SwissPalm

Q8RWZ5 SD25_ARATH

General info Cross-references Sequences Orthologs Ortholog sequences Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

1/1 article for arabidopsis thaliana
13 orthologs

Palmitoyl-proteome experiments

Validation experiments

0 experiment
0 ortholog

Curated sites & Enzymes

0 site from validation experiments^*
0 site from palmitoyl-proteomes^*
No PAT known
No APT known
^*In main isoform only

Predictions

Predicted

1 cysteine in main isoform

Predictions

Protein general information from UniProt

Protein names

G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5, EC 2.7.11.1; S-domain-2; SD2 receptor kinase 5, SD2-5

Subcellular location

Membrane (Probable)

Isoforms & protein length

Isoform 1 (main): 821 aa

Known functions

Cross-references

Source	Identifiers
UniProt gene names	SD25, At4g32300, F10M6.60, F8B4.10
UniProt secondary AC	O49361
Refseq protein ID	NP_194957.2
IPI ID	IPI00548805

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Techniques	Sites	Predicted
F1N0Z0	F1N0Z0_BOVIN	MetaPhors	B. taurus	PTK2B	Non-specific protein-tyrosine kinase	0/2	0	0	No
Q12866	MERTK_HUMAN	MetaPhors	H. sapiens	MERTK, MER	Tyrosine-protein kinase Mer, EC 2.7.10.1	0/22	0	0	Yes
Q9URT9	GSK31_SCHPO	MetaPhors	S. pombe	gsk31, pi064, SPBC8D2.01	Protein kinase gsk31	0/1	0	0	No
P50528	PLO1_SCHPO	MetaPhors	S. pombe	plo1, SPAC23C11.16	Serine/threonine-protein kinase plo1	0/1	0	0	No
P54759	EPHA7_RAT	MetaPhors	R. norvegicus	Epha7, Ehk-3, Ehk3	Ephrin type-A receptor 7, EC 2.7.10.1	0/3	0	0	Yes
Q61772	EPHA7_MOUSE	MetaPhors	M. musculus	Epha7, Ebk, Ehk3, Mdk1	Ephrin type-A receptor 7, EC 2.7.10.1	0/23	0	0	Yes
Q01279	EGFR_MOUSE	MetaPhors	M. musculus	Egfr	Epidermal growth factor receptor, EC 2.7.10.1	5/23	2	10	Yes
Q9VE06	Q9VE06_DROME	MetaPhors	D. melanogaster	cdi, 91F, B9.3, CDI, Cdi, Dmel\CG6027, l(3)07013, TESK1, TSKI, CG6027, Dmel_CG6027	Center divider, isoform A	0/1	0	0	Yes
E1BKA8	E1BKA8_BOVIN	MetaPhors	B. taurus	RIPK3	Receptor interacting serine/threonine kinase 3	0/2	0	0	No
P41892	CDC7_SCHPO	MetaPhors	S. pombe	cdc7, SPBC21.06c	Cell division control protein 7	0/1	0	0	Yes
Q9VL70	Q9VL70_DROME	MetaPhors	D. melanogaster	YIP2, ACAA, Dmel\CG4600, Yip2, yip2, CG4600, Dmel_CG4600	HL08109p	0/1	0	0	No
Q13546	RIPK1_HUMAN	MetaPhors	H. sapiens	RIPK1, RIP, RIP1	Receptor-interacting serine/threonine-protein kinase 1, EC 2.7.11.1	0/22	0	0	No
Q9Y572	RIPK3_HUMAN	MetaPhors	H. sapiens	RIPK3, RIP3	Receptor-interacting serine/threonine-protein kinase 3, EC 2.7.11.1	0/22	0	0	Yes
Q9Z2P5	RIPK3_RAT	MetaPhors	R. norvegicus	Ripk3, Rip3	Receptor-interacting serine/threonine-protein kinase 3, EC 2.7.11.1	0/3	0	0	No
D3ZYL0	D3ZYL0_RAT	MetaPhors	R. norvegicus	Ripk1, Ripk1_predicted, rCG_43941	Receptor	0/3	0	0	Yes
Q4V8A9	SG196_RAT	MetaPhors	R. norvegicus	Sgk196, Pomk	Protein O-mannose kinase, POMK, EC 2.7.1.183	0/3	0	0	No
Q60855	RIPK1_MOUSE	MetaPhors	M. musculus	Ripk1, Rinp, Rip	Receptor-interacting serine/threonine-protein kinase 1, EC 2.7.11.1	0/23	0	0	Yes
Q9QZL0	RIPK3_MOUSE	MetaPhors	M. musculus	Ripk3, Rip3	Receptor-interacting serine/threonine-protein kinase 3, EC 2.7.11.1	0/23	0	0	No
Q3TUA9	SG196_MOUSE	MetaPhors	M. musculus	Sgk196, Pomk	Protein O-mannose kinase, POMK, EC 2.7.1.183	0/23	0	0	No
F1MUZ2	F1MUZ2_BOVIN	MetaPhors	B. taurus	POMK	Protein O-mannose kinase	0/2	0	0	No
P54756	EPHA5_HUMAN	InParanoid	H. sapiens	EPHA5, BSK, EHK1, HEK7, TYRO4	Ephrin type-A receptor 5, EC 2.7.10.1	1/22	2	0	Yes
P54764	EPHA4_HUMAN	InParanoid	H. sapiens	EPHA4, HEK8, SEK, TYRO1	Ephrin type-A receptor 4, EC 2.7.10.1	0/22	0	0	Yes
P29322	EPHA8_HUMAN	InParanoid	H. sapiens	EPHA8, EEK, HEK3, KIAA1459	Ephrin type-A receptor 8, EC 2.7.10.1	0/22	0	0	Yes
P29320	EPHA3_HUMAN	InParanoid	H. sapiens	EPHA3, ETK, ETK1, HEK, TYRO4	Ephrin type-A receptor 3, EC 2.7.10.1	1/22	2	0	Yes
