SwissPalm

Q7KRY7 SCRIB_DROME

General info Cross-references Enzymes Sequences Orthologs Ortholog sequences Validation experiments Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

1/1 article for fruit fly
7 orthologs

Palmitoyl-proteome experiments

Validation experiments

2 experiments
1 ortholog

Validation experiments

Curated sites & Enzymes

0 site from validation experiments^*
0 site from palmitoyl-proteomes^*
DHHC-PATs : A8JUM5_DROME
No APT known
^*In main isoform only

Predictions

Predicted

2 cysteines in main isoform

Predictions

Protein general information from UniProt

Protein names

Protein lap4; Protein scribble; Protein smell-impaired

Subcellular location

Tight junction; tight junction; Cell junction (Probable); Cell membrane (By similarity); Cytoplasm (Probable)

Isoforms & protein length

Isoform 1 (main): 1851 aa; Isoform 2 : 1756 aa; Isoform 3 : 1247 aa; Isoform 4 : 1205 aa; Isoform 5 : 1707 aa; Isoform 6 : 1200 aa; Isoform 7 : 1939 aa; Isoform 8 : 1711 aa; Isoform 9 : 1850 aa; Isoform 10 : 2331 aa; Isoform 11 : 1729 aa

Known functions

Required for polarization of the embryonic, imaginal disk and follicular epithelia. Specifically restricts apical membrane determinants to the apical cell surface; acts to exclude crb from the basolateral domain and define adherens junction position. Regulates cellular growth and differentiation; acts as a tumor suppressor. Essential for odor guided behavior. Localized to epithelial septate junction at the boundary of the apical and basolateral cell surfaces. Required for polarization of the embryonic, imaginal disk and follicular epithelia. Specifically restricts apical membrane determinants to the apical cell surface; acts to exclude crb from the basolateral domain and define adherens junction position. Regulates cellular growth and differentiation; acts as a tumor suppressor. Essential for odor guided behavior. Localized to epithelial septate junction at the boundary of the apical and basolateral cell surfaces. Required for polarization of the embryonic, imaginal disk and follicular epithelia. Specifically restricts apical membrane determinants to the apical cell surface; acts to exclude crb from the basolateral domain and define adherens junction position. Regulates cellular growth and differentiation; acts as a tumor suppressor. Essential for odor guided behavior. Localized to epithelial septate junction at the boundary of the apical and basolateral cell surfaces.

Cross-references

Source	Identifiers
UniProt gene names	CG5462, vart, smi, scrib
UniProt secondary AC	Q9VBE4, Q95SV4, Q8T003, Q8IMR9, Q8IMR8, Q86QT0, Q86QS9, Q86QS8, Q86QS7, Q7KA36, Q7K9X1, Q6AWK8, Q59DT8, Q59DT7, A4V3G5
Refseq protein ID	NP_733156.1, NP_733155.2, NP_733154.1, NP_524754.2, NP_001247318.1, NP_001036761.3, NP_001014670.2, NP_001014669.1

Source	Identifiers
Ensembl gene	FBgn0263289

Enzymes

PAT/APT	Enzyme	Experiments
PAT	A8JUM5_DROME	SPalmE:1258 Strassburger K et al. (2019) []

