SwissPalm

Q948K6 RABG1_ARATH

General info Cross-references Sequences Orthologs Ortholog sequences Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

1/1 article for arabidopsis thaliana
18 orthologs

Palmitoyl-proteome experiments

Validation experiments

0 experiment
7 orthologs

Curated sites & Enzymes

0 site from validation experiments^*
0 site from palmitoyl-proteomes^*
No PAT known
No APT known
^*In main isoform only

Predictions

Predicted

1 cysteine in main isoform

Predictions

Protein general information from UniProt

Protein names

Ras-related protein RABG1; AtRABG1; Ras-related protein Rab78; AtRab78

Subcellular location

Cell membrane (By similarity)

Isoforms & protein length

Isoform 1 (main): 204 aa

Known functions

Intracellular vesicle trafficking and protein transport. Belongs to the small GTPase superfamily. Rab family. Intracellular vesicle trafficking and protein transport. Belongs to the small GTPase superfamily. Rab family.

Cross-references

Source	Identifiers
UniProt gene names	MIJ24.90, At5g39620, RAB78, RABG1
UniProt secondary AC	Q9FK99
Refseq protein ID	NP_568566.1
IPI ID	IPI00545888

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Times validated	Techniques	Sites	Predicted
F1MJQ1	F1MJQ1_BOVIN	MetaPhors	B. taurus	RAB7A	Ras-related protein Rab-7a	0/1	0	0	0	Yes
M9PE35	M9PE35_DROME	MetaPhors	D. melanogaster	Dmel_CG12015, CG12015, rabx6, rabX6, DmRabX6, Dmel\CG12015, RabX6	RabX6, isoform B	0/1	0	0	0	No
Q9VS10	Q9VS10_DROME	MetaPhors	D. melanogaster	Dmel_CG8641, CG8641, Q9VS10, CG8641-RA, Dmel\CG8641	MIP08469p	0/1	0	0	0	Yes
O96692	O96692_DROME	MetaPhors	D. melanogaster	Rap2L, Rap21, Rap2, O96692, l(2)SH2 0581, l(2)SH0581, Dmel\CG3204, Dm Rap21, Dmel_CG3204, CG3204, Rap2l	RE63021p	1/1	0	2	0	Yes
Q9VRY2	Q9VRY2_DROME	MetaPhors	D. melanogaster	Dmel_CG8519, CG8519, Dmel\CG8519	RE30129p	0/1	0	0	0	Yes
D3ZM99	D3ZM99_RAT	MetaPhors	R. norvegicus	Rergl	RERG-like	0/2	0	0	0	No
Q5BJZ5	Q5BJZ5_RAT	MetaPhors	R. norvegicus	rCG_57132, Rhoh	Ras homolog family member H	0/2	0	0	0	Yes
Q4KLY1	Q4KLY1_RAT	MetaPhors	R. norvegicus	rCG_37288, Rem1	GTP-binding protein	0/2	0	0	0	No
A6H634	A6H634_MOUSE	MetaPhors	M. musculus	Gm266	Gene model 266,	0/17	0	0	0	No
Q3T0F5	RAB7A_BOVIN	MetaPhors	B. taurus	RAB7, RAB7A	Ras-related protein Rab-7a	0/1	0	0	0	Yes
O75628	REM1_HUMAN	MetaPhors	H. sapiens	REM, GES, REM1	GTP-binding protein REM 1	0/17	0	0	0	No
Q15669	RHOH_HUMAN	MetaPhors	H. sapiens	TTF, ARHH, RHOH	Rho-related GTP-binding protein RhoH	0/17	0	0	0	Yes
P51149	RAB7A_HUMAN	MetaPhors	H. sapiens	RAB7, RAB7A	Ras-related protein Rab-7a	5/17	4	3	2	Yes
P01116	RASK_HUMAN	MetaPhors	H. sapiens	RASK2, KRAS2, KRAS	GTPase KRas	7/17	0	2	0	No
P10301	RRAS_HUMAN	MetaPhors	H. sapiens	RRAS	Ras-related protein R-Ras	11/17	4	3	1	Yes
Q96A58	RERG_HUMAN	MetaPhors	H. sapiens	RERG	Ras-related and estrogen-regulated growth inhibitor	0/17	0	0	0	No
Q96D21	RHES_HUMAN	MetaPhors	H. sapiens	TEM2, RASD2	GTP-binding protein Rhes	0/17	0	0	0	Yes
Q96L33	RHOV_HUMAN	MetaPhors	H. sapiens	WRCH2, ARHV, RHOV	Rho-related GTP-binding protein RhoV	0/17	0	0	0	Yes