Q15375	EPHA7_HUMAN	InParanoid	H. sapiens	EPHA7, EHK3, HEK11	Ephrin type-A receptor 7, EC 2.7.10.1	3/22	3	0	Yes
Q9UF33	EPHA6_HUMAN	InParanoid	H. sapiens	EPHA6, EHK2, HEK12	Ephrin type-A receptor 6, EC 2.7.10.1	1/22	2	0	Yes
P29323	EPHB2_HUMAN	InParanoid	H. sapiens	EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5	Ephrin type-B receptor 2, EC 2.7.10.1	4/22	3	0	Yes
P54762	EPHB1_HUMAN	InParanoid	H. sapiens	EPHB1, ELK, EPHT2, HEK6, NET	Ephrin type-B receptor 1, EC 2.7.10.1	1/22	2	0	Yes
P54753	EPHB3_HUMAN	InParanoid	H. sapiens	EPHB3, ETK2, HEK2, TYRO6	Ephrin type-B receptor 3, EC 2.7.10.1	3/22	3	0	Yes
P29317	EPHA2_HUMAN	InParanoid	H. sapiens	EPHA2, ECK	Ephrin type-A receptor 2, EC 2.7.10.1	3/22	3	0	Yes
P54760	EPHB4_HUMAN	InParanoid	H. sapiens	EPHB4, HTK, MYK1, TYRO11	Ephrin type-B receptor 4, EC 2.7.10.1	4/22	3	0	Yes
Q5JZY3	EPHAA_HUMAN	InParanoid	H. sapiens	EPHA10	Ephrin type-A receptor 10, EC 2.7.10.1	0/22	0	0	Yes
P21709	EPHA1_HUMAN	InParanoid	H. sapiens	EPHA1, EPH, EPHT, EPHT1	Ephrin type-A receptor 1, hEpha1, EC 2.7.10.1	1/22	2	0	Yes
O15197	EPHB6_HUMAN	InParanoid	H. sapiens	EPHB6	Ephrin type-B receptor 6	0/22	0	0	Yes
Q02763	TIE2_HUMAN	InParanoid	H. sapiens	TEK, TIE2, VMCM, VMCM1	Angiopoietin-1 receptor, EC 2.7.10.1	0/22	0	0	Yes
Q9Z139	ROR1_MOUSE	InParanoid	M. musculus	Ror1, Ntrkr1	Inactive tyrosine-protein kinase transmembrane receptor ROR1, mROR1	0/23	0	0	Yes
Q9Z138	ROR2_MOUSE	InParanoid	M. musculus	Ror2	Tyrosine-protein kinase transmembrane receptor ROR2, mROR2, EC 2.7.10.1	2/23	3	0	Yes
P15209	NTRK2_MOUSE	InParanoid	M. musculus	Ntrk2, Trkb	BDNF/NT-3 growth factors receptor, EC 2.7.10.1	3/23	2	0	No
Q6VNS1	NTRK3_MOUSE	InParanoid	M. musculus	Ntrk3, TrkC	NT-3 growth factor receptor, EC 2.7.10.1	0/23	0	0	Yes
F1PIX7	F1PIX7_CANLF	InParanoid	C. familiaris	ROR1	Receptor tyrosine kinase like orphan receptor 1	0/1	0	0	Yes
F1PSD7	F1PSD7_CANLF	InParanoid	C. familiaris	ROR2	Receptor tyrosine kinase like orphan receptor 2	0/1	0	0	Yes
F1Q2E3	F1Q2E3_CANLF	InParanoid	C. familiaris	FGFR2	Fibroblast growth factor receptor	0/1	0	0	Yes
F1PHH3	F1PHH3_CANLF	InParanoid	C. familiaris	PTK7	Uncharacterized protein	0/1	0	0	Yes
E2R186	E2R186_CANLF	InParanoid	C. familiaris	FGFR1	Fibroblast growth factor receptor	0/1	0	0	Yes
F1PG91	F1PG91_CANLF	InParanoid	C. familiaris	TYRO3	TYRO3 protein tyrosine kinase	0/1	0	0	No
F1PJY4	F1PJY4_CANLF	InParanoid	C. familiaris	MERTK	MER proto-oncogene, tyrosine kinase	0/1	0	0	No
F1PGV4	F1PGV4_CANLF	InParanoid	C. familiaris	AXL	AXL receptor tyrosine kinase	0/1	0	0	Yes
D3ZZ97	D3ZZ97_RAT	InParanoid	R. norvegicus	RGD1559469_predicted, rCG_53423, Ror1	Receptor tyrosine kinase-like orphan receptor 1	0/3	0	0	Yes
D3ZNY8	D3ZNY8_RAT	InParanoid	R. norvegicus	Ror2, Ror2_predicted, rCG_44131	Receptor tyrosine kinase-like orphan receptor 2	0/3	0	0	Yes
Q62838	MUSK_RAT	InParanoid	R. norvegicus	Musk	Muscle, skeletal receptor tyrosine protein kinase, EC 2.7.10.1	0/3	0	0	Yes
D3ZHG3	D3ZHG3_RAT	InParanoid	R. norvegicus	Srf_predicted, rCG_43517, Ptk7	Protein tyrosine kinase 7	0/3	0	0	Yes
P55146	TYRO3_RAT	InParanoid	R. norvegicus	Tyro3, Sky	Tyrosine-protein kinase receptor TYRO3, EC 2.7.10.1	0/3	0	0	No
P57097	MERTK_RAT	InParanoid	R. norvegicus	Mertk, Mer	Tyrosine-protein kinase Mer, EC 2.7.10.1	0/3	0	0	Yes
P43481	KIT_BOVIN	InParanoid	B. taurus	KIT	Mast/stem cell growth factor receptor Kit, SCFR, EC 2.7.10.1	0/2	0	0	Yes
F1MX49	F1MX49_BOVIN	InParanoid	B. taurus	PDGFRA	Platelet-derived growth factor receptor alpha	0/2	0	0	Yes
F1N759	F1N759_BOVIN	InParanoid	B. taurus	PDGFRB	Platelet-derived growth factor receptor beta	0/2	0	0	No
A4IFL5	A4IFL5_BOVIN	InParanoid	B. taurus	FGFR1	Fibroblast growth factor receptor	0/2	0	0	Yes
F6PVB0	F6PVB0_BOVIN	InParanoid	B. taurus	FGFR3	Fibroblast growth factor receptor	0/2	0	0	No

