SwissPalm

Protein general information from UniProt

Protein names

Stress-induced-phosphoprotein 1, STI1, mSTI1; Hsc70/Hsp90-organizing protein, Hop

Subcellular location

Cytoplasm; Nucleus; Dynein axonemal particle (Potential)

Isoforms & protein length

Isoform 1 (main): 543 aa

Known functions

Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (By similarity). Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (PubMed:8999875). Interacts with PACRG. Interacts with EEF1AKMT3 (By similarity). Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction. Interacts with FLCN, FNIP1 and FNIP2. Interacts with HSPA8/HSC70 (By similarity). Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation (By similarity). The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90 (By similarity). In vitro kinase assay failed to detect phosphorylation by MAPKAPK2. Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (PubMed:8999875). Interacts with PACRG. Interacts with METTL21B. Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction. Interacts with FLCN, FNIP1 and FNIP2. Interacts with HSPA8/HSC70 (By similarity). Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation (By similarity). The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90 (By similarity). In vitro kinase assay failed to detect phosphorylation by MAPKAPK2. Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (By similarity). Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (PubMed:8999875). Interacts with PACRG. Interacts with METTL21B. Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction. Interacts with FLCN, FNIP1 and FNIP2. Interacts with HSPA8/HSC70 (By similarity). Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation (By similarity). The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90 (By similarity). In vitro kinase assay failed to detect phosphorylation by MAPKAPK2.

Cross-references

Source	Identifiers
UniProt gene names	Stip1
UniProt secondary AC	Q3TT16, Q8BPH3, Q99L66
Refseq protein ID	NP_058017.1
IPI ID	IPI00121514, IPI00387501, IPI00338069, IPI00320247, IPI00223485, IPI00172078

Source	Identifiers
Ensembl protein	ENSMUSP00000025918
Ensembl gene	ENSMUSG00000024966
MGI ID	MGI:109130

