SwissPalm

Q8I5L4 Q8I5L4_PLAF7

General info Cross-references Sequences Orthologs Ortholog sequences Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

1/1 article for plasmodium falciparum
6 orthologs

Palmitoyl-proteome experiments

Validation experiments

0 experiment
0 ortholog

Curated sites & Enzymes

0 site from validation experiments^*
0 site from palmitoyl-proteomes^*
No PAT known
No APT known
^*In main isoform only

Predictions

Predicted

3 cysteines in main isoform

Predictions

Protein general information from UniProt

Protein names

Phospholipid-transporting ATPase

Subcellular location

Membrane (Probable)

Isoforms & protein length

Isoform 1 (main): 1555 aa

Known functions

Cross-references

Source	Identifiers
UniProt gene names	PF3D7_1219600

Source	Identifiers
EuPathDb ID	PFL0950c

Copy in clipboard UniProt feature viewer

Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

Select all Deselect all

UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Techniques	Predicted
F1M585	F1M585_RAT	OMA	R. norvegicus	Atp8a1, ATP8A1	Phospholipid-transporting ATPase	1/3	1	Yes
P70704	AT8A1_MOUSE	OMA, InParanoid	M. musculus	Atp8a1, Atpc1	Phospholipid-transporting ATPase IA, EC 7.6.2.1	1/23	2	Yes
P98198	AT8B2_HUMAN	InParanoid	H. sapiens	ATP8B2, ATPID, KIAA1137	Phospholipid-transporting ATPase ID, EC 7.6.2.1	1/22	2	Yes
O60423	AT8B3_HUMAN	InParanoid	H. sapiens	ATP8B3, ATP1K, FOS37502_2	Phospholipid-transporting ATPase IK, EC 7.6.2.1	0/22	0	Yes
Q9NTI2	AT8A2_HUMAN	InParanoid	H. sapiens	ATP8A2, ATPIB	Phospholipid-transporting ATPase IB, EC 7.6.2.1	0/22	0	Yes
Q9P241	AT10D_HUMAN	InParanoid	H. sapiens	ATP10D, ATPVD, KIAA1487	Phospholipid-transporting ATPase VD, EC 7.6.2.1	0/22	0	Yes
O60312	AT10A_HUMAN	InParanoid	H. sapiens	ATP10A, ATP10C, ATPVA, ATPVC, KIAA0566	Phospholipid-transporting ATPase VA, EC 7.6.2.1	0/22	0	Yes
O94823	AT10B_HUMAN	InParanoid	H. sapiens	ATP10B, ATPVB, KIAA0715	Phospholipid-transporting ATPase VB, EC 7.6.2.1	0/22	0	Yes
P98199	AT8B2_MOUSE	InParanoid	M. musculus	Atp8b2	Phospholipid-transporting ATPase ID, EC 7.6.2.1	0/23	0	Yes
A3FIN4	AT8B5_MOUSE	InParanoid	M. musculus	Atp8b5, Feta	Phospholipid-transporting ATPase FetA, EC 7.6.2.1	0/23	0	Yes
Q6UQ17	AT8B3_MOUSE	InParanoid	M. musculus	Atp8b3	Phospholipid-transporting ATPase IK, EC 7.6.2.1	1/23	2	Yes
P98200	AT8A2_MOUSE	InParanoid	M. musculus	Atp8a2	Phospholipid-transporting ATPase IB, EC 7.6.2.1	0/23	0	Yes
Q8K2X1	AT10D_MOUSE	InParanoid	M. musculus	Atp10d	Phospholipid-transporting ATPase VD, EC 7.6.2.1	0/23	0	Yes
O54827	AT10A_MOUSE	InParanoid	M. musculus	Atp10a, Atpc5, Pfatp	Phospholipid-transporting ATPase VA, EC 7.6.2.1	0/23	0	Yes
B1AWN4	AT10B_MOUSE	InParanoid	M. musculus	Atp10b	Phospholipid-transporting ATPase VB, EC 7.6.2.1	0/23	0	Yes