Ortholog sequence alignment (CLUSTALW)

Cysteine summary and predictions

Pos in alignment	11	284	290	296	302	304	315	323	363	367	371	373	385	555
Subcell. location	U	E	E	E	E	E	E	E	E	E	E	E	E	C
Disulfide	no	yes	yes	yes	yes	no	no	no	yes	yes	no	yes	yes	no
PSIPRED v.4.02 prediction	helix	coil	coil	strand	strand	coil	coil	coil	helix	helix	coil	strand	strand	strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys¹¹ HC	Cys²⁸⁴	Cys²⁹⁰	Cys²⁹⁶	Cys³⁰²	Cys³⁰⁴	Cys³¹⁵	Cys³²³	Cys³⁶³	Cys³⁶⁷ LC	Cys³⁷¹ MC	Cys³⁷³ HC	Cys³⁸⁵	Cys⁵⁵⁵

Pos in alignment	610	617	703	746	806
Subcell. location	C	C	C	C	C
Disulfide	no	no	no	no	no
PSIPRED v.4.02 prediction	helix	coil	coil	helix	coil
UniProt secondary structure	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁶¹⁰	Cys⁶¹⁷	Cys⁷⁰³	Cys⁷⁴⁶	Cys⁸⁰⁶

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

Tip: Keep CTRL key pressed down while clicking on column headers to do multiple sorting. This applies to any sortable table on this site.

