors	A. thaliana	CRK18, At4g23260, F21P8.150	Cysteine-rich receptor-like protein kinase 18, Cysteine-rich RLK18, EC 2.7.11.-	0/1	0	0	0	Yes
Q9SYQ8	CLV1_ARATH	MetaPhors	A. thaliana	CLV1, At1g75820, T4O12.5	Receptor protein kinase CLAVATA1, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LYN8	EMS1_ARATH	MetaPhors	A. thaliana	EXS, EMS1, ESP, At5g07280, T28J14.220	Leucine-rich repeat receptor protein kinase EMS1, EC 2.7.11.1	0/1	0	0	0	No
Q9FE20	PBS1_ARATH	MetaPhors	A. thaliana	PBS1, At5g13160, T19L5.120	Serine/threonine-protein kinase PBS1, EC 2.7.11.1	0/1	2	0	2	Yes
P47735	RLK5_ARATH	MetaPhors	A. thaliana	RLK5, HAE, At4g28490, F21O9.180	Receptor-like protein kinase 5, EC 2.7.10.1, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FL51	Y5694_ARATH	MetaPhors	A. thaliana	At5g06940, MOJ9.11	Probably inactive leucine-rich repeat receptor-like protein kinase At5g06940	0/1	0	0	0	No
Q9FRS6	PXL1_ARATH	MetaPhors	A. thaliana	PXL1, At1g08590, F22O13.7	Leucine-rich repeat receptor-like protein kinase PXL1, EC 2.7.11.1	0/1	0	0	0	No
Q9FYK0	TMK2_ARATH	MetaPhors	A. thaliana	TMK2, BLK3, At1g24650, F21J9.31, F5A9.23	Receptor-like kinase TMK2, EC 2.7.11.1	0/1	0	0	0	Yes
C0LGG6	Y5189_ARATH	MetaPhors	A. thaliana	At1g51890, T14L22.10	Probable LRR receptor-like protein kinase At1g51890, EC 2.7.11.1	0/1	0	0	0	No
Q9T020	Y4391_ARATH	MetaPhors	A. thaliana	At4g39110, F19H22.210, T22F8.10	Probable receptor-like protein kinase At4g39110, EC 2.7.11.-	0/1	0	0	0	No
Q93ZS4	NIK3_ARATH	MetaPhors	A. thaliana	NIK3, At1g60800, F8A5.31	Protein NSP-INTERACTING KINASE 3, EC 2.7.11.1	0/1	0	0	0	No
Q9C823	Y1523_ARATH	MetaPhors	A. thaliana	At1g52310, F19K6.8	C-type lectin receptor-like tyrosine-protein kinase At1g52310, EC 2.7.10.1	0/1	0	0	0	Yes
Q9FII5	TDR_ARATH	MetaPhors	A. thaliana	TDR, PXY, At5g61480, MCI2.4	Leucine-rich repeat receptor-like protein kinase TDR, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FLW0	Y5241_ARATH	MetaPhors	A. thaliana	At5g24010, MZF18.11	Probable receptor-like protein kinase At5g24010, EC 2.7.11.-	0/1	0	0	0	Yes
Q9M0G7	MIK1_ARATH	MetaPhors	A. thaliana	MIK1, PXL2, At4g28650, T5F17.100	MDIS1-interacting receptor like kinase 1, AtMIK1	0/1	0	0	0	Yes
Q9SGP2	HSL1_ARATH	MetaPhors	A. thaliana	HSL1, At1g28440, F3M18.12	Receptor-like protein kinase HSL1, EC 2.7.11.1	0/1	0	0	0	Yes
Q9SN80	Q9SN80_ARATH	MetaPhors	A. thaliana	F1P2.130, LRR-RLK, At3g47580	Leucine-rich repeat protein kinase family protein	0/1	0	0	0	Yes
