SwissPalm

Q9VUW9 HIP14_DROME

General info Cross-references PAT activity Sequences Orthologs Ortholog sequences Validation experiments Predictions Palmitoyl-proteomes References

Palmitoyl-proteomes

1/1 article for fruit fly
5 orthologs

Palmitoyl-proteome experiments

Validation experiments

0 experiment
3 orthologs

Curated sites & Enzymes

0 site from validation experiments^*
0 site from palmitoyl-proteomes^*
No PAT known
No APT known
^*In main isoform only

Predictions

Predicted

4 cysteines in main isoform

Predictions

Protein general information from UniProt

Protein names

Palmitoyltransferase Hip14; EC 2.3.1.225; Huntingtin-interacting protein 14 homolog

Subcellular location

Golgi apparatus membrane; Cell junction; synapse; presynaptic cell membrane; Synapse; Presynaptic cell membrane

Isoforms & protein length

Isoform 1 (main): 637 aa

Known functions

The DHHC domain is required for palmitoyltransferase activity. RNAi-mediated knockdown causes reduced basal secretion of Sog. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. Probable palmitoyltransferase which is required for photoreceptor synaptic transmission and for the correct expression and localization of palmitoylated protein Csp and synaptosomal-associated protein Snap25 (PubMed:18158335, PubMed:18032660). Probably palmitoylates Csp (PubMed:18158335). Probably also palmitoylates the dorsal-ventral patterning protein Sog and promotes its secretion and activity and the stabilization of the membrane-bound form (PubMed:20599894). Required for synaptic vesicle exocytosis (PubMed:18158335). hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] Interacts with dorsal-ventral patterning protein Sog. Localizes to the Golgi apparatus in non-neuronal cells and located primarily in presynaptic terminals in neurons. In stage 13-15 embryos, expressed in the central nervous system. At the third instar larval stage, expressed in the ventral nerve cord and is enriched in the neuropil. Interacts with dorsal-ventral patterning protein Sog. Probable palmitoyltransferase which is required for photoreceptor synaptic transmission and for the correct expression and localization of palmitoylated protein Csp and synaptosomal-associated protein Snap25 (PubMed:18158335, PubMed:18032660). Probably palmitoylates Csp (PubMed:18158335). Probably also palmitoylates the dorsal-ventral patterning protein Sog and promotes its secretion and activity and the stabilization of the membrane-bound form (PubMed:20599894). Required for synaptic vesicle exocytosis (PubMed:18158335). Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA. Localizes to the Golgi apparatus in non-neuronal cells and located primarily in presynaptic terminals in neurons. In stage 13-15 embryos, expressed in the central nervous system. At the third instar larval stage, expressed in the ventral nerve cord and is enriched in the neuropil. The DHHC domain is required for palmitoyltransferase activity. RNAi-mediated knockdown causes reduced basal secretion of Sog. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.

Cross-references

Source	Identifiers
UniProt gene names	Dmel_CG6017, CG6017, Hip14

Source	Identifiers
Ensembl gene	FBgn0259824

Protein acyltransferase activity (PAT)

Substrate UniProt ID	Substrate description	Substrate isoform AC (site position)	Experiments
DNJC5_DROME	DnaJ homolog subfamily C member 5 homolog	Q03751	SPalmE:759 Ohyama T et al. (2007)
Q5U110_DROME	Mothers against decapentaplegic homolog	Q5U110 (556)	SPalmE:915 Li W et al. (2017)

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Isoform sequence alignment

Tip: Hover over an amino acid to display its position!

