SwissPalm

Protein general information from UniProt

Protein names

Palmitoyltransferase ZDHHC17, EC 2.3.1.225; Acyltransferase ZDHHC17, EC 2.3.1.-; DHHC domain-containing cysteine-rich protein 17, DHHC-17; Huntingtin-interacting protein 14; Zinc finger DHHC domain-containing protein 17

Subcellular location

Presynaptic cell membrane (Potential); Synapse (Probable); presynaptic cell membrane; synapse (Probable); Cell junction (Probable); Cytoplasmic vesicle membrane; Golgi apparatus membrane (Probable)

Isoforms & protein length

Isoform 1 (main): 632 aa; Isoform 2 : 429 aa

Known functions

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:15489887, PubMed:15603741, PubMed:25253725, PubMed:27911442). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (PubMed:28167757). Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15489887, PubMed:15603741, PubMed:25253725). Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (By similarity). Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (PubMed:26232532). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (By similarity). May play a role in Mg(2+) transport (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (PubMed:18596047). Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation (PubMed:27911442). hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S-tetradecanoyl-L-cysteinyl-[protein] L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S-octadecanoyl-L-cysteinyl-[protein] Interacts (via ANK repeats) with numerous proteins (via the consensus sequence motif [VIAP]-[VIT]-x-x-Q-P) (By similarity). Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with HTT (PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (PubMed:26198635). Interacts (via ANK repeats) with SNAP25 (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with EVL (By similarity). Interacts with SPRED1 and SPRED3 (PubMed:24705354). Interacts with GPM6A and OPTN (By similarity). May interact (via ANK repeats) with SPRED2 (PubMed:28882895). May interact with NTRK1; may regulate its localization and function (PubMed:26232532). Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles. Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15489887, PubMed:15603741, PubMed:25253725). Palmitoylates MPP1 in erythrocytes (By similarity). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (By similarity). May play a role in Mg(2+) transport (By similarity). Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA. Interacts (via ANK repeats) with numerous proteins (via the consensus sequence motif [VIAP]-[VIT]-x-x-Q-P) (By similarity). Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with HTT (PubMed:26198635). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (PubMed:26198635). Interacts (via ANK repeats) with SNAP25 (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with EVL (By similarity). May interact (via ANK repeats) with SPRED2 (PubMed:28882895). Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles. Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15489887, PubMed:15603741, PubMed:25253725). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (By similarity). May play a role in Mg(2+) transport (By similarity). hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] Interacts (via ANK repeats) with numerous proteins (via the consensus sequence motif [VIAP]-[VIT]-x-x-Q-P) (By similarity). Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with HTT (PubMed:26198635). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (PubMed:26198635). Interacts (via ANK repeats) with SNAP25 (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with EVL (By similarity). May interact (via ANK repeats) with SPRED2 (PubMed:28882895). Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles.

Cross-references

Source	Identifiers
UniProt gene names	Kiaa0946, Hip14, Zdhhc17
UniProt secondary AC	Q8BYQ6, Q8BYQ2, Q8BJ08
Refseq protein ID	NP_766142.2
IPI ID	IPI00115114, IPI00403296, IPI00626811, IPI00410778, IPI00308479

Source	Identifiers
Ensembl protein	ENSMUSP00000043279
Ensembl gene	ENSMUSG00000035798
MGI ID	MGI:2445110
BrainPalmSeq	zdhhcs-2/search-by-gene-zdhhc17

Protein acyltransferase activity (PAT)

