General info Cross-references Sequences Orthologs Ortholog sequences Predictions Palmitoyl-proteomes References
Palmitoyl-proteomes
1/1
article for
4 orthologs
4 orthologs
Validation experiments
0
experiment
0 ortholog
0 ortholog
Curated sites & Enzymes
0
site from validation experiments*
0 site from palmitoyl-proteomes*
No PAT known
No APT known
*In main isoform only
0 site from palmitoyl-proteomes*
No PAT known
No APT known
*In main isoform only
Predictions
Not predicted
Protein names
Fatty acyl CoA synthetase 3
Subcellular location
Isoforms & protein length
Isoform 1 (main): 702 aa
Known functions
Source | Identifiers |
---|---|
UniProt gene names | Tb09.160.2810 |
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UniProt AC | st. | UniProt ID | Orthology source | Organism | Gene names | Protein name | Palmitome articles | Times validated | Techniques | Sites | Predicted |
---|---|---|---|---|---|---|---|---|---|---|---|
P47912 | LCF4_YEAST | InParanoid | S. cerevisiae S288c | YM9408.08, YMR246W, FAA4 | Long-chain-fatty-acid--CoA ligase 4 | 0/1 | 0 | 0 | 0 | Yes | |
P30624 | LCF1_YEAST | InParanoid | S. cerevisiae S288c | O6136, YOR317W, FAA1 | Long-chain-fatty-acid--CoA ligase 1 | 0/1 | 0 | 0 | 0 | Yes | |
Q9SJD4 | LACS8_ARATH | InParanoid | A. thaliana | T23O15.3, T1O3, At2g04350, LACS8 | Long chain acyl-CoA synthetase 8 | 0/1 | 0 | 0 | 0 | No | |
Q9CAP8 | LACS9_ARATH | InParanoid | A. thaliana | T5M16.18, At1g77590, LACS9 | Long chain acyl-CoA synthetase 9, chloroplastic | 0/1 | 0 | 0 | 0 | No | |
F1MEX9 | F1MEX9_BOVIN | InParanoid | B. taurus | ACSL3 | Acyl-CoA synthetase long chain family member 3 | 0/1 | 0 | 0 | 0 | Yes | |
F1MBW3 | F1MBW3_BOVIN | InParanoid | B. taurus | ACSL4 | Acyl-CoA synthetase long chain family member 4 | 0/1 | 0 | 0 | 0 | Yes | |
Q8I535 | Q8I535_PLAF7 | InParanoid | P. falciparum | PF3D7_1238800 | Acyl-CoA synthetase | 0/1 | 0 | 0 | 0 | Yes | |
Q8I3L4 | Q8I3L4_PLAF7 | InParanoid | P. falciparum | PF3D7_0525100 | Acyl-CoA synthetase | 0/1 | 0 | 0 | 0 | Yes | |
A1Z7H2 | A1Z7H2_DROME | InParanoid | D. melanogaster | l(2)SH2 0465, l(2)SH0465, l(2)k05304, l(2)7447, l(2)05847, FCS, FACS, Dmel\CG8732, dFAC, dAcsl, anon-WO0172774.173, ACSL1, 7447, Dmel_CG8732, CG8732, l(2)44DEa, Acsl | Acyl-CoA synthetase long-chain, isoform D | 0/1 | 0 | 0 | 0 | No | |
O60135 | LCF1_SCHPO | InParanoid | S. pombe | SPBC18H10.02, lcf1 | Long-chain-fatty-acid--CoA ligase 1 | 0/1 | 0 | 0 | 0 | Yes | |
Q63151 | ACSL3_RAT | InParanoid | R. norvegicus | Facl3, Acs3, Acsl3 | Long-chain-fatty-acid--CoA ligase 3 | 0/2 | 0 | 0 | 0 | Yes | |
O35547 | ACSL4_RAT | InParanoid | R. norvegicus | Facl4, Acs4, Acsl4 | Long-chain-fatty-acid--CoA ligase 4 | 0/2 | 0 | 0 | 0 | Yes | |
Q9CZW4 | ACSL3_MOUSE | InParanoid | M. musculus | Facl3, Acs3, Acsl3 | Long-chain-fatty-acid--CoA ligase 3 | 2/17 | 0 | 2 | 0 | Yes | |
Q9QUJ7 | ACSL4_MOUSE | InParanoid | M. musculus | Facl4, Acs4, Acsl4 | Long-chain-fatty-acid--CoA ligase 4 | 4/17 | 0 | 2 | 1 | Yes | |
