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Q15375 EPHA7_HUMAN

General info Cross-references Sequences Orthologs Ortholog sequences Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

3/22 articles for human
13 orthologs

Palmitoyl-proteome experiments

Validation experiments

0 experiment
1 ortholog

Curated sites & Enzymes

0 site from validation experiments^*
0 site from palmitoyl-proteomes^*
No PAT known
No APT known
^*In main isoform only

Predictions

Predicted

1 cysteine in main isoform

Predictions

Protein general information from UniProt

Protein names

Ephrin type-A receptor 7, EC 2.7.10.1; EPH homology kinase 3, EHK-3; EPH-like kinase 11, EK11, hEK11

Subcellular location

Cell membrane (By similarity)

Isoforms & protein length

Isoform 1 (main): 998 aa; Isoform 2 : 993 aa; Isoform 3 : 279 aa; Isoform 4 : 994 aa; Isoform 5 : 449 aa

Known functions

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity).

Cross-references

Source	Identifiers
UniProt gene names	EPHA7, EHK3, HEK11
UniProt secondary AC	A0AUX7, B2R8W1, B7ZLJ9, B7ZLK0, Q59G40, Q5VTU0, Q8N368, Q9H124
Refseq protein ID	NP_004431.1, XP_005248726.1, XP_005248727.1, NP_001275558.1, NP_001275559.1
IPI ID	IPI00016645, IPI00607655, IPI00607878

Source	Identifiers
Ensembl protein	ENSP00000358303, ENSP00000358309
Ensembl gene	ENSG00000135333

