SwissPalm

P54762 EPHB1_HUMAN

General info Cross-references Sequences Orthologs Ortholog sequences Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

1/22 article for human
17 orthologs

Palmitoyl-proteome experiments

Validation experiments

0 experiment
0 ortholog

Curated sites & Enzymes

0 site from validation experiments^*
0 site from palmitoyl-proteomes^*
No PAT known
No APT known
^*In main isoform only

Predictions

Predicted

1 cysteine in main isoform

Predictions

Protein general information from UniProt

Protein names

Ephrin type-B receptor 1, EC 2.7.10.1; ELK; EPH tyrosine kinase 2; EPH-like kinase 6, EK6, hEK6; Neuronally-expressed EPH-related tyrosine kinase, NET; Tyrosine-protein kinase receptor EPH-2

Subcellular location

Cell membrane (By similarity); Early endosome membrane; Cell projection; dendrite; Dendrite (Probable)

Isoforms & protein length

Isoform 1 (main): 984 aa; Isoform 5 : 545 aa; Isoform 6 : 242 aa

Known functions

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts with EPHB6; transphosphorylates EPHB6 to form an active signaling complex. Interacts with PICK1 (By similarity). Interacts (through Tyr-594) with NCK1 (via SH2 domain); activates the JUN cascade to regulate cell adhesion (By similarity). The ligand-activated form interacts (through Tyr-928) with GRB7 and GRB10 (via SH2 domains). The ligand-activated form interacts (residues within the catalytic domain) with GRB2 (via SH2 domain). Interacts with GRB2, SHC1 and SRC; activates the MAPK/ERK cascade to regulate cell migration. Interacts with CBL; regulates receptor degradation through ubiquitination. Interacts with ACP1. Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts with EPHB6; transphosphorylates EPHB6 to form an active signaling complex. Interacts with PICK1 (By similarity). Interacts (through Tyr-594) with NCK1 (via SH2 domain); activates the JUN cascade to regulate cell adhesion (By similarity). The ligand-activated form interacts (through Tyr-928) with GRB7 and GRB10 (via SH2 domains). The ligand-activated form interacts (residues within the catalytic domain) with GRB2 (via SH2 domain). Interacts with GRB2, SHC1 and SRC; activates the MAPK/ERK cascade to regulate cell migration. Interacts with CBL; regulates receptor degradation through ubiquitination. Interacts with ACP1. Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts with EPHB6; transphosphorylates EPHB6 to form an active signaling complex. Interacts with PICK1 (By similarity). Interacts (through Tyr-594) with NCK1 (via SH2 domain); activates the JUN cascade to regulate cell adhesion (By similarity). The ligand-activated form interacts (through Tyr-928) with GRB7 and GRB10 (via SH2 domains). The ligand-activated form interacts (residues within the catalytic domain) with GRB2 (via SH2 domain). Interacts with GRB2, SHC1 and SRC; activates the MAPK/ERK cascade to regulate cell migration. Interacts with CBL; regulates receptor degradation through ubiquitination. Interacts with ACP1.

Cross-references

Source	Identifiers
UniProt gene names	EPHB1, ELK, EPHT2, HEK6, NET
UniProt secondary AC	A8K593, B3KTB2, B5A969, O43569, O95142, O95143, Q0VG87
Refseq protein ID	NP_004432.1
IPI ID	IPI00008315, IPI00643146, IPI00219244, IPI00098720, IPI00066860, IPI00037618

Source	Identifiers
Ensembl protein	ENSP00000419574, ENSP00000381097
Ensembl gene	ENSG00000154928