Orthologs

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UniProt AC	UniProt ID	Orthology source	Organism	Gene names	Protein name	Palmitome articles	Times validated	Techniques	Sites	Predicted
P39010	AKR1_YEAST	OMA, InParanoid	S. cerevisiae S288c	YD9230B.03C, D9954.9, YDR264C, AKR1	Palmitoyltransferase AKR1	1/1	3	1	0	No
Q8IUH4	ZDH13_HUMAN	OrthoDB, Ensembl, InParanoid	H. sapiens	HIP3RP, HIP14L, ZDHHC13	Palmitoyltransferase ZDHHC13	5/17	1	3	0	Yes
Q80TN5	ZDH17_MOUSE	OMA, OrthoDB, Ensembl, InParanoid	M. musculus	Kiaa0946, Hip14, Zdhhc17	Palmitoyltransferase ZDHHC17	4/17	3	2	2	Yes
Q8IUH5	ZDH17_HUMAN	OMA, OrthoDB, Ensembl, InParanoid	H. sapiens	HSPC294, KIAA0946, HYPH, HIP3, HIP14, ZDHHC17	Palmitoyltransferase ZDHHC17	3/17	0	2	0	Yes
Q9CWU2	ZDH13_MOUSE	OrthoDB, Ensembl	M. musculus	Hip14l, Zdhhc13	Palmitoyltransferase ZDHHC13	6/17	0	3	0	Yes
E1BJK1	E1BJK1_BOVIN	OMA, OrthoDB, Ensembl, InParanoid	B. taurus	ZDHHC17	Palmitoyltransferase	0/1	0	0	0	Yes
E9PTT0	ZDH17_RAT	OMA, OrthoDB, Ensembl, InParanoid	R. norvegicus	Zdhhc17	Palmitoyltransferase ZDHHC17	0/2	0	0	0	Yes
E9PU37	E9PU37_RAT	Ensembl	R. norvegicus	Zdhhc13	Palmitoyltransferase	0/2	0	0	0	Yes
Q3TRB3	Q3TRB3_MOUSE	Ensembl	M. musculus	Zdhhc17	Uncharacterized protein	0/17	0	0	0	No
D3YY07	D3YY07_MOUSE	Ensembl	M. musculus	Zdhhc13	Palmitoyltransferase	0/17	0	0	0	No
Q3EC11	ZDHC2_ARATH	OMA	A. thaliana	PAT23, T1O16.20, At2g14255	Probable protein S-acyltransferase 23	0/1	0	0	0	No
Q12013	AKR2_YEAST	InParanoid	S. cerevisiae S288c	OR26.25, YOR034C, AKR2	Probable palmitoyltransferase AKR2	0/1	0	0	0	No
Q09701	AKR1_SCHPO	InParanoid	S. pombe	SPAC2F7.10, akr1	Palmitoyltransferase akr1	0/1	0	0	0	No
Q8IE90	Q8IE90_PLAF7	OMA, InParanoid	P. falciparum	PF3D7_1322500	Palmitoyltransferase	0/1	0	0	0	Yes
I1VCB2	I1VCB2_ARATH	OMA	A. thaliana	TIP1, At5g20350.1	S-acyltransferase	0/1	0	0	0	Yes
F1MCX6	F1MCX6_BOVIN	OrthoDB, Ensembl	B. taurus	ZDHHC13	Palmitoyltransferase	0/1	0	0	0	Yes
F8VX48	F8VX48_HUMAN	Ensembl	H. sapiens	ZDHHC17	Palmitoyltransferase ZDHHC17	0/17	0	0	0	No
H0YIK0	H0YIK0_HUMAN	Ensembl	H. sapiens	ZDHHC17	Palmitoyltransferase ZDHHC17	0/17	0	0	0	No
F8VPW2	F8VPW2_HUMAN	Ensembl	H. sapiens	ZDHHC17	Palmitoyltransferase ZDHHC17	0/17	0	0	0	No
H0YI74	H0YI74_HUMAN	Ensembl	H. sapiens	ZDHHC17	Palmitoyltransferase ZDHHC17	0/17	0	0	0	Yes

Ortholog sequence alignment (CLUSTALW)

Validation experiments

ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)
SPalmE:759	Ohyama T et al.	2007	Drosophila melanogaster	Brain	Total cell lysate	IF localization, NH2OH cleavage of thioester bond, PAT localization by fluorescent tag
SPalmE:915	Li W et al.	2017	Drosophila melanogaster	S2	Plasma Membrane	2BP inhibition, Co-IP of PAT and substrate, NH2OH cleavage of thioester bond, PAT KO, PAT overexpression, Point mutation, Substrate overexpression, Thiopropyl captivation