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Times validated	Techniques	Sites	Predicted
F1N780	F1N780_BOVIN	Ensembl, OrthoDB, OMA, InParanoid, MetaPhors	B. taurus	EPHA7	Receptor protein-tyrosine kinase	0/2	0	0	0	Yes
Q9USY7	FZO1_SCHPO	MetaPhors	S. pombe	fzo1, SPBC1706.03, SPBC839.01	Transmembrane GTPase fzo1	0/1	0	0	0	Yes
O94487	PPK35_SCHPO	MetaPhors	S. pombe	ppk35, mug27, SPCC417.06c	Serine/threonine-protein kinase ppk35	0/1	0	0	0	No
Q9LXA5	LRK91_ARATH	MetaPhors	A. thaliana	LECRK91, At5g10530, F12B17.120	L-type lectin-domain containing receptor kinase IX.1, LecRK-IX.1, EC 2.7.11.1	0/1	0	0	0	Yes
O65238	Y5537_ARATH	InParanoid	A. thaliana	At5g35370, T26D22.12	G-type lectin S-receptor-like serine/threonine-protein kinase At5g35370, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FXF2	RKF1_ARATH	InParanoid	A. thaliana	RKF1, At1g29750, F1N18.19, T3M22.1	Probable LRR receptor-like serine/threonine-protein kinase RFK1, EC 2.7.11.1	0/1	0	0	0	Yes
Q8RWZ1	SUB_ARATH	InParanoid	A. thaliana	SUB, SCM, At1g11130, At1g11135, At1g11140, T19D16.1, T19D16.8, T28P6.18	Protein STRUBBELIG	0/1	0	0	0	Yes
C0LGN2	Y3148_ARATH	InParanoid	A. thaliana	LRR-RLK, At3g14840, T21E2.2	Probable leucine-rich repeat receptor-like serine/threonine-protein kinase At3g14840, EC 2.7.11.1	1/1	0	1	0	Yes
C0LGE0	Y1765_ARATH	InParanoid	A. thaliana	At1g07650, F24B9.28, F24B9.29	Probable LRR receptor-like serine/threonine-protein kinase At1g07650, EC 2.7.11.1	0/1	0	0	0	Yes
C0LGG7	Y1534_ARATH	InParanoid, MetaPhors	A. thaliana	At1g53420, F12M16.30	Probable LRR receptor-like serine/threonine-protein kinase At1g53420, EC 2.7.11.1	0/1	0	0	0	Yes
F4I337	F4I337_ARATH	InParanoid	A. thaliana	At1g29740, F1N18.20, F1N18_20	Leucine-rich repeat transmembrane protein kinase	0/1	0	0	0	Yes
Q9ASQ6	Y1972_ARATH	InParanoid	A. thaliana	RFK1, At1g29720, F1N18.22, T3M22.6	Probable LRR receptor-like serine/threonine-protein kinase At1g29720, EC 2.7.11.1	0/1	0	0	0	Yes
Q6R2K3	SRF3_ARATH	InParanoid	A. thaliana	SRF3, At4g03390, F4C21.35	Protein STRUBBELIG-RECEPTOR FAMILY 3	1/1	0	1	0	Yes
F4I336	F4I336_ARATH	InParanoid	A. thaliana	At1g29730, T3M22.3	Leucine-rich repeat transmembrane protein kinase	0/1	0	0	0	Yes
C0LGG8	Y5343_ARATH	InParanoid	A. thaliana	At1g53430, T3F20.25	Probable LRR receptor-like serine/threonine-protein kinase At1g53430, EC 2.7.11.1	0/1	0	0	0	Yes
C0LGG9	Y5344_ARATH	InParanoid	A. thaliana	At1g53440, T3F20.24	Probable LRR receptor-like serine/threonine-protein kinase At1g53440, EC 2.7.11.1	0/1	0	0	0	Yes
Q06BH3	SRF1_ARATH	InParanoid	A. thaliana	SRF1, At2g20850, F5H14.18	Protein STRUBBELIG-RECEPTOR FAMILY 1	0/1	0	0	0	Yes
Q6R2K1	SRF5_ARATH	InParanoid	A. thaliana	SRF5, At1g78980, YUP8H12R.40	Protein STRUBBELIG-RECEPTOR FAMILY 5	0/1	0	0	0	No
Q6R2J8	SRF8_ARATH	InParanoid	A. thaliana	SRF8, At4g22130, F1N20.230	Protein STRUBBELIG-RECEPTOR FAMILY 8	0/1	0	0	0	Yes
F4I3K4	F4I3K4_ARATH	InParanoid	A. thaliana	At1g56145	Leucine-rich repeat transmembrane protein kinase	0/1	0	0	0	Yes
C0LGH3	Y5614_ARATH	InParanoid, MetaPhors	A. thaliana	At1g56140, F14G9.24, T6H22.8.1	Probable LRR receptor-like serine/threonine-protein kinase At1g56140, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LUL4	SRF7_ARATH	InParanoid	A. thaliana	SRF7, At3g14350, MLN21.15	Protein STRUBBELIG-RECEPTOR FAMILY 7	0/1	0	0	0	Yes
Q9C8M9	SRF6_ARATH	InParanoid	A. thaliana	SRF6, At1g53730, F22G10.3, F22G10.31	Protein STRUBBELIG-RECEPTOR FAMILY 6	0/1	0	0	0	Yes
C0LGH2	Y1561_ARATH	InParanoid	A. thaliana	At1g56130, F14G9.25, T6H22.8	Probable LRR receptor-like serine/threonine-protein kinase At1g56130, EC 2.7.11.1	0/1	0	0	0	Yes
F4I3K0	F4I3K0_ARATH	InParanoid	A. thaliana	At1g56120, T6H22.9, T6H22_9	Leucine-rich repeat transmembrane protein kinase	0/1	0	0	0	Yes