O95573 | ACSL3_HUMAN | InParanoid | H. sapiens | LACS3, FACL3, ACS3, ACSL3 | Long-chain-fatty-acid--CoA ligase 3 | 4/17 | 0 | 3 | 0 | Yes | |
O60488 | ACSL4_HUMAN | InParanoid | H. sapiens | LACS4, FACL4, ACS4, ACSL4 | Long-chain-fatty-acid--CoA ligase 4 | 4/17 | 0 | 3 | 0 | Yes | |
P39002 | LCF3_YEAST | OMA, InParanoid | S. cerevisiae S288c | YIL009W, FAA3 | Long-chain-fatty-acid--CoA ligase 3 | 0/1 | 0 | 0 | 0 | No | |
Q9P7D7 | LCF2_SCHPO | OMA, InParanoid | S. pombe | SPBP4H10.11c, lcf2 | Long-chain-fatty-acid--CoA ligase 2 | 0/1 | 0 | 0 | 0 | Yes |
Pos in alignment | 4 | 44 | 70 | 79 | 195 | 200 | 237 | 307 | 315 | 340 | 467 | 592 | 603 | 702 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subcell. location | U | U | U | U | U | U | U | U | U | U | U | U | U | U |
Disulfide | no | no | no | no | no | no | no | no | no | no | no | no | no | no |
PSIPRED v.4.02 prediction | helix | coil | coil | helix | coil | strand | strand | coil | strand | coil | coil | strand | strand | coil |
UniProt secondary structure | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Pos in isoform 1 [Main]
CSS-Palm 4.0 PalmPred |
Cys4 MC |
Cys44 |
Cys70 |
Cys79 |
Cys195 |
Cys200 |
Cys237 |
Cys307 |
Cys315 |
Cys340 |
Cys467 |
Cys592 |
Cys603 |
Cys702 |
Legend
Subcell. location | U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear |
Prediction confidence |
Cysteine position:
Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted. PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted. |
List of palmitoyl-proteomes
Summary table by organism
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ID of the experiment | Reference | Year | Organism | Cell type | Subcellular location | Technique(s) | Found? | In list | All lists |
---|---|---|---|---|---|---|---|---|---|
SPalmE:14 | Roth AF et al. | 2006 | Saccharomyces cerevisiae | Isogenic LRB759 | Total membrane | ABE | x | HC HC: 48 hits | |
SPalmE:13 | Kang R et al. | 2008 | Rattus norvegicus | Cortical neuron | Synaptosomal membrane | ABE | x |
HC: 107 hits LC: 308 hits |
|
SPalmE:6 | Martin BR et al. | 2009 | Homo sapiens | Jurkat | Total membrane | Click chemistry | Ortholog | in LC [ACSL3, ACSL4] |
HC: 127 hits LC: 188 hits List: 0 hits |
SPalmE:10 | Yount JS et al. | 2010 | Mus musculus | Dendritic cell | Total cell lysate | Click chemistry | x |
HC: 59 hits LC: 105 hits |
|
SPalmE:577 | Yang W et al. | 2010 | Homo sapiens | DU145 | Non-lipid raft | ABE | Ortholog | in LC [ACSL3, ACSL4] |
HC: 63 hits LC: 147 hits |
SPalmE:578 | Yang W et al. | 2010 | Homo sapiens | DU145 | Lipid raft | ABE | x |
HC: 102 hits LC: 73 hits |
|
SPalmE:1 | Yang W et al. | 2010 | Homo sapiens | DU145 | Total membrane | ABE | Ortholog | in LC [ACSL3, ACSL4] |
HC: 162 hits LC: 218 hits |
SPalmE:2 | Dowal L et al. | 2011 | Homo sapiens | Platelet | Total membrane | ABE | x | List: 214 hits | |
SPalmE:5 | Forrester MT et al. | 2011 | Homo sapiens | HEK293 | Total membrane | ARAC | x | List: 69 hits | |
SPalmE:7 | Wilson JP et al. | 2011 | Homo sapiens | Jurkat | Total cell lysate | Click chemistry | x |
HC: 164 hits LC: 178 hits |