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Times validated	Techniques	Sites	Predicted
D3ZWS0	D3ZWS0_RAT	OrthoDB, Ensembl	R. norvegicus	rCG_60094, RGD1565055_predicted, Scrib	Scribble planar cell polarity protein	1/3	0	1	0	Yes
F1MZ10	F1MZ10_BOVIN	Ensembl	B. taurus	LRRC1	Leucine rich repeat containing 1	0/2	0	0	0	Yes
Q9BTT6	LRRC1_HUMAN	Ensembl	H. sapiens	LANO, LRRC1	Leucine-rich repeat-containing protein 1	12/22	0	4	2	Yes
Q80U72	SCRIB_MOUSE	Ensembl, InParanoid	M. musculus	Scrib1, Lap4, Kiaa0147, Scrib	Protein scribble homolog, Scribble	10/23	0	3	1	Yes
G3X9W3	G3X9W3_MOUSE	Ensembl	M. musculus	Lrrc1	Leucine-rich repeat-containing protein 1	0/23	0	0	0	Yes
Q80VQ1	LRRC1_MOUSE	Ensembl	M. musculus	Lrrc1	Leucine-rich repeat-containing protein 1	5/23	0	3	1	Yes
E2RNR2	E2RNR2_CANLF	Ensembl	C. familiaris	LRRC1	Leucine rich repeat containing 1	1/1	0	2	0	Yes
J9NVX1	J9NVX1_CANLF	Ensembl	C. familiaris	LRRC1	Leucine rich repeat containing 1	0/1	0	0	0	Yes
F1PKY2	F1PKY2_CANLF	OrthoDB, Ensembl, InParanoid	C. familiaris	SCRIB	Scribbled planar cell polarity protein	1/1	0	2	0	Yes
F1N0Y1	F1N0Y1_BOVIN	OrthoDB, Ensembl, InParanoid	B. taurus	SCRIB	Scribble planar cell polarity protein	0/2	0	0	0	Yes
G3V6R4	G3V6R4_RAT	OrthoDB, Ensembl	R. norvegicus	Lrrc1	Leucine-rich repeat-containing 1	0/3	0	0	0	Yes
F6RIN9	F6RIN9_MOUSE	OrthoDB, Ensembl	M. musculus	Scrib	Protein scribble homolog	0/23	0	0	0	No
H0YCG0	H0YCG0_HUMAN	OrthoDB, Ensembl	H. sapiens	SCRIB	SCRIB overlapping open reading frame protein	0/22	0	0	0	No
Q14160	SCRIB_HUMAN	Ensembl, InParanoid	H. sapiens	VARTUL, SCRB1, LAP4, KIAA0147, CRIB1, SCRIB	Protein scribble homolog, Scribble, hScrib	14/22	6	4	2	Yes

Ortholog sequence alignment (CLUSTALW)

Validation experiments

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)
SPalmE:1258	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO
SPalmE:1366	Khoury MJ et al.	2020	Drosophila melanogaster	NA	Total cell lysate	ABE, NH2OH cleavage of thioester bond