Q9FG24	SRF2_ARATH	InParanoid	A. thaliana	SRF2, At5g06820, MPH15.19	Protein STRUBBELIG-RECEPTOR FAMILY 2	0/1	0	0	0	No
Q8RWZ5	SD25_ARATH	InParanoid	A. thaliana	SD25, At4g32300, F10M6.60, F8B4.10	G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5, EC 2.7.11.1	1/1	0	1	0	Yes
Q6R2K2	SRF4_ARATH	InParanoid	A. thaliana	SRF4, At3g13065, MGH6.19	Protein STRUBBELIG-RECEPTOR FAMILY 4	0/1	0	0	0	Yes
Q9FLV4	Y5248_ARATH	InParanoid	A. thaliana	At5g24080, MZF18.3	G-type lectin S-receptor-like serine/threonine-protein kinase At5g24080, EC 2.7.11.1	0/1	0	0	0	Yes
Q9XID3	Y1343_ARATH	InParanoid	A. thaliana	At1g34300, F23M19.5	G-type lectin S-receptor-like serine/threonine-protein kinase At1g34300, EC 2.7.11.1	0/1	0	0	0	Yes
Q8VYT3	Y4052_ARATH	InParanoid	A. thaliana	At4g30520, F17I23_140	Probable LRR receptor-like serine/threonine-protein kinase At4g30520, EC 2.7.11.1	0/1	0	0	0	Yes
Q94AG2	SERK1_ARATH	InParanoid	A. thaliana	SERK1, At1g71830, F14O23.21, F14O23_24	Somatic embryogenesis receptor kinase 1, AtSERK1, EC 2.7.10.1, EC 2.7.11.1	0/1	0	0	0	Yes
Q9SKG5	SERK4_ARATH	InParanoid	A. thaliana	SERK4, BKK1, At2g13790, F13J11.14	Somatic embryogenesis receptor kinase 4, AtSERK4, EC 2.7.10.1, EC 2.7.11.1	0/1	0	0	0	No
Q8W4S5	Y5371_ARATH	InParanoid	A. thaliana	At5g63710, MBK5.19	Probable LRR receptor-like serine/threonine-protein kinase At5g63710, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LVI6	RLK90_ARATH	InParanoid	A. thaliana	RLK902, At3g17840, MEB5.6	Probable inactive receptor kinase RLK902	0/1	0	0	0	No
Q39202	RLK1_ARATH	InParanoid	A. thaliana	RLK1, At5g60900, MSL3.2	G-type lectin S-receptor-like serine/threonine-protein kinase RLK1, EC 2.7.11.1	0/1	0	0	0	Yes
Q8LFN2	Y3037_ARATH	InParanoid	A. thaliana	At3g03770, F20H23.20	Probable inactive leucine-rich repeat receptor-like protein kinase At3g03770	0/1	0	0	0	Yes
Q9LP77	Y1848_ARATH	InParanoid	A. thaliana	RKL1, At1g48480, T1N15.9	Probable inactive receptor kinase At1g48480	1/1	0	1	0	Yes
Q9LSI9	BIR2_ARATH	InParanoid	A. thaliana	BIR2, At3g28450, MFJ20.14	Inactive LRR receptor-like serine/threonine-protein kinase BIR2	0/1	0	0	0	Yes
Q9M9C5	Y1680_ARATH	InParanoid	A. thaliana	At1g68400, T2E12.5	Probable leucine-rich repeat receptor-like protein kinase At1g68400, EC 2.7.11.1	0/1	0	0	0	Yes
O48788	Y2267_ARATH	InParanoid	A. thaliana	At2g26730, F18A8.10	Probable inactive receptor kinase At2g26730	1/1	0	1	0	Yes
Q9FMD7	Y5659_ARATH	InParanoid	A. thaliana	At5g16590, MTG13.3	Probable inactive receptor kinase At5g16590	1/1	0	1	0	Yes
Q9FRI1	Q9FRI1_ARATH	InParanoid	A. thaliana	F4F7_29, F4F7.29, LRR-RLK, At1g25320	At1g25320/F4F7_17	1/1	0	1	0	Yes
C0LGK4	Y2165_ARATH	InParanoid	A. thaliana	At2g16250, F16F14.25	Probable LRR receptor-like serine/threonine-protein kinase At2g16250, EC 2.7.11.1	0/1	0	0	0	Yes
Q9M8T0	Y3288_ARATH	InParanoid	A. thaliana	At3g02880, F13E7.17	Probable inactive receptor kinase At3g02880	1/1	0	1	0	Yes
Q9LVN2	Y5815_ARATH	InParanoid	A. thaliana	At5g58150, MCK7.2	Probably inactive leucine-rich repeat receptor-like protein kinase At5g58150	0/1	0	0	0	No
Q9SUQ3	Y4374_ARATH	InParanoid	A. thaliana	At4g23740, F9D16.210	Probable inactive receptor kinase At4g23740	0/1	0	0	0	Yes
O04567	Y1719_ARATH	InParanoid	A. thaliana	At1g27190, T7N9.25	Probable inactive receptor kinase At1g27190	0/1	0	0	0	Yes
Q9FHK7	Y5516_ARATH	InParanoid	A. thaliana	At5g05160, K2A11.3	Probable leucine-rich repeat receptor-like protein kinase At5g05160, EC 2.7.11.-	0/1	0	0	0	No
C0LGI5	Y1699_ARATH	InParanoid	A. thaliana	At1g69990, F20P5.27	Probable LRR receptor-like serine/threonine-protein kinase At1g69990, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LVM0	Y5830_ARATH	InParanoid	A. thaliana	At5g58300, MCK7.17	Probable inactive receptor kinase At5g58300	1/1	0	1	0	Yes