Q9S7D9	ACCR1_ARATH	MetaPhors	A. thaliana	CCR1, CRR1, At3g09780, F11F8.37, F8A24.17	Serine/threonine-protein kinase-like protein CCR1, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FIL7	CRCK1_ARATH	MetaPhors	A. thaliana	CRCK1, At5g58940, K19M22.13	Calmodulin-binding receptor-like cytoplasmic kinase 1, EC 2.7.11.1	0/1	0	0	0	No
Q9FM85	PBL16_ARATH	MetaPhors	A. thaliana	PBL16, At5g56460, MCD7.23	Probable serine/threonine-protein kinase PBL16, EC 2.7.11.1	0/1	0	0	0	Yes
Q9SY91	PBL15_ARATH	MetaPhors	A. thaliana	PBL15, PIX1, At1g61590, T25B24.6	Probable serine/threonine-protein kinase PBL15, EC 2.7.11.1	0/1	0	0	0	Yes
Q9ZUF4	RIPK_ARATH	MetaPhors	A. thaliana	RIPK, PBL14, PIX8, At2g05940	Serine/threonine-protein kinase RIPK, EC 2.7.11.1	0/1	0	0	0	Yes
F4K6B8	RGI4_ARATH	MetaPhors	A. thaliana	RGI4, RGFR2, MDA7.8, MDA7_8, SKM2, At5g56040	Leucine-rich repeat receptor-like serine/threonine-protein kinase RGI4, EC 2.7.11.1	0/1	0	0	0	Yes
C0LGX3	HSL2_ARATH	MetaPhors	A. thaliana	HSL2, At5g65710, F6H11.160, MPA24.6	LRR receptor-like serine/threonine-protein kinase HSL2, EC 2.7.11.1	0/1	0	0	0	Yes
Q1PE89	PBL24_ARATH	MetaPhors	A. thaliana	PBL24, At4g13190, F17N18.80	Probable serine/threonine-protein kinase PBL24, EC 2.7.11.1	0/1	0	0	0	Yes
C0LGQ5	GSO1_ARATH	MetaPhors	A. thaliana	SGN3, GSO1, At4g20140, F1C12.60	LRR receptor-like serine/threonine-protein kinase GSO1, EC 2.7.11.1	0/1	0	0	0	Yes
C0LGR3	RGI3_ARATH	MetaPhors	A. thaliana	RGFR3, RGI3, RGFR1, At4g26540, M3E9.30	LRR receptor-like serine/threonine-protein kinase RGI3, EC 2.7.11.1	0/1	0	0	0	Yes
C0LGQ7	Y4245_ARATH	MetaPhors	A. thaliana	At4g20450, F9F13.100	Probable LRR receptor-like serine/threonine-protein kinase At4g20450, EC 2.7.11.1	0/1	0	0	0	No
Q9FIZ3	GSO2_ARATH	MetaPhors	A. thaliana	GSO2, EDA23, At5g44700, K23L20.3	LRR receptor-like serine/threonine-protein kinase GSO2, EC 2.7.11.1	0/1	0	0	0	Yes
C0LGP4	Y3475_ARATH	MetaPhors	A. thaliana	At3g47570, F1P2.120	Probable LRR receptor-like serine/threonine-protein kinase At3g47570, EC 2.7.11.1	0/1	0	0	0	Yes
Q8GXQ3	WAKLF_ARATH	MetaPhors	A. thaliana	WAKL6, At1g16110, T24D18.19, T24D18_30	Wall-associated receptor kinase-like 6, EC 2.7.11.-	0/1	0	0	0	Yes
A0A384KW53	A0A384KW53_ARATH	MetaPhors	A. thaliana	AXX17_At1g42280, AN1_LOCUS3939, C24_LOCUS3820	Protein kinase domain-containing protein	0/1	0	0	0	No
O64649	O64649_ARATH	MetaPhors	A. thaliana	At2g45700, F4I18.32	Sterile alpha motif	0/1	0	0	0	No
A0A654EQA1	A0A654EQA1_ARATH	MetaPhors	A. thaliana	AN1_LOCUS5176, C24_LOCUS5055	Protein kinase domain-containing protein	0/1	0	0	0	No
F4I5S1	F4I5S1_ARATH	MetaPhors	A. thaliana	At1g04700, T1G11.5, T1G11_5	PB1 domain-containing protein tyrosine kinase	0/1	0	0	0	No

