SwissPalm

Q8K0H1 S47A1_MOUSE

General info Cross-references Sequences Orthologs Ortholog sequences Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

1/23 article for mouse
0 ortholog

Palmitoyl-proteome experiments

Validation experiments

0 experiment
0 ortholog

Curated sites & Enzymes

0 site from validation experiments^*
0 site from palmitoyl-proteomes^*
No PAT known
No APT known
^*In main isoform only

Predictions

Predicted

3 cysteines in main isoform

Predictions

Protein general information from UniProt

Protein names

Multidrug and toxin extrusion protein 1, MATE-1, mMATE-1; Solute carrier family 47 member 1

Subcellular location

Cell membrane (By similarity)

Isoforms & protein length

Isoform 1 (main): 567 aa; Isoform 2 : 425 aa

Known functions

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes (By similarity). Optimum pH is 8.0-8.5. Active from pH 6 to 8.5. Predominantly localized to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver). Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes (By similarity). Optimum pH is 8.0-8.5. Active from pH 6 to 8.5. Predominantly localized to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver). Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes (By similarity). Optimum pH is 8.0-8.5. Active from pH 6 to 8.5. Predominantly localized to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver).

Cross-references

Source	Identifiers
UniProt gene names	Slc47a1, Mate1
UniProt secondary AC	Q5SS45, Q9CQ64
Refseq protein ID	XP_011247491.1, NP_080459.2, XP_006534055.1
IPI ID	IPI00132092, IPI00280005, IPI00169572

Source	Identifiers
Ensembl protein	ENSMUSP00000010267
Ensembl gene	ENSMUSG00000010122
MGI ID	MGI:1914723

