General info Cross-references Sequences Orthologs Ortholog sequences Validation experiments Sites Predictions Palmitoyl-proteomes References
Palmitoyl-proteomes
9/17
articles for mouse
3 orthologs
3 orthologs
Validation experiments
1
experiment
0 ortholog
0 ortholog
Curated sites & Enzymes
5
sites from validation experiments*
Cys159, Cys161, Cys163, Cys164, Cys166
5 sites from palmitoyl-proteomes* Cys126, Cys127, Cys217, Cys215, Cys212
No PAT known
No APT known
*In main isoform only
5 sites from palmitoyl-proteomes* Cys126, Cys127, Cys217, Cys215, Cys212
No PAT known
No APT known
*In main isoform only
Predictions
Predicted
7
cysteines in main isoform
Protein names
Phospholipid scramblase 3; PL scramblase 3; Ca; 2+-dependent phospholipid scramblase 3
Subcellular location
Mitochondrion membrane (Potential)
Isoforms & protein length
Isoform 1 (main): 296 aa
Known functions
Source | Identifiers |
---|---|
UniProt gene names | Plscr3 |
Refseq protein ID | XP_006534220.1, XP_006534219.1, NP_076053.1, NP_001161969.1 |
IPI ID | IPI00263912, IPI00310627 |
Source | Identifiers |
---|---|
Ensembl protein | ENSMUSP00000104273, ENSMUSP00000104272, ENSMUSP00000019605 |
Ensembl gene | ENSMUSG00000019461 |
MGI ID | MGI:1917560 |
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UniProt AC | st. | UniProt ID | Orthology source | Organism | Gene names | Protein name | Palmitome articles | Times validated | Techniques | Sites | Predicted |
---|---|---|---|---|---|---|---|---|---|---|---|
Q9SI32 | Q9SI32_ARATH | InParanoid, MetaPhors | A. thaliana | F1O13_7, F1O13.7, At2g04940 | Phospholipid scramblase | 0/1 | 0 | 0 | 0 | No | |
Q8IQD7 | Q8IQD7_DROME | OrthoDB, Ensembl | D. melanogaster | Dmel_CG32056, scramb1-RB, scramb1, Scramb1, Dmel\CG32056, CT20492, CG6590, CG32056 | Phospholipid scramblase | 1/1 | 0 | 2 | 0 | Yes | |
Q9VZW1 | Q9VZW1_DROME | Ensembl, MetaPhors | D. melanogaster | Dmel_CG1893, CG1893, scramb2, Scramb2, Dmel\CG1893 | Phospholipid scramblase | 0/1 | 0 | 0 | 0 | Yes | |
Q9UT84 | YIP6_SCHPO | InParanoid, MetaPhors | S. pombe | SPAC343.06c | Phospholipid scramblase family protein C343.06c | 0/1 | 0 | 0 | 0 | No | |
P47140 | AIM25_YEAST | InParanoid | S. cerevisiae S288c | J1946, YJR100C, AIM25 | Altered inheritance rate of mitochondria protein 25 | 0/1 | 0 | 0 | 0 | Yes | |
Q8IJH8 | Q8IJH8_PLAF7 | InParanoid | P. falciparum | PF3D7_1022700 | Phospholipid scramblase | 1/1 | 0 | 2 | 0 | Yes | |
Q6QBQ4 | PLS3_RAT | OrthoDB, Ensembl, InParanoid, MetaPhors | R. norvegicus | Pls3, Plscr3 | Phospholipid scramblase 3 | 0/2 | 0 | 0 | 0 | Yes | |
Q9NRY6 | PLS3_HUMAN | OrthoDB, InParanoid, MetaPhors | H. sapiens | PLSCR3 | Phospholipid scramblase 3 | 11/17 | 0 | 4 | 7 | Yes | |
Q1RMW0 | Q1RMW0_BOVIN | OrthoDB, Ensembl, InParanoid, MetaPhors | B. taurus | PLSCR3 | Phospholipid scramblase | 0/1 | 0 | 0 | 0 | Yes | |
Q8SZE1 | Q8SZE1_DROME | OrthoDB | D. melanogaster | CG1893, scramb2 | Phospholipid scramblase | 0/1 | 0 | 0 | 0 | Yes | |
Q8IQD8 | Q8IQD8_DROME | Ensembl | D. melanogaster | Dmel_CG32056, scramb1, Scramb1, Dmel\CG32056, CT20492, CG6590, CG32056 | Phospholipid scramblase | 0/1 | 0 | 0 | 0 | Yes | |
Q9VT88 | Q9VT88_DROME | Ensembl, MetaPhors | D. melanogaster | Dmel_CG32056, CG6590, scramb1, Scramb1, Dmel\CG32056, CT20492, CG32056 | Phospholipid scramblase | 0/1 | 0 | 0 | 0 | Yes |