E2RSY9	E2RSY9_CANLF	InParanoid	C. familiaris	ATP8B2	Phospholipid-transporting ATPase	0/1	0	Yes
J9P5Q0	J9P5Q0_CANLF	InParanoid	C. familiaris	ATP8B4	Phospholipid-transporting ATPase	0/1	0	Yes
E2QV99	E2QV99_CANLF	InParanoid	C. familiaris	ATP8B1	Phospholipid-transporting ATPase	0/1	0	Yes
F1PNZ3	F1PNZ3_CANLF	InParanoid	C. familiaris	ATP8A2	Phospholipid-transporting ATPase	0/1	0	Yes
E2QWZ0	E2QWZ0_CANLF	InParanoid	C. familiaris	ATP8B3	Phospholipid-transporting ATPase	0/1	0	Yes
E2RG44	E2RG44_CANLF	InParanoid	C. familiaris	ATP10D	Phospholipid-transporting ATPase	0/1	0	Yes
J9P951	J9P951_CANLF	InParanoid	C. familiaris	ATP10B	Phospholipid-transporting ATPase	0/1	0	Yes
F1PRJ6	F1PRJ6_CANLF	InParanoid	C. familiaris	LOC486036	Phospholipid-transporting ATPase	0/1	0	Yes
E2RB85	E2RB85_CANLF	InParanoid	C. familiaris	ATP10A	Phospholipid-transporting ATPase	0/1	0	Yes
Q9VGD4	Q9VGD4_DROME	InParanoid	D. melanogaster	atp8b, ATP8B, dATP8B, DmCG14741, Dmel\CG14741, CG14741, Dmel_CG14741	Phospholipid-transporting ATPase	0/1	0	Yes
F1N4D5	F1N4D5_BOVIN	InParanoid	B. taurus	ATP8B2	Phospholipid-transporting ATPase	0/2	0	Yes
F1MQK2	F1MQK2_BOVIN	InParanoid	B. taurus	ATP8B4	Phospholipid-transporting ATPase	0/2	0	Yes
E1BPC3	E1BPC3_BOVIN	InParanoid	B. taurus	ATP8B1	Phospholipid-transporting ATPase	0/2	0	Yes
F1MFC4	F1MFC4_BOVIN	InParanoid	B. taurus	ATP8B3	Phospholipid-transporting ATPase	0/2	0	Yes
Q29449	AT8A1_BOVIN	InParanoid	B. taurus	ATP8A1	Probable phospholipid-transporting ATPase IA, EC 7.6.2.1	0/2	0	Yes
F1N0B2	F1N0B2_BOVIN	InParanoid	B. taurus	LOC536660	Phospholipid-transporting ATPase	0/2	0	Yes
F1MSL3	F1MSL3_BOVIN	InParanoid	B. taurus	ATP10D	Phospholipid-transporting ATPase	0/2	0	Yes
F1MZ89	F1MZ89_BOVIN	InParanoid	B. taurus	ATP10A	Phospholipid-transporting ATPase	0/2	0	Yes
E1BNB9	E1BNB9_BOVIN	InParanoid	B. taurus	ATP10B	Phospholipid-transporting ATPase	0/2	0	Yes
Q9SLK6	ALA6_ARATH	InParanoid	A. thaliana	ALA6, At1g54280, F20D21.10	Phospholipid-transporting ATPase 6, AtALA6, EC 7.6.2.1	0/1	0	Yes
Q9LVK9	ALA7_ARATH	InParanoid	A. thaliana	ALA7, At3g13900, MDC16.2	Probable phospholipid-transporting ATPase 7, AtALA7, EC 7.6.2.1	0/1	0	Yes
Q9LNQ4	ALA4_ARATH	InParanoid	A. thaliana	ALA4, At1g17500, F1L3.21	Probable phospholipid-transporting ATPase 4, AtALA4, EC 7.6.2.1	1/1	1	Yes
Q9SX33	ALA9_ARATH	InParanoid	A. thaliana	ALA9, At1g68710, F24J5.6	Putative phospholipid-transporting ATPase 9, AtALA9, EC 7.6.2.1	0/1	0	Yes
Q9LI83	ALA10_ARATH	InParanoid	A. thaliana	ALA10, At3g25610, T5M7.5	Phospholipid-transporting ATPase 10, AtALA10, EC 7.6.2.1	0/1	0	Yes
Q9LK90	ALA8_ARATH	InParanoid	A. thaliana	ALA8, At3g27870, K16N12.9	Probable phospholipid-transporting ATPase 8, AtALA8, EC 7.6.2.1	0/1	0	Yes
Q9SAF5	ALA11_ARATH	InParanoid	A. thaliana	ALA11, At1g13210, F3F19.24	Probable phospholipid-transporting ATPase 11, AtALA11, EC 7.6.2.1	0/1	0	Yes
