SwissPalm

Q5VST6 AB17B_HUMAN

General info Cross-references APT activity Sequences Orthologs Ortholog sequences Validation experiments Sites Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

12/22 articles for human
7 orthologs

Palmitoyl-proteome experiments

Validation experiments

1 experiment
0 ortholog

Validation experiments

Curated sites & Enzymes

0 site from validation experiments^*
1 site from palmitoyl-proteomes^* Cys²¹⁰
No PAT known
No APT known
^*In main isoform only

Sites

Predictions

Predicted

6 cysteines in main isoform

Predictions

Protein general information from UniProt

Protein names

Alpha/beta hydrolase domain-containing protein 17B, Abhydrolase domain-containing protein 17B, EC 3.1.2.22

Subcellular location

Secreted (By similarity); Cell membrane (By similarity); Recycling endosome membrane; Cell projection; Dendritic spine (Potential); Cell junction (Probable); Synapse (Probable); Postsynaptic cell membrane (Probable); Postsynaptic density (Potential); Postsynaptic density membrane (Probable)

Isoforms & protein length

Isoform 1 (main): 288 aa; Isoform 2 : 293 aa

Known functions

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913). H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein] Inhibited by palmostatin-B. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913). H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein] Inhibited by palmostatin-B.

Cross-references

Source	Identifiers
UniProt gene names	ABHD17B, C9orf77, FAM108B1, CGI-67, FAM108B
UniProt secondary AC	A8KAJ5, Q5VST7, Q86YB6, Q8IY03, Q9Y377
Refseq protein ID	XP_006717197.1, XP_011517061.1, NP_001020951.1, NP_057098.2
IPI ID	IPI00412592, IPI00643071, IPI00006566

Source	Identifiers
Ensembl protein	ENSP00000330222, ENSP00000366240
Ensembl gene	ENSG00000107362
CellPalmSeq	de-palmitoylating-enzymes/abhd17b

Protein thioesterase activity (APT)

Substrate UniProt ID	Substrate description	Substrate isoform AC (site position)	Experiments
RASN_HUMAN	GTPase NRas, EC 3.6.5.2	P01111	SPalmE:952 Lin DT et al. (2015) SPalmE:953 Lin DT et al. (2015)
DLG4_HUMAN	Disks large homolog 4	P78352	SPalmE:952 Lin DT et al. (2015)