Q9FK10	Y5332_ARATH	InParanoid	A. thaliana	At5g53320, K19E1.12	Probable inactive receptor kinase At5g53320	0/1	0	0	0	Yes
Q9M9S4	Y1143_ARATH	InParanoid	A. thaliana	At1g14390, F14L17.16	Probable LRR receptor-like serine/threonine-protein kinase At1g14390, EC 2.7.11.1	0/1	0	0	0	No
Q9SKB2	SBIR1_ARATH	InParanoid	A. thaliana	SOBIR1, EVR, At2g31880, F20M17.8	Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1, EC 2.7.10.1, EC 2.7.11.1	1/1	0	1	0	Yes
C0LGS3	Y4372_ARATH	InParanoid	A. thaliana	At4g37250, AP22.22, C7A10.110	Probable LRR receptor-like serine/threonine-protein kinase At4g37250, EC 2.7.11.1	0/1	0	0	0	Yes
Q3E991	PRK6_ARATH	InParanoid	A. thaliana	PRK6, At5g20690, T1M15.90	Pollen receptor-like kinase 6, AtPRK6	0/1	0	0	0	No
Q8LEB6	Y5185_ARATH	InParanoid	A. thaliana	At5g18500, T28N17.1	Probable receptor-like protein kinase At5g18500, EC 2.7.11.1	0/1	0	0	0	No
Q9SH71	Y1421_ARATH	InParanoid	A. thaliana	At1g64210, F22C12.3	Putative inactive receptor-like protein kinase At1g64210	0/1	0	0	0	Yes
Q9FIF0	LRK22_ARATH	InParanoid	A. thaliana	LECRK22, At5g59270, MNC17.20	Putative L-type lectin-domain containing receptor kinase II.2, LecRK-II.2, EC 2.7.11.1	0/1	0	0	0	Yes
Q9M1L7	PRK3_ARATH	InParanoid	A. thaliana	PRK3, At3g42880, F18P9.40	Pollen receptor-like kinase 3, AtPRK3, EC 2.7.11.1	0/1	0	0	0	Yes
Q9C9Y8	Y3868_ARATH	InParanoid	A. thaliana	At3g08680, F17O14.15	Probable inactive receptor kinase At3g08680	1/1	0	1	0	Yes
Q940B9	Q940B9_ARATH	InParanoid	A. thaliana	At1g10850, At1g10860	Leucine-rich repeat protein kinase family protein	0/1	0	0	0	No
Q9SNE4	Q9SNE4_ARATH	InParanoid	A. thaliana	F11C1_70, LRR-RLK, At3g50230	Leucine-rich repeat protein kinase family protein	0/1	0	0	0	No
C0LGR9	Y4312_ARATH	InParanoid, MetaPhors	A. thaliana	At4g31250, F8F16.70	Probable LRR receptor-like serine/threonine-protein kinase At4g31250, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LPT1	PRK5_ARATH	InParanoid	A. thaliana	PRK5, PRKB, At1g50610, F11F12.7, F17J6.13	Pollen receptor-like kinase 5, AtPRK5, EC 2.7.11.1	0/1	0	0	0	No
Q84MA9	Y1063_ARATH	InParanoid	A. thaliana	At1g60630, F8A5.15	Inactive leucine-rich repeat receptor-like serine/threonine-protein kinase At1g60630	0/1	0	0	0	Yes
C0LGU0	PRK1_ARATH	InParanoid, MetaPhors	A. thaliana	PRK1, PRKD, RLK, At5g35390, T26D22.9	Pollen receptor-like kinase 1, AtPRK1, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FL63	Y5410_ARATH	InParanoid	A. thaliana	At5g24100, MZF18.1	Inactive leucine-rich repeat receptor-like serine/threonine-protein kinase At5g24100	0/1	0	0	0	No
F4I5D4	F4I5D4_ARATH	InParanoid	A. thaliana	At1g70250, F20P5.3, F20P5_3	Receptor serine/threonine kinase	0/1	0	0	0	Yes
C0LGJ9	Y2278_ARATH	InParanoid	A. thaliana	At2g02780, T20F6.8	Probable LRR receptor-like serine/threonine-protein kinase At2g02780, EC 2.7.11.1	0/1	0	0	0	Yes
A0A0B4KHV7	A0A0B4KHV7_DROME	MetaPhors	D. melanogaster	SKIP, CG13863, CG13864, CG5736, CG7086, CG7087, Dmel\CG31163, CG31163, Dmel_CG31163	Shal K[+] channel interacting protein, isoform I	0/1	0	0	0	Yes
F4HRJ4	M3K3A_ARATH	MetaPhors	A. thaliana	MAPKKK3, MAP3KA, At1g53570, F22G10.18, T3F20.12	Mitogen-activated protein kinase kinase kinase 3, EC 2.7.11.25	0/1	0	0	0	Yes
Q8L7S7	Q8L7S7_ARATH	MetaPhors	A. thaliana	At4g14350, Dl3215c, FCAALL.182	AGC	0/1	0	0	0	No
O59790	ARK1_SCHPO	MetaPhors	S. pombe	ark1, sex1, SPCC320.13c, SPCC330.16	Serine/threonine-protein kinase ark1	1/1	0	1	0	No
Q9FE20	PBS1_ARATH	MetaPhors	A. thaliana	PBS1, At5g13160, T19L5.120	Serine/threonine-protein kinase PBS1, EC 2.7.11.1	0/1	2	0	2	Yes
O22833	LRK54_ARATH	MetaPhors	A. thaliana	LECRK54, LECRKC1, At2g43700, F18O19.19	L-type lectin-domain containing receptor kinase V.4, Arabidopsis thaliana lectin-receptor kinase c1, AthlecRK-c1, LecRK-V.4, EC 2.7.11.1	0/1	0	0	0	Yes