P57792	ALA12_ARATH	InParanoid	A. thaliana	ALA12, At1g26130, F14G11.10, F28B23.19	Probable phospholipid-transporting ATPase 12, AtALA12, EC 7.6.2.1	0/1	0	Yes
Q8TF62	AT8B4_HUMAN	OMA, InParanoid	H. sapiens	ATP8B4, KIAA1939	Probable phospholipid-transporting ATPase IM, EC 7.6.2.1	0/22	0	Yes
O43520	AT8B1_HUMAN	OMA, InParanoid	H. sapiens	ATP8B1, ATPIC, FIC1, PFIC	Phospholipid-transporting ATPase IC, EC 7.6.2.1	3/22	3	Yes
Q148W0	AT8B1_MOUSE	OMA, InParanoid	M. musculus	Atp8b1	Phospholipid-transporting ATPase IC, EC 7.6.2.1	0/23	0	Yes
A2ANX3	A2ANX3_MOUSE	OMA, InParanoid	M. musculus	Atp8b4	Phospholipid-transporting ATPase	0/23	0	Yes
D3YXQ5	D3YXQ5_MOUSE	OMA	M. musculus	Atp8b2	Phospholipid-transporting ATPase	0/23	0	Yes
Q8BR88	Q8BR88_MOUSE	OMA	M. musculus	Atp8a1	Probable phospholipid-transporting ATPase IA	0/23	0	Yes
F1PHG9	F1PHG9_CANLF	OMA, InParanoid	C. familiaris	ATP8A1	Phospholipid-transporting ATPase	0/1	0	Yes
Q9XIE6	ALA3_ARATH	OMA, InParanoid	A. thaliana	ALP3, ALA3, ITB2, At1g59820, F23H11.14	Phospholipid-transporting ATPase 3, AtALA3, EC 7.6.2.1	0/1	0	Yes
Q9SGG3	ALA5_ARATH	OMA, InParanoid	A. thaliana	ALA5, At1g72700, F28P22.11	Probable phospholipid-transporting ATPase 5, AtALA5, EC 7.6.2.1	0/1	0	Yes
O94296	YOOC_SCHPO	OMA, InParanoid	S. pombe	SPBC887.12	Probable phospholipid-transporting ATPase C887.12	0/1	0	Yes
P39524	ATC3_YEAST	OMA, InParanoid	S. cerevisiae S288c	DRS2, YAL026C, FUN38	Probable phospholipid-transporting ATPase DRS2, EC 7.6.2.1	0/1	0	Yes
Q9Y2Q0	AT8A1_HUMAN	OMA, InParanoid	H. sapiens	ATP8A1, ATPIA	Phospholipid-transporting ATPase IA, EC 7.6.2.1	0/22	0	Yes
E1BN98	E1BN98_BOVIN	OMA	B. taurus	ATP8A1	Phospholipid-transporting ATPase	0/2	0	Yes
M0R7E2	M0R7E2_RAT	InParanoid	R. norvegicus	Atp8b5p, LOC691125	Phospholipid-transporting ATPase	0/3	0	Yes
D4AA47	AT8B1_RAT	InParanoid	R. norvegicus	Atp8b1	Phospholipid-transporting ATPase IC, EC 7.6.2.1	0/3	0	Yes
D3ZE62	D3ZE62_RAT	InParanoid	R. norvegicus	Atp8b3	Phospholipid-transporting ATPase	0/3	0	Yes
D4A3X6	D4A3X6_RAT	InParanoid	R. norvegicus	Atp8a2, LOC691889	Phospholipid-transporting ATPase	0/3	0	Yes
D3ZN41	D3ZN41_RAT	InParanoid	R. norvegicus	Atp10d	Phospholipid-transporting ATPase	0/3	0	Yes
D4A4W5	D4A4W5_RAT	InParanoid	R. norvegicus	Atp10b	Phospholipid-transporting ATPase	0/3	0	Yes
Q9UT43	YFRD_SCHPO	InParanoid	S. pombe	SPAC821.13c, SPAC955.01c	Putative phospholipid-transporting ATPase C821.13c	0/1	0	Yes
Q09891	ATCX_SCHPO	InParanoid	S. pombe	SPAC24B11.12c	Putative phospholipid-transporting ATPase C24B11.12c	0/1	0	Yes
P32660	ATC5_YEAST	InParanoid	S. cerevisiae S288c	DNF1, YER166W, SYGP-ORF7	Phospholipid-transporting ATPase DNF1, EC 7.6.2.1	0/1	0	Yes
Q12675	ATC4_YEAST	InParanoid	S. cerevisiae S288c	DNF2, YDR093W, YD8557.01	Phospholipid-transporting ATPase DNF2, EC 7.6.2.1	0/1	0	Yes