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Techniques	Sites	Predicted
Q6AY17	AB17B_RAT	OrthoDB, OMA, Ensembl, InParanoid, MetaPhors	R. norvegicus	Abhd17b, RGD1305246	Alpha/beta hydrolase domain-containing protein 17B, Abhydrolase domain-containing protein 17B, EC 3.1.2.22	1/3	1	0	Yes
Q99JW1	AB17A_MOUSE	OrthoDB	M. musculus	Abhd17a, D10Bwg1364e	Alpha/beta hydrolase domain-containing protein 17A, Abhydrolase domain-containing protein 17A, EC 3.1.2.22	8/23	3	1	Yes
Q8VCV1	AB17C_MOUSE	OrthoDB	M. musculus	Abhd17c	Alpha/beta hydrolase domain-containing protein 17C, Abhydrolase domain-containing protein 17C, EC 3.1.2.22	5/23	3	1	Yes
Q1PF04	Q1PF04_ARATH	InParanoid, MetaPhors	A. thaliana	At2g24320, T28I24.5, T28I24_5	Alpha/beta-Hydrolases superfamily protein	0/1	0	0	No
Q9LI62	Q9LI62_ARATH	InParanoid, MetaPhors	A. thaliana	At3g30380	Alpha/beta-Hydrolases superfamily protein	0/1	0	0	Yes
A0A654G640	A0A654G640_ARATH	MetaPhors	A. thaliana	AN1_LOCUS23968, C24_LOCUS23811	Hydrolase_4 domain-containing protein	0/1	0	0	No
A0A654FSL2	A0A654FSL2_ARATH	MetaPhors	A. thaliana	AN1_LOCUS19218, AT9943_LOCUS16574, C24_LOCUS19117		0/1	0	0	No
B5DFK7	AB17C_RAT	OrthoDB	R. norvegicus	Abhd17c, Fam108c1, RGD1308210, rCG_24780	Alpha/beta hydrolase domain-containing protein 17C, Abhydrolase domain-containing protein 17C, EC 3.1.2.22	1/3	1	0	Yes
Q7M759	AB17B_MOUSE	OrthoDB, OMA, Ensembl, InParanoid, MetaPhors	M. musculus	Abhd17b	Alpha/beta hydrolase domain-containing protein 17B, Abhydrolase domain-containing protein 17B, EC 3.1.2.22	11/23	3	2	Yes
E2QX09	E2QX09_CANLF	OrthoDB	C. familiaris	ABHD17A	Abhydrolase domain containing 17A	0/1	0	0	Yes
F1MYM8	F1MYM8_BOVIN	OrthoDB	B. taurus	ABHD17A	Alpha/beta hydrolase domain-containing protein 17A	0/2	0	0	Yes
Q9VBX8	Q9VBX8_DROME	OrthoDB, Ensembl, InParanoid, MetaPhors	D. melanogaster	Dmel\CG33096, CG11935, CG33096, Dmel_CG33096	IP15857p	1/1	2	0	Yes
Q9SB70	Q9SB70_ARATH	OMA, InParanoid	A. thaliana	F22K18_40, F22K18.40, At4g24760	Alpha/beta-Hydrolases superfamily protein	0/1	0	0	No
Q84JV3	Q84JV3_ARATH	OMA, InParanoid, MetaPhors	A. thaliana	F6I18.70, F6I18_70, At4g31020	Alpha/beta-Hydrolases superfamily protein	0/1	0	0	No
Q9S7U7	Q9S7U7_ARATH	OMA, InParanoid, MetaPhors	A. thaliana	F28J7.1, F4P13.23, At3g01690, F4P13_23	Alpha/beta-Hydrolases superfamily protein	0/1	0	0	Yes
Q9LY90	Q9LY90_ARATH	OMA, InParanoid	A. thaliana	F18O22.180, F18O22_180, At5g14390	Alpha/beta-Hydrolases superfamily protein	0/1	0	0	Yes
Q9FF34	Q9FF34_ARATH	OMA, InParanoid	A. thaliana	MXA21.9, MXA21_9, At5g38220	Alpha/beta-Hydrolases superfamily protein	0/1	0	0	Yes
Q9FZ68	Q9FZ68_ARATH	OMA, InParanoid, MetaPhors	A. thaliana	F21F23.4, F13B4.9, At1g13610	Alpha/beta-Hydrolases superfamily protein	0/1	0	0	No
Q8VYT1	Q8VYT1_ARATH	OMA, InParanoid, MetaPhors	A. thaliana	T4O24.3, T4O24_3, At1g66900	Alpha/beta-Hydrolases superfamily protein	0/1	0	0	No
E2RM24	E2RM24_CANLF	OMA, Ensembl, OrthoDB, InParanoid	C. familiaris	ABHD17B	Abhydrolase domain containing 17B	1/1	2	0	Yes
A7MBG2	A7MBG2_BOVIN	OMA, Ensembl, OrthoDB, InParanoid, MetaPhors	B. taurus	ABHD17B, FAM108B1	Abhydrolase domain containing 17B, depalmitoylase	0/2	0	0	Yes
C0H4R4	C0H4R4_PLAF7	InParanoid, OMA	P. falciparum	PF3D7_0805000	Alpha/beta hydrolase, putative	0/1	0	0	Yes

Ortholog sequence alignment (CLUSTALW)

Validation experiments

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)
SPalmE:332	Martin BR et al.	2009	Homo sapiens	HEK293T	Plasma Membrane	Click chemistry, NH2OH cleavage of thioester bond
SPalmE:952	Lin DT et al.	2015	Homo sapiens	COS7	Total cell lysate	Click chemistry, Thioesterases overexpression
SPalmE:953	Lin DT et al.	2015	Homo sapiens	HEK293T	Total cell lysate	, Click chemistry, Palmostatin B inhibition

Sites (from validation or large-scale experiments)