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Techniques	Predicted
Q9USI5	STI1_SCHPO	OMA, InParanoid, MetaPhors	S. pombe	sti1, stil, SPCC645.14c	Heat shock protein sti1 homolog	1/1	1	No
P31948	STIP1_HUMAN	OMA, Ensembl, InParanoid	H. sapiens	STIP1	Stress-induced-phosphoprotein 1, STI1	7/22	4	No
Q1PEM5	PERK3_ARATH	MetaPhors	A. thaliana	PERK3, At3g24540, MOB24.4	Proline-rich receptor-like protein kinase PERK3, EC 2.7.11.1	0/1	0	Yes
F4J5Y7	F4J5Y7_ARATH	MetaPhors	A. thaliana	At3g58690	Protein kinase superfamily protein	0/1	0	Yes
Q8GUH1	PUB33_ARATH	MetaPhors	A. thaliana	PUB33, At2g45910, F4I18.11	U-box domain-containing protein 33	0/1	0	Yes
C0LGD7	Y1684_ARATH	MetaPhors	A. thaliana	At1g06840, F4H5.8	Probable LRR receptor-like serine/threonine-protein kinase At1g06840, EC 2.7.11.1	0/1	0	Yes
C0LGL4	Y2289_ARATH	MetaPhors	A. thaliana	At2g28960, T9I4.4	Probable LRR receptor-like serine/threonine-protein kinase At2g28960, EC 2.7.11.1	0/1	0	Yes
Q0WRY5	PBL7_ARATH	MetaPhors	A. thaliana	CDL1, At5g02800, F9G14.110, PBL7	Probable serine/threonine-protein kinase PBL7, EC 2.7.11.1	0/1	0	Yes
F4K964	F4K964_ARATH	MetaPhors	A. thaliana	At5g57035	U-box domain-containing protein kinase family protein	0/1	0	Yes
C0LGQ7	Y4245_ARATH	MetaPhors	A. thaliana	At4g20450, F9F13.100	Probable LRR receptor-like serine/threonine-protein kinase At4g20450, EC 2.7.11.1	0/1	0	No
Q9FKG5	PUB51_ARATH	MetaPhors	A. thaliana	PUB51, At5g61560, K11J9.9	U-box domain-containing protein 51	0/1	0	No
Q9SW11	PUB35_ARATH	MetaPhors	A. thaliana	PUB35, At4g25160, F13M23.300, F24A6.13	U-box domain-containing protein 35	0/1	0	Yes
Q9SGY7	PEK11_ARATH	MetaPhors	A. thaliana	PERK11, At1g10620, F20B24.6	Putative proline-rich receptor-like protein kinase PERK11, EC 2.7.11.1	0/1	0	No
Q1PE30	Q1PE30_ARATH	MetaPhors	A. thaliana	At4g31230, F8F16.50, F8F16_50	Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein	0/1	0	No
Q9LMN8	WAK3_ARATH	MetaPhors	A. thaliana	WAK3, At1g21240, F16F4.8	Wall-associated receptor kinase 3, EC 2.7.11.-	0/1	0	Yes
Q9XEC6	CRK36_ARATH	MetaPhors	A. thaliana	CRK36, At4g04490, T26N6.10	Cysteine-rich receptor-like protein kinase 36, Cysteine-rich RLK36, EC 2.7.11.1	0/1	0	No
Q9SYS7	CRK39_ARATH	MetaPhors	A. thaliana	CRK39, At4g04540, F4H6.4, T26N6.15	Putative cysteine-rich receptor-like protein kinase 39, Cysteine-rich RLK39, EC 2.7.11.-	0/1	0	No
Q9SYS3	CRK40_ARATH	MetaPhors	A. thaliana	CRK40, At4g04570, F4H6.9	Cysteine-rich receptor-like protein kinase 40, Cysteine-rich RLK40, EC 2.7.11.-	0/1	0	Yes
Q9SY91	PBL15_ARATH	MetaPhors	A. thaliana	PBL15, PIX1, At1g61590, T25B24.6	Probable serine/threonine-protein kinase PBL15, EC 2.7.11.1	0/1	0	Yes