Ortholog sequence alignment (CLUSTALW)

Cysteine summary and predictions

Pos in alignment	34	120	156	168	208	215	222	340	391	445	517	585	667	675
Subcell. location	U	U	U	U	U	U	U	U	U	T	U	U	U	U
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	strand	strand	coil	strand	coil	strand	coil	coil	helix	coil	coil	strand	strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys³⁴	Cys¹²⁰	Cys¹⁵⁶ LC	Cys¹⁶⁸	Cys²⁰⁸	Cys²¹⁵	Cys²²²	Cys³⁴⁰	Cys³⁹¹	Cys⁴⁴⁵ HC	Cys⁵¹⁷ HC	Cys⁵⁸⁵	Cys⁶⁶⁷	Cys⁶⁷⁵

Pos in alignment	753	822	921	933	970	1132	1183	1188	1398	1445	1544
Subcell. location	U	U	U	U	U	U	U	U	T	T	U
Disulfide	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	strand	strand	strand	strand	strand	coil	coil	strand	helix	coil	helix
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁷⁵³	Cys⁸²²	Cys⁹²¹	Cys⁹³³	Cys⁹⁷⁰	Cys¹¹³²	Cys¹¹⁸³	Cys¹¹⁸⁸	Cys¹³⁹⁸	Cys¹⁴⁴⁵ HC	Cys¹⁵⁴⁴

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

Tip: Keep CTRL key pressed down while clicking on column headers to do multiple sorting. This applies to any sortable table on this site.