Isoforms	Position	Probability	Studies	Techniques
Q5VST6, Q5VST6-2	210	1.0	SPalmE:1185 Thinon E et al. (2018) []*	Alk16 Labeling, LC-MS, NH2OH cleavage of thioester bond

Cysteine summary and predictions

Pos in alignment	10	11	14	15	18	39	68	81	86	120	210	250
Subcell. location	U	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	helix	helix	helix	coil	coil	strand	strand	strand	coil	coil	coil	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys¹⁰ HC	Cys¹¹ HC	Cys¹⁴ HC	Cys¹⁵ HC	Cys¹⁸ HC	Cys³⁹ HC	Cys⁶⁸	Cys⁸¹	Cys⁸⁶	Cys¹²⁰	Cys²¹⁰	Cys²⁵⁰
Pos in isoform 2 CSS-Palm 4.0 PalmPred	Cys¹⁰ HC	Cys¹¹ HC	Cys¹⁴ HC	Cys¹⁵ HC	Cys¹⁸ HC	Cys³⁹ HC	Cys⁶⁸	Cys⁸¹	Cys⁸⁶	Cys¹²⁰	Cys²¹⁰	Cys²⁵⁰

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

Tip: Keep CTRL key pressed down while clicking on column headers to do multiple sorting. This applies to any sortable table on this site.

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	Ortholog	in HC [AB17B, AB17C]	HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	Found	in HC	HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	Found	in HC	HC: 162 hits LC: 218 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	Found	in HC	HC: 102 hits LC: 73 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	Ortholog	in HC [AB17A, AB17C, AB17B]	HC HC: 352 hits LC LC: 8 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	Found	in List	List: 214 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	Found	in HC	HC: 164 hits LC: 178 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	Ortholog	in HC [AB17A, AB17C, AB17B]	HC HC: 254 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	x		List: 154 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	Ortholog	in List [AB17A, AB17C, AB17B]	List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	x		HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	x		List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	x		List: 238 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	x		List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	Ortholog	in List [AB17A, AB17C, AB17B]	List: 436 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	x		Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	Found	in List	List: 354 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	Found	in List	List: 1348 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	Found	in List	List: 354 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	Found	in List	List: 226 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	Found	in List	List: 274 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	x		HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	Ortholog	in HC [AB17A, AB17C, AB17B]	HC: 1079 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		List: 865 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Ortholog	in LC [AB17A, AB17C, AB17B]	HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	x		List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	x		List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	Ortholog	in HC [AB17A, AB17C, AB17B]	HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in LPS treatment [AB17A, AB17C, AB17B]	LPS treatment: 646 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in List [AB17A, AB17C, AB17B]	List: 646 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	Found	in Trypsin	Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Ortholog	in MC [AB17A, AB17C, AB17B]	HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	Ortholog	in List [Q9VBX8]	List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	Found	in List	List: 2929 hits
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 590 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [AB17A, AB17C, AB17B]	List: 370 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Found	in HC	HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 600 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	Found	in	Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	Found	in List	List: 185 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Found	in HC	HC: 1869 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [AB17A, AB17C, AB17B]	List: 1093 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 687 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Found	in List	List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Found	in List	List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 199 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 399 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [AB17A, AB17C, AB17B]	List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [AB17A, AB17C, AB17B]	List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [AB17A, AB17C, AB17B]	List: 1040 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC,MC [AB17A, AB17C, AB17B]	HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [E2RM24]	List: 464 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [AB17A, AB17C, AB17B]	HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [AB17A, AB17C, AB17B]	HC: 4107 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [AB17A, AB17C, AB17B]	List: 1597 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [AB17A, AB17C, AB17B]	List: 1378 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [AB17A, AB17C, AB17B]	HC: 3870 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	3	4	1	25.0	AB17B_RAT , AB17C_RAT
H. sapiens	22	38	19	50.0	NA
M. musculus	23	37	21	56.8	AB17A_MOUSE , AB17C_MOUSE , AB17B_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	0	0.0	NA
S. pombe	1	1	0	0.0	NA
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	1	50.0	Q9VBX8_DROME
C. familiaris	1	1	1	100.0	E2RM24_CANLF

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Lin DT et al.	2015	ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization.	26701913
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