Cysteine summary and predictions

Pos in alignment	6	14	146	148	190	302	329	381	392	432	435	446	449	452
Subcell. location	C	C	C	C	C	T	T	T	T	C	C	C	C	C
Disulfide	no	no	no	no	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	coil	coil	helix	coil	helix	helix	helix	helix	coil	strand	coil	coil	strand
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁶ HC	Cys¹⁴	Cys¹⁴⁶ HC	Cys¹⁴⁸ MC	Cys¹⁹⁰ MC	Cys³⁰²	Cys³²⁹ LC	Cys³⁸¹	Cys³⁹²	Cys⁴³²	Cys⁴³⁵	Cys⁴⁴⁶	Cys⁴⁴⁹ HC	Cys⁴⁵²

Pos in alignment	460	466	486	501	518	542	549	589	591	626
Subcell. location	C	C	T	E	E	C	C	C	C	C
Disulfide	no	no	no	no	no	no	no	no	no	no
PSIPRED v.4.02 prediction	coil	helix	helix	coil	coil	helix	helix	coil	coil	coil
UniProt secondary structure	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Pos in isoform 1 [Main] CSS-Palm 4.0 PalmPred	Cys⁴⁶⁰	Cys⁴⁶⁶	Cys⁴⁸⁶ HC	Cys⁵⁰¹	Cys⁵¹⁸	Cys⁵⁴²	Cys⁵⁴⁹	Cys⁵⁸⁹	Cys⁵⁹¹	Cys⁶²⁶

Legend

Subcell. location

U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear

Prediction confidence

Cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) and validated (in terms of disulfide bonds and cellular location) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
PalmPred: High confidence (score > 0.4), Medium confidence (0.1 < score < 0.4), Low confidence (score < 0.1), Not predicted.