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	x		HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	x		HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	x		HC: 162 hits LC: 218 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	x		HC: 102 hits LC: 73 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	x		HC HC: 352 hits LC LC: 8 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	x		List: 214 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	x		HC HC: 254 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	x		List: 154 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	Ortholog	in List [EGFR, ROR2, NTRK2]	List: 664 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	Found	in LC	HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	x		List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	x		List: 238 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	x		List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	Ortholog	in List [EGFR, ROR2, NTRK2]	List: 436 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	x		Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	Ortholog	in List [EPHB4, EPHA7, EPHB3, EPHB2, EPHB1, EPHA2, EPHA3, EPHA5, EPHA6, EPHA1]	List: 354 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	Ortholog	in List [EPHB4, EPHA7, EPHB3, EPHB2, EPHB1, EPHA2, EPHA3, EPHA5, EPHA6, EPHA1]	List: 1348 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	Ortholog	in List [EPHB4, EPHA7, EPHB3, EPHB2, EPHB1, EPHA2, EPHA3, EPHA5, EPHA6, EPHA1]	List: 354 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	x		List: 226 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	Ortholog	in List [EGFR, ROR2, NTRK2]	List: 780 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	x		List: 274 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	x		HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	x		HC: 1079 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	Ortholog	in List [EGFR, ROR2, NTRK2]	List: 865 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	x		List: 1394 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	x		List: 1404 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	x		HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		LPS treatment: 646 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		List: 646 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	x		Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1433	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, LB-ABE, ABE	Ortholog	in List [EPHB4, EPHA7, EPHB3, EPHB2, EPHB1, EPHA2, EPHA3, EPHA5, EPHA6, EPHA1]	List: 2929 hits
SPalmE:1432	Zhou B et al.	2019	Homo sapiens	LNCaP	Total cell lysate	ABE, SILAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [EPHB4, EPHA7, EPHB3, EPHB2, EPHB1, EPHA2, EPHA3, EPHA5, EPHA6, EPHA1]	List: 590 hits
SPalmE:1434	Wegleiter T et al.	2019	Mus musculus	Neural stem cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [EGFR, ROR2, NTRK2]	List: 370 hits
SPalmE:1438	Mariscal J et al.	2020	Homo sapiens	PC3	Total membrane	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [EPHB4, EPHA7, EPHB3, EPHB2, EPHB1, EPHA2, EPHA3, EPHA5, EPHA6, EPHA1]	HC: 1837 hits
SPalmE:1439	Mariscal J et al.	2020	Homo sapiens	PC3	Large Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [EPHB4, EPHA7, EPHB3, EPHB2, EPHB1, EPHA2, EPHA3, EPHA5, EPHA6, EPHA1]	HC: 1350 hits
SPalmE:1440	Mariscal J et al.	2020	Homo sapiens	PC3	Small Extracellular Vesicles	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [EPHB4, EPHA7, EPHB3, EPHB2, EPHB1, EPHA2, EPHA3, EPHA5, EPHA6, EPHA1]	HC: 600 hits
SPalmE:1435	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Unstimulated: 37 hits
SPalmE:1436	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		List: 185 hits
SPalmE:1458	Morrison E et al.	2020	Homo sapiens	Jurkat	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS, SILAC	x		Stimulated: 148 hits
SPalmE:1437	Mariscal J et al.	2020	Homo sapiens	PC3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS, LB-ABE	Ortholog	in HC [EPHB4, EPHA7, EPHB3, EPHB2, EPHB1, EPHA2, EPHA3, EPHA5, EPHA6, EPHA1]	HC: 1869 hits
SPalmE:1450	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [EGFR, ROR2, NTRK2]	List: 1093 hits
SPalmE:1444	Miles MR et al.	2021	Homo sapiens	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [EPHB4, EPHA7, EPHB3, EPHB2, EPHB1, EPHA2, EPHA3, EPHA5, EPHA6, EPHA1]	List: 687 hits
SPalmE:1447	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Ortholog	in List [EPHB4, EPHA7, EPHB3, EPHB2, EPHB1, EPHA2, EPHA3, EPHA5, EPHA6, EPHA1]	List: 1173 hits
SPalmE:1448	Pradhan AJ et al.	2021	Homo sapiens	HT-29	Total cell lysate	Labeling of substrate with C20 AlkFA (Alk-18), LC-MS	Ortholog	in List [EPHB4, EPHA7, EPHB3, EPHB2, EPHB1, EPHA2, EPHA3, EPHA5, EPHA6, EPHA1]	List: 770 hits
SPalmE:1449	Ripamonti M et al.	2021	Mus musculus	NIH-3T3	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 199 hits
SPalmE:1445	Miles MR et al.	2021	Rattus norvegicus	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 399 hits
SPalmE:1451	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [EGFR, ROR2, NTRK2]	List: 1048 hits
SPalmE:1452	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [EGFR, ROR2, NTRK2]	List: 1112 hits
SPalmE:1453	Zaręba-Kozioł M et al.	2021	Mus musculus	Brain	Synaptoneurosomal fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [EGFR, ROR2, NTRK2]	List: 1040 hits
SPalmE:1455	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in MC [EGFR, ROR2, NTRK2]	HC: 850 hits MC: 303 hits LC: 21 hits
SPalmE:1446	Miles MR et al.	2021	Canis familiaris	Heart	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	x		List: 464 hits
SPalmE:1454	Ziemlińska E et al.	2021	Mus musculus	Liver	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [EGFR, ROR2, NTRK2]	HC: 675 hits MC: 360 hits LC: 27 hits
SPalmE:1443	Uzbekova S et al.	2021	Bos taurus	Bovine follicular cells	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 80 hits
SPalmE:1456	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [EGFR, ROR2, NTRK2]	HC: 4107 hits
SPalmE:1442	Gorenberg EL et al.	2022	Mus musculus	Brain	Total cell lysate	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [EGFR, ROR2, NTRK2]	List: 1597 hits
SPalmE:1441	Gorenberg EL et al.	2022	Mus musculus	Brain	Synaptic fraction	ARAC, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in List [EGFR, ROR2, NTRK2]	List: 1378 hits
SPalmE:1457	Gao J et al.	2022	Mus musculus	Testis	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in HC [EGFR, ROR2, NTRK2]	HC: 3870 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	3	4	0	0.0	NA
H. sapiens	22	38	12	31.6	EPHB4_HUMAN , EPHA7_HUMAN , EPHB3_HUMAN , EPHB2_HUMAN , EPHB1_HUMAN , EPHA2_HUMAN , EPHA3_HUMAN , EPHA5_HUMAN , EPHA6_HUMAN , EPHA1_HUMAN
M. musculus	23	37	15	40.5	EGFR_MOUSE , ROR2_MOUSE , NTRK2_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	1	100.0	NA
S. pombe	1	1	0	0.0	NA
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	2	2	0	0.0	NA
D. melanogaster	1	2	0	0.0	Q9VL70_DROME
C. familiaris	1	1	0	0.0	NA