Q6T310	RSLBA_HUMAN	MetaPhors	H. sapiens	RASL11A	Ras-like protein family member 11A	0/17	0	0	0	No
P61225	RAP2B_HUMAN	MetaPhors	H. sapiens	RAP2B	Ras-related protein Rap-2b	14/17	3	3	2	Yes
Q15382	RHEB_HUMAN	MetaPhors	H. sapiens	RHEB2, RHEB	GTP-binding protein Rheb	1/17	0	1	0	No
P62070	RRAS2_HUMAN	MetaPhors	H. sapiens	TC21, RRAS2	Ras-related protein R-Ras2	11/17	0	3	0	Yes
P10114	RAP2A_HUMAN	MetaPhors	H. sapiens	RAP2A	Ras-related protein Rap-2a	10/17	2	3	2	Yes
Q9Y3L5	RAP2C_HUMAN	MetaPhors	H. sapiens	RAP2C	Ras-related protein Rap-2c	13/17	2	3	3	Yes
Q9HDY0	YPT71_SCHPO	MetaPhors	S. pombe	SPAPB1A10.10c, ypt71	GTP-binding protein ypt71	0/1	0	0	0	Yes
O94655	YPT7_SCHPO	MetaPhors	S. pombe	SPBC405.04c, ypt7	GTP-binding protein ypt7	0/1	0	0	0	Yes
O76742	O76742_DROME	MetaPhors	D. melanogaster	Dmel_CG5915, CG5915, rab7, Rab7, Rab7A, RAB7, Rab-r7, Rab-7, O76742, drab7, dRab7, Drab7, DRab7, DRAB7, DmRab7, Dmel\CG5915, Dm Rab7, AAF56218	CG5915 protein	0/1	0	0	0	Yes
Q2MGM2	Q2MGM2_DROME	MetaPhors	D. melanogaster	Dmel_CG3204, CG3204, Rap2l	Ras-associated protein 2-like, isoform B	0/1	0	0	0	No
Q9VH66	Q9VH66_DROME	MetaPhors	D. melanogaster	Dmel_CG8500, CG8500, CG8500-RA, Dmel\CG8500, Q9VH66	FI18258p1	0/1	0	0	0	No
Q9Z1Y0	RHOV_RAT	MetaPhors	R. norvegicus	Rhov	Rho-related GTP-binding protein RhoV	0/2	1	0	1	Yes
P09527	RAB7A_RAT	MetaPhors	R. norvegicus	Rab7, Rab7a	Ras-related protein Rab-7a	1/2	0	1	0	Yes
D3Z8L7	RRAS_RAT	MetaPhors	R. norvegicus	Rras	Ras-related protein R-Ras	1/2	0	1	0	No
P61227	RAP2B_RAT	MetaPhors	R. norvegicus	Rap2b	Ras-related protein Rap-2b	0/2	0	0	0	Yes
P08644	RASK_RAT	MetaPhors	R. norvegicus	Kras2, Kras	GTPase KRas	1/2	0	1	0	Yes
Q5BJU0	Q5BJU0_RAT	MetaPhors	R. norvegicus	rCG_40097, Rras2	RAS-related 2	0/2	0	0	0	Yes
P63033	RHES_RAT	MetaPhors	R. norvegicus	Rasd2	GTP-binding protein Rhes	0/2	0	0	0	Yes
D3ZK56	D3ZK56_RAT	MetaPhors	R. norvegicus	rCG_53223, Rap2c	RAP2C, member of RAS oncogene family	0/2	0	0	0	Yes
P61226	RAP2B_MOUSE	MetaPhors	M. musculus	Rap2b	Ras-related protein Rap-2b	10/17	0	2	0	Yes
Q9D3G9	RHOH_MOUSE	MetaPhors	M. musculus	Arhh, Rhoh	Rho-related GTP-binding protein RhoH	0/17	0	0	0	Yes
P32883	RASK_MOUSE	MetaPhors	M. musculus	Kras2, Kras	GTPase KRas	3/17	0	2	0	Yes
P10833	RRAS_MOUSE	MetaPhors	M. musculus	Rras	Ras-related protein R-Ras	9/17	2	2	1	No
O88667	RAD_MOUSE	MetaPhors	M. musculus	Rrad	GTP-binding protein RAD	0/17	0	0	0	No
Q921J2	RHEB_MOUSE	MetaPhors	M. musculus	Rheb	GTP-binding protein Rheb	0/17	0	0	0	No
Q8R367	RERG_MOUSE	MetaPhors	M. musculus	Rerg	Ras-related and estrogen-regulated growth inhibitor	0/17	0	0	0	No
O35929	REM1_MOUSE	MetaPhors	M. musculus	Rem, Rem1	GTP-binding protein REM 1	0/17	0	0	0	No
P51150	RAB7A_MOUSE	MetaPhors	M. musculus	Rab7, Rab7a	Ras-related protein Rab-7a	6/17	0	2	2	Yes
P62071	RRAS2_MOUSE	MetaPhors	M. musculus	Rras2	Ras-related protein R-Ras2	8/17	0	2	0	Yes
Q8VDU1	RHOV_MOUSE	MetaPhors	M. musculus	Rhov	Rho-related GTP-binding protein RhoV	0/17	0	0	0	Yes
Q6IMB1	RSLBA_MOUSE	MetaPhors	M. musculus	Rasl11a	Ras-like protein family member 11A	0/17	0	0	0	No
Q8BU31	RAP2C_MOUSE	MetaPhors	M. musculus	Rap2c	Ras-related protein Rap-2c	10/17	0	2	0	Yes