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Techniques	Predicted
P09759	EPHB1_RAT	OrthoDB, Ensembl, OMA, InParanoid, MetaPhors	R. norvegicus	Ephb1, Elk, Epth2, EFNB3	Ephrin type-B receptor 1, EC 2.7.10.1	1/3	1	Yes
Q6R2K3	SRF3_ARATH	InParanoid	A. thaliana	SRF3, At4g03390, F4C21.35	Protein STRUBBELIG-RECEPTOR FAMILY 3	1/1	1	Yes
Q8RWZ5	SD25_ARATH	InParanoid	A. thaliana	SD25, At4g32300, F10M6.60, F8B4.10	G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5, EC 2.7.11.1	1/1	1	Yes
Q9LP77	Y1848_ARATH	InParanoid	A. thaliana	RKL1, At1g48480, T1N15.9	Probable inactive receptor kinase At1g48480	1/1	1	Yes
O48788	Y2267_ARATH	InParanoid	A. thaliana	At2g26730, F18A8.10	Probable inactive receptor kinase At2g26730	1/1	1	Yes
Q9FMD7	Y5659_ARATH	InParanoid	A. thaliana	At5g16590, MTG13.3	Probable inactive receptor kinase At5g16590	1/1	1	Yes
Q9FRI1	Q9FRI1_ARATH	InParanoid	A. thaliana	F4F7_29, F4F7.29, LRR-RLK, At1g25320	At1g25320/F4F7_17	1/1	1	Yes
Q9M8T0	Y3288_ARATH	InParanoid	A. thaliana	At3g02880, F13E7.17	Probable inactive receptor kinase At3g02880	1/1	1	Yes
Q9LVM0	Y5830_ARATH	InParanoid	A. thaliana	At5g58300, MCK7.17	Probable inactive receptor kinase At5g58300	1/1	1	Yes
Q9SKB2	SBIR1_ARATH	InParanoid	A. thaliana	SOBIR1, EVR, At2g31880, F20M17.8	Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1, EC 2.7.10.1, EC 2.7.11.1	1/1	1	Yes
C0LGM1	C0LGM1_ARATH	MetaPhors	A. thaliana	T2N18.19, T2N18_19, LRR-RLK, At2g37050	Leucine-rich repeat protein kinase family protein	1/1	1	Yes
O59790	ARK1_SCHPO	MetaPhors	S. pombe	ark1, sex1, SPCC320.13c, SPCC330.16	Serine/threonine-protein kinase ark1	1/1	1	No
Q9USY7	FZO1_SCHPO	MetaPhors	S. pombe	fzo1, SPBC1706.03, SPBC839.01	Transmembrane GTPase fzo1	0/1	0	Yes
O94487	PPK35_SCHPO	MetaPhors	S. pombe	ppk35, mug27, SPCC417.06c	Serine/threonine-protein kinase ppk35	0/1	0	No
P83099	KPC4_DROME	MetaPhors	D. melanogaster	Pkcdelta, CG10524	Putative protein kinase C delta type homolog, EC 2.7.11.13	0/1	0	No
Q9ZVR7	PSKR1_ARATH	MetaPhors	A. thaliana	PSKR1, PSKR, At2g02220, F5O4.1	Phytosulfokine receptor 1, AtPSKR1, EC 2.7.11.1, EC 4.6.1.2	0/1	0	Yes
O22834	LRK53_ARATH	MetaPhors	A. thaliana	LECRK53, LECRKC2, At2g43690, F18O19.20	Probable L-type lectin-domain containing receptor kinase V.3, Arabidopsis thaliana lectin-receptor kinase c2, AthlecRK-c2, LecRK-V.3, EC 2.7.11.1	0/1	0	No
O64782	SD129_ARATH	MetaPhors	A. thaliana	LORE, SD129, At1g61380, T1F9.13	G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29, EC 2.7.12.1	0/1	0	Yes
O80939	LRK41_ARATH	MetaPhors	A. thaliana	LECRK41, LECRKE, LRK1, At2g37710, F13M22.21	L-type lectin-domain containing receptor kinase IV.1, Arabidopsis thaliana lectin-receptor kinase e, AthlecRK-e, LecRK-IV.1, EC 2.7.11.1	0/1	0	No
O81291	LRK44_ARATH	MetaPhors	A. thaliana	LECRK44, At4g02420, T14P8.4	L-type lectin-domain containing receptor kinase IV.4, LecRK-IV.4, EC 2.7.11.1	0/1	0	No
O81292	LRK43_ARATH	MetaPhors	A. thaliana	LECRK43, At4g02410, T14P8.3	L-type lectin-domain containing receptor kinase IV.3, LecRK-IV.3, EC 2.7.11.1	0/1	0	No
Q96285	LRK55_ARATH	MetaPhors	A. thaliana	LECRK55, LECRKA1, At3g59700, T16L24.250	L-type lectin-domain containing receptor kinase V.5, Arabidopsis thaliana lectin-receptor kinase a1, Ath.lecRK1, AthlecRK-a1, LecRK-V.5, EC 2.7.11.1	0/1	0	Yes
Q9ASS4	Y5838_ARATH	MetaPhors	A. thaliana	At5g48380, K23F3.10, MJE7.1	Probably inactive leucine-rich repeat receptor-like protein kinase At5g48380	0/1	0	Yes
Q9C9N5	Y1668_ARATH	MetaPhors	A. thaliana	At1g66830, F4N21.23	Probable inactive leucine-rich repeat receptor-like protein kinase At1g66830	0/1	0	Yes