ID of the experiment | Reference | Year | Organism | Cell type | Subcellular location | Technique(s) |
---|---|---|---|---|---|---|
SPalmE:330 | Merrick BA et al. | 2011 | Mus musculus | HEK293 | Total cell lysate | Point mutation, [3H]palmitic acid labeling |
Isoforms | Position | Probability | Studies | Techniques |
---|---|---|---|---|
Q9JIZ9 | 159 | NA | SPalmE:330 Merrick BA et al. (2011) | Point mutation, [3H]palmitic acid labeling |
Q9JIZ9 | 161 | NA | SPalmE:330 Merrick BA et al. (2011) | Point mutation, [3H]palmitic acid labeling |
Q9JIZ9 | 163 | NA | SPalmE:330 Merrick BA et al. (2011) | Point mutation, [3H]palmitic acid labeling |
Q9JIZ9 | 164 | NA | SPalmE:330 Merrick BA et al. (2011) | Point mutation, [3H]palmitic acid labeling |
Q9JIZ9 | 166 | NA | SPalmE:330 Merrick BA et al. (2011) | Point mutation, [3H]palmitic acid labeling |
Q9JIZ9 | 126 | NA | SPalmE:903 Collins MO et al. (2017)* SPalmE:855 Shen LF et al. (2017)* | ABE, ARAC |
Q9JIZ9 | 127 | NA | SPalmE:903 Collins MO et al. (2017)* SPalmE:855 Shen LF et al. (2017)* | ABE, ARAC |
Q9JIZ9 | 217 | NA | SPalmE:903 Collins MO et al. (2017)* | ABE |
Q9JIZ9 | 215 | NA | SPalmE:903 Collins MO et al. (2017)* | ABE |
Q9JIZ9 | 212 | NA | SPalmE:903 Collins MO et al. (2017)* | ABE |
Pos in alignment | 104 | 126 | 127 | 131 | 132 | 159 | 161 | 163 | 164 | 166 | 212 | 215 | 217 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subcell. location | C | C | C | C | C | C | C | C | C | C | C | C | C |
Disulfide | no | no | no | no | no | no | no | no | no | no | no | no | no |
PSIPRED v.4.02 prediction | coil | coil | strand | helix | coil | strand | coil | coil | coil | coil | coil | coil | coil |
UniProt secondary structure | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Pos in isoform 1 [Main]
CSS-Palm 4.0 PalmPred |
Cys104 |
Cys126 HC |
Cys127 |
Cys131 HC MC |
Cys132 HC MC |
Cys159 HC |
Cys161 MC |
Cys163 HC MC |
Cys164 HC |
Cys166 HC |
Cys212 |
Cys215 LC |
Cys217 |
Legend
Subcell. location | U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear |
Prediction confidence |
Cysteine position:
Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted. PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted. |
List of palmitoyl-proteomes
Summary table by organism
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ID of the experiment | Reference | Year | Organism | Cell type | Subcellular location | Technique(s) | Found? | In list | All lists |
---|---|---|---|---|---|---|---|---|---|
SPalmE:14 | Roth AF et al. | 2006 | Saccharomyces cerevisiae | Isogenic LRB759 | Total membrane | ABE | x | HC HC: 48 hits | |
SPalmE:13 | Kang R et al. | 2008 | Rattus norvegicus | Cortical neuron | Synaptosomal membrane | ABE | x |
HC: 107 hits LC: 308 hits |
|
SPalmE:6 | Martin BR et al. | 2009 | Homo sapiens | Jurkat | Total membrane | Click chemistry | x |
HC: 127 hits LC: 188 hits List: 0 hits |
|
SPalmE:10 | Yount JS et al. | 2010 | Mus musculus | Dendritic cell | Total cell lysate | Click chemistry | x |
HC: 59 hits LC: 105 hits |
|
SPalmE:577 | Yang W et al. | 2010 | Homo sapiens | DU145 | Non-lipid raft | ABE | Ortholog | in HC [PLS3] |
HC: 63 hits LC: 147 hits |