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Predicted
Q9UT92	YL47_SCHPO	MetaPhors	S. pombe	SPAC323.07c	Uncharacterized transporter C323.07c	0/1	No
Q9USK3	YJ2D_SCHPO	MetaPhors	S. pombe	SPCC4B3.13	Uncharacterized transporter C4B3.13	0/1	No
Q10085	YAO6_SCHPO	MetaPhors	S. pombe	SPAC11D3.06	Uncharacterized transporter C11D3.06	0/1	No
Q9NUN7	ACER3_HUMAN	MetaPhors	H. sapiens	ACER3, APHC, PHCA	Alkaline ceramidase 3, AlkCDase 3, Alkaline CDase 3, EC 3.5.1.-, EC 3.5.1.23	0/22	Yes
Q96FL8	S47A1_HUMAN	MetaPhors, OrthoDB	H. sapiens	SLC47A1, MATE1	Multidrug and toxin extrusion protein 1, MATE-1, hMATE-1	0/22	Yes
F4JH46	DTX34_ARATH	MetaPhors	A. thaliana	DTX34, At4g00350, A_IG005I10.20, F5I10.20	Protein DETOXIFICATION 34, AtDTX34	0/1	No
F4J158	DTX24_ARATH	MetaPhors	A. thaliana	DTX24, At3g03620, T12J13.10	Protein DETOXIFICATION 24, AtDTX24	0/1	No
F4HZH9	DTX11_ARATH	MetaPhors	A. thaliana	DTX11, At1g15160, F9L1.10	Protein DETOXIFICATION 11, AtDTX11	0/1	Yes
F4HQ05	DTX8_ARATH	MetaPhors	A. thaliana	DTX8, At1g66780, F4N21_9	Protein DETOXIFICATION 8, AtDTX8	0/1	No
F4IHU9	DTX15_ARATH	MetaPhors	A. thaliana	DTX15, At2g34360, F13P17.20	Protein DETOXIFICATION 15, AtDTX15	0/1	No
Q9SIA3	DTX4_ARATH	MetaPhors	A. thaliana	DTXL2, DTX1, DTX4, At2g04070, F3L12.10	Protein DETOXIFICATION 4, AtDTX4	0/1	Yes
F4I4Q3	DTX32_ARATH	MetaPhors	A. thaliana	DTX32, At1g23300, F26F24.14	Protein DETOXIFICATION 32, AtDTX32	0/1	No
F4HPH1	DTX22_ARATH	MetaPhors	A. thaliana	DTX22, At1g33090, F9L11.23, T9L6.17	Protein DETOXIFICATION 22, AtDTX22	0/1	No
F4JKB9	DTX38_ARATH	MetaPhors	A. thaliana	DTX38, At4g21903, T8O5	Protein DETOXIFICATION 38, AtDTX38	0/1	No
F4HPH2	DTX20_ARATH	MetaPhors	A. thaliana	DTX20, At1g33100, F9L11.27, T9L6.18	Protein DETOXIFICATION 20, AtDTX20	0/1	Yes
Q9SIA1	DTX5_ARATH	MetaPhors	A. thaliana	DTXL4, DTX5, At2g04090, F3L12.8	Protein DETOXIFICATION 5, AtDTX5	0/1	Yes
Q1PFG9	DTX7_ARATH	MetaPhors	A. thaliana	DTX7, At1g64820, F13O11.12	Protein DETOXIFICATION 7, AtDTX7	0/1	Yes
Q1PDX9	DTX26_ARATH	MetaPhors	A. thaliana	DTX26, At5g10420, F12B17_230	Protein DETOXIFICATION 26, AtDTX26	0/1	Yes
Q9ZVH5	DTX53_ARATH	MetaPhors	A. thaliana	DTX53, At2g38510, T6A23.29	Protein DETOXIFICATION 53, AtDTX53	0/1	No
Q9SZE2	DTX51_ARATH	MetaPhors	A. thaliana	DTX51, ABS3, ADP1, ADS1, NIC4, At4g29140, F19B15.170	Protein DETOXIFICATION 51, AtDTX51	0/1	Yes
Q9SX83	DTX33_ARATH	MetaPhors	A. thaliana	DTX33, At1g47530, F16N3.20	Protein DETOXIFICATION 33, AtDTX33	0/1	No
Q9SLV0	DTX48_ARATH	MetaPhors	A. thaliana	DTX48, ABS4, BCD1, ZF14, ZRZ, At1g58340, F19C14.5	Protein DETOXIFICATION 48, AtDTX48	0/1	Yes
Q9SIA5	DTX1_ARATH	MetaPhors	A. thaliana	DTX1, DTX4, TX1, At2g04040, F3L12.13	Protein DETOXIFICATION 1, AtDTX1	0/1	No
Q9SIA4	DTX3_ARATH	MetaPhors	A. thaliana	DTXL1, DTX3, At2g04050, F3L12.12	Protein DETOXIFICATION 3, AtDTX3	0/1	Yes
Q9SAB0	DTX36_ARATH	MetaPhors	A. thaliana	DTX36, At1g11670, F25C20.18	Protein DETOXIFICATION 36, AtDTX36	0/1	No
Q9LVD9	DTX40_ARATH	MetaPhors	A. thaliana	DTX40, At3g21690, MIL23.25	Protein DETOXIFICATION 40, AtDTX40	0/1	No
Q9LUH3	DTX18_ARATH	MetaPhors	A. thaliana	LAL5, DTX18, At3g23550, MDB19.3	Protein DETOXIFICATION 18, AtDTX18	0/1	No