Ortholog sequence alignment (CLUSTALW)

Cysteine summary and predictions

Pos in alignment	62	97	107	184	197	226	241	254	256	269	272	286	289	303
Subcell. location	E	E	E	E	E	E	E	E	E	E	E	E	E	E
Disulfide	yes	yes	yes	yes	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	strand	helix	coil	strand	coil	strand	strand	strand	strand	strand	coil	coil	coil	strand
UniProt secondary structure	NA	helix	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁶²	Cys⁹⁷	Cys¹⁰⁷	Cys¹⁸⁴	Cys¹⁹⁷	Cys²²⁶	Cys²⁴¹	Cys²⁵⁴	Cys²⁵⁶ MC	Cys²⁶⁹	Cys²⁷² LC	Cys²⁸⁶	Cys²⁸⁹	Cys³⁰³
Pos in isoform 2 CSS-Palm 4.0 PalmPred	Cys⁶²	Cys⁹⁷	Cys¹⁰⁷	Cys¹⁸⁴	Cys¹⁹⁷	Cys²²⁶	Cys²⁴¹	Cys²⁵⁴	Cys²⁵⁶ MC	Cys²⁶⁹	Cys²⁷² LC	Cys²⁸⁶	Cys²⁸⁹	Cys³⁰³
Pos in isoform 3 CSS-Palm 4.0 PalmPred	Cys⁶²	Cys⁹⁷	Cys¹⁰⁷	Cys¹⁸⁴	Cys¹⁹⁷	Cys²²⁶	Cys²⁴¹	Cys²⁵⁴	Cys²⁵⁶ MC	Cys²⁶⁹	Cys²⁷² LC	Cys²⁸⁶	Cys²⁸⁹	Cys³⁰³

Pos in alignment	305	321	362	365	372	375	565	621	637	761	852	863	1003	1013
Subcell. location	E	E	E	E	E	E	C	C	C	C	C	C	C	C
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	coil	strand	coil	coil	coil	helix
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys³⁰⁵	Cys³²¹	Cys³⁶²	Cys³⁶⁵	Cys³⁷²	Cys³⁷⁵	Cys⁵⁶⁵ MC HC	Cys⁶²⁰ LC	Cys⁶³⁶	Cys⁷⁶⁰	Cys⁸⁵¹	Cys⁸⁶²	Cys¹⁰⁰²	Cys¹⁰¹²
Pos in isoform 2 CSS-Palm 4.0 PalmPred	Cys³⁰⁵	Cys³²¹	Cys³⁶²	Cys³⁶⁵	Cys³⁷²	Cys³⁷⁵	Cys⁵⁶⁵ MC HC	Cys⁶²⁰ LC	Cys⁶³⁶	Cys⁷⁶⁰	Cys⁸⁵¹	Cys⁸⁶²
Pos in isoform 3 CSS-Palm 4.0 PalmPred	Cys³⁰⁵	Cys³²¹	Cys³⁶²	Cys³⁶⁵	Cys³⁷²	Cys³⁷⁵	Cys⁵⁶⁵ LC HC	Cys⁶²¹ LC	Cys⁶³⁷	Cys⁷⁶¹	Cys⁸⁵²	Cys⁸⁶³

Pos in alignment	1052	1054
Subcell. location	C	C
Disulfide	no	no
PSIPRED v.4.02 prediction
UniProt secondary structure
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys¹⁰⁵¹ HC	Cys¹⁰⁵³ MC
Pos in isoform 2 CSS-Palm 4.0 PalmPred
Pos in isoform 3 CSS-Palm 4.0 PalmPred

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

Tip: Keep CTRL key pressed down while clicking on column headers to do multiple sorting. This applies to any sortable table on this site.

