SwissPalm

Protein general information from UniProt

Protein names

Palmitoyltransferase ZDHHC7; EC 2.3.1.225; Zinc finger DHHC domain-containing protein 7; DHHC-7

Subcellular location

Golgi apparatus membrane (Probable)

Isoforms & protein length

Isoform 1 (main): 308 aa; Isoform 2 : 345 aa

Known functions

Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity). Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA. Palmitoyltransferase with broad specificity (PubMed:22031296, PubMed:28196865). Palmitoylates JAM3 (PubMed:28196865). Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity). hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]

Cross-references

Source	Identifiers
UniProt gene names	ZNF370, ZDHHC7
UniProt secondary AC	Q9NVD8, Q8WV42, D3DUM1
Refseq protein ID	NP_060210.2, NP_001139020.1, XP_011521523.1
IPI ID	IPI00019325, IPI00103014, IPI00180886, IPI00295279, IPI00221179, IPI00015608

Source	Identifiers
Ensembl protein	ENSP00000456782, ENSP00000341681, ENSP00000315604
Ensembl gene	ENSG00000153786

Enzymes

PAT/APT	Enzyme	Experiments
PAT	ZDHC7_HUMAN	SPalmE:1356 Li Q et al. (2020) []

Protein acyltransferase activity (PAT)

Substrate UniProt ID	Substrate description	Substrate isoform AC (site position)	Experiments
A4_HUMAN	Amyloid-beta precursor protein	P05067 (186,187)	SPalmE:309 Bhattacharyya R et al. (2013)
CFTR_HUMAN	Cystic fibrosis transmembrane conductance regulator	P13569	SPalmE:1113 McClure ML et al. (2014)
GNAQ_HUMAN	Guanine nucleotide-binding protein G	P50148	SPalmE:111 Tsutsumi R et al. (2009)
P4K2A_HUMAN	Phosphatidylinositol 4-kinase type 2-alpha	Q9BTU6	SPalmE:109 Lu D et al. (2012)
NDE1_HUMAN	Nuclear distribution protein nudE homolog 1	Q9NXR1 (274)	SPalmE:67 Shmueli A et al. (2010)
NDEL1_HUMAN	Nuclear distribution protein nudE-like 1	Q9GZM8 (273)	SPalmE:67 Shmueli A et al. (2010)
STMN2_RAT	Stathmin-2	P21818 (22,24)	SPalmE:1052 Levy AD et al. (2011) SPalmE:1053 Levy AD et al. (2011)
STMN3_RAT	Stathmin-3	Q9JHU6	SPalmE:1052 Levy AD et al. (2011)
ESR1_HUMAN	Estrogen receptor	P03372	SPalmE:102 Pedram A et al. (2012)
PRGR_HUMAN	Progesterone receptor	P06401	SPalmE:102 Pedram A et al. (2012)
ANDR_HUMAN	Androgen receptor	P10275	SPalmE:103 Pedram A et al. (2012)
FYN_HUMAN	Tyrosine-protein kinase Fyn	P06241	SPalmE:148 Mill P et al. (2009)
NOS3_HUMAN	Nitric oxide synthase, endothelial	P29474	SPalmE:141 Fernández-Hernando C et al. (2006)
TNR6_HUMAN	Tumor necrosis factor receptor superfamily member 6	P25445-1 (199) P25445 (199)	SPalmE:411 Rossin A et al. (2015) SPalmE:839 Rossin A et al. (2017)
SCRIB_HUMAN	Protein scribble homolog	Q14160 (4,10)	SPalmE:796 Chen B et al. (2016) SPalmE:798 Chen B et al. (2016)
JAM3_HUMAN	Junctional adhesion molecule C	Q9BX67 (264,265)	SPalmE:832 Aramsangtienchai P et al. (2017) SPalmE:835 Aramsangtienchai P et al. (2017)
IFM3_HUMAN	Interferon-induced transmembrane protein 3	Q01628	SPalmE:916 McMichael TM et al. (2017)

Copy in clipboard UniProt feature viewer

Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

Select all Deselect all

UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Techniques	Predicted
Q7K3T4	Q7K3T4_DROME	OrthoDB, InParanoid	D. melanogaster	anon-WO0118547.93, Dmel\CG8314, Dmel_CG8314, CG8314	Palmitoyltransferase	1/1	2	Yes
Q91WU6	ZDHC7_MOUSE	OMA, OrthoDB, InParanoid	M. musculus	Gramp2, Zdhhc7	Palmitoyltransferase ZDHHC7	1/17	1	Yes
Q923G5	ZDHC7_RAT	OrthoDB, InParanoid	R. norvegicus	Serz, Zdhhc7	Palmitoyltransferase ZDHHC7	0/2	0	Yes
F1N6U3	F1N6U3_BOVIN	OrthoDB	B. taurus	ZDHHC7	Palmitoyltransferase	0/1	0	Yes

Ortholog sequence alignment (CLUSTALW)