References

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Marin EP et al.	2012	Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.	22496122
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
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Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Merrick BA et al.	2011	Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.	21785166
Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
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Hemsley PA et al.	2013	A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis.	23252521
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
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Serwa RA et al.	2015	Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.	26256475
Morrison E et al.	2015	Quantitative analysis of the human T cell palmitome.	26111759
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
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Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
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Gould NS et al.	2015	Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.	26165157
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Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Zhou B et al.	2019	Low-background Acyl-biotinyl Exchange Largely Eliminates the Co-isolation of Non-S-acylated Proteins and Enables Deep S-acylproteomic Analysis.	31251020
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Wegleiter T et al.	2019	Palmitoylation of BMPR1a regulates neural stem cell fate.	31772009
Morrison E et al.	2020	Dynamic palmitoylation events following T-cell receptor signaling.	32651440
Mariscal J et al.	2020	Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles.	32944167
Gorenberg EL et al.	2022	Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.	35358180
Uzbekova S et al.	2021	Protein Palmitoylation in Bovine Ovarian Follicle.	34769186
Miles MR et al.	2021	Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart.	33636221
Pradhan AJ et al.	2021	Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis.	33848465
Ripamonti M et al.	2021	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.	33782527
Zaręba-Kozioł M et al.	2021	S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity.	34200797
Ziemlińska E et al.	2021	Palm Oil-Rich Diet Affects Murine Liver Proteome and <i>S</i>-Palmitoylome.	34884899
Gao J et al.	2022	Proteome-wide identification of palmitoylated proteins in mouse testis.	35477839