SPalmE:578 | Yang W et al. | 2010 | Homo sapiens | DU145 | Lipid raft | ABE | x |
HC: 102 hits LC: 73 hits |
|
SPalmE:1 | Yang W et al. | 2010 | Homo sapiens | DU145 | Total membrane | ABE | Ortholog | in HC [PLS3] |
HC: 162 hits LC: 218 hits |
SPalmE:2 | Dowal L et al. | 2011 | Homo sapiens | Platelet | Total membrane | ABE | Ortholog | in List [PLS3] | List: 214 hits |
SPalmE:5 | Forrester MT et al. | 2011 | Homo sapiens | HEK293 | Total membrane | ARAC | x | List: 69 hits | |
SPalmE:7 | Wilson JP et al. | 2011 | Homo sapiens | Jurkat | Total cell lysate | Click chemistry | x |
HC: 164 hits LC: 178 hits |
|
SPalmE:8 | Merrick BA et al. | 2011 | Mus musculus | Macrophage Raw 264.7 | Total membrane | ABE | Found | in List | List: 69 hits |
SPalmE:12 | Martin BR et al. | 2011 | Mus musculus | BW5147-derived mouse T-cell hybridoma cell | Total membrane | Click chemistry | Found | in HC |
HC HC: 352 hits LC LC: 8 hits |
SPalmE:511 | Emmer BT et al. | 2011 | Trypanosoma brucei brucei | NA | Total cell lysate | ABE | x | List: 126 hits | |
SPalmE:3 | Ivaldi C et al. | 2012 | Homo sapiens | B-cell | Total membrane | ABE | Ortholog | in HC [PLS3] | HC HC: 93 hits |
SPalmE:4 | Marin EP et al. | 2012 | Homo sapiens | Umbilical vein blood | NA | ABE | Ortholog | in List [PLS3] | List: 154 hits |
SPalmE:11 | Li Y et al. | 2012 | Mus musculus | Neural stem cell | Total cell lysate | Click chemistry | Found | in HC | HC HC: 254 hits |
SPalmE:162 | Jones ML et al. | 2012 | Plasmodium falciparum | Whole organism | Total cell lysate | ABE | Ortholog | in HC [Q8IJH8] |
HC: 100 hits LC: 217 hits |
SPalmE:580 | Jones ML et al. | 2012 | Plasmodium falciparum | Whole organism | Total cell lysate | Click chemistry, SILAC | Ortholog | in HC [Q8IJH8] |
HC: 79 hits LC: 89 hits |
SPalmE:15 | Hemsley PA et al. | 2013 | Arabidopsis thaliana | Heyn Col-4 ecotype root cell suspension | Microsomal membrane | ABE | x |
HC: 122 hits MC: 94 hits LC: 366 hits |
|
SPalmE:119 | Wan J et al. | 2013 | Mus musculus | Brain | Total cell lysate | ABE | x | List: 378 hits | |
SPalmE:160 | Zhang MM et al. | 2013 | Schizosaccharomyces pombe | Whole organism | Total cell lysate | Click chemistry | x | List: 238 hits | |
SPalmE:9 | Ren W et al. | 2013 | Mus musculus | 3T3-L1 and epididymal fat pads | Total membrane | ARAC | Found | in List | List: 664 hits |
SPalmE:184 | Wei X et al. | 2014 | Homo sapiens | HUVEC | Total cell lysate | ABE | Ortholog | in List [PLS3] |
Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits |
SPalmE:507 | Chesarino NM et al. | 2014 | Mus musculus | DC2.4 | Total cell lysate | Click chemistry | x | List: 246 hits | |
SPalmE:508 | Chesarino NM et al. | 2014 | Mus musculus | MEF | Total cell lysate | Click chemistry | x | List: 436 hits | |
SPalmE:504 | Serwa RA et al. | 2015 | Homo sapiens | RPE-1 | Total cell lysate | SILAC, 16-HDYA labeling | Ortholog | in List [PLS3] | List: 1348 hits |
SPalmE:505 | Morrison E et al. | 2015 | Homo sapiens | Primary CD4 + T cells | Total cell lysate | ABE, In gel SILAC labeling | Ortholog | in List [PLS3] | List: 274 hits |
SPalmE:506 | Morrison E et al. | 2015 | Homo sapiens | Jurkat | Total cell lysate | Click chemistry, SILAC | Ortholog | in List [PLS3] | List: 226 hits |