Q39191	WAK1_ARATH	MetaPhors	A. thaliana	WAK1, PRO25, At1g21250, F16F4.6	Wall-associated receptor kinase 1, EC 2.7.11.-	0/1	0	0	0	Yes
Q66GN2	LRK64_ARATH	MetaPhors	A. thaliana	LECRK64, LECRKA4.3, At5g01560, F7A7.80	Lectin-domain containing receptor kinase VI.4, LecRK-VI.4, EC 2.7.11.1	0/1	0	0	0	Yes
Q8VZG8	MIK2_ARATH	MetaPhors	A. thaliana	MIK2, At4g08850, T32A17.160	MDIS1-interacting receptor like kinase 2, AtMIK2	1/1	0	1	0	Yes
Q96285	LRK55_ARATH	MetaPhors	A. thaliana	LECRK55, LECRKA1, At3g59700, T16L24.250	L-type lectin-domain containing receptor kinase V.5, Arabidopsis thaliana lectin-receptor kinase a1, Ath.lecRK1, AthlecRK-a1, LecRK-V.5, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FG33	LRKS5_ARATH	MetaPhors	A. thaliana	LECRKS5, At5g06740, MPH15.10	Probable L-type lectin-domain containing receptor kinase S.5, LecRK-S.5, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FHG4	LRKS7_ARATH	MetaPhors	A. thaliana	LECRKS7, At5g55830, MDF20.27	Probable L-type lectin-domain containing receptor kinase S.7, LecRK-S.7, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FK63	CARLK_ARATH	MetaPhors	A. thaliana	CAMRLK, MEE62, At5g45800, MRA19.24	Calmodulin-binding receptor kinase CaMRLK, EC 2.7.11.1	0/1	0	0	0	No
Q9LMP1	WAK2_ARATH	MetaPhors	A. thaliana	WAK2, At1g21270, F16F4.5	Wall-associated receptor kinase 2, EC 2.7.11.-	0/1	0	0	0	Yes
Q9LRT1	Y3804_ARATH	MetaPhors	A. thaliana	At3g28040, MMG15.21	Probably inactive leucine-rich repeat receptor-like protein kinase At3g28040	0/1	0	0	0	No
Q9LSL5	LRK92_ARATH	MetaPhors	A. thaliana	LECRK92, At5g65600, K21L13.11	L-type lectin-domain containing receptor kinase IX.2, LecRK-IX.2, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LSS0	LRK17_ARATH	MetaPhors	A. thaliana	At5g60270, LECRK17, F15L12.9	L-type lectin-domain containing receptor kinase I.7, LecRK-I.7, EC 2.7.11.1	0/1	0	0	0	Yes
Q9LZV7	PXC2_ARATH	MetaPhors	A. thaliana	PXC2, At5g01890	Leucine-rich repeat receptor-like protein kinase PXC2	0/1	0	0	0	Yes
Q9M020	LRK63_ARATH	MetaPhors	A. thaliana	LECRK63, LECRKA4.2, At5g01550, F7A7.70	Lectin-domain containing receptor kinase VI.3, LecRK-VI.3, EC 2.7.11.1	0/1	0	0	0	Yes
Q9T020	Y4391_ARATH	MetaPhors	A. thaliana	At4g39110, F19H22.210, T22F8.10	Probable receptor-like protein kinase At4g39110, EC 2.7.11.-	0/1	0	0	0	No
Q9FLW0	Y5241_ARATH	MetaPhors	A. thaliana	At5g24010, MZF18.11	Probable receptor-like protein kinase At5g24010, EC 2.7.11.-	0/1	0	0	0	Yes
Q9FN37	PSKR2_ARATH	MetaPhors	A. thaliana	PSKR2, At5g53890, K19P17.5	Phytosulfokine receptor 2, AtPSKR2, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FN92	Y5597_ARATH	MetaPhors	A. thaliana	At5g59700, T5I8.2	Probable receptor-like protein kinase At5g59700, EC 2.7.11.-	0/1	0	0	0	Yes
Q9LX66	HERK_ARATH	MetaPhors	A. thaliana	HERK1, At3g46290, F12M12.260, F18L15.10	Receptor-like protein kinase HERK 1, EC 2.7.11.-	0/1	0	0	0	Yes
Q9S7D9	ACCR1_ARATH	MetaPhors	A. thaliana	CCR1, CRR1, At3g09780, F11F8.37, F8A24.17	Serine/threonine-protein kinase-like protein CCR1, EC 2.7.11.1	0/1	0	0	0	Yes
O81906	B120_ARATH	MetaPhors	A. thaliana	B120, At4g21390, F18E5.10, T6K22.120	G-type lectin S-receptor-like serine/threonine-protein kinase B120, EC 2.7.11.1	0/1	0	0	0	Yes
Q8RY17	WAKLI_ARATH	MetaPhors	A. thaliana	WAKL22, RFO1, At1g79670, F20B17_27	Wall-associated receptor kinase-like 22, EC 2.7.11.-	0/1	0	0	0	Yes
Q8VYG0	LRL13_ARATH	MetaPhors	A. thaliana	LRK10L-1.3, LRK10L3, At5g38210, MXA21.10	LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-like 1.3, EC 2.7.11.1	0/1	0	0	0	Yes
Q9C9L5	WAKLH_ARATH	MetaPhors	A. thaliana	WAKL9, At1g69730, T6C23.7	Wall-associated receptor kinase-like 9, EC 2.7.11.-	0/1	0	0	0	Yes