Q9FIF1	LRK21_ARATH	MetaPhors	A. thaliana	LECRK21, At5g59260, MNC17.17	Probable L-type lectin-domain containing receptor kinase II.1, LecRK-II.1, EC 2.7.11.1	0/1	0	No
Q9FZB6	Q9FZB6_ARATH	MetaPhors	A. thaliana	At1g51830, T14L22.4, T14L22_4	Leucine-rich repeat protein kinase family protein	0/1	0	Yes
Q9LEA3	LRK56_ARATH	MetaPhors	A. thaliana	LECRK56, LECRKA2, At3g59730, T16L24.280	Putative L-type lectin-domain containing receptor kinase V.6, Arabidopsis thaliana lectin-receptor kinase a2, AthlecRK-a2, LecRK-V.6, EC 2.7.11.1	0/1	0	No
Q9LFH9	LRK81_ARATH	MetaPhors	A. thaliana	LECRK81, At3g53380, F4P12.80	L-type lectin-domain containing receptor kinase VIII.1, LecRK-VIII.1, EC 2.7.11.1	0/1	0	Yes
Q9LRT1	Y3804_ARATH	MetaPhors	A. thaliana	At3g28040, MMG15.21	Probably inactive leucine-rich repeat receptor-like protein kinase At3g28040	0/1	0	No
Q9M021	LRK62_ARATH	MetaPhors	A. thaliana	LECRK62, LECRKA4.1, At5g01540, F7A7.60	L-type lectin-domain containing receptor kinase VI.2, LecRK-VI.2, EC 2.7.11.1	0/1	0	Yes
Q9M1Z9	LRK58_ARATH	MetaPhors	A. thaliana	LECRK58, At3g59750, F24G16.20	Putative L-type lectin-domain containing receptor kinase V.8, LecRK-V.8, EC 2.7.11.1	0/1	0	No
Q9M345	LRK42_ARATH	MetaPhors	A. thaliana	LECRK42, LECRKA4, SGC, At3g53810, F5K20.110	L-type lectin-domain containing receptor kinase IV.2, Arabidopsis thaliana lectin-receptor kinase a4, AthlecRK-a4, LecRK-IV.2, EC 2.7.11.1	0/1	0	Yes
Q9M3D8	LRK13_ARATH	MetaPhors	A. thaliana	LECRK13, AtLecRK2, SR1, At3g45410, F18N11.170	L-type lectin-domain containing receptor kinase I.3, AtLecRK2, LecRK-I.3, EC 2.7.11.1	0/1	0	Yes
Q9M9E0	LRKS1_ARATH	MetaPhors	A. thaliana	LECRKS1, At1g15530, T16N11.4	L-type lectin-domain containing receptor kinase S.1, LecRK-S.1, EC 2.7.11.1	0/1	0	Yes
Q9S9U1	LRK71_ARATH	MetaPhors	A. thaliana	LECRK71, At4g04960, T32N4.9	L-type lectin-domain containing receptor kinase VII.1, LecRK-VII.1, EC 2.7.11.1	0/1	0	No
Q9SH71	Y1421_ARATH	MetaPhors	A. thaliana	At1g64210, F22C12.3	Putative inactive receptor-like protein kinase At1g64210	0/1	0	Yes
Q9SR87	LRK61_ARATH	MetaPhors	A. thaliana	LECRK61, At3g08870, T16O11.20	Probable L-type lectin-domain containing receptor kinase VI.1, LecRK-VI.1, EC 2.7.11.1	0/1	0	Yes
Q9SY95	Y1155_ARATH	MetaPhors	A. thaliana	At1g61550, T25B24.10	G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550, EC 2.7.11.1	0/1	0	Yes
Q9ZW09	LRK31_ARATH	MetaPhors	A. thaliana	LECRK31, At2g29220, F16P2.40	Probable inactive L-type lectin-domain containing receptor kinase III.1, LecRK-III.1	0/1	0	Yes
Q9ZW11	LRK32_ARATH	MetaPhors	A. thaliana	LECRK32, At2g29250, F16P2.37	Putative inactive L-type lectin-domain containing receptor kinase III.2, LecRK-III.2	0/1	0	Yes
Q9FHK7	Y5516_ARATH	MetaPhors	A. thaliana	At5g05160, K2A11.3	Probable leucine-rich repeat receptor-like protein kinase At5g05160, EC 2.7.11.-	0/1	0	No
Q9LSR9	LRK18_ARATH	MetaPhors	A. thaliana	LECRK18, At5g60280, F15L12.12	L-type lectin-domain containing receptor kinase I.8, LecRK-I.8, EC 2.7.11.1	0/1	0	No
Q3E884	LK110_ARATH	MetaPhors	A. thaliana	LECRK110, At5g60310, F15L12.19	Putative L-type lectin-domain containing receptor kinase I.10, LecRK-I.10, EC 2.7.11.1	0/1	0	No
Q9C9L5	WAKLH_ARATH	MetaPhors	A. thaliana	WAKL9, At1g69730, T6C23.7	Wall-associated receptor kinase-like 9, EC 2.7.11.-	0/1	0	Yes
Q9FGG7	Q9FGG7_ARATH	MetaPhors	A. thaliana	MQJ2.16, MQJ2_16, At5g58540	Protein kinase superfamily protein	0/1	0	No
Q9LFS4	NIK1_ARATH	MetaPhors	A. thaliana	NIK1, At5g16000, F1N13_140	Protein NSP-INTERACTING KINASE 1, AtNIK1, EC 2.7.11.1	0/1	0	Yes
Q9LVG5	Q9LVG5_ARATH	MetaPhors	A. thaliana	MGO3.7, MGO3_7, At5g60090	Protein kinase superfamily protein	0/1	0	Yes