SPalmE:509 | Santiago-Tirado FH et al. | 2015 | Cryptococcus neoformans | NA | Total cell lysate | Click chemistry | x | List: 426 hits | |
SPalmE:510 | Santiago-Tirado FH et al. | 2015 | Cryptococcus neoformans | NA | Total cell lysate | Click chemistry | x | List: 354 hits | |
SPalmE:529 | Colquhoun DR et al. | 2015 | Homo sapiens | 174 x CEM.T1 | Total cell lysate | Click-IT Palmitic Acid labeling | Ortholog | in List [PLS3] | List: 113 hits |
SPalmE:536 | Foe IT et al. | 2015 | Toxoplasma gondii | NA | Total membrane | Click chemistry | x |
HC: 210 hits MC: 72 hits |
|
SPalmE:540 | Gould NS et al. | 2015 | Mus musculus | Liver | Total cell lysate | APE | x | List: 780 hits | |
SPalmE:619 | Peng T et al. | 2015 | Homo sapiens | HEK293 | Total cell lysate | Alk16 Labeling | x | List: 354 hits | |
SPalmE:620 | Peng T et al. | 2015 | Homo sapiens | HEK293 | Total cell lysate | Photo cleavable x-alk16 labeling | x | List: 354 hits | |
SPalmE:698 | Pinner AL et al. | 2016 | Homo sapiens | Brain | Total cell lysate | ABE | x | List: 216 hits | |
SPalmE:723 | Hernandez JL et al. | 2016 | Homo sapiens | MCF7 | Total cell lysate | Alk16 Labeling | Ortholog | in List [PLS3] | List: 1353 hits |
SPalmE:724 | Fang C et al. | 2016 | Homo sapiens | SW480 | NA | ARAC | x | List: 100 hits | |
SPalmE:829 | Upadhyay S et al. | 2016 | Aspergillus fumigatus | Conidia | NA | ABE | x | List: 133 hits | |
SPalmE:902 | Caballero MC et al. | 2016 | Toxoplasma gondii | whole parasite lysates | NA | ABE | x | HC: 164 hits | |
SPalmE:909 | Thinon E et al. | 2016 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | Alk16 Labeling | Found | in LC |
HC: 197 hits MC: 143 hits LC: 302 hits |
SPalmE:903 | Collins MO et al. | 2017 | Mus musculus | Forebrain | NA | ABE | Found | in HC | HC: 1079 hits |
SPalmE:906 | Edmonds MJ et al. | 2017 | Rattus norvegicus | Brain | NA | ABE | x | List: 193 hits | |
SPalmE:907 | Edmonds MJ et al. | 2017 | Rattus norvegicus | Brain | NA | ARAC | x | List: 95 hits | |
SPalmE:855 | Shen LF et al. | 2017 | Mus musculus | Liver | Total membrane | ARAC | Found | in List | List: 865 hits |
SPalmE:993 | Shen LF et al. | 2017 | Mus musculus | Liver | Total membrane | ARAC | x | ZDHHC13 substrates: 16 hits | |
SPalmE:1187 | Thinon E et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | ARAC | Found | in MC |
HC: 281 hits MC: 139 hits LC: 113 hits |
SPalmE:908 | Sobocińska J et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | Click chemistry | x |
Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits |
|
SPalmE:919 | Sobocińska J et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | Click chemistry | Found | in List | List: 646 hits |
SPalmE:920 | Sobocińska J et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | Click chemistry | Found | in LPS treatment | LPS treatment: 646 hits |
SPalmE:1183 | Thinon E et al. | 2018 | Homo sapiens | HeLa | Total cell lysate | NH2OH cleavage of thioester bond, Alk16 Labeling | x |
HC: 132 hits MC: 138 hits LC: 110 hits |
|
SPalmE:1182 | Thinon E et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | ARAC | Found | in MC |
HC: 198 hits MC: 143 hits LC: 120 hits |
SPalmE:1192 | Won SJ et al. | 2018 | Homo sapiens | HAP1 | Total cell lysate | Click chemistry | x | List: 984 hits | |