Q9FIL7	CRCK1_ARATH	MetaPhors	A. thaliana	CRCK1, At5g58940, K19M22.13	Calmodulin-binding receptor-like cytoplasmic kinase 1, EC 2.7.11.1	0/1	0	0	0	No
Q9LK43	TMK4_ARATH	MetaPhors	A. thaliana	TMK4, BARK1, At3g23750, MYM9.9	Receptor-like kinase TMK4, EC 2.7.11.1	0/1	0	0	0	No
Q9LRP3	Y3174_ARATH	MetaPhors	A. thaliana	At3g17420, MTO12.1	Probable receptor-like protein kinase At3g17420, EC 2.7.11.1	0/1	0	0	0	No
Q9M0X5	CRK25_ARATH	MetaPhors	A. thaliana	CRK25, At4g05200, C17L7.120, C6L9.3	Cysteine-rich receptor-like protein kinase 25, Cysteine-rich RLK25, EC 2.7.11.-	0/1	0	0	0	Yes
Q9SA26	Q9SA26_ARATH	MetaPhors	A. thaliana	At1g16270, F3O9.7, F3O9_7	F3O9.7 protein	0/1	0	0	0	No
Q9SJG2	Y2296_ARATH	MetaPhors	A. thaliana	At2g42960, F7D19.4	Probable receptor-like protein kinase At2g42960, EC 2.7.11.1	0/1	0	0	0	No
Q8VYA3	WAKLJ_ARATH	MetaPhors	A. thaliana	WAKL10, At1g79680, F20B17.10	Wall-associated receptor kinase-like 10, EC 2.7.11.-	0/1	0	0	0	Yes
Q9LN59	WAKLK_ARATH	MetaPhors	A. thaliana	WAKL11, At1g19390, F18O14.11	Putative wall-associated receptor kinase-like 11, EC 2.7.11.-	0/1	0	0	0	Yes
Q9ZR79	LRK57_ARATH	MetaPhors	A. thaliana	LECRK57, LECRKA3, At3g59740, F24G16.10, T16L24.290	L-type lectin-domain containing receptor kinase V.7, Arabidopsis thaliana lectin-receptor kinase a3, AthlecRK-a3, LecRK-V.7, EC 2.7.11.1	0/1	0	0	0	No
Q9ZP16	CRK11_ARATH	MetaPhors	A. thaliana	CRK11, RLK3, At4g23190, F21P8.80	Cysteine-rich receptor-like protein kinase 11, Cysteine-rich RLK11, EC 2.7.11.-	0/1	0	0	0	Yes
O23081	CRK41_ARATH	MetaPhors	A. thaliana	CRK41, At4g00970, A_TM018A10.18, T18A10.9	Cysteine-rich receptor-like protein kinase 41, Cysteine-rich RLK41, EC 2.7.11.-	0/1	0	0	0	Yes
C0LGU5	Y5457_ARATH	MetaPhors	A. thaliana	At5g45780, MRA19.22	Probable LRR receptor-like serine/threonine-protein kinase At5g45780, EC 2.7.11.1	0/1	0	0	0	No
Q8GXQ3	WAKLF_ARATH	MetaPhors	A. thaliana	WAKL6, At1g16110, T24D18.19, T24D18_30	Wall-associated receptor kinase-like 6, EC 2.7.11.-	0/1	0	0	0	Yes
F4JTP5	STY46_ARATH	MetaPhors	A. thaliana	STY46, At4g38470, F20M13.30	Serine/threonine-protein kinase STY46, EC 2.7.11.1	0/1	0	0	0	No
Q9LPZ3	Y1141_ARATH	MetaPhors	A. thaliana	At1g11410, T23J18.8	G-type lectin S-receptor-like serine/threonine-protein kinase At1g11410, EC 2.7.11.1	0/1	0	0	0	Yes
Q9FX99	Y1497_ARATH	MetaPhors	A. thaliana	At1g49730, F14J22.6	Probable receptor-like protein kinase At1g49730, EC 2.7.11.1	0/1	0	0	0	Yes
Q1PEM5	PERK3_ARATH	MetaPhors	A. thaliana	PERK3, At3g24540, MOB24.4	Proline-rich receptor-like protein kinase PERK3, EC 2.7.11.1	0/1	0	0	0	Yes
O64649	O64649_ARATH	MetaPhors	A. thaliana	At2g45700, F4I18.32	Sterile alpha motif	0/1	0	0	0	No
Q9FGG5	Q9FGG5_ARATH	MetaPhors	A. thaliana	MUF8.1, MUF8_1, At5g41730	Protein kinase family protein	0/1	0	0	0	No
Q944S4	Q944S4_ARATH	MetaPhors	A. thaliana	At1g64300, F15H21.13, F15H21_13	At1g64300/F15H21_13	0/1	0	0	0	No
A0A5S9S1U7	A0A5S9S1U7_ARATH	MetaPhors	A. thaliana	C24_LOCUS83	Protein kinase domain-containing protein	0/1	0	0	0	No
A0A654EQA1	A0A654EQA1_ARATH	MetaPhors	A. thaliana	AN1_LOCUS5176, C24_LOCUS5055	Protein kinase domain-containing protein	0/1	0	0	0	No
E2R7J5	E2R7J5_CANLF	Ensembl, OrthoDB, OMA, InParanoid	C. familiaris	EPHA7	EPH receptor A7	0/1	0	0	0	Yes
Q61772	EPHA7_MOUSE	Ensembl, OrthoDB, OMA, InParanoid, MetaPhors	M. musculus	Epha7, Ebk, Ehk3, Mdk1	Ephrin type-A receptor 7, EC 2.7.10.1	0/23	0	0	0	Yes
P54759	EPHA7_RAT	Ensembl, OrthoDB, OMA, InParanoid, MetaPhors	R. norvegicus	Epha7, Ehk-3, Ehk3	Ephrin type-A receptor 7, EC 2.7.10.1	0/3	0	0	0	Yes
D1YSF9	D1YSF9_DROME	Ensembl, OrthoDB	D. melanogaster	CT3831, DEK, Dek, dek, Dek7, Deph, Dmel\CG1511, Ek7, eph, lincRNA.923, RPTK Dek7, Eph, CG1511, Dmel_CG1511	Receptor protein-tyrosine kinase	0/1	0	0	0	No