Q9LU47	PUB53_ARATH	MetaPhors	A. thaliana	PUB53, At5g51270, MWD22.22	Putative U-box domain-containing protein 53	0/1	0	No
Q9LFV3	CRLK2_ARATH	MetaPhors	A. thaliana	CRLK2, At5g15730, F14F8.110	Calcium/calmodulin-regulated receptor-like kinase 2, AtCRLK2, EC 2.7.11.1	0/1	0	No
Q94A51	PUB32_ARATH	MetaPhors	A. thaliana	PUB32, At3g49060, T2J13.100	U-box domain-containing protein 32, EC 2.3.2.27	0/1	0	Yes
Q8S8S7	PUB34_ARATH	MetaPhors	A. thaliana	PUB34, At2g19410, F27F23.21	U-box domain-containing protein 34	0/1	0	Yes
O49840	PBL3_ARATH	MetaPhors	A. thaliana	PBL3, KIN2, PIX14, APK2B, At2g02800, T20F6.6	Probable serine/threonine-protein kinase PBL3, EC 2.7.11.1	0/1	0	Yes
O49839	PBL2_ARATH	MetaPhors	A. thaliana	PBL2, KIN1, APK2A, At1g14370, F14L17.14	Probable serine/threonine-protein kinase PBL2, EC 2.7.11.1	0/1	0	Yes
Q9SZV2	Q9SZV2_ARATH	MetaPhors	A. thaliana	At4g29990, F6G3.20, F6G3_20	Leucine-rich repeat transmembrane protein kinase protein	0/1	0	Yes
Q5XF79	PBL18_ARATH	MetaPhors	A. thaliana	PBL18, At1g69790, T6C23.1	Probable serine/threonine-protein kinase PBL18, EC 2.7.11.1	0/1	0	Yes
Q9ZQQ7	Y2144_ARATH	MetaPhors	A. thaliana	At2g14440, T13P21.18	Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14440, EC 2.7.11.1	0/1	0	Yes
O81069	Y2899_ARATH	MetaPhors	A. thaliana	At2g28990, T9I4.7	Probable leucine-rich repeat receptor-like protein kinase At2g28990, EC 2.7.11.1	0/1	0	No
Q9SF86	PCRK1_ARATH	MetaPhors	A. thaliana	PCRK1, At3g09830, F8A24.12	Serine/threonine-protein kinase PCRK1, EC 2.7.11.1	0/1	0	Yes
Q9LXA5	LRK91_ARATH	MetaPhors	A. thaliana	LECRK91, At5g10530, F12B17.120	L-type lectin-domain containing receptor kinase IX.1, LecRK-IX.1, EC 2.7.11.1	0/1	0	Yes
Q9LV48	PERK1_ARATH	MetaPhors	A. thaliana	PERK1, At3g24550, MOB24.13	Proline-rich receptor-like protein kinase PERK1, EC 2.7.11.1	1/1	1	Yes
Q9LMN7	WAK5_ARATH	MetaPhors	A. thaliana	WAK5, At1g21230, F16F4.9	Wall-associated receptor kinase 5, EC 2.7.11.-	0/1	0	Yes
Q8GX23	PERK5_ARATH	MetaPhors	A. thaliana	PERK5, At4g34440, T4L20.20	Proline-rich receptor-like protein kinase PERK5, EC 2.7.11.1	0/1	0	Yes
Q39191	WAK1_ARATH	MetaPhors	A. thaliana	WAK1, PRO25, At1g21250, F16F4.6	Wall-associated receptor kinase 1, EC 2.7.11.-	0/1	0	Yes
O65924	Y2921_ARATH	MetaPhors	A. thaliana	At2g19210, F27F23.1	Putative leucine-rich repeat receptor-like protein kinase At2g19210, EC 2.7.11.1	0/1	0	Yes
P43293	PBL11_ARATH	MetaPhors	A. thaliana	PBL11, NAK, At5g02290, T1E22_50	Probable serine/threonine-protein kinase PBL11, EC 2.7.11.1	0/1	0	Yes
Q9FKG6	PUB52_ARATH	MetaPhors	A. thaliana	PUB52, At5g61550, K11J9.12	U-box domain-containing protein 52	0/1	0	Yes