SPalmE:1194 | Won SJ et al. | 2018 | Homo sapiens | HAP1 | Total cell lysate | ARAC, | Ortholog | in List [PLS3] | List: 1404 hits |
SPalmE:1193 | Won SJ et al. | 2018 | Homo sapiens | HAP1 | Total cell lysate | ARAC | Ortholog | in List [PLS3] | List: 1394 hits |
SPalmE:1203 | Zhang X et al. | 2018 | Mus musculus | Brain | Total membrane | Enrichment by magnetic nanoparticles | Ortholog | in MC [Q3T9B7, Q5F284] |
HC: 917 hits MC: 352 hits LC: 15 hits |
SPalmE:1184 | Thinon E et al. | 2018 | Homo sapiens | HeLa | Total cell lysate | ARAC | Ortholog | in MC [PLS3] |
HC: 545 hits MC: 415 hits LC: 219 hits |
SPalmE:1185 | Thinon E et al. | 2018 | Homo sapiens | HeLa | Total cell lysate | NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling | Ortholog | in Chymotrypsin [PLS3] |
Chymotrypsin: 286 hits Trypsin: 1291 hits |
SPalmE:1191 | Won SJ et al. | 2018 | Homo sapiens | HEK293T | Total cell lysate | Click chemistry | x | List: 195 hits | |
SPalmE:1181 | Thinon E et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | NH2OH cleavage of thioester bond, Alk16 Labeling | Found | in HC |
HC: 244 hits MC: 187 hits LC: 120 hits |
SPalmE:1186 | Thinon E et al. | 2018 | Mus musculus | Macrophage Raw 264.7 | Total cell lysate | NH2OH cleavage of thioester bond, Alk16 Labeling | Found | in HC |
HC: 177 hits MC: 162 hits LC: 123 hits |
SPalmE:1260 | Wang Z et al. | 2018 | Bos taurus | Lens fiber cell | Total cell lysate | ABE, NH2OH cleavage of thioester bond, LC-MS | x | List: 52 hits | |
SPalmE:1259 | Dumoulin A et al. | 2018 | Mus musculus | F11 | Total membrane | ABE, NH2OH cleavage of thioester bond, LC-MS | x |
HC: 1 hits MC: 10 hits LC: 4 hits |
|
SPalmE:1303 | Zaręba-Kozioł M et al. | 2019 | Mus musculus | Brain | Postsynaptic density fraction | ABE, NH2OH cleavage of thioester bond, LC-MS | x | ||
SPalmE:1270 | Strassburger K et al. | 2019 | Drosophila melanogaster | Circa 160 L2 larvae | Total cell lysate | ABE, NH2OH cleavage of thioester bond, PAT KO, MS | x | List: 13 hits | |
SPalmE:1266 | Strassburger K et al. | 2019 | Drosophila melanogaster | Circa 160 L2 larvae | Total cell lysate | ABE, NH2OH cleavage of thioester bond, PAT KO, MS | Ortholog | in List [Q9VZW1, Q8IQD8, Q9VT88, Q8IQD7] | List: 157 hits |
SPalmE:1265 | Wang J et al. | 2019 | Mus musculus | 3T3-L1 | Total membrane | MS, BioID | x | List: 9 hits |
Summary table by organism
Organism | Total number of palmitoyl-proteome articles | Total number of palmitoyl-proteomes | Number of palmitoyl-proteomes containing this protein or an ortholog | % of palmitoyl-proteomes containing this protein or an ortholog | Orthologs |
---|---|---|---|---|---|
S. cerevisiae S288c | 1 | 1 | 0 | 0.0 | NA |
R. norvegicus | 2 | 3 | 0 | 0.0 | NA |
H. sapiens | 17 | 26 | 15 | 57.7 | PLS3_HUMAN |
M. musculus | 17 | 24 | 14 | 58.3 | Q3T9B7_MOUSE , Q5F284_MOUSE |
T. brucei brucei | 1 | 1 | 0 | 0.0 | NA |
P. falciparum | 1 | 2 | 2 | 100.0 | Q8IJH8_PLAF7 |
A. thaliana | 1 | 1 | 0 | 0.0 | NA |
S. pombe | 1 | 1 | 0 | 0.0 | NA |
C. neoformans var. grubii serotype A strain H99 | 1 | 2 | 0 | 0.0 | NA |
T. gondii | 2 | 2 | 0 | 0.0 | NA |
A. fumigatus | 1 | 1 | 0 | 0.0 | NA |
B. taurus | 1 | 1 | 0 | 0.0 | NA |
D. melanogaster | 1 | 2 | 1 | 50.0 | Q9VZW1_DROME , Q8IQD8_DROME , Q9VT88_DROME , Q8IQD7_DROME |