Ortholog sequence alignment (CLUSTALW)

Cysteine summary and predictions

Pos in alignment	14	74	109	119	192	205	234	250	263	265	276	279	293	296
Subcell. location	U	E	E	E	E	E	E	E	E	E	E	E	E	E
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	helix	strand	helix	coil	strand	coil	strand	strand	strand	strand	strand	coil	coil	coil
UniProt secondary structure	NA	strand	coil	NA	strand	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys¹⁴	Cys⁷⁴	Cys¹⁰⁹	Cys¹¹⁹	Cys¹⁹²	Cys²⁰⁵	Cys²³⁴	Cys²⁵⁰	Cys²⁶³	Cys²⁶⁵	Cys²⁷⁶	Cys²⁷⁹	Cys²⁹³	Cys²⁹⁶
Pos in isoform 2 CSS-Palm 4.0 PalmPred	Cys¹⁴	Cys⁷⁴	Cys¹⁰⁹	Cys¹¹⁹	Cys¹⁹²	Cys²⁰⁵	Cys²³⁴	Cys²⁵⁰	Cys²⁶³	Cys²⁶⁵	Cys²⁷⁶	Cys²⁷⁹	Cys²⁹³	Cys²⁹⁶
Pos in isoform 3 CSS-Palm 4.0 PalmPred	Cys¹⁴	Cys⁷⁴	Cys¹⁰⁹	Cys¹¹⁹	Cys¹⁹²	Cys²⁰⁵	Cys²³⁴	Cys²⁵⁰	Cys²⁶³	Cys²⁶⁵	Cys²⁷⁶ MC
Pos in isoform 4 CSS-Palm 4.0 PalmPred	Cys¹⁴	Cys⁷⁴	Cys¹⁰⁹	Cys¹¹⁹	Cys¹⁹²	Cys²⁰⁵	Cys²³⁴	Cys²⁵⁰	Cys²⁶³	Cys²⁶⁵	Cys²⁷⁶	Cys²⁷⁹	Cys²⁹³	Cys²⁹⁶
Pos in isoform 5 CSS-Palm 4.0 PalmPred	Cys¹⁴	Cys⁷⁴	Cys¹⁰⁹	Cys¹¹⁹	Cys¹⁹²	Cys²⁰⁵	Cys²³⁴	Cys²⁵⁰	Cys²⁶³	Cys²⁶⁵	Cys²⁷⁶	Cys²⁷⁹	Cys²⁹³	Cys²⁹⁶