Palmitoyl-proteome experiments

List of palmitoyl-proteomes

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ID of the experiment	Reference	Year	Organism	Cell type	Subcellular location	Technique(s)	Found?	In list	All lists
SPalmE:14	Roth AF et al.	2006	Saccharomyces cerevisiae	Isogenic LRB759	Total membrane	ABE	Ortholog	in HC [AKR1]	HC HC: 48 hits
SPalmE:13	Kang R et al.	2008	Rattus norvegicus	Cortical neuron	Synaptosomal membrane	ABE	x		HC: 107 hits LC: 308 hits
SPalmE:6	Martin BR et al.	2009	Homo sapiens	Jurkat	Total membrane	Click chemistry	Ortholog	in LC [ZDH17, ZDH13]	HC: 127 hits LC: 188 hits List: 0 hits
SPalmE:10	Yount JS et al.	2010	Mus musculus	Dendritic cell	Total cell lysate	Click chemistry	x		HC: 59 hits LC: 105 hits
SPalmE:577	Yang W et al.	2010	Homo sapiens	DU145	Non-lipid raft	ABE	x		HC: 63 hits LC: 147 hits
SPalmE:578	Yang W et al.	2010	Homo sapiens	DU145	Lipid raft	ABE	x		HC: 102 hits LC: 73 hits
SPalmE:1	Yang W et al.	2010	Homo sapiens	DU145	Total membrane	ABE	x		HC: 162 hits LC: 218 hits
SPalmE:2	Dowal L et al.	2011	Homo sapiens	Platelet	Total membrane	ABE	x		List: 214 hits
SPalmE:5	Forrester MT et al.	2011	Homo sapiens	HEK293	Total membrane	ARAC	x		List: 69 hits
SPalmE:7	Wilson JP et al.	2011	Homo sapiens	Jurkat	Total cell lysate	Click chemistry	x		HC: 164 hits LC: 178 hits
SPalmE:8	Merrick BA et al.	2011	Mus musculus	Macrophage Raw 264.7	Total membrane	ABE	x		List: 69 hits
SPalmE:12	Martin BR et al.	2011	Mus musculus	BW5147-derived mouse T-cell hybridoma cell	Total membrane	Click chemistry	x		HC HC: 352 hits LC LC: 8 hits
SPalmE:511	Emmer BT et al.	2011	Trypanosoma brucei brucei	NA	Total cell lysate	ABE	x		List: 126 hits
SPalmE:3	Ivaldi C et al.	2012	Homo sapiens	B-cell	Total membrane	ABE	x		HC HC: 93 hits
SPalmE:4	Marin EP et al.	2012	Homo sapiens	Umbilical vein blood	NA	ABE	x		List: 154 hits
SPalmE:11	Li Y et al.	2012	Mus musculus	Neural stem cell	Total cell lysate	Click chemistry	Ortholog	in HC [ZDH13, ZDH17]	HC HC: 254 hits
SPalmE:162	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	ABE	x		HC: 100 hits LC: 217 hits
SPalmE:580	Jones ML et al.	2012	Plasmodium falciparum	Whole organism	Total cell lysate	Click chemistry, SILAC	x		HC: 79 hits LC: 89 hits
SPalmE:15	Hemsley PA et al.	2013	Arabidopsis thaliana	Heyn Col-4 ecotype root cell suspension	Microsomal membrane	ABE	x		HC: 122 hits MC: 94 hits LC: 366 hits
SPalmE:119	Wan J et al.	2013	Mus musculus	Brain	Total cell lysate	ABE	x		List: 378 hits
SPalmE:160	Zhang MM et al.	2013	Schizosaccharomyces pombe	Whole organism	Total cell lysate	Click chemistry	x		List: 238 hits
SPalmE:9	Ren W et al.	2013	Mus musculus	3T3-L1 and epididymal fat pads	Total membrane	ARAC	x		List: 664 hits
SPalmE:184	Wei X et al.	2014	Homo sapiens	HUVEC	Total cell lysate	ABE	Ortholog	in List [ZDH17, ZDH13]	Palm decreased: 40 hits Palm increased: 33 hits List: 367 hits
SPalmE:507	Chesarino NM et al.	2014	Mus musculus	DC2.4	Total cell lysate	Click chemistry	Ortholog	in List [ZDH13, ZDH17]	List: 246 hits
SPalmE:508	Chesarino NM et al.	2014	Mus musculus	MEF	Total cell lysate	Click chemistry	x		List: 436 hits
SPalmE:504	Serwa RA et al.	2015	Homo sapiens	RPE-1	Total cell lysate	SILAC, 16-HDYA labeling	Ortholog	in List [ZDH17, ZDH13]	List: 1348 hits
SPalmE:505	Morrison E et al.	2015	Homo sapiens	Primary CD4 + T cells	Total cell lysate	ABE, In gel SILAC labeling	Ortholog	in List [ZDH17, ZDH13]	List: 274 hits
SPalmE:506	Morrison E et al.	2015	Homo sapiens	Jurkat	Total cell lysate	Click chemistry, SILAC	Ortholog	in List [ZDH17, ZDH13]	List: 226 hits
SPalmE:509	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 426 hits
SPalmE:510	Santiago-Tirado FH et al.	2015	Cryptococcus neoformans	NA	Total cell lysate	Click chemistry	x		List: 354 hits
SPalmE:529	Colquhoun DR et al.	2015	Homo sapiens	174 x CEM.T1	Total cell lysate	Click-IT Palmitic Acid labeling	x		List: 113 hits
SPalmE:536	Foe IT et al.	2015	Toxoplasma gondii	NA	Total membrane	Click chemistry	x		HC: 210 hits MC: 72 hits
SPalmE:540	Gould NS et al.	2015	Mus musculus	Liver	Total cell lysate	APE	x		List: 780 hits
SPalmE:619	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Alk16 Labeling	Ortholog	in List [ZDH17, ZDH13]	List: 354 hits