Q9LUH2	DTX19_ARATH	MetaPhors	A. thaliana	ALF5, DTX19, At3g23560, MDB19.4	Protein DETOXIFICATION 19, AtDTX19	0/1	No
Q9LS19	DTX30_ARATH	MetaPhors	A. thaliana	DTX30, At5g38030, F16F17.3	Protein DETOXIFICATION 30, AtDTX30	0/1	No
Q9LPV4	DTX31_ARATH	MetaPhors	A. thaliana	DTX31, RHS2, At1g12950, F13K23.21	Protein DETOXIFICATION 31, AtDTX31	0/1	No
Q9LE20	DTX54_ARATH	MetaPhors	A. thaliana	DTX54, NIC2, At1g71870, F14O23.25, F17M19.2	Protein DETOXIFICATION 54, AtDTX54	0/1	No
Q9FNC1	DTX28_ARATH	MetaPhors	A. thaliana	DTX28, At5g44050, MRH10.16	Protein DETOXIFICATION 28, AtDTX28	0/1	No
Q9FKQ1	DTX27_ARATH	MetaPhors	A. thaliana	DTX27, At5g65380, MNA5.11	Protein DETOXIFICATION 27, AtDTX27	0/1	Yes
Q9FJ87	DTX50_ARATH	MetaPhors	A. thaliana	DTX50, ABS3L1, At5g52050, MSG15.13	Protein DETOXIFICATION 50, AtDTX50	0/1	No
Q9FHB6	DTX16_ARATH	MetaPhors	A. thaliana	DTX16, At5g52450, K24M7.20	Protein DETOXIFICATION 16, AtDTX16	0/1	No
Q9FH21	DTX55_ARATH	MetaPhors	A. thaliana	DTX55, NIC3, At5g49130, K20J1.11	Protein DETOXIFICATION 55, AtDTX55	0/1	No
Q9C9U1	DTX17_ARATH	MetaPhors	A. thaliana	DTX17, At1g73700, F25P22.12	Protein DETOXIFICATION 17, AtDTX17	0/1	Yes
Q9C9M8	DTX9_ARATH	MetaPhors	A. thaliana	DTX9, At1g66760, F4N21_11	Protein DETOXIFICATION 9, AtDTX9	0/1	Yes
Q9C994	DTX14_ARATH	MetaPhors	A. thaliana	DTX14, At1g71140, F23N20.13	Protein DETOXIFICATION 14, AtDTX14	0/1	Yes
Q94AL1	DTX13_ARATH	MetaPhors	A. thaliana	DTX13, At1g15180, F9L1.12	Protein DETOXIFICATION 13, AtDTX13	0/1	Yes
Q8W488	DTX21_ARATH	MetaPhors	A. thaliana	DTX21, At1g33110, T9L6.1	Protein DETOXIFICATION 21, AtDTX21	0/1	Yes
Q8VYL8	DTX10_ARATH	MetaPhors	A. thaliana	DTX10, At1g15150, F9L1.9	Protein DETOXIFICATION 10, AtDTX10	0/1	No
Q8RXK1	DTX23_ARATH	MetaPhors	A. thaliana	DTX23, At1g33080, F9L11.22, T9L6.14	Protein DETOXIFICATION 23, AtDTX23	0/1	No
Q8RWF5	DTX6_ARATH	MetaPhors	A. thaliana	DTXL5, DTX6, At2g04100, F3L12.7	Protein DETOXIFICATION 6, AtDTX6	0/1	Yes
Q8L731	DTX12_ARATH	MetaPhors	A. thaliana	DTX12, At1g15170, F9L1.11	Protein DETOXIFICATION 12, AtDTX12	0/1	No
Q8L616	DTX25_ARATH	MetaPhors	A. thaliana	DTX25, At5g17700, MVA3.5	Protein DETOXIFICATION 25, AtDTX25	0/1	No
Q8GXM8	DTX2_ARATH	MetaPhors	A. thaliana	DTXL3, DTX2, At2g04080, F3L12.9	Protein DETOXIFICATION 2, AtDTX2	0/1	No
Q4PSF4	DTX52_ARATH	MetaPhors	A. thaliana	DTX52, ABS3L2, At5g19700, T29J13.120	Protein DETOXIFICATION 52, AtDTX52	0/1	Yes
Q38956	DTX29_ARATH	MetaPhors	A. thaliana	DTX29, At3g26590, MFE16.12	Protein DETOXIFICATION 29, AtDTX29	0/1	No
O82752	DTX49_ARATH	MetaPhors	A. thaliana	DTX49, NIC1, At4g23030, F7H19.220	Protein DETOXIFICATION 49, AtDTX49	0/1	Yes
O80695	DTX37_ARATH	MetaPhors	A. thaliana	DTX37, At1g61890, F8K4.9	Protein DETOXIFICATION 37, AtDTX37	0/1	No
O49660	DTX56_ARATH	MetaPhors	A. thaliana	DTX56, RHC1, At4g22790, T12H17.180	Protein DETOXIFICATION 56, AtDTX56	0/1	Yes
Q9LYT3	DTX41_ARATH	MetaPhors	A. thaliana	TDS3, TT12, DTX41, At3g59030, F17J16_80	Protein DETOXIFICATION 41, AtDTX41	0/1	No
Q5I0E9	S47A1_RAT	MetaPhors, OrthoDB	R. norvegicus	Slc47a1, Mate1	Multidrug and toxin extrusion protein 1, MATE-1, rMATE-1	0/3	Yes
Q8S8A9	Q8S8A9_ARATH	MetaPhors	A. thaliana	At2g04066, F3L12.17, F3L12_17	MATE efflux family protein	0/1	No