Q9SIZ4	Y2027_ARATH	MetaPhors	A. thaliana	At2g40270, T3G21, T7M7.19	Inactive receptor-like serine/threonine-protein kinase At2g40270	0/1	0	Yes
Q8VYA3	WAKLJ_ARATH	MetaPhors	A. thaliana	WAKL10, At1g79680, F20B17.10	Wall-associated receptor kinase-like 10, EC 2.7.11.-	0/1	0	Yes
O65238	Y5537_ARATH	MetaPhors	A. thaliana	At5g35370, T26D22.12	G-type lectin S-receptor-like serine/threonine-protein kinase At5g35370, EC 2.7.11.1	0/1	0	Yes
C0LGU5	Y5457_ARATH	MetaPhors	A. thaliana	At5g45780, MRA19.22	Probable LRR receptor-like serine/threonine-protein kinase At5g45780, EC 2.7.11.1	0/1	0	No
P0C5E2	LRL12_ARATH	MetaPhors	A. thaliana	LRK10L-1.2, LRK10L1, At1g18390, F15H18.11, F15H18.25	LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-like 1.2, EC 2.7.11.1	0/1	0	Yes
F4IB71	F4IB71_ARATH	MetaPhors	A. thaliana	At1g51870, T14L22.8, T14L22_8	Protein kinase family protein	0/1	0	Yes
C0LGU7	MDIS1_ARATH	MetaPhors	A. thaliana	MDIS1, At5g45840, K15I22.4	Protein MALE DISCOVERER 1, AtMDIS1	0/1	0	Yes
O22932	CIPKB_ARATH	MetaPhors	A. thaliana	CIPK11, PKS5, SIP4, SnRK3.22, At2g30360, T9D9.17	CBL-interacting serine/threonine-protein kinase 11, EC 2.7.11.1	0/1	0	No
Q9FLW0	Y5241_ARATH	MetaPhors	A. thaliana	At5g24010, MZF18.11	Probable receptor-like protein kinase At5g24010, EC 2.7.11.-	0/1	0	Yes
Q9S7D9	ACCR1_ARATH	MetaPhors	A. thaliana	CCR1, CRR1, At3g09780, F11F8.37, F8A24.17	Serine/threonine-protein kinase-like protein CCR1, EC 2.7.11.1	0/1	0	Yes
Q9SY91	PBL15_ARATH	MetaPhors	A. thaliana	PBL15, PIX1, At1g61590, T25B24.6	Probable serine/threonine-protein kinase PBL15, EC 2.7.11.1	0/1	0	Yes
Q8GXQ3	WAKLF_ARATH	MetaPhors	A. thaliana	WAKL6, At1g16110, T24D18.19, T24D18_30	Wall-associated receptor kinase-like 6, EC 2.7.11.-	0/1	0	Yes
Q9LPZ3	Y1141_ARATH	MetaPhors	A. thaliana	At1g11410, T23J18.8	G-type lectin S-receptor-like serine/threonine-protein kinase At1g11410, EC 2.7.11.1	0/1	0	Yes
Q8CBF3	EPHB1_MOUSE	MetaPhors, OrthoDB	M. musculus	Ephb1	Ephrin type-B receptor 1, EC 2.7.10.1	0/23	0	Yes
Q84JF8	Q84JF8_ARATH	MetaPhors	A. thaliana	MLE2.4, LRR-RLK, MLE2_4, At5g63410	Leucine-rich repeat protein kinase family protein	0/1	0	No
Q9FLL2	Q9FLL2_ARATH	MetaPhors	A. thaliana	MEE6.25, LRR-RLK, MEE6_25, At5g41180	Leucine-rich repeat receptor-like protein kinase	0/1	0	No
O64649	O64649_ARATH	MetaPhors	A. thaliana	At2g45700, F4I18.32	Sterile alpha motif	0/1	0	No
A0A654EQA1	A0A654EQA1_ARATH	MetaPhors	A. thaliana	AN1_LOCUS5176, C24_LOCUS5055	Protein kinase domain-containing protein	0/1	0	No
C0LGN2	Y3148_ARATH	MetaPhors	A. thaliana	LRR-RLK, At3g14840, T21E2.2	Probable leucine-rich repeat receptor-like serine/threonine-protein kinase At3g14840, EC 2.7.11.1	1/1	1	Yes
Q9SXB8	Y1133_ARATH	MetaPhors	A. thaliana	At1g11330, T28P6.2	G-type lectin S-receptor-like serine/threonine-protein kinase At1g11330, EC 2.7.11.1	1/1	1	Yes
Q8VZG8	MIK2_ARATH	MetaPhors	A. thaliana	MIK2, At4g08850, T32A17.160	MDIS1-interacting receptor like kinase 2, AtMIK2	1/1	1	Yes
Q9C9Y8	Y3868_ARATH	MetaPhors, InParanoid	A. thaliana	At3g08680, F17O14.15	Probable inactive receptor kinase At3g08680	1/1	1	Yes
Q9SA72	Y1357_ARATH	MetaPhors	A. thaliana	At1g30570, T5I8.2	Probable receptor-like protein kinase At1g30570, EC 2.7.11.-	1/1	1	Yes
F1PNA5	F1PNA5_CANLF	OrthoDB	C. familiaris	EPHB1	EPH receptor B1	0/1	0	Yes
F1MII5	F1MII5_BOVIN	OrthoDB	B. taurus	EPHB1	Receptor protein-tyrosine kinase	0/2	0	Yes
D1YSF9	D1YSF9_DROME	OrthoDB	D. melanogaster	CT3831, DEK, Dek, dek, Dek7, Deph, Dmel\CG1511, Ek7, eph, lincRNA.923, RPTK Dek7, Eph, CG1511, Dmel_CG1511	Receptor protein-tyrosine kinase	0/1	0	No