F4IK85	F4IK85_ARATH	MetaPhors	A. thaliana	At2g07020, T4E14.13, T4E14_13	Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein	0/1	0	No
F4JZW1	PBL13_ARATH	MetaPhors	A. thaliana	PBL13, At5g35580, K2K18.3	Serine/threonine-protein kinase PBL13, EC 2.7.11.1	0/1	0	Yes
F4IDG2	F4IDG2_ARATH	MetaPhors	A. thaliana	YUP8H12R.45, YUP8H12R_45, At1g78940	Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein	0/1	0	No
Q8GWU3	Q8GWU3_ARATH	MetaPhors	A. thaliana	At3g20200, At3g20200/MAL21_24	At3g20200	0/1	0	No
Q1PF03	Q1PF03_ARATH	MetaPhors	A. thaliana	At2g24370, T28I24.10, T28I24_10	Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein	0/1	0	No
Q0WVJ0	Q0WVJ0_ARATH	MetaPhors	A. thaliana	At5g12000, F14F18.170, F14F18_170	Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein	0/1	0	No
A0A178W3E3	A0A178W3E3_ARATH	MetaPhors	A. thaliana	AXX17_At1g70820, AN1_LOCUS6673, C24_LOCUS6559	Protein kinase domain-containing protein	0/1	0	No
A0A654EQA1	A0A654EQA1_ARATH	MetaPhors	A. thaliana	AN1_LOCUS5176, C24_LOCUS5055	Protein kinase domain-containing protein	0/1	0	No
F4JZT9	F4JZT9_ARATH	MetaPhors	A. thaliana	At5g35380, T26D22.11, T26D22_11	Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein	0/1	0	No
O35814	STIP1_RAT	OrthoDB, Ensembl, InParanoid, OMA, MetaPhors	R. norvegicus	Stip1, Hop	Stress-induced-phosphoprotein 1, STI1	1/3	1	No
G3XAD8	G3XAD8_HUMAN	OrthoDB, OMA	H. sapiens	STIP1, hCG_21368	Stress-induced-phosphoprotein 1	0/22	0	No
F1P7V6	F1P7V6_CANLF	OrthoDB, OMA, Ensembl, InParanoid	C. familiaris	STIP1	Stress induced phosphoprotein 1	0/1	0	No
Q3ZBZ8	STIP1_BOVIN	OrthoDB, OMA, Ensembl, InParanoid, MetaPhors	B. taurus	STIP1	Stress-induced-phosphoprotein 1, STI1	0/2	0	No
O61650	O61650_DROME	OrthoDB, InParanoid	D. melanogaster	Stip1, Hop, CG2720	Stress-induced-phosphoprotein 1	0/1	0	No
P15705	STI1_YEAST	OMA, InParanoid	S. cerevisiae S288c	STI1, YOR027W, OR26.17	Heat shock protein STI1	0/1	0	No
Q9STH1	HSOP3_ARATH	OMA, InParanoid, MetaPhors	A. thaliana	HOP3, T4C9.240, AT4g12400, AT4G12400, At4g12400	Hsp70-Hsp90 organizing protein 3, AtHop3	0/1	0	No
Q9LNB6	HSOP1_ARATH	OMA, InParanoid, MetaPhors	A. thaliana	HOP1, F5O11.2, AT1G12270, At1g12270	Hsp70-Hsp90 organizing protein 1, AtHop1	0/1	0	No
Q5XEP2	HSOP2_ARATH	OMA, InParanoid, MetaPhors	A. thaliana	HOP2, F23N19.10, AT1G62740, At1g62740	Hsp70-Hsp90 organizing protein 2, AtHop2	0/1	0	No
Q8ILC1	STI1L_PLAF7	OMA, InParanoid	P. falciparum	PF14_0324	STI1-like protein	0/1	0	Yes
R9PXW7	R9PXW7_RAT	OMA	R. norvegicus	Stip1, rCG_47532	Stress-induced phosphoprotein 1, isoform CRA_a	0/3	0	No