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	x		HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	x		HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	x		HC: 162 hits LC: 218 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	x		HC: 102 hits LC: 73 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	x		HC HC: 352 hits LC LC: 8 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	x		List: 214 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	x		HC HC: 254 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	x		List: 154 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	x		List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	Ortholog	in HC,MC,LC [Y3868, Y3148, PTI13, Y5659, Y5830, SRF3, Y1848, Q9FRI1, SD25, SBIR1, Y3288, Y2267]	HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	x		List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	Ortholog	in List [ARK1]	List: 238 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	x		List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	Ortholog	in List [EPHB2]	List: 436 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	x		Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	x		List: 354 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	Found	in List	List: 1348 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	x		List: 354 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	x		List: 226 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	x		List: 274 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	x		HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	x		HC: 1079 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		List: 865 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	x		List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	x		List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	x		HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		LPS treatment: 646 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		List: 646 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	Found	in List	List: 2929 hits
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 590 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 370 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Found	in HC	HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Found	in HC	HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 600 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		List: 185 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1869 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1093 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 687 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	x		List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	x		List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 199 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 399 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1040 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 464 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 4107 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1597 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1378 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 3870 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	3	4	0	0.0	NA
H. sapiens	22	38	5	13.2	NA
M. musculus	23	37	1	2.7	EPHB2_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	1	100.0	Y3868_ARATH , Y3148_ARATH , PTI13_ARATH , Y5659_ARATH , Y5830_ARATH , SRF3_ARATH , Y1848_ARATH , Q9FRI1_ARATH , SD25_ARATH , SBIR1_ARATH , Y3288_ARATH , Y2267_ARATH
S. pombe	1	1	1	100.0	ARK1_SCHPO
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	0	0.0	NA
C. familiaris	1	1	0	0.0	NA

References

Authors	Year	Reference title	PMID
Kang R et al.	2008	Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.	19092927
Ren W et al.	2013	Proteomic analysis of protein palmitoylation in adipocytes.	23599907
Marin EP et al.	2012	Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.	22496122
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
Martin BR et al.	2011	Global profiling of dynamic protein palmitoylation.	22056678
Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Merrick BA et al.	2011	Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.	21785166
Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
Yang W et al.	2010	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	19801377
Martin BR et al.	2009	Large-scale profiling of protein palmitoylation in mammalian cells.	19137006
Roth AF et al.	2006	Global analysis of protein palmitoylation in yeast.	16751107
Hemsley PA et al.	2013	A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis.	23252521
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
Wei X et al.	2014	Insulin-regulated protein palmitoylation impacts endothelial cell function.	24357059
Serwa RA et al.	2015	Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.	26256475
Morrison E et al.	2015	Quantitative analysis of the human T cell palmitome.	26111759
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
Santiago-Tirado FH et al.	2015	A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.	25970403
Emmer BT et al.	2011	Global analysis of protein palmitoylation in African trypanosomes.	21193548
Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
Foe IT et al.	2015	Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.	26468752
Gould NS et al.	2015	Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.	26165157
Peng T et al.	2015	Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.	25575299
Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Zhou B et al.	2019	Low-background Acyl-biotinyl Exchange Largely Eliminates the Co-isolation of Non-S-acylated Proteins and Enables Deep S-acylproteomic Analysis.	31251020
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Wegleiter T et al.	2019	Palmitoylation of BMPR1a regulates neural stem cell fate.	31772009
Morrison E et al.	2020	Dynamic palmitoylation events following T-cell receptor signaling.	32651440
Mariscal J et al.	2020	Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles.	32944167
Gorenberg EL et al.	2022	Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.	35358180
Uzbekova S et al.	2021	Protein Palmitoylation in Bovine Ovarian Follicle.	34769186
Miles MR et al.	2021	Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart.	33636221
Pradhan AJ et al.	2021	Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis.	33848465
Ripamonti M et al.	2021	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.	33782527
Zaręba-Kozioł M et al.	2021	S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity.	34200797
Ziemlińska E et al.	2021	Palm Oil-Rich Diet Affects Murine Liver Proteome and <i>S</i>-Palmitoylome.	34884899
Gao J et al.	2022	Proteome-wide identification of palmitoylated proteins in mouse testis.	35477839