|
SPalmE:8 | Merrick BA et al. | 2011 | Mus musculus | Macrophage Raw 264.7 | Total membrane | ABE | x | List: 69 hits | |
SPalmE:12 | Martin BR et al. | 2011 | Mus musculus | BW5147-derived mouse T-cell hybridoma cell | Total membrane | Click chemistry | Ortholog | in HC [ACSL3, ACSL4] |
HC HC: 352 hits LC LC: 8 hits |
SPalmE:511 | Emmer BT et al. | 2011 | Trypanosoma brucei brucei | NA | Total cell lysate | ABE | Found | List: 126 hits | |
SPalmE:3 | Ivaldi C et al. | 2012 | Homo sapiens | B-cell | Total membrane | ABE | x | HC HC: 93 hits | |
SPalmE:4 | Marin EP et al. | 2012 | Homo sapiens | Umbilical vein blood | NA | ABE | x | List: 154 hits | |
SPalmE:11 | Li Y et al. | 2012 | Mus musculus | Neural stem cell | Total cell lysate | Click chemistry | x | HC HC: 254 hits | |
SPalmE:162 | Jones ML et al. | 2012 | Plasmodium falciparum | Whole organism | Total cell lysate | ABE | x |
HC: 100 hits LC: 217 hits |
|
SPalmE:580 | Jones ML et al. | 2012 | Plasmodium falciparum | Whole organism | Total cell lysate | Click chemistry, SILAC | x |
HC: 79 hits LC: 89 hits |
|
SPalmE:15 | Hemsley PA et al. | 2013 | Arabidopsis thaliana | Heyn Col-4 ecotype root cell suspension | Microsomal membrane | ABE | x |
HC: 122 hits MC: 94 hits LC: 366 hits |
|
SPalmE:119 | Wan J et al. | 2013 | Mus musculus | Brain | Total cell lysate | ABE | x | List: 378 hits | |
SPalmE:160 | Zhang MM et al. | 2013 | Schizosaccharomyces pombe | Whole organism | Total cell lysate | Click chemistry | x | List: 238 hits | |
SPalmE:9 | Ren W et al. | 2013 | Mus musculus | 3T3-L1 and epididymal fat pads | Total membrane | ARAC | x | List: 664 hits | |
SPalmE:184 | Wei X et al. | 2014 | Homo sapiens | HUVEC | Total cell lysate | ABE | x |
Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits |
|
SPalmE:507 | Chesarino NM et al. | 2014 | Mus musculus | DC2.4 | Total cell lysate | Click chemistry | x | List: 246 hits | |
SPalmE:508 | Chesarino NM et al. | 2014 | Mus musculus | MEF | Total cell lysate | Click chemistry | x | List: 436 hits | |
SPalmE:504 | Serwa RA et al. | 2015 | Homo sapiens | RPE-1 | Total cell lysate | SILAC, 16-HDYA labeling | Ortholog | in List [ACSL3, ACSL4] | List: 1348 hits |
SPalmE:505 | Morrison E et al. | 2015 | Homo sapiens | Primary CD4 + T cells | Total cell lysate | ABE, In gel SILAC labeling | x | List: 274 hits | |
SPalmE:506 | Morrison E et al. | 2015 | Homo sapiens | Jurkat | Total cell lysate | Click chemistry, SILAC | x | List: 226 hits | |
SPalmE:509 | Santiago-Tirado FH et al. | 2015 | Cryptococcus neoformans | NA | Total cell lysate | Click chemistry | x | List: 426 hits | |
SPalmE:510 | Santiago-Tirado FH et al. | 2015 | Cryptococcus neoformans | NA | Total cell lysate | Click chemistry | x | List: 354 hits | |
SPalmE:529 | Colquhoun DR et al. | 2015 | Homo sapiens | 174 x CEM.T1 | Total cell lysate | Click-IT Palmitic Acid labeling | x | List: 113 hits | |
SPalmE:536 | Foe IT et al. | 2015 | Toxoplasma gondii | NA | Total membrane | Click chemistry | x |
HC: 210 hits MC: 72 hits |
|