Ortholog sequence alignment (CLUSTALW)

Cysteine summary and predictions

Pos in alignment	48	80	81	143	202	204
Subcell. location	U	U	U	U	U	U
Disulfide	no	no	no	no	no	no
PSIPRED v.4.02 prediction	strand	strand	strand	helix	coil	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁴⁸	Cys⁸⁰ HC	Cys⁸¹	Cys¹⁴³	Cys²⁰² LC	Cys²⁰⁴ MC

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

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ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	Ortholog	in LC,HC [RAB7A, RRAS, RASK]	HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	Ortholog	in HC [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	Ortholog	in HC [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	HC: 59 hits LC: 105 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	Ortholog	in HC [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	HC: 63 hits LC: 147 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	Ortholog	in HC [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	HC: 102 hits LC: 73 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	Ortholog	in HC [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	HC: 162 hits LC: 218 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 214 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	Ortholog	in LC [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	HC: 164 hits LC: 178 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	Ortholog	in List [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	List: 69 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	Ortholog	in HC [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	HC HC: 352 hits LC LC: 8 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	Ortholog	in HC [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	HC HC: 93 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 154 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	Ortholog	in HC [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	HC HC: 254 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	Found	in LC	HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	Ortholog	in List [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	x		List: 238 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	Ortholog	in List [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	List: 664 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	Ortholog	in List [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	Ortholog	in List [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	List: 436 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 1348 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 274 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 226 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 113 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 354 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 354 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 216 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 1353 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	Ortholog	in MC,LC,HC [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	Ortholog	in HC [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	HC: 1079 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	Ortholog	in List [RAB7A, RRAS, RASK]	List: 193 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	Ortholog	in List [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	List: 865 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Ortholog	in HC,MC [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in Palm. up with LPS [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in List [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	List: 646 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in LPS treatment [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	LPS treatment: 646 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	Ortholog	in MC,LC,HC [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Ortholog	in HC [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 984 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 1404 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 1394 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	Ortholog	in HC,LC [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	Ortholog	in MC,HC [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	Ortholog	in List [RAP2B, RAB7A, RRAS2, RAP2C, RAP2A, RRAS, RASK, RHEB]	List: 195 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	Ortholog	in HC,MC [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	Ortholog	in LC,MC,HC [RAB7A, RAP2C, RAP2B, RRAS, RASK, RRAS2]	HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	Ortholog	in List [O96692, Q2MGM2]	List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	2	3	2	66.7	RAB7A_RAT , RRAS_RAT , RASK_RAT
H. sapiens	17	26	23	88.5	RAP2B_HUMAN , RAB7A_HUMAN , RRAS2_HUMAN , RAP2C_HUMAN , RAP2A_HUMAN , RRAS_HUMAN , RASK_HUMAN , RHEB_HUMAN
M. musculus	17	25	19	76.0	RAB7A_MOUSE , RAP2C_MOUSE , RAP2B_MOUSE , RRAS_MOUSE , RASK_MOUSE , RRAS2_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	1	100.0	NA
S. pombe	1	1	0	0.0	NA
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	1	1	0	0.0	NA
D. melanogaster	1	2	1	50.0	O96692_DROME , Q2MGM2_DROME

References

Authors	Year	Reference title	PMID
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Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Kang R et al.	2008	Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.	19092927
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Yang W et al.	2010	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	19801377
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Martin BR et al.	2009	Large-scale profiling of protein palmitoylation in mammalian cells.	19137006
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Wei X et al.	2014	Insulin-regulated protein palmitoylation impacts endothelial cell function.	24357059
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Peng T et al.	2015	Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.	25575299
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
Santiago-Tirado FH et al.	2015	A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.	25970403
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Martin BR et al.	2011	Global profiling of dynamic protein palmitoylation.	22056678
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
Foe IT et al.	2015	Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.	26468752
Gould NS et al.	2015	Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.	26165157
Serwa RA et al.	2015	Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.	26256475
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Morrison E et al.	2015	Quantitative analysis of the human T cell palmitome.	26111759
Marin EP et al.	2012	Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.	22496122
Merrick BA et al.	2011	Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.	21785166
Emmer BT et al.	2011	Global analysis of protein palmitoylation in African trypanosomes.	21193548
Ren W et al.	2013	Proteomic analysis of protein palmitoylation in adipocytes.	23599907
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Roth AF et al.	2006	Global analysis of protein palmitoylation in yeast.	16751107
Hemsley PA et al.	2013	A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis.	23252521