Cysteine summary and predictions

Pos in alignment	4	11	23	289	335	358	414	920	1072	1117	1375	1399	1539	1567
Subcell. location	C	C	C	C	C	C	C	C	C	C	C	C	C	C
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	coil	coil	coil	coil	coil	strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁴ MC	Cys¹¹ HC	Cys²³ HC	Cys²⁸⁹	Cys³³⁵	Cys³⁵⁸	Cys⁴¹⁴	Cys⁸⁰⁶	Cys⁹⁵⁸	Cys¹⁰⁰³	Cys¹²⁶¹	Cys¹²⁸⁵	Cys¹⁴²⁵ LC	Cys¹⁴⁵³
Pos in isoform 2 CSS-Palm 4.0 PalmPred	Cys⁴ MC	Cys¹¹ HC	Cys²³ HC	Cys²⁸⁹	Cys³³⁵	Cys³⁵⁸	Cys⁴¹⁴	Cys⁸⁰⁶	Cys⁹⁵⁸	Cys¹⁰⁰³	Cys¹¹⁶⁶	Cys¹¹⁹⁰	Cys¹³³⁰ LC	Cys¹³⁵⁸
Pos in isoform 3 CSS-Palm 4.0 PalmPred	Cys⁴ MC	Cys¹¹ HC	Cys²³ HC	Cys²⁸⁹	Cys³³⁵	Cys³⁵⁸	Cys⁴¹⁴	Cys⁸⁰⁶	Cys⁹⁵⁸	Cys¹⁰⁰³
Pos in isoform 4 CSS-Palm 4.0 PalmPred	Cys⁴ MC	Cys¹¹ HC	Cys²³ HC	Cys²⁵⁰	Cys²⁹⁶	Cys³¹⁹	Cys³⁷⁵				Cys⁶¹⁵	Cys⁶³⁹	Cys⁷⁷⁹ LC	Cys⁸⁰⁷
Pos in isoform 5 CSS-Palm 4.0 PalmPred	Cys⁴ MC	Cys¹¹ HC	Cys²³ HC	Cys²⁸⁹	Cys³³⁵	Cys³⁵⁸	Cys⁴¹⁴	Cys⁸⁰⁶	Cys⁹⁵⁸	Cys¹⁰⁰³	Cys¹²⁶¹	Cys¹²⁸⁵	Cys¹⁴²⁵ LC	Cys¹⁴⁵³
Pos in isoform 6 CSS-Palm 4.0 PalmPred	Cys⁴ MC	Cys¹¹ HC	Cys²³ HC	Cys²⁴⁸	Cys²⁹⁴	Cys³¹⁷	Cys³⁷³				Cys⁶¹⁴	Cys⁶³⁸	Cys⁷⁷⁸ LC	Cys⁸⁰⁶
Pos in isoform 7 CSS-Palm 4.0 PalmPred	Cys⁴ MC	Cys¹¹ HC	Cys²³ HC	Cys²⁸⁹	Cys³³⁵	Cys³⁵⁸	Cys⁴¹⁴	Cys⁸⁹⁵	Cys¹⁰⁴⁷	Cys¹⁰⁹²	Cys¹³⁴⁹	Cys¹³⁷³	Cys¹⁵¹³ LC	Cys¹⁵⁴¹
Pos in isoform 8 CSS-Palm 4.0 PalmPred	Cys⁴ MC	Cys¹¹ HC	Cys²³ HC	Cys²⁸⁹	Cys³³⁵	Cys³⁵⁸	Cys⁴¹⁴	Cys⁸⁰⁶	Cys⁹⁵⁸	Cys¹⁰⁰³	Cys¹²⁶¹	Cys¹²⁸⁵	Cys¹⁴²⁵ LC	Cys¹⁴⁵³
Pos in isoform 9 CSS-Palm 4.0 PalmPred	Cys⁴ MC	Cys¹¹ HC	Cys²³ HC	Cys²⁸⁹	Cys³³⁵	Cys³⁵⁸	Cys⁴¹⁴	Cys⁸⁰⁶	Cys⁹⁵⁸	Cys¹⁰⁰³	Cys¹²⁶⁰	Cys¹²⁸⁴	Cys¹⁴²⁴ LC	Cys¹⁴⁵²
Pos in isoform 10 CSS-Palm 4.0 PalmPred	Cys⁴ MC	Cys¹¹ HC	Cys²³ HC	Cys²⁸⁹	Cys³³⁵	Cys³⁵⁸	Cys⁴¹⁴	Cys⁸⁰⁶	Cys⁹⁵⁸	Cys¹⁰⁰³	Cys¹¹⁶⁶	Cys¹¹⁹⁰	Cys¹³³⁰ LC	Cys¹³⁵⁸
Pos in isoform 11 CSS-Palm 4.0 PalmPred	Cys⁴ MC	Cys¹¹ HC	Cys²³ HC	Cys²⁸⁹	Cys³³⁵	Cys³⁵⁸	Cys⁴¹⁴	Cys⁸³¹	Cys⁹⁸³	Cys¹⁰²⁸	Cys¹²⁸⁶	Cys¹³¹⁰	Cys¹⁴⁵⁰ LC	Cys¹⁴⁷⁸

Pos in alignment	1812	2002	2370
Subcell. location	U	U	U
Disulfide
PSIPRED v.4.02 prediction
UniProt secondary structure
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred
Pos in isoform 2 CSS-Palm 4.0 PalmPred
Pos in isoform 3 CSS-Palm 4.0 PalmPred
Pos in isoform 4 CSS-Palm 4.0 PalmPred
Pos in isoform 5 CSS-Palm 4.0 PalmPred	Cys¹⁶⁹⁴
Pos in isoform 6 CSS-Palm 4.0 PalmPred
Pos in isoform 7 CSS-Palm 4.0 PalmPred
Pos in isoform 8 CSS-Palm 4.0 PalmPred	Cys¹⁶⁹⁸
Pos in isoform 9 CSS-Palm 4.0 PalmPred
Pos in isoform 10 CSS-Palm 4.0 PalmPred		Cys¹⁷⁹³	Cys²¹⁶¹
Pos in isoform 11 CSS-Palm 4.0 PalmPred