SPalmE:540 | Gould NS et al. | 2015 | Mus musculus | Liver | Total cell lysate | APE | x | List: 780 hits | |
SPalmE:619 | Peng T et al. | 2015 | Homo sapiens | HEK293 | Total cell lysate | Alk16 Labeling | x | List: 354 hits | |
SPalmE:620 | Peng T et al. | 2015 | Homo sapiens | HEK293 | Total cell lysate | Photo cleavable x-alk16 labeling | x | List: 354 hits | |
SPalmE:698 | Pinner AL et al. | 2016 | Homo sapiens | Brain | Total cell lysate | ABE | x | List: 216 hits | |
SPalmE:723 | Hernandez JL et al. | 2016 | Homo sapiens | MCF7 | Total cell lysate | Alk16 Labeling | Ortholog | in List [ACSL3, ACSL4] | List: 1353 hits |
SPalmE:724 | Fang C et al. | 2016 | Homo sapiens | SW480 | NA | ARAC | x | List: 100 hits | |
SPalmE:829 | Upadhyay S et al. | 2016 | Aspergillus fumigatus | Conidia | NA | ABE | x | List: 133 hits | |
SPalmE:902 | Caballero MC et al. | 2016 | Toxoplasma gondii | whole parasite lysates | NA | ABE | x | HC: 164 hits | |
SPalmE:909 | Thinon E et al. | 2016 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | Alk16 Labeling | Ortholog | in LC [ACSL3, ACSL4] |
HC: 197 hits MC: 143 hits LC: 302 hits |
SPalmE:903 | Collins MO et al. | 2017 | Mus musculus | Forebrain | NA | ABE | Ortholog | in HC [ACSL3, ACSL4] | HC: 1079 hits |
SPalmE:906 | Edmonds MJ et al. | 2017 | Rattus norvegicus | Brain | NA | ABE | x | List: 193 hits | |
SPalmE:907 | Edmonds MJ et al. | 2017 | Rattus norvegicus | Brain | NA | ARAC | x | List: 95 hits | |
SPalmE:855 | Shen LF et al. | 2017 | Mus musculus | Liver | Total membrane | ARAC | x | List: 865 hits | |
SPalmE:993 | Shen LF et al. | 2017 | Mus musculus | Liver | Total membrane | ARAC | x | ZDHHC13 substrates: 16 hits | |
SPalmE:1187 | Thinon E et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | ARAC | x |
HC: 281 hits MC: 139 hits LC: 113 hits |
|
SPalmE:908 | Sobocińska J et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | Click chemistry | Ortholog | in Palm. down with LPS [ACSL3, ACSL4] |
Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits |
SPalmE:919 | Sobocińska J et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | Click chemistry | Ortholog | in List [ACSL3, ACSL4] | List: 646 hits |
SPalmE:920 | Sobocińska J et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | Click chemistry | Ortholog | in LPS treatment [ACSL3, ACSL4] | LPS treatment: 646 hits |
SPalmE:1183 | Thinon E et al. | 2018 | Homo sapiens | HeLa | Total cell lysate | NH2OH cleavage of thioester bond, Alk16 Labeling | x |
HC: 132 hits MC: 138 hits LC: 110 hits |
|
SPalmE:1182 | Thinon E et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | ARAC | Ortholog | in LC [ACSL3, ACSL4] |
HC: 198 hits MC: 143 hits LC: 120 hits |
SPalmE:1192 | Won SJ et al. | 2018 | Homo sapiens | HAP1 | Total cell lysate | Click chemistry | x | List: 984 hits | |
SPalmE:1194 | Won SJ et al. | 2018 | Homo sapiens | HAP1 | Total cell lysate | ARAC, | Ortholog | in List [ACSL3, ACSL4] | List: 1404 hits |
SPalmE:1193 | Won SJ et al. | 2018 | Homo sapiens | HAP1 | Total cell lysate | ARAC | Ortholog | in List [ACSL3, ACSL4] | List: 1394 hits |