Ortholog sequence alignment (CLUSTALW)

Cysteine summary and predictions

Pos in alignment	61	96	106	183	196	225	240	253	255	267	270	284	287	301
Subcell. location	E	E	E	E	E	E	E	E	E	E	E	E	E	E
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	strand	helix	strand	strand	coil	strand	strand	strand	strand	coil	coil	coil	coil	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁶¹	Cys⁹⁶	Cys¹⁰⁶	Cys¹⁸³	Cys¹⁹⁶	Cys²²⁵	Cys²⁴⁰	Cys²⁵³	Cys²⁵⁵	Cys²⁶⁷	Cys²⁷⁰	Cys²⁸⁴	Cys²⁸⁷	Cys³⁰¹
Pos in isoform 5 CSS-Palm 4.0 PalmPred
Pos in isoform 6 CSS-Palm 4.0 PalmPred	Cys⁶¹	Cys⁹⁶	Cys¹⁰⁶

Pos in alignment	303	319	360	363	370	373	389	522	563	758	849	860
Subcell. location	E	E	E	E	E	E	E	E	T	C	C	C
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	coil	strand	coil	coil	coil	coil	strand	helix	strand	coil	helix
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	strand	NA	strand	NA	helix
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys³⁰³	Cys³¹⁹	Cys³⁶⁰	Cys³⁶³	Cys³⁷⁰	Cys³⁷³	Cys³⁸⁹	Cys⁵²²	Cys⁵⁶³ HC	Cys⁷⁵⁸	Cys⁸⁴⁹	Cys⁸⁶⁰ LC
Pos in isoform 5 CSS-Palm 4.0 PalmPred								Cys⁸³	Cys¹²⁴ HC	Cys³¹⁹	Cys⁴¹⁰	Cys⁴²¹ LC
Pos in isoform 6 CSS-Palm 4.0 PalmPred

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

Tip: Keep CTRL key pressed down while clicking on column headers to do multiple sorting. This applies to any sortable table on this site.