Substrate UniProt ID	Substrate description	Substrate isoform AC (site position)	Experiments
HD_HUMAN	Huntingtin	P42858	SPalmE:135 Huang K et al. (2009)
GRIA1_HUMAN	Glutamate receptor 1, GluR-1	P42261	SPalmE:135 Huang K et al. (2009)
DCE2_HUMAN	Glutamate decarboxylase 2, EC 4.1.1.15	Q05329	SPalmE:135 Huang K et al. (2009)
GRIA2_HUMAN	Glutamate receptor 2, GluR-2	P42262	SPalmE:135 Huang K et al. (2009)
SNP25_HUMAN	Synaptosomal-associated protein 25, SNAP-25	P60880	SPalmE:135 Huang K et al. (2009)
DNJC5_BOVIN	DnaJ homolog subfamily C member 5	Q29455	SPalmE:142 Greaves J et al. (2008)
Q9EQ27_MOUSE	Ca2+ voltage sensitive potassium channel STREX variant	Q9EQ27 (12,13)	SPalmE:182 Tian L et al. (2010)
CLIP3_HUMAN	CAP-Gly domain-containing linker protein 3	Q96DZ5	SPalmE:113 Ren W et al. (2013)
DNJC5_RAT	DnaJ homolog subfamily C member 5	P60905	SPalmE:418 Lemonidis K et al. (2014)
SNP25_RAT	Synaptosomal-associated protein 25, SNAP-25	P60881	SPalmE:418 Lemonidis K et al. (2014)
DLG4_MOUSE	Disks large homolog 4	Q62108	SPalmE:697 Singaraja RR et al. (2011)
SNP25_MOUSE	Synaptosomal-associated protein 25, SNAP-25	P60879	SPalmE:1091 Huang K et al. (2011)
HD_MOUSE	Huntingtin	P42859	SPalmE:697 Singaraja RR et al. (2011)
MSHR_HUMAN	Melanocyte-stimulating hormone receptor, MSH-R	Q01726 (315)	SPalmE:991 Chen S et al. (2017) SPalmE:990 Chen S et al. (2017)
ZDHC3_MOUSE	Palmitoyltransferase ZDHHC3, EC 2.3.1.225	Q8R173	SPalmE:1003 Hines RM et al. (2010) SPalmE:1002 Hines RM et al. (2010)
DCE2_MOUSE	Glutamate decarboxylase 2, EC 4.1.1.15	P48320	SPalmE:1122 Rush DB et al. (2012)
NMDE2_MOUSE	Glutamate receptor ionotropic, NMDA 2B, GluN2B	Q01097 (1215,1218,1239,1242,1245)	SPalmE:1234 Kang R et al. (2019) []
SC6A3_RAT	Sodium-dependent dopamine transporter, DA transporter, DAT	P23977	SPalmE:1239 Bolland DE et al. (2019) [] SPalmE:1240 Bolland DE et al. (2019) []
M3K12_MOUSE	Mitogen-activated protein kinase kinase kinase 12, EC 2.7.11.25	Q60700 (436)	SPalmE:1421 Niu J et al. (2020) []
NMNA2_MOUSE	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2, NMN/NaMN adenylyltransferase 2, EC 2.7.7.1, EC 2.7.7.18	Q8BNJ3	SPalmE:1421 Niu J et al. (2020) []

Copy in clipboard UniProt feature viewer

Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

Select all Deselect all

UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Times validated	Techniques	Sites	Predicted
P39010	AKR1_YEAST	OMA, InParanoid	S. cerevisiae S288c	YD9230B.03C, D9954.9, YDR264C, AKR1	Palmitoyltransferase AKR1, EC 2.3.1.225	1/1	3	1	0	No
M9PFE4	M9PFE4_DROME	MetaPhors, OMA, Ensembl	D. melanogaster	HIP14, Dmel_CG6017, CG6017, Hip14, l(3)72Ad, hip14, Dmel\CG6017, dHIP14, CG 6017, 3L1	Palmitoyltransferase	0/1	0	0	0	Yes
J9P6L2	J9P6L2_CANLF	Ensembl	C. familiaris	ZDHHC17	Palmitoyltransferase	0/1	0	0	0	Yes
Q09701	AKR1_SCHPO	MetaPhors, InParanoid	S. pombe	SPAC2F7.10, akr1	Palmitoyltransferase akr1	0/1	0	0	0	No
Q52T38	ZDH22_ARATH	InParanoid	A. thaliana	PAT24, F5O24.240, At5g20350, TIP1	Protein S-acyltransferase 24, EC 2.3.1.225	1/1	1	1	1	Yes
F4J4V1	F4J4V1_ARATH	MetaPhors	A. thaliana	F7O18_18, F7O18.18, At3g04710, tetratricopeptide repeat 10, TPR10	Ankyrin repeat family protein	0/1	0	0	0	No
E9PTT0	ZDH17_RAT	MetaPhors, OrthoDB, OMA, Ensembl, InParanoid	R. norvegicus	Zdhhc17	Palmitoyltransferase ZDHHC17, EC 2.3.1.225	1/3	0	2	0	Yes
Q8IUH5	ZDH17_HUMAN	MetaPhors, OrthoDB, OMA, Ensembl, InParanoid	H. sapiens	HSPC294, KIAA0946, HYPH, HIP3, HIP14, ZDHHC17	Palmitoyltransferase ZDHHC17, EC 2.3.1.225	6/22	0	3	0	Yes
F1PRB8	F1PRB8_CANLF	OrthoDB, OMA, Ensembl, InParanoid	C. familiaris	ZDHHC17	Palmitoyltransferase	0/1	0	0	0	Yes
E1BJK1	E1BJK1_BOVIN	MetaPhors, OrthoDB, OMA, Ensembl, InParanoid	B. taurus	ZDHHC17	Palmitoyltransferase	0/2	0	0	0	Yes
Q9VUW9	HIP14_DROME	MetaPhors, OrthoDB, Ensembl, OMA, InParanoid	D. melanogaster	Dmel_CG6017, CG6017, Hip14	Palmitoyltransferase Hip14, EC 2.3.1.225	1/1	0	2	0	Yes
Q12013	AKR2_YEAST	OMA, InParanoid	S. cerevisiae S288c	OR26.25, YOR034C, AKR2	Probable palmitoyltransferase AKR2, EC 2.3.1.225	0/1	0	0	0	No
Q3EC11	ZDHC2_ARATH	OMA, InParanoid	A. thaliana	PAT23, T1O16.20, At2g14255	Probable protein S-acyltransferase 23, EC 2.3.1.225	0/1	0	0	0	No
I1VCB2	I1VCB2_ARATH	OMA	A. thaliana	TIP1, At5g20350.1	S-acyltransferase	0/1	0	0	0	Yes
Q8IE90	Q8IE90_PLAF7	OMA, InParanoid	P. falciparum	PF3D7_1322500	Palmitoyltransferase	0/1	0	0	0	Yes
F8VX48	F8VX48_HUMAN	Ensembl	H. sapiens	ZDHHC17	Palmitoyltransferase ZDHHC17	0/22	0	0	0	No
H0YIK0	H0YIK0_HUMAN	Ensembl	H. sapiens	ZDHHC17	Palmitoyltransferase ZDHHC17	0/22	0	0	0	No
F8VPW2	F8VPW2_HUMAN	Ensembl	H. sapiens	ZDHHC17	Palmitoyltransferase ZDHHC17	0/22	0	0	0	No
H0YI74	H0YI74_HUMAN	Ensembl	H. sapiens	ZDHHC17	Palmitoyltransferase ZDHHC17	0/22	0	0	0	Yes