SPalmE:1203 | Zhang X et al. | 2018 | Mus musculus | Brain | Total membrane | Enrichment by magnetic nanoparticles | Ortholog | in HC [ACSL3, ACSL4] |
HC: 917 hits MC: 352 hits LC: 15 hits |
SPalmE:1184 | Thinon E et al. | 2018 | Homo sapiens | HeLa | Total cell lysate | ARAC | x |
HC: 545 hits MC: 415 hits LC: 219 hits |
|
SPalmE:1185 | Thinon E et al. | 2018 | Homo sapiens | HeLa | Total cell lysate | NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling | x |
Chymotrypsin: 286 hits Trypsin: 1291 hits |
|
SPalmE:1191 | Won SJ et al. | 2018 | Homo sapiens | HEK293T | Total cell lysate | Click chemistry | x | List: 195 hits | |
SPalmE:1181 | Thinon E et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | NH2OH cleavage of thioester bond, Alk16 Labeling | x |
HC: 244 hits MC: 187 hits LC: 120 hits |
|
SPalmE:1186 | Thinon E et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | NH2OH cleavage of thioester bond, Alk16 Labeling | x |
HC: 177 hits MC: 162 hits LC: 123 hits |
|
SPalmE:1260 | Wang Z et al. | 2018 | Bos taurus | Lens fiber cell | Total cell lysate | ABE, NH2OH cleavage of thioester bond, LC-MS | x | List: 52 hits | |
SPalmE:1259 | Dumoulin A et al. | 2018 | Mus musculus | F11 | Total membrane | ABE, NH2OH cleavage of thioester bond, LC-MS | x |
HC: 1 hits MC: 10 hits LC: 4 hits |
|
SPalmE:1303 | Zaręba-Kozioł M et al. | 2019 | Mus musculus | Brain | Postsynaptic density fraction | ABE, NH2OH cleavage of thioester bond, LC-MS | x | ||
SPalmE:1333 | Zaręba-Kozioł M et al. | 2019 | Mus musculus | Brain | Postsynaptic density fraction | ABE, NH2OH cleavage of thioester bond, LC-MS | x | ||
SPalmE:1270 | Strassburger K et al. | 2019 | Drosophila melanogaster | Circa 160 L2 larvae | Total cell lysate | ABE, NH2OH cleavage of thioester bond, PAT KO, MS | x | List: 13 hits | |
SPalmE:1266 | Strassburger K et al. | 2019 | Drosophila melanogaster | Circa 160 L2 larvae | Total cell lysate | ABE, NH2OH cleavage of thioester bond, PAT KO, MS | x | List: 157 hits | |
SPalmE:1265 | Wang J et al. | 2019 | Mus musculus | 3T3-L1 | Total membrane | MS, BioID | x | List: 9 hits |
Summary table by organism
Organism | Total number of palmitoyl-proteome articles | Total number of palmitoyl-proteomes | Number of palmitoyl-proteomes containing this protein or an ortholog | % of palmitoyl-proteomes containing this protein or an ortholog | Orthologs |
---|---|---|---|---|---|
S. cerevisiae S288c | 1 | 1 | 0 | 0.0 | NA |
R. norvegicus | 2 | 3 | 0 | 0.0 | ACSL4_RAT |
H. sapiens | 17 | 26 | 7 | 26.9 | ACSL3_HUMAN , ACSL4_HUMAN |
M. musculus | 17 | 25 | 8 | 32.0 | ACSL3_MOUSE , ACSL4_MOUSE |
T. brucei brucei | 1 | 1 | 1 | 100.0 | NA |
P. falciparum | 1 | 2 | 0 | 0.0 | NA |
A. thaliana | 1 | 1 | 0 | 0.0 | NA |
S. pombe | 1 | 1 | 0 | 0.0 | NA |
C. neoformans var. grubii serotype A strain H99 | 1 | 2 | 0 | 0.0 | NA |
T. gondii | 2 | 2 | 0 | 0.0 | NA |
A. fumigatus | 1 | 1 | 0 | 0.0 | NA |
B. taurus | 1 | 1 | 0 | 0.0 | NA |
D. melanogaster | 1 | 2 | 0 | 0.0 | NA |