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	Ortholog	in HC [EPHB1]	HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	x		HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	x		HC: 162 hits LC: 218 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	x		HC: 102 hits LC: 73 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	x		HC HC: 352 hits LC LC: 8 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	x		List: 214 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	x		HC HC: 254 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	x		List: 154 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	x		List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	Ortholog	in HC,LC,MC [Y3868, MIK2, Y3148, Y1357, Y1133, C0LGM1, Y5659, Y5830, SRF3, Y1848, Q9FRI1, SD25, SBIR1, Y3288, Y2267]	HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	x		List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	Ortholog	in List [ARK1]	List: 238 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	x		List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	x		List: 436 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	x		Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	x		List: 354 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	x		List: 1348 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	x		List: 354 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	x		List: 226 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	x		List: 274 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	x		HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	x		HC: 1079 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		List: 865 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	x		List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	x		List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	x		HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		LPS treatment: 646 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		List: 646 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	Found	in List	List: 2929 hits
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 590 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 370 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 600 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		List: 185 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1869 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1093 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 687 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	x		List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	x		List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 199 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 399 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1040 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 464 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 4107 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1597 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1378 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 3870 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	3	4	1	25.0	EPHB1_RAT
H. sapiens	22	38	1	2.6	NA
M. musculus	23	37	0	0.0	NA
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	1	100.0	Y3868_ARATH , MIK2_ARATH , Y3148_ARATH , Y1357_ARATH , Y1133_ARATH , C0LGM1_ARATH , Y5659_ARATH , Y5830_ARATH , SRF3_ARATH , Y1848_ARATH , Q9FRI1_ARATH , SD25_ARATH , SBIR1_ARATH , Y3288_ARATH , Y2267_ARATH
S. pombe	1	1	1	100.0	ARK1_SCHPO
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	0	0.0	NA
C. familiaris	1	1	0	0.0	NA

References

Authors	Year	Reference title	PMID
Kang R et al.	2008	Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.	19092927
Ren W et al.	2013	Proteomic analysis of protein palmitoylation in adipocytes.	23599907
Marin EP et al.	2012	Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.	22496122
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
Martin BR et al.	2011	Global profiling of dynamic protein palmitoylation.	22056678
Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Merrick BA et al.	2011	Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.	21785166
Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
Yang W et al.	2010	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	19801377
Martin BR et al.	2009	Large-scale profiling of protein palmitoylation in mammalian cells.	19137006
Roth AF et al.	2006	Global analysis of protein palmitoylation in yeast.	16751107
Hemsley PA et al.	2013	A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis.	23252521
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
Wei X et al.	2014	Insulin-regulated protein palmitoylation impacts endothelial cell function.	24357059
Serwa RA et al.	2015	Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.	26256475
Morrison E et al.	2015	Quantitative analysis of the human T cell palmitome.	26111759
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
Santiago-Tirado FH et al.	2015	A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.	25970403
Emmer BT et al.	2011	Global analysis of protein palmitoylation in African trypanosomes.	21193548
Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
Foe IT et al.	2015	Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.	26468752
Gould NS et al.	2015	Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.	26165157
Peng T et al.	2015	Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.	25575299
Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Zhou B et al.	2019	Low-background Acyl-biotinyl Exchange Largely Eliminates the Co-isolation of Non-S-acylated Proteins and Enables Deep S-acylproteomic Analysis.	31251020
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Wegleiter T et al.	2019	Palmitoylation of BMPR1a regulates neural stem cell fate.	31772009
Morrison E et al.	2020	Dynamic palmitoylation events following T-cell receptor signaling.	32651440
Mariscal J et al.	2020	Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles.	32944167
Gorenberg EL et al.	2022	Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.	35358180
Uzbekova S et al.	2021	Protein Palmitoylation in Bovine Ovarian Follicle.	34769186
Miles MR et al.	2021	Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart.	33636221
Pradhan AJ et al.	2021	Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis.	33848465
Ripamonti M et al.	2021	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.	33782527
Zaręba-Kozioł M et al.	2021	S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity.	34200797
Ziemlińska E et al.	2021	Palm Oil-Rich Diet Affects Murine Liver Proteome and <i>S</i>-Palmitoylome.	34884899
Gao J et al.	2022	Proteome-wide identification of palmitoylated proteins in mouse testis.	35477839