Ortholog sequence alignment (CLUSTALW)

Validation experiments

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)
SPalmE:113	Ren W et al.	2013	Homo sapiens	HEK293	Total cell lysate	Co-IP of PAT and substrate, PAT overexpression, Thiopropyl captivation, [3H]palmitic acid labeling
SPalmE:114	Ren W et al.	2013	Homo sapiens	HEK293	Total cell lysate	Thiopropyl captivation
SPalmE:135	Huang K et al.	2009	Chlorocebus aethiops	COS	Total cell lysate	ABE
SPalmE:142	Greaves J et al.	2008	Homo sapiens	HEK293	Total cell lysate	PAT overexpression, PAT point mutation, [3H]palmitic acid labeling
SPalmE:182	Tian L et al.	2010	Homo sapiens	HEK293	Total cell lysate	2BP inhibition, Co-IP of PAT and substrate, Depletion of PAT by siRNA, PAT overexpression, Point mutation, Substrate truncation, [3H]palmitic acid labeling
SPalmE:418	Lemonidis K et al.	2014	Homo sapiens	HEK293T	Total cell lysate	Co-IP of PAT and substrate, PAT localization by IF, PAT overexpression, [3H]palmitic acid labeling
SPalmE:697	Singaraja RR et al.	2011	Mus musculus	NA	NA	ABE, NH2OH cleavage of thioester bond, PAT overexpression
SPalmE:990	Chen S et al.	2017	Homo sapiens	B16 melanoma	Total cell lysate	2BP inhibition, ABE, MS, NH2OH cleavage of thioester bond, Palmostatin B inhibition, Point mutation
SPalmE:991	Chen S et al.	2017	Homo sapiens	Human primary melanocytes	Total cell lysate	2BP inhibition, ABE, Co-IP of PAT and substrate, Depletion of PAT by shRNA, MS, NH2OH cleavage of thioester bond, PAT overexpression, Palmostatin B inhibition, Point mutation
SPalmE:1002	Hines RM et al.	2010	Xenopus laevis	xenopus ovocytes	Total cell lysate	2BP inhibition, ABE, NH2OH cleavage of thioester bond, PAT overexpression, PAT point mutation, Point mutation, Substrate localization by fluorescence tag
SPalmE:1003	Hines RM et al.	2010	Homo sapiens	COS7	Total cell lysate	2BP inhibition, ABE, NH2OH cleavage of thioester bond, PAT overexpression, PAT point mutation, Point mutation, Substrate localization by fluorescence tag
SPalmE:1091	Huang K et al.	2011	Rattus norvegicus	Brain	NA	PAT overexpression, [3H]palmitoyl-CoA labeling
SPalmE:1092	Huang K et al.	2011	Mus musculus	Brain	Total cell lysate	ABE, NH2OH cleavage of thioester bond, Substrate overexpression
SPalmE:1093	Huang K et al.	2011	Mus musculus	Cortical neuron	Total cell lysate	ABE, NH2OH cleavage of thioester bond
SPalmE:1122	Rush DB et al.	2012	Mus musculus	Neuro-2a	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT overexpression
SPalmE:1234	Kang R et al.	2019	Chlorocebus aethiops	COS7	Total cell lysate	ABE, PAT overexpression, Point mutation
SPalmE:1239	Bolland DE et al.	2019	Sus scrofa	LLC-PK1	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT overexpression, [3H]palmitic acid labeling
SPalmE:1240	Bolland DE et al.	2019	Rattus norvegicus	Neuro-2a	Total cell lysate	2BP inhibition, ABE, NH2OH cleavage of thioester bond, PAT overexpression, [3H]palmitic acid labeling
SPalmE:1421	Niu J et al.	2020	Mus musculus	NA	NA	ABE, Co-IP of PAT and substrate, IF localization, PAT KO, PAT localization by IF, PAT localization by fluorescent tag, Point mutation