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

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ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	Ortholog	in LC [D3ZWS0]	HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	Ortholog	in LC,HC [LRRC1, SCRIB]	HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	Ortholog	in HC [LRRC1, SCRIB]	HC: 102 hits LC: 73 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	Ortholog	in HC [LRRC1, SCRIB]	HC: 162 hits LC: 218 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	Ortholog	in HC [SCRIB, LRRC1]	HC HC: 352 hits LC LC: 8 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	x		List: 214 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	x		List: 154 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	Ortholog	in HC [SCRIB, LRRC1]	HC HC: 254 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	x		List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	x		List: 238 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	x		List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	x		HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	Ortholog	in List [LRRC1, SCRIB]	Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	Ortholog	in List [SCRIB, LRRC1]	List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	Ortholog	in List [SCRIB, LRRC1]	List: 436 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	Ortholog	in List [LRRC1, SCRIB]	List: 1348 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	Ortholog	in List [LRRC1, SCRIB]	List: 274 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	Ortholog	in List [LRRC1, SCRIB]	List: 226 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	Ortholog	in List [LRRC1, SCRIB]	List: 354 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	Ortholog	in List [LRRC1, SCRIB]	List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	Ortholog	in List [LRRC1, SCRIB]	List: 1353 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	x		HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	Ortholog	in List [SCRIB, LRRC1]	List: 865 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	Ortholog	in HC [SCRIB, LRRC1]	HC: 1079 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in List [SCRIB, LRRC1]	List: 646 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in LPS treatment [SCRIB, LRRC1]	LPS treatment: 646 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	Ortholog	in LC [SCRIB, LRRC1]	HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Ortholog	in HC [SCRIB, LRRC1]	HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	Ortholog	in HC [LRRC1, SCRIB]	HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	Ortholog	in HC [LRRC1, SCRIB]	HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	Ortholog	in Trypsin [LRRC1, SCRIB]	Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	Ortholog	in LC [SCRIB, LRRC1]	HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Ortholog	in HC [SCRIB, LRRC1]	HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	Ortholog	in List [LRRC1, SCRIB]	List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	Ortholog	in List [LRRC1, SCRIB]	List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	Ortholog	in List [LRRC1, SCRIB]	List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	x		HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	Found	in List	List: 157 hits
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	Found	in List	List: 13 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [LRRC1, SCRIB]	List: 590 hits
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	Ortholog	in List [LRRC1, SCRIB]	List: 2929 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [SCRIB, LRRC1]	List: 370 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x	in [LRRC1, SCRIB]	Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	Ortholog	in List [LRRC1, SCRIB]	List: 185 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [LRRC1, SCRIB]	HC: 1869 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [LRRC1, SCRIB]	HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [LRRC1, SCRIB]	HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [LRRC1, SCRIB]	HC: 600 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [SCRIB, LRRC1]	HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [SCRIB, LRRC1]	HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [LRRC1, SCRIB]	List: 687 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 399 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [E2RNR2, F1PKY2]	List: 464 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Ortholog	in List [LRRC1, SCRIB]	List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Ortholog	in List [LRRC1, SCRIB]	List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [SCRIB, LRRC1]	List: 199 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [SCRIB, LRRC1]	List: 1093 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [SCRIB, LRRC1]	List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [SCRIB, LRRC1]	List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [SCRIB, LRRC1]	List: 1040 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [SCRIB, LRRC1]	HC: 4107 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [SCRIB, LRRC1]	HC: 3870 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1378 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1597 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	3	4	1	25.0	D3ZWS0_RAT
H. sapiens	22	38	27	71.1	LRRC1_HUMAN , SCRIB_HUMAN
M. musculus	23	37	22	59.5	SCRIB_MOUSE , LRRC1_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
S. pombe	1	1	0	0.0	NA
A. thaliana	1	1	0	0.0	NA
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	2	100.0	NA
C. familiaris	1	1	1	100.0	E2RNR2_CANLF , F1PKY2_CANLF

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