Ortholog sequence alignment (CLUSTALW)

Sites (from validation or large-scale experiments)

Isoforms	Position	Probability	Studies	Techniques
Q60864	26	NA	SPalmE:855 Shen LF et al. (2017)*	ARAC

Cysteine summary and predictions

Pos in alignment	26	62	278	282	339	370	403	417	420	461	471
Subcell. location	C	C	C	C	C	C	C	C	C	C	C
Disulfide	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	helix	helix	helix	helix	helix	helix	helix	helix	helix	coil	helix
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys²⁶	Cys⁶²	Cys²⁷⁸	Cys²⁸²	Cys³³⁹	Cys³⁷⁰	Cys⁴⁰³	Cys⁴¹⁷	Cys⁴²⁰ LC	Cys⁴⁶¹	Cys⁴⁷¹

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

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ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	x		HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	x		HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	x		HC: 162 hits LC: 218 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	x		HC: 102 hits LC: 73 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	x		HC HC: 352 hits LC LC: 8 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	x		List: 214 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	Ortholog	in LC [STIP1]	HC: 164 hits LC: 178 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	x		HC HC: 254 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	Ortholog	in List [STIP1]	List: 154 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	x		List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	Ortholog	in MC [PERK1]	HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	Found	in List	List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	Ortholog	in List [STI1]	List: 238 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	x		List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	x		List: 436 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	x		Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	x		List: 354 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	Ortholog	in List [STIP1]	List: 1348 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	x		List: 354 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	x		List: 226 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	x		List: 274 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	Found	in LC	HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	x		HC: 1079 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	Ortholog	in List [STIP1]	List: 193 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	Found	in List	List: 865 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	Ortholog	in List [STIP1]	List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	Ortholog	in List [STIP1]	List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	Ortholog	in List [STIP1]	List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	x		HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Found	in LPS treatment	LPS treatment: 646 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Found	in List	List: 646 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	Ortholog	in List [STIP1]	List: 2929 hits
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 590 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 370 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [STIP1]	HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [STIP1]	HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [STIP1]	HC: 600 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		List: 185 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [STIP1]	HC: 1869 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1093 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 687 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Ortholog	in List [STIP1]	List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	x		List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 199 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 399 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 1040 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 464 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [Q3THQ5]	HC: 4107 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 1597 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 1378 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [Q3THQ5]	HC: 3870 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	3	4	1	25.0	STIP1_RAT
H. sapiens	22	38	12	31.6	STIP1_HUMAN
M. musculus	23	37	12	32.4	Q3THQ5_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	1	100.0	PERK1_ARATH
S. pombe	1	1	1	100.0	STI1_SCHPO
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	0	0.0	NA
C. familiaris	1	1	0	0.0	NA

References

Authors	Year	Reference title	PMID
Kang R et al.	2008	Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.	19092927
Ren W et al.	2013	Proteomic analysis of protein palmitoylation in adipocytes.	23599907
Marin EP et al.	2012	Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.	22496122
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
Martin BR et al.	2011	Global profiling of dynamic protein palmitoylation.	22056678
Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Merrick BA et al.	2011	Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.	21785166
Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
Yang W et al.	2010	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	19801377
Martin BR et al.	2009	Large-scale profiling of protein palmitoylation in mammalian cells.	19137006
Roth AF et al.	2006	Global analysis of protein palmitoylation in yeast.	16751107
Hemsley PA et al.	2013	A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis.	23252521
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
Wei X et al.	2014	Insulin-regulated protein palmitoylation impacts endothelial cell function.	24357059
Serwa RA et al.	2015	Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.	26256475
Morrison E et al.	2015	Quantitative analysis of the human T cell palmitome.	26111759
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
Santiago-Tirado FH et al.	2015	A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.	25970403
Emmer BT et al.	2011	Global analysis of protein palmitoylation in African trypanosomes.	21193548
Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
Foe IT et al.	2015	Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.	26468752
Gould NS et al.	2015	Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.	26165157
Peng T et al.	2015	Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.	25575299
Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Zhou B et al.	2019	Low-background Acyl-biotinyl Exchange Largely Eliminates the Co-isolation of Non-S-acylated Proteins and Enables Deep S-acylproteomic Analysis.	31251020
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Wegleiter T et al.	2019	Palmitoylation of BMPR1a regulates neural stem cell fate.	31772009
Morrison E et al.	2020	Dynamic palmitoylation events following T-cell receptor signaling.	32651440
Mariscal J et al.	2020	Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles.	32944167
Gorenberg EL et al.	2022	Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.	35358180
Uzbekova S et al.	2021	Protein Palmitoylation in Bovine Ovarian Follicle.	34769186
Miles MR et al.	2021	Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart.	33636221
Pradhan AJ et al.	2021	Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis.	33848465
Ripamonti M et al.	2021	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.	33782527
Zaręba-Kozioł M et al.	2021	S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity.	34200797
Ziemlińska E et al.	2021	Palm Oil-Rich Diet Affects Murine Liver Proteome and <i>S</i>-Palmitoylome.	34884899
Gao J et al.	2022	Proteome-wide identification of palmitoylated proteins in mouse testis.	35477839

Q60864 STIP1_MOUSE