Pos in alignment	310	312	328	369	372	379	382	583	604	632	648	681	731	772
Subcell. location	E	E	E	E	E	E	E	C	U	C	C	C	U	C
Disulfide	no	no	no	no	no	no	no	no		no	no	no		no
PSIPRED v.4.02 prediction	strand	strand	coil	strand	coil	coil	coil	coil		helix	strand	helix		strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA		helix	strand	helix		strand
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys³¹⁰	Cys³¹²	Cys³²⁸ LC	Cys³⁶⁹	Cys³⁷²	Cys³⁷⁹	Cys³⁸²	Cys⁵⁸³ HC		Cys⁶³²	Cys⁶⁴⁸	Cys⁶⁸¹		Cys⁷⁷²
Pos in isoform 2 CSS-Palm 4.0 PalmPred	Cys³¹⁰	Cys³¹²	Cys³²⁸	Cys³⁶⁹	Cys³⁷²	Cys³⁷⁹	Cys³⁸²	Cys⁵⁷⁸ HC		Cys⁶²⁷	Cys⁶⁴³	Cys⁶⁷⁶		Cys⁷⁶⁷
Pos in isoform 3 CSS-Palm 4.0 PalmPred
Pos in isoform 4 CSS-Palm 4.0 PalmPred	Cys³¹⁰	Cys³¹²	Cys³²⁸	Cys³⁶⁹	Cys³⁷²	Cys³⁷⁹	Cys³⁸²	Cys⁵⁸³ LC	Cys⁶⁰⁰	Cys⁶²⁸	Cys⁶⁴⁴	Cys⁶⁷⁷		Cys⁷⁶⁸
Pos in isoform 5 CSS-Palm 4.0 PalmPred	Cys³¹⁰	Cys³¹²	Cys³²⁸	Cys³⁶⁹	Cys³⁷²	Cys³⁷⁹	Cys³⁸²						Cys⁴⁴⁵

Pos in alignment	861	872	907	926
Subcell. location	C	C	C	C
Disulfide	no	no	no	no
PSIPRED v.4.02 prediction	coil	helix	coil	coil
UniProt secondary structure	NA	helix	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁸⁶¹	Cys⁸⁷²	Cys⁹⁰⁷	Cys⁹²⁶
Pos in isoform 2 CSS-Palm 4.0 PalmPred	Cys⁸⁵⁶	Cys⁸⁶⁷	Cys⁹⁰²	Cys⁹²¹
Pos in isoform 3 CSS-Palm 4.0 PalmPred
Pos in isoform 4 CSS-Palm 4.0 PalmPred	Cys⁸⁵⁷	Cys⁸⁶⁸	Cys⁹⁰³	Cys⁹²²
Pos in isoform 5 CSS-Palm 4.0 PalmPred

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

Tip: Keep CTRL key pressed down while clicking on column headers to do multiple sorting. This applies to any sortable table on this site.

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	x		HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	x		HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	x		HC: 162 hits LC: 218 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	x		HC: 102 hits LC: 73 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	x		HC HC: 352 hits LC LC: 8 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	x		List: 214 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	x		HC HC: 254 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	x		List: 154 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	x		List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	Ortholog	in HC,MC,LC [Y3868, MIK2, Y3148, Y5659, Y5830, SRF3, Y1848, Q9FRI1, SD25, SBIR1, Y3288, Y2267]	HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	x		List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	Ortholog	in List [ARK1]	List: 238 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	x		List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	x		List: 436 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	x		Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	Found	in List	List: 354 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	x		List: 1348 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	Found	in List	List: 354 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	x		List: 226 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	x		List: 274 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	x		HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	x		HC: 1079 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		List: 865 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	x		List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	x		List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	x		HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		LPS treatment: 646 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		List: 646 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	Found	in List	List: 2929 hits
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 590 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 370 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 600 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		List: 185 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1869 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1093 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 687 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	x		List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	x		List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 199 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 399 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1040 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 464 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 4107 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1597 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1378 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 3870 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	3	4	0	0.0	NA
H. sapiens	22	38	5	13.2	NA
M. musculus	23	37	0	0.0	NA
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	1	100.0	Y3868_ARATH , MIK2_ARATH , Y3148_ARATH , Y5659_ARATH , Y5830_ARATH , SRF3_ARATH , Y1848_ARATH , Q9FRI1_ARATH , SD25_ARATH , SBIR1_ARATH , Y3288_ARATH , Y2267_ARATH
S. pombe	1	1	1	100.0	ARK1_SCHPO
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	0	0.0	NA
C. familiaris	1	1	0	0.0	NA

References

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Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
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Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
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Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
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Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Zhou B et al.	2019	Low-background Acyl-biotinyl Exchange Largely Eliminates the Co-isolation of Non-S-acylated Proteins and Enables Deep S-acylproteomic Analysis.	31251020
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Wegleiter T et al.	2019	Palmitoylation of BMPR1a regulates neural stem cell fate.	31772009
Morrison E et al.	2020	Dynamic palmitoylation events following T-cell receptor signaling.	32651440
Mariscal J et al.	2020	Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles.	32944167
Gorenberg EL et al.	2022	Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.	35358180
Uzbekova S et al.	2021	Protein Palmitoylation in Bovine Ovarian Follicle.	34769186
Miles MR et al.	2021	Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart.	33636221
Pradhan AJ et al.	2021	Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis.	33848465
Ripamonti M et al.	2021	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.	33782527
Zaręba-Kozioł M et al.	2021	S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity.	34200797
Ziemlińska E et al.	2021	Palm Oil-Rich Diet Affects Murine Liver Proteome and <i>S</i>-Palmitoylome.	34884899
Gao J et al.	2022	Proteome-wide identification of palmitoylated proteins in mouse testis.	35477839