Sites (from validation or large-scale experiments)

Isoforms	Position	Probability	Studies	Techniques
Q80TN5	590	NA	SPalmE:903 Collins MO et al. (2017)* SPalmE:855 Shen LF et al. (2017)*	ABE, ARAC
Q80TN5	467	NA	SPalmE:903 Collins MO et al. (2017)*	ABE

Cysteine summary and predictions

Pos in alignment	24	73	158	160	439	442	453	456	459	467	473	494	500	508
Subcell. location	C	C	C	C	C	C	C	C	C	C	C	T	T	E
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	helix	coil	helix	coil	strand	coil	coil	helix	coil	coil	helix	helix	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys²⁴	Cys⁷³	Cys¹⁵⁸	Cys¹⁶⁰ MC	Cys⁴³⁹	Cys⁴⁴²	Cys⁴⁵³	Cys⁴⁵⁶	Cys⁴⁵⁹	Cys⁴⁶⁷	Cys⁴⁷³	Cys⁴⁹⁴	Cys⁵⁰⁰	Cys⁵⁰⁸
Pos in isoform 2 CSS-Palm 4.0 PalmPred	Cys²⁴	Cys⁷³	Cys¹⁵⁸	Cys¹⁶⁰ MC

Pos in alignment	527	551	558	590	602	603
Subcell. location	E	C	C	C	C	C
Disulfide	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	helix	helix	helix	coil	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁵²⁷	Cys⁵⁵¹ HC	Cys⁵⁵⁸	Cys⁵⁹⁰	Cys⁶⁰² HC	Cys⁶⁰³ MC
Pos in isoform 2 CSS-Palm 4.0 PalmPred

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

Tip: Keep CTRL key pressed down while clicking on column headers to do multiple sorting. This applies to any sortable table on this site.

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	Ortholog	in HC [AKR1]	HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	x		HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	Ortholog	in LC [ZDH17]	HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	x		HC: 102 hits LC: 73 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	x		HC: 162 hits LC: 218 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	x		HC HC: 352 hits LC LC: 8 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	x		List: 214 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	x		List: 154 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	x		HC HC: 254 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	x		List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	x		List: 238 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	x		List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	Ortholog	in HC [ZDH22]	HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	x		Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	x		List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	x		List: 436 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	Ortholog	in List [ZDH17]	List: 1348 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	Ortholog	in List [ZDH17]	List: 274 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	Ortholog	in List [ZDH17]	List: 226 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	x		List: 354 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	x		List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	x		HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	Found	in List	List: 865 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	Found	in HC	HC: 1079 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Found	in Palm. up with LPS	Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Found	in List	List: 646 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Found	in LPS treatment	LPS treatment: 646 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Found	in MC	HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Found	in MC	HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	x		List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	x		List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	Ortholog	in MC [Q0VFY6]	HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	Ortholog	in List [HIP14, M9PFE4]	List: 157 hits
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [ZDH17]	List: 590 hits
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	Ortholog	in List [ZDH17]	List: 2929 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 370 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		List: 185 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [ZDH17]	HC: 1869 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [ZDH17]	HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [ZDH17]	HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 600 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in MC	HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in MC	HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 687 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [ZDH17]	List: 399 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 464 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Ortholog	in List [ZDH17]	List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Ortholog	in List [ZDH17]	List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 199 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 1093 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in List	List: 1040 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in HC	HC: 4107 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in HC	HC: 3870 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1378 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1597 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	1	100.0	AKR1_YEAST
R. norvegicus	3	4	1	25.0	ZDH17_RAT
H. sapiens	22	38	11	28.9	ZDH17_HUMAN
M. musculus	23	37	16	43.2	Q0VFY6_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
S. pombe	1	1	0	0.0	NA
A. thaliana	1	1	1	100.0	ZDH22_ARATH
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	1	50.0	HIP14_DROME , M9PFE4_DROME
C. familiaris	1	1	0	0.0	NA