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	Ortholog	in LC [F1M585]	HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	x		HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	x		HC: 162 hits LC: 218 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	x		HC: 102 hits LC: 73 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	x		HC HC: 352 hits LC LC: 8 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	x		List: 214 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	Found	in HC	HC: 100 hits LC: 217 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	x		HC HC: 254 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	x		List: 154 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	x		List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	Ortholog	in LC [ALA4]	HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	x		List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	x		List: 238 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	x		List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	x		List: 436 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	x		Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	x		List: 354 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	x		List: 1348 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	x		List: 354 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	x		List: 226 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	x		List: 274 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	x		HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	x		HC: 1079 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		List: 865 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	x		List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	x		List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	x		HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		LPS treatment: 646 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		List: 646 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	Ortholog	in List [AT8B1, AT8B2]	List: 2929 hits
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [AT8B1, AT8B2]	List: 590 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 370 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [AT8B1, AT8B2]	HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [AT8B1, AT8B2]	HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [AT8B1, AT8B2]	HC: 600 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		List: 185 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [AT8B1, AT8B2]	HC: 1869 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1093 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 687 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Ortholog	in List [AT8B1, AT8B2]	List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	x		List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 199 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 399 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1040 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 464 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [AT8A1, AT8B3]	HC: 4107 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1597 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [AT8A1, AT8B3]	List: 1378 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [AT8A1, AT8B3]	HC: 3870 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	3	4	1	25.0	F1M585_RAT
H. sapiens	22	38	7	18.4	AT8B1_HUMAN , AT8B2_HUMAN
M. musculus	23	37	3	8.1	AT8A1_MOUSE , AT8B3_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	1	50.0	NA
A. thaliana	1	1	1	100.0	ALA4_ARATH
S. pombe	1	1	0	0.0	NA
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	0	0.0	NA
C. familiaris	1	1	0	0.0	NA

References

Authors	Year	Reference title	PMID
Kang R et al.	2008	Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.	19092927
Ren W et al.	2013	Proteomic analysis of protein palmitoylation in adipocytes.	23599907
Marin EP et al.	2012	Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.	22496122
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
Martin BR et al.	2011	Global profiling of dynamic protein palmitoylation.	22056678
Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Merrick BA et al.	2011	Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.	21785166
Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
Yang W et al.	2010	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	19801377
Martin BR et al.	2009	Large-scale profiling of protein palmitoylation in mammalian cells.	19137006
Roth AF et al.	2006	Global analysis of protein palmitoylation in yeast.	16751107
Hemsley PA et al.	2013	A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis.	23252521
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
Wei X et al.	2014	Insulin-regulated protein palmitoylation impacts endothelial cell function.	24357059
Serwa RA et al.	2015	Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.	26256475
Morrison E et al.	2015	Quantitative analysis of the human T cell palmitome.	26111759
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
Santiago-Tirado FH et al.	2015	A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.	25970403
Emmer BT et al.	2011	Global analysis of protein palmitoylation in African trypanosomes.	21193548
Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
Foe IT et al.	2015	Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.	26468752
Gould NS et al.	2015	Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.	26165157
Peng T et al.	2015	Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.	25575299
Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Zhou B et al.	2019	Low-background Acyl-biotinyl Exchange Largely Eliminates the Co-isolation of Non-S-acylated Proteins and Enables Deep S-acylproteomic Analysis.	31251020
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Wegleiter T et al.	2019	Palmitoylation of BMPR1a regulates neural stem cell fate.	31772009
Morrison E et al.	2020	Dynamic palmitoylation events following T-cell receptor signaling.	32651440
Mariscal J et al.	2020	Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles.	32944167
Gorenberg EL et al.	2022	Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.	35358180
Uzbekova S et al.	2021	Protein Palmitoylation in Bovine Ovarian Follicle.	34769186
Miles MR et al.	2021	Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart.	33636221
Pradhan AJ et al.	2021	Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis.	33848465
Ripamonti M et al.	2021	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.	33782527
Zaręba-Kozioł M et al.	2021	S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity.	34200797
Ziemlińska E et al.	2021	Palm Oil-Rich Diet Affects Murine Liver Proteome and <i>S</i>-Palmitoylome.	34884899
Gao J et al.	2022	Proteome-wide identification of palmitoylated proteins in mouse testis.	35477839