Validation experiments

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)
SPalmE:67	Shmueli A et al.	2010	Homo sapiens	HEK293	NA	PAT overexpression
SPalmE:102	Pedram A et al.	2012	Homo sapiens	MCF7	Non-nuclear membrane	Depletion of PAT by siRNA, [3H]palmitic acid labeling
SPalmE:103	Pedram A et al.	2012	Homo sapiens	LNCaP C4-2	Non-nuclear membrane	Depletion of PAT by siRNA, PAT overexpression, [3H]palmitic acid labeling
SPalmE:109	Lu D et al.	2012	Homo sapiens	HeLa	Total cell lysate	Depletion of PAT by siRNA, Substrate localization by fluorescence tag, [3H]palmitic acid labeling
SPalmE:111	Tsutsumi R et al.	2009	Homo sapiens	HeLa	Total cell lysate	2BP inhibition, Depletion of PAT by siRNA, IF localization, PAT localization by IF, PAT localization by fluorescent tag, PAT point mutation, Substrate localization by fluorescence tag, [3H]palmitic acid labeling
SPalmE:141	Fernández-Hernando C et al.	2006	Homo sapiens	EA.hy 926	Total cell lysate	Depletion of PAT by siRNA, [3H]palmitic acid labeling
SPalmE:148	Mill P et al.	2009	Homo sapiens	HEK293	NA	PAT overexpression, Point mutation, [3H]palmitic acid labeling
SPalmE:309	Bhattacharyya R et al.	2013	Homo sapiens	CHO	Lipid raft	, 2BP inhibition, ABE, NH2OH cleavage of thioester bond, Photo cleavable x-alk16 labeling, Point mutation, [3H]palmitic acid labeling
SPalmE:411	Rossin A et al.	2015	Homo sapiens	SW480	Total cell lysate	ABE, Co-IP of PAT and substrate, Depletion of PAT by siRNA, NH2OH cleavage of thioester bond, PAT point mutation, Point mutation
SPalmE:796	Chen B et al.	2016	Homo sapiens	HEK293-A	Total cell lysate	15-HDYA labeling, 2BP inhibition, Co-IP of PAT and substrate, Depletion of PAT by siRNA, MS, NH2OH cleavage of thioester bond, PAT overexpression, PAT point mutation, Point mutation
SPalmE:798	Chen B et al.	2016	Homo sapiens	MCF-10A	Total cell lysate	Depletion of PATs by SgRNA, IF localization, Point mutation
SPalmE:832	Aramsangtienchai P et al.	2017	Homo sapiens	HEK293T	Total cell lysate	C14N3 labeling, Depletion of PAT by shRNA, NH2OH cleavage of thioester bond, PAT overexpression, PAT point mutation, Point mutation
SPalmE:835	Aramsangtienchai P et al.	2017	Homo sapiens	A-549	Total cell lysate	C14N3 labeling, Depletion of PAT by shRNA
SPalmE:839	Rossin A et al.	2017	Homo sapiens	SW480	Total cell lysate	ABE, NH2OH cleavage of thioester bond, Point mutation
SPalmE:916	McMichael TM et al.	2017	Homo sapiens	HAP1	Total cell lysate	Alk16 Labeling, Depletion of PAT by siRNA
SPalmE:1052	Levy AD et al.	2011	Rattus norvegicus	HeLa	Golgi apparatus	Co-IP of PAT and substrate, PAT localization by IF, PAT localization by fluorescent tag, PAT overexpression, Point mutation, Substrate localization by fluorescence tag
SPalmE:1053	Levy AD et al.	2011	Rattus norvegicus	HEK293T	Total cell lysate	PAT overexpression, [3H]palmitic acid labeling
SPalmE:1113	McClure ML et al.	2014	Homo sapiens	HEK293T	Golgi apparatus	2BP inhibition, Co-IP of PAT and substrate, IF localization, NH2OH cleavage of thioester bond, PAT localization by IF, PAT overexpression, [3H]palmitic acid labeling
SPalmE:1356	Li Q et al.	2020	Homo sapiens	NA	NA	15-Hexadecynoyl-CoA labeling

Cysteine summary and predictions

Pos in alignment	46	50	88	111	116	130	169	172	173	174	183	186	189	197
Subcell. location	U	U	T	U	U	U	U	U	U	U	U	U	U	U
Disulfide	no	no	no				no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	helix	helix
UniProt secondary structure	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁴⁶	Cys⁵⁰	Cys⁸⁸				Cys¹³² HC	Cys¹³⁵ HC	Cys¹³⁶ HC	Cys¹³⁷ HC	Cys¹⁴⁶	Cys¹⁴⁹	Cys¹⁵²	Cys¹⁶⁰
Pos in isoform 2 CSS-Palm 4.0 PalmPred	Cys⁴⁶	Cys⁵⁰	Cys⁸⁸	Cys¹¹¹	Cys¹¹⁶	Cys¹³⁰	Cys¹⁶⁹ HC	Cys¹⁷² HC	Cys¹⁷³ HC	Cys¹⁷⁴ HC	Cys¹⁸³	Cys¹⁸⁶	Cys¹⁸⁹	Cys¹⁹⁷