SPalmE:620	Peng T et al.	2015	Homo sapiens	HEK293	Total cell lysate	Photo cleavable x-alk16 labeling	Ortholog	in List [ZDH17, ZDH13]	List: 354 hits
SPalmE:698	Pinner AL et al.	2016	Homo sapiens	Brain	Total cell lysate	ABE	x		List: 216 hits
SPalmE:723	Hernandez JL et al.	2016	Homo sapiens	MCF7	Total cell lysate	Alk16 Labeling	x		List: 1353 hits
SPalmE:724	Fang C et al.	2016	Homo sapiens	SW480	NA	ARAC	x		List: 100 hits
SPalmE:829	Upadhyay S et al.	2016	Aspergillus fumigatus	Conidia	NA	ABE	x		List: 133 hits
SPalmE:902	Caballero MC et al.	2016	Toxoplasma gondii	whole parasite lysates	NA	ABE	x		HC: 164 hits
SPalmE:909	Thinon E et al.	2016	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Alk16 Labeling	Ortholog	in LC [ZDH13, ZDH17]	HC: 197 hits MC: 143 hits LC: 302 hits
SPalmE:903	Collins MO et al.	2017	Mus musculus	Forebrain	NA	ABE	Ortholog	in HC [ZDH13, ZDH17]	HC: 1079 hits
SPalmE:906	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ABE	x		List: 193 hits
SPalmE:907	Edmonds MJ et al.	2017	Rattus norvegicus	Brain	NA	ARAC	x		List: 95 hits
SPalmE:855	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	Ortholog	in List [ZDH13, ZDH17]	List: 865 hits
SPalmE:993	Shen LF et al.	2017	Mus musculus	Liver	Total membrane	ARAC	x		ZDHHC13 substrates: 16 hits
SPalmE:1187	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Ortholog	in HC,MC [ZDH13, ZDH17]	HC: 281 hits MC: 139 hits LC: 113 hits
SPalmE:908	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in Palm. up with LPS [ZDH13, ZDH17]	Palm. up with LPS: 156 hits Palm. down with LPS: 189 hits
SPalmE:919	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in List [ZDH13, ZDH17]	List: 646 hits
SPalmE:920	Sobocińska J et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	Click chemistry	Ortholog	in LPS treatment [ZDH13, ZDH17]	LPS treatment: 646 hits
SPalmE:1183	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	x		HC: 132 hits MC: 138 hits LC: 110 hits
SPalmE:1182	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	ARAC	Ortholog	in HC,MC [ZDH13, ZDH17]	HC: 198 hits MC: 143 hits LC: 120 hits
SPalmE:1192	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	Click chemistry	x		List: 984 hits
SPalmE:1194	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC,	Ortholog	in List [ZDH17, ZDH13]	List: 1404 hits
SPalmE:1193	Won SJ et al.	2018	Homo sapiens	HAP1	Total cell lysate	ARAC	Ortholog	in List [ZDH17, ZDH13]	List: 1394 hits
SPalmE:1203	Zhang X et al.	2018	Mus musculus	Brain	Total membrane	Enrichment by magnetic nanoparticles	x		HC: 917 hits MC: 352 hits LC: 15 hits
SPalmE:1184	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	ARAC	x		HC: 545 hits MC: 415 hits LC: 219 hits
SPalmE:1185	Thinon E et al.	2018	Homo sapiens	HeLa	Total cell lysate	NH2OH cleavage of thioester bond, LC-MS, Alk16 Labeling	x		Chymotrypsin: 286 hits Trypsin: 1291 hits
SPalmE:1191	Won SJ et al.	2018	Homo sapiens	HEK293T	Total cell lysate	Click chemistry	x		List: 195 hits
SPalmE:1181	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	Ortholog	in MC [ZDH13, ZDH17]	HC: 244 hits MC: 187 hits LC: 120 hits
SPalmE:1186	Thinon E et al.	2018	Mus musculus	Macrophage Raw 264.7	Total cell lysate	NH2OH cleavage of thioester bond, Alk16 Labeling	Ortholog	in MC [ZDH13, ZDH17]	HC: 177 hits MC: 162 hits LC: 123 hits
SPalmE:1260	Wang Z et al.	2018	Bos taurus	Lens fiber cell	Total cell lysate	ABE, NH2OH cleavage of thioester bond, LC-MS	x		List: 52 hits
SPalmE:1259	Dumoulin A et al.	2018	Mus musculus	F11	Total membrane	ABE, NH2OH cleavage of thioester bond, LC-MS	Ortholog	in LC [ZDH13, ZDH17]	HC: 1 hits MC: 10 hits LC: 4 hits
SPalmE:1303	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1333	Zaręba-Kozioł M et al.	2019	Mus musculus	Brain	Postsynaptic density fraction	ABE, NH2OH cleavage of thioester bond, LC-MS	x
SPalmE:1270	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	x		List: 13 hits
SPalmE:1266	Strassburger K et al.	2019	Drosophila melanogaster	Circa 160 L2 larvae	Total cell lysate	ABE, NH2OH cleavage of thioester bond, PAT KO, MS	Found	in List	List: 157 hits
SPalmE:1265	Wang J et al.	2019	Mus musculus	3T3-L1	Total membrane	MS, BioID	x		List: 9 hits