Ortholog sequence alignment (CLUSTALW)

Cysteine summary and predictions

Pos in alignment	25	63	96	126	127	130	252	271	351	357	393	395	445	448
Subcell. location	C	E	C	T	T	T	C	T	T	T	C	C	T	T
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	helix	helix	helix	helix	helix	helix	helix	helix	helix	helix	helix	helix	helix
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys²⁵	Cys⁶³ HC	Cys⁹⁶	Cys¹²⁶ HC	Cys¹²⁷ HC	Cys¹³⁰	Cys²⁵²	Cys²⁷¹	Cys³⁵¹	Cys³⁵⁷ HC	Cys³⁹³	Cys³⁹⁵	Cys⁴⁴⁵	Cys⁴⁴⁸
Pos in isoform 2 CSS-Palm 4.0 PalmPred							Cys¹¹⁰	Cys¹²⁹	Cys²⁰⁹	Cys²¹⁵ HC	Cys²⁵¹	Cys²⁵³	Cys³⁰³	Cys³⁰⁶

Pos in alignment	452	466	494
Subcell. location	T	C	C
Disulfide	no	no	no
PSIPRED v.4.02 prediction	helix	helix	coil
UniProt secondary structure	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁴⁵²	Cys⁴⁶⁶	Cys⁴⁹⁴
Pos in isoform 2 CSS-Palm 4.0 PalmPred	Cys³¹⁰	Cys³²⁴	Cys³⁵²

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

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ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	x		HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	x		HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	x		HC: 162 hits LC: 218 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	x		HC: 102 hits LC: 73 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	x		HC HC: 352 hits LC LC: 8 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	x		List: 214 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	x		HC HC: 254 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	x		List: 154 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	x		List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	x		HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	x		List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	x		List: 238 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	x		List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	x		List: 436 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	x		Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	x		List: 354 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	x		List: 1348 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	x		List: 354 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	x		List: 226 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	x		List: 274 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	x		HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	x		HC: 1079 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		List: 865 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	x		List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	x		List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	x		HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		LPS treatment: 646 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		List: 646 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	x		List: 2929 hits
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 590 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 370 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 600 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		List: 185 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	x		HC: 1869 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1093 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 687 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	x		List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	x		List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 199 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 399 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 1040 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in HC	HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 464 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Found	in HC	HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 4107 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1597 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 1378 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 3870 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	3	4	0	0.0	NA
H. sapiens	22	38	0	0.0	NA
M. musculus	23	37	2	5.4	NA
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	0	0.0	NA
S. pombe	1	1	0	0.0	NA
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	0	0.0	NA
C. familiaris	1	1	0	0.0	NA

References

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Ren W et al.	2013	Proteomic analysis of protein palmitoylation in adipocytes.	23599907
Marin EP et al.	2012	Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.	22496122
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
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Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Merrick BA et al.	2011	Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.	21785166
Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
Yang W et al.	2010	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	19801377
Martin BR et al.	2009	Large-scale profiling of protein palmitoylation in mammalian cells.	19137006
Roth AF et al.	2006	Global analysis of protein palmitoylation in yeast.	16751107
Hemsley PA et al.	2013	A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis.	23252521
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
Wei X et al.	2014	Insulin-regulated protein palmitoylation impacts endothelial cell function.	24357059
Serwa RA et al.	2015	Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.	26256475
Morrison E et al.	2015	Quantitative analysis of the human T cell palmitome.	26111759
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
Santiago-Tirado FH et al.	2015	A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.	25970403
Emmer BT et al.	2011	Global analysis of protein palmitoylation in African trypanosomes.	21193548
Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
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Gould NS et al.	2015	Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.	26165157
Peng T et al.	2015	Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.	25575299
Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Zhou B et al.	2019	Low-background Acyl-biotinyl Exchange Largely Eliminates the Co-isolation of Non-S-acylated Proteins and Enables Deep S-acylproteomic Analysis.	31251020
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Wegleiter T et al.	2019	Palmitoylation of BMPR1a regulates neural stem cell fate.	31772009
Morrison E et al.	2020	Dynamic palmitoylation events following T-cell receptor signaling.	32651440
Mariscal J et al.	2020	Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles.	32944167
Gorenberg EL et al.	2022	Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.	35358180
Uzbekova S et al.	2021	Protein Palmitoylation in Bovine Ovarian Follicle.	34769186
Miles MR et al.	2021	Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart.	33636221
Pradhan AJ et al.	2021	Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis.	33848465
Ripamonti M et al.	2021	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.	33782527
Zaręba-Kozioł M et al.	2021	S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity.	34200797
Ziemlińska E et al.	2021	Palm Oil-Rich Diet Affects Murine Liver Proteome and <i>S</i>-Palmitoylome.	34884899
Gao J et al.	2022	Proteome-wide identification of palmitoylated proteins in mouse testis.	35477839