Pos in alignment	203	230	237	245	261	283
Subcell. location	U	T	U	U	T	U
Disulfide	no	no	no	no	no	no
PSIPRED v.4.02 prediction
UniProt secondary structure
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys¹⁶⁶	Cys¹⁹³	Cys²⁰⁰	Cys²⁰⁸	Cys²²⁴	Cys²⁴⁶
Pos in isoform 2 CSS-Palm 4.0 PalmPred	Cys²⁰³	Cys²³⁰	Cys²³⁷	Cys²⁴⁵	Cys²⁶¹	Cys²⁸³

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

Tip: Keep CTRL key pressed down while clicking on column headers to do multiple sorting. This applies to any sortable table on this site.

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	x		HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	x		HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	x		HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	x		HC: 102 hits LC: 73 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	x		HC: 162 hits LC: 218 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	x		List: 214 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	x		HC HC: 352 hits LC LC: 8 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	x		List: 154 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	x		HC HC: 254 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	x		HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	x		List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	x		List: 238 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	x		List: 664 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	x		Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	x		List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	x		List: 436 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	x		List: 1348 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	x		List: 274 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	x		List: 226 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	x		List: 354 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	x		List: 354 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	x		HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	x		HC: 1079 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		List: 865 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in Palm. up with LPS [ZDHC7]	Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in List [ZDHC7]	List: 646 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in LPS treatment [ZDHC7]	LPS treatment: 646 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	x		HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	x		List: 1404 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	x		List: 1394 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	x		HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	x		HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	Ortholog	in List [Q7K3T4]	List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	0	0.0	NA
R. norvegicus	2	3	0	0.0	NA
H. sapiens	17	26	0	0.0	NA
M. musculus	17	25	3	12.0	ZDHC7_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	0	0.0	NA
S. pombe	1	1	0	0.0	NA
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	1	1	0	0.0	NA
D. melanogaster	1	2	1	50.0	Q7K3T4_DROME

References

Authors	Year	Reference title	PMID
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Kang R et al.	2008	Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.	19092927
Aramsangtienchai P et al.	2017	S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration.	28196865
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Yang W et al.	2010	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	19801377
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Shmueli A et al.	2010	Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity.	19927128
Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Lu D et al.	2012	Phosphatidylinositol 4-kinase IIα is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent manner.	22535966
Bhattacharyya R et al.	2013	Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts.	23825420
Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Chen B et al.	2016	ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity.	27380321
Martin BR et al.	2009	Large-scale profiling of protein palmitoylation in mammalian cells.	19137006
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Wei X et al.	2014	Insulin-regulated protein palmitoylation impacts endothelial cell function.	24357059
McClure ML et al.	2014	S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment.	24475974
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Rossin A et al.	2015	Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability.	25301068
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Peng T et al.	2015	Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.	25575299
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
Santiago-Tirado FH et al.	2015	A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.	25970403
Wang Z et al.	2018	Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.	30489624
Rossin A et al.	2017	Detection of S-Acylated CD95 by Acyl-Biotin Exchange.	28078593
Wilson JP et al.	2011	Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants.	21076176
Mill P et al.	2009	Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.	19956733
Levy AD et al.	2011	Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases.	21471001
Strassburger K et al.	2019	Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.	30735487
Martin BR et al.	2011	Global profiling of dynamic protein palmitoylation.	22056678
Jones ML et al.	2012	Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.	22901544
Foe IT et al.	2015	Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.	26468752
Gould NS et al.	2015	Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.	26165157
Fernández-Hernando C et al.	2006	Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase.	16864653
Serwa RA et al.	2015	Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.	26256475
Hernandez JL et al.	2016	Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.	27030425
Zaręba-Kozioł M et al.	2019	Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins.	31311849
Thinon E et al.	2018	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.	29575903
Tsutsumi R et al.	2009	Identification of G protein alpha subunit-palmitoylating enzyme.	19001095
Li Q et al.	2020	Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.	32259481
Morrison E et al.	2015	Quantitative analysis of the human T cell palmitome.	26111759
Marin EP et al.	2012	Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.	22496122
Merrick BA et al.	2011	Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.	21785166
Emmer BT et al.	2011	Global analysis of protein palmitoylation in African trypanosomes.	21193548
Ren W et al.	2013	Proteomic analysis of protein palmitoylation in adipocytes.	23599907
Pedram A et al.	2012	DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.	22031296
Fang C et al.	2016	Identification of Palmitoylated Transitional Endoplasmic Reticulum ATPase by Proteomic Technique and Pan Antipalmitoylation Antibody.	26865113
Roth AF et al.	2006	Global analysis of protein palmitoylation in yeast.	16751107
McMichael TM et al.	2017	The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity.	29079573
Hemsley PA et al.	2013	A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis.	23252521

Q9NXF8 ZDHC7_HUMAN