References

Authors	Year	Reference title	PMID
Chen S et al.	2017	Palmitoylation-dependent activation of MC1R prevents melanomagenesis.	28869973
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Kang R et al.	2008	Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.	19092927
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Yang W et al.	2010	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	19801377
Zaręba-Kozioł M et al.	2021	S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity.	34200797
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Wegleiter T et al.	2019	Palmitoylation of BMPR1a regulates neural stem cell fate.	31772009
Greaves J et al.	2008	Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein.	18596047
Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Lemonidis K et al.	2014	The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity.	25253725
Niu J et al.	2020	Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17.	33207199
Mariscal J et al.	2020	Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles.	32944167
Tian L et al.	2010	Multiple palmitoyltransferases are required for palmitoylation-dependent regulation of large conductance calcium- and voltage-activated potassium channels.	20507996
Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Martin BR et al.	2009	Large-scale profiling of protein palmitoylation in mammalian cells.	19137006
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Huang K et al.	2009	Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity.	19299482
Zhou B et al.	2019	Low-background Acyl-biotinyl Exchange Largely Eliminates the Co-isolation of Non-S-acylated Proteins and Enables Deep S-acylproteomic Analysis.	31251020
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Miles MR et al.	2021	Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart.	33636221
Wei X et al.	2014	Insulin-regulated protein palmitoylation impacts endothelial cell function.	24357059
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Peng T et al.	2015	Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.	25575299
Gao J et al.	2022	Proteome-wide identification of palmitoylated proteins in mouse testis.	35477839
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Kang R et al.	2019	Altered Regulation of Striatal Neuronal <i>N</i>-Methyl-D-Aspartate Receptor Trafficking by Palmitoylation in Huntington Disease Mouse Model.	30846936
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Pradhan AJ et al.	2021	Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis.	33848465
Hines RM et al.	2010	Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transport.	19955568
Morrison E et al.	2020	Dynamic palmitoylation events following T-cell receptor signaling.	32651440
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
Santiago-Tirado FH et al.	2015	A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.	25970403
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Ren W et al.	2013	DHHC17 palmitoylates ClipR-59 and modulates ClipR-59 association with the plasma membrane.	24001771
Martin BR et al.	2011	Global profiling of dynamic protein palmitoylation.	22056678
Ziemlińska E et al.	2021	Palm Oil-Rich Diet Affects Murine Liver Proteome and <i>S</i>-Palmitoylome.	34884899
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
Foe IT et al.	2015	Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.	26468752
Gould NS et al.	2015	Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.	26165157
Serwa RA et al.	2015	Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.	26256475
Huang K et al.	2011	Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.	21636527
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Uzbekova S et al.	2021	Protein Palmitoylation in Bovine Ovarian Follicle.	34769186
Ripamonti M et al.	2021	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.	33782527
Singaraja RR et al.	2011	Altered palmitoylation and neuropathological deficits in mice lacking HIP14.	21775500
Morrison E et al.	2015	Quantitative analysis of the human T cell palmitome.	26111759
Marin EP et al.	2012	Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.	22496122
Merrick BA et al.	2011	Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.	21785166
Emmer BT et al.	2011	Global analysis of protein palmitoylation in African trypanosomes.	21193548
Ren W et al.	2013	Proteomic analysis of protein palmitoylation in adipocytes.	23599907
Bolland DE et al.	2019	Palmitoylation by Multiple DHHC Enzymes Enhances Dopamine Transporter Function and Stability.	30965003
Gorenberg EL et al.	2022	Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.	35358180
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Roth AF et al.	2006	Global analysis of protein palmitoylation in yeast.	16751107
Rush DB et al.	2012	Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington's disease.	22103299
Hemsley PA et al.	2013	A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis.	23252521

Q80TN5 ZDH17_MOUSE