Summary table by organism

Organism	Total number of palmitoyl-proteome articles	Total number of palmitoyl-proteomes	Number of palmitoyl-proteomes containing this protein or an ortholog	% of palmitoyl-proteomes containing this protein or an ortholog	Orthologs
S. cerevisiae S288c	1	1	1	100.0	AKR1_YEAST
R. norvegicus	2	3	0	0.0	NA
H. sapiens	17	26	9	34.6	ZDH17_HUMAN , ZDH13_HUMAN
M. musculus	17	25	13	52.0	ZDH13_MOUSE , ZDH17_MOUSE
T. brucei brucei	1	1	0	0.0	NA
P. falciparum	1	2	0	0.0	NA
A. thaliana	1	1	0	0.0	NA
S. pombe	1	1	0	0.0	NA
C. neoformans var. grubii serotype A strain H99	1	2	0	0.0	NA
T. gondii	2	2	0	0.0	NA
A. fumigatus	1	1	0	0.0	NA
B. taurus	1	1	0	0.0	NA
D. melanogaster	1	2	1	50.0	M9PFE4_DROME

References

Authors	Year	Reference title	PMID
Edmonds MJ et al.	2017	Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.	28607426
Collins MO et al.	2017	Global, site-specific analysis of neuronal protein S-acylation.	28680068
Colquhoun DR et al.	2015	Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.	25914232
Ohyama T et al.	2007	Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles.	18158335
Li Y et al.	2012	DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.	22081607
Thinon E et al.	2016	Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.	27350074
Kang R et al.	2008	Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.	19092927
Wang J et al.	2019	DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.	30605677
Yang W et al.	2010	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	19801377
Upadhyay S et al.	2016	Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation.	27879337
Won SJ et al.	2018	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	29733200
Pinner AL et al.	2016	Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.	26876311
Dowal L et al.	2011	Proteomic analysis of palmitoylated platelet proteins.	21813449
Martin BR et al.	2009	Large-scale profiling of protein palmitoylation in mammalian cells.	19137006
Chesarino NM et al.	2014	Chemoproteomics reveals Toll-like receptor fatty acylation.	25371237
Li W et al.	2017	Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling.	29180412
Ivaldi C et al.	2012	Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.	22615937
Caballero MC et al.	2016	Identification of new palmitoylated proteins in Toxoplasma gondii.	26825284
Wei X et al.	2014	Insulin-regulated protein palmitoylation impacts endothelial cell function.	24357059
Dumoulin A et al.	2018	S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.	30319353
Forrester MT et al.	2011	Site-specific analysis of protein S-acylation by resin-assisted capture.	21044946
Zhang MM et al.	2013	Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.	23843742
Zhang X et al.	2018	Ultradeep Palmitoylomics Enabled by Dithiodipyridine-Functionalized Magnetic Nanoparticles.	29660268
Peng T et al.	2015	Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.	25575299
Wan J et al.	2013	Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.	24211138
Shen LF et al.	2017	Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.	28526873
Sobocińska J et al.	2018	Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies.	29217618
Yount JS et al